CELL INJURY and CELL DEATH -...
Transcript of CELL INJURY and CELL DEATH -...
CELL INJURY and CELL DEATH: Part 1
Jhia Anjela D. RiveraDepartment of Biological SciencesSchool of Science and TechnologyCentro Escolar University
CELL INJURY
A sequence of events that occur if the limits of adaptive capability are exceeded or no adaptive response is possible.
Causes:
• Ischemia
• Hypoxia
• Chemical injury and;
• Injury produced by infectious agents
CELL INJURY: Ischemia
Deficient supply of blood to a body part that is due to obstruction of the inflow of arterial blood
CELL INJURY: Hypoxia
Oxygen deficiency (reaching the tissues of the body)
CELL INJURY: Chemical Injury
Exposure or intake of chemicals
CELL INJURY: Infectious Agents
Bacteria, Virus etc.
CELL INJURY OVERVIEW
NORMAL CELL
MECHANISMS OF CELL INJURY
1) Depletion of ATP2) Mitochondrial Damage3) Influx of Intracellular Calcium and Loss of Calcium
Homeostasis4) Accumulation of Oxygen-Derived free radical (Oxidative
stress)5) Defects in Membrane Permeability
CELL INJURY• Reversible Injury• Cell swelling develops when cells are incapable of fluid
an ion homeostasis (↓ function of ATP dependent pumps).
• Irreversible injury (Necrosis)o Two basic processes underlie the morphologic changes of
necrosis1) Denaturation of protein2) Enzymatic digestion of cell components
CELL INJURY AND CELL DEATH
CELL INJURY AND CELL DEATH