CentoCloud®

THE DIGITAL BIOINFORMATICS SOLUTION

Accelerate your lab´s capabilities

You outsource complex samples forNGS analysis

Bioinformatics analysis can’t be executeddue to missing diagnostic software

You want to invest in cost-e� ectiveNGS technology

You lack trained professionals in NGS

You want to build and strengthen your local NGS knowledge and capabilities

You want to implement e� cient test systems with new technology

You want to expand your diagnostic portfolio

You want to bene� t from local regulationand reimbursement policies when testing is done locally

When is CentoCloud® rightfor your lab?

Molecular diagnostics – shifting the paradigm

Clinical interpretation is the real challenge of any diagnostic lab – CentoCloud® is CENTOGENE’s unique one‑stop solution!

Quality medical reports require effi cient access to diagnostic bioinformatics, variant annotation, and clinical interpretation.

PRESENT

Sequencing

Diagnostic interpretation

PAST

Sequencing

Diagnostic interpretation

What is CentoCloud®?

CentoCloud® is a service specifi cally designed for human genetic laboratories to support the execution of high standard next generation sequencing diagnostics.

This fully automated bioinformatics pipeline analyzes pre‑produced NGS data based on CENTOGENE’s validated gene panels, annotated with data from our proprietary mutation database (CentoMD®).

How it works

What it offers

Bioinformatics pipeline development and an efficient gene panel design

Direct access to CentoMD®, the world‘s largest and best‑curated databank of rare genetic disorders

Comprehensive curation of clinical evidence and interpretation by medical experts

Fully validated bioinformatics pipeline

Workstation setup & validation ‑ if necessary quality management and accreditation

Technical & medical consulting ‑ training and mentoring in all relevant questions

Sequencingwith CENTOGENE gene panels and

ready-to-use protocols

Information on variant classification

& interpretation(reporting optional)

Fully-automatedbioinformatics

solution

CentoMD® annotation

Interpretation & reporting

(optional)

Data transfer via FileCloud

Data transfer via FileCloud

CentoCloud® significantly reduces costs

CentoCloud® digital services making a real difference

FULLY-AUTOMATED BIOINFORMATICS SOLUTION

Highly automated bioinformatics pipeline for accelerated diagnostics:

• Conversion of raw sequencing reads to FASTQ format

• Alignment to genomic reference sequence

• Variant calling and annotation with public databases

CentoMD® ANNOTATION

INTERPRETATION & REPORTING BY MEDICAL EXPERTS

Filtered variant list with CentoMD® annotation (genotype‑phenotype database for rare diseases)

• Clear diagnostic statement

• Classification of identified variants following international guidelines (CMGS/ACMG)

• References to publications supporting sources

• Description of the applied testing method

No need to order large batch sizes of enrichment reactions

Optimize your enrichment storage: only store what you need

Our built-in sources: OMIM, HGMD-Professional, CentoMD®

CENTOGENE provides regular technical and medical updates

Benefit from our extensive validation of NGS-kits incl. CNV

No third party softwarerequired for interpretation

Benefit from wholesalerebates from CENTOGENE

Assay-development

Storage Assay-validation

Softwarelicensing

Technical updates

Consumablecosts

Validated diagnostic

Bioinformaticpipeline

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CLIA #99D2049715

customer.support@centogene.com+49 (0)381 80 113 - 416+49 (0)381 80 113 - 401

Please visit our website for more information:

www.centogene.com

CONTACT DETAILS:

CENTOGENE GmbHAm Strande 718055 RostockGermany