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Cells: The Building Blocks of Life ...and SAL Scientific!!!Dr Steve Game & Dr Alasdair RobertsonDirectorsSAL Scientific

SAL Scientific LtdOverview:Life science business based at University of Southampton Science Park.Provide cell biology products and services to organisations using mammalian cells in their drug discovery workflows.Winners of 2015 Test Valley Business Awards "New Business of the Year" and 2013 USSP Catalyst Competition.

Growth Strategy:Initial offering comprising a range of cell biology contract research services to generate early revenues.Use service revenues and other funding sources to develop new high-value, high-margin cell biology products and services.

ServicesCustom generation of recombinant monoclonal cell lines expressing a target of interest.The development and optimisation of cell-based assays and assay reagents across a range of imaging modalities & instrument platformsProvision of cells as bulk frozen prepsCloning of high-expressing biopharmaceutical producer cell linesDevelopment and optimisation of defined cell culture mediaMonoclonal antibody production.

ProductsInstiGRO, InstiTHAW & InstiSHAKE. Commercially important cells typically grown in sub-optimal conditions (in the absence of serum).Suffer from high attrition and slow growth, particularly when subjected to stress.Overcome by InstiGro, InstiThaw, and InstiSHAKE.

Why Cells?Cells are the basic functional and structural unit of all living organisms.Simple model to understand intracellular biochemistry within a physiologically relevant context.Easy to maintain large quantities of cells in culture.Experimentally tractable (e.g. easy to manipulate gene expression and treat with drugs).Well suited to high throughput approaches (can be grown, manipulated and imaged in multi-well plates).Usually human in origin

However!Unlike cell cultures, tissues contain multiple cell types working togetherCell cultures are typically 2D, tissues are 3DAnimal models still dominate pre-clinical tissue models in drug discovery

Cost of failure in clinical trials accounts for >80% of the cost of a new drugDue to poor translation of pre-clinical data into humans.Driving rapid growth in the market for advanced cell culture technologies.

Innovation for GrowthTechnology opportunity identified (Smart Biochip) to model epithelial tissue responses in preclinical drug discovery.Will use reprogrammed human stem cells as a source of tissue.Delivers more physiologically relevant data than current models.Initially focused on respiratory tissue.COPD and Asthma represent a key unmet need. Pharma Respiratory Pre-clinical R&D spend - $2.6 billionDevelop in partnership with UoS & major pharma end-user.Awarded Innovate UK collaborative grant, to fund the development programme.

Development PlanInitially high-value services, then high-value product range.2016201720182019IUK Collaborative R&D GrantSMART/SME Instrument?Design and DevelopmentProductisation/CommercialisationStem Cell ServicesSmart Biochip ServicesSmart Biochip Products

Growth RoadmapDrug Discovery Services Cell Culture ReagentsDrug Discovery Services Cell Culture ReagentsStem Cell ServicesDrug Discovery Services Cell Culture ReagentsStem Cell ServicesSmart Biochip ServicesDrug Discovery Services Cell Culture ReagentsStem Cell ServicesSmart Biochip ServicesSmart Biochip ProductsTimeCell Biology BusinessLeading-edge Cell Biology BusinessHigh-value Proprietary ServicesHigh-value Proprietary Products and ServicesRevenues

Thank You!+44 (0)2381 290 272www.salscientific.cominfo@salscientific.com www.linkedin.com/company/sal-scientific-ltd-/@salscientific

Interactive Listen and Learn Session

wagamamaInnovation through PeopleAndy Moat, People Director

15purpose of the next 20 mins

to share with you wagamamas story over the last 2 years

to highlight transferable learnings

to create some new customers!

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who are wagamama?17323046NorthLondon South8Scotland39Overseas restaurants

opened our first doors in londons bloomsbury in 1992inspired by fast-paced, japanese ramen bars and a celebration of asian fooda unique and innovative dining experience20+ years of kaizen philosophyfood and consumer focused established leader in the casual dining market

116 restaurants in the UK39 overseas restaurants across 16 marketsserving c.15m meals a yearand still growing fast!!

why is wagamama here?because we are what we eat

at wagamama, we believe that eating is the most important activity of our daily lives

what we eat shapes our physical health and wellbeing. the way we eat animates our spirit

20it is too easy to eat junk: artificial, industrial foods that are the philosophical opposite of real cooking and leave us flat, exhausted and ill

21positive eating sustains body, mind and soul, leaving us feeling optimistic, energetic and fully alive

wagamama makes positive eating easy

22what does wagamama believe?23our conviction

at wagamama, we believe that eating is the most important activity of our daily lives

what we eat shapes our physical health and wellbeing. the way we eat animates our spirit our purpose

to spread positivity from bowl to soul and beyondour values

fresh | playful | restless | free

what happened24like-for-like sales outperformance of the market for 72 consecutive weeks0415 turnover CAGR0415 turnover CAGR17.6%Turnover (m)continued (and accelerating) turnover growthhow did it happen? business examples25top team manager/leader makes the difference (+ resource)

clarity on mission and customer need state clear work experience seekers

customer communication eg placemats

people/operations investment (am investment, coaching, beliefs, growth mindset), tools eg smart rotas

kaizen philosophy thinking small to hit big + a big organising idea (project kaizen)

how did it happen? people examples27leadership shadow - invested in coaching

created a learning & development agenda

introduced greater honesty & challenge around performance

kaizen service be you | be wagamama

challenged some unhelpful beliefs but celebrated the helpful ones

created a network of centres of brilliance to train in consistencyinnovation examples - qkr28

innovation examples vidleo training29innovation examples restaurant design30

innovation examples communication31

summary some personal learnings32challenge beliefs fixed vs growth mind-sets

high support | high challenge london Olympics learnings

you get what you inspect not what you expect

listen to the right people your people and your customer (george davies)

golden circle thinking why, how, what (smart rotas)

a problem is just the absence of the right conversation (w erhart)

sundown rule - WalmartReflections on the event and looking forward.Closing Session