Center for Cancer Research Overview/uploads/... · • Advanced Preclinical Research •...
Transcript of Center for Cancer Research Overview/uploads/... · • Advanced Preclinical Research •...
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Center for Cancer Research Overview
Center to Reduce Cancer Health Disparities Workshop
Glenn Merlino, Ph.D.
Acting Scientific Director for Basic Research
May 2016
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CCR is part of the Intramural Research Program (IRP) of NIH
EXTRAMURAL
Grants Programs Centers
INTRA MURAL
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VISION Integrate basic, translational, and clinical
research to make cancer preventable, curable, or chronically manageable
Discovery-driven Basic Research
Clinical Trials & Patient Care
Translational Research
Clinical Research
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225 PIs ~ $400M budget
Bethesda & Frederick
24 Basic
Science Laboratories
19 Clinical
Research Branches
3 Goal/Theme-
Oriented Programs
The CCR in numbers
190 postbaccalaureate/ predoctoral students 767 postdoctoral/ clinical fellows
335 summer students
226 staff scientists/staff clinicians 430 technical lab staff
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A network of Labs/Branches • 46 Labs/Branches/Programs
• NIH Interest Groups - More than 80
• Centers of Excellence • Chromosome Biology • Immunology • Genomics • Genitourinary Malignancies • HIV
• Initiatives
• Rare Tumors • Advanced Preclinical Research • Comparative Oncology • Microbiome
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The NCI CCR is a distinctive research environment
§ Bottom-up environment: Projects are investigator-driven
§ High-risk, high-impact research and technology development is encouraged
§ Secure resources
§ Highly interactive, interdisciplinary culture amongst basic and clinical scientists
§ Efficient bench-to-bedside-to-bench translation through access to the world’s largest clinical research hospital
§ Emphasis on underdeveloped research topics, emerging areas, rare cancers and underserved patient populations
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What kind of research do we do?
Basic 49%
Clinical Translational
51%
§ Full spectrum from basic to clinical
§ High-risk, high-reward
§ Long time horizon
§ Creative, innovative, transformational, unique
§ Work that might not be possible in the extramural environment due to limitations in funding, infrastructure, patient populations
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Interdisciplinary Strengths of CCR’s Research Portfolio
33%
14%
11%
11%
11%
8%
7% 5%
Cancer Biology
Immunology
Chromosome Biology/Epigenetics
Chemistry/Structural Biology/Biophysics
Cell and Developmental Biology
HIV/ Cancer Virology
Molecular Biology/Biochemistry/Microbiology
Genetics and Genomics
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The NCI Intramural Clinical Research Program § The NIH is home to the largest clinical research center in the world
§ The NCI is one of its major users
§ The NIH clinical center is not a regular hospital § It is dedicated to patient-intensive clinical research and to develop new
approaches for prevention, diagnosis, and treatment of cancer
§ The NCI intramural clinical program is a resource for both basic and clinical scientists
§ Translate basic discoveries to the point of first-in-human use
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Examples of groundbreaking CCR research
§ Human Papilloma Virus
§ Gene therapy
§ Immunotherapy
§ Imaging methods (basic and clinical)
§ Chromatin biology
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CCR Training
Training programs exist for: High School students
College students
Post Baccalaureate students
Veterinary School students
Medical and Dental School students
Post Doctoral Training -- Ph.D. / D.V.M.
Post Doctoral Training -- M.D.
Clinical Fellowship Program
Professor, Scientist, Clinician, Tech, Admin, etc.
Student
Undergrad
Graduate
Postdoc
Junior PI
CCR offers training to young scientists at several levels of education:
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• State-of-the-art laboratory facilities, technology, and equipment
• Scientific and professional skills workshops and training
• Lectures and courses by eminent scientists
• Mentoring in a collaborative, team-focused environment
• Competitive stipends, paid leave, and medical insurance
Why Train at the NIH?
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CCR Cores
Animal Resources
Imaging and
Microscopy
Nanotechnology
Clinical Research Support
Bioinformatics/ Computing
Flow Cytometry
Metabolomics
Drug Discovery
Chemistry/ Structural Biology
Cell Banking
and Aliquoting
Pharmacology
Genetics/ Genomics
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Specialty CCR Programs
• Johns Hopkins University partnership in Drug Discovery Technologies • Associate Clinical Investigator Development Program • NCI/FDA Interagency Oncology Task Force (IOTF) Research and Regulatory Review
Fellowship • Summer Cancer Research Interns (CRI) Program for students from underrepresented
groups or disadvantaged backgrounds • Comparative Molecular Pathology Research Training Program • Sallie Rosen Kaplan fellowship program to retain women in independent science careers • Center for Cancer Training, Intramural Workforce Diversity Branch to increase scientific
workforce diversity
https://ccr.cancer.gov/training
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Comparative Biomedical Scientists Training Program Trainees
Michigan(State(University(NCI(
Laboratory(of(Cancer(Biology((and(Gene:cs(
Metasta&c(Prostate((Cancer(
Ian&Moore,&D.V.M.( Anne&Sally&Davis,&D.V.M.(Heather&Tillman,&D.V.M.&Diplomate,&ACVP( Leah&Zadrozny,&D.V.M.(
Michigan(State(University(NIAID(
Laboratory(of(Infec:ous(Diseases(
Pandemic(Influenza(A(
NC(State(University(NIAID(
Laboratory(of(Infec:ous(Diseases(
Pandemic(Influenza(A(
NC(State(University(NHLBI(
Laboratory(of(Cardiac(Energe:cs(
Coronary(Atherosclerosis(
!
Sarah&Cramer,&D.V.M.&Diplomate,&ACVP(
Helen&Michael,&D.V.M.&Diplomate,&ACVP(
University(of(Maryland(NCI(
((((Laboratory(of(Cancer(Biology(and(Gene:cs(Melanoma(
University(of(Maryland(NCI(
Laboratory(of(Experimental(Immunology(
Effects(of(Microbiome(On(Cancer(
Purdue(University(NIAID(
Laboratory(of(Virology(Highly(Pathogenic(
Viruses(
Current Trainees - 2014
Michigan(State(University(NCI&
Pathology(Training/(Graduate(Studies(
Caroline&Andrews,&D.V.M.&Laura&Baseler,&D.V.M.&Diplomate,&ACVP(
Tiffany&Lyle,&D.V.M.&Diplomate,&ACVP(Purdue(University(
NCI(Laboratory(of(Molecular(
Pharmacology(Breast(Cancer((
Metastases(in(Brain(
Kara&Corps,&D.V.M.(NC(State(University(NINDS(
Neuroimmunology(Branch(Trauma&c(Brain(Injury(
Amy&McCalla,&D.V.M.(NC(State(University(
NCI(Pediatric(Oncology(Branch(Ewing’s(Sarcoma(((
Michigan(State(University(NCI&
Pathology(Training/(Graduate(Studies(
Jessica&Beck,&D.V.M.&Joy&Gary,&D.V.M.&Diplomate,&ACVP(
Michigan(State(University(NCI(
Laboratory(of(Cancer(Biology((and(Gene:cs(
Plasma(Cell(Tumors(
University(of(Maryland(NINDS&
Pathology(Training/(Graduate(Studies(
Ryan&Traslavina,&D.V.M.&Diplomate,&ACVP&
Trainees are graduate D.V.M. veterinarians aiming for a Ph.D. & specialty board certification!
Current and Former Trainees
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Distinctive Alumni
CCR is consistently rated among the top ins4tu4ons in which to train*
*The Scien4st: Best Places for Postdocs Harold Varmus Former Director NIH, NCI
Kenneth Olden Former Director NIEHS
• 10 National Academy Members • 11 Institute of Medicine Members • 11 Academy of Arts & Sciences Members
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How to start your career with us
https://ccr.cancer.gov/careers
@NCIResearchCtr
ccr.cancer.gov
www.cancer.gov