Cell and Molecular Biology Graduate Group Newsletter · Mi Kwon (CBP) Univ. of Pennsylvania ......

Stephen Goldstein (GTV) George Washington Univ. Colleen Harrington (CB) Univ. of Virginia Aryel Heller (DSRB) Rutgers Univ. Christin Herrmann (MVP) Friedrich Schiller Univ. - Jena Yangpeiwei Huang (CB) Peking Univ. Kelsey Johnson (GGR) Univ. of Wisconsin-Madison Anna King (DSRB) Univ. of California-Davis Terra Kuhn (GGR) Univ. of Arizona

(Continued on page 2)

Arwa Abbas (MVP) Rutgers Univ. Stephen Bart (MVP) Univ. of Pittsburgh, Johnstown Joseph Benci (CB) Cornell Univ. Christopher Cali (GGR) Villanova Univ.

Priya Chatterji (GGR) Vellore Inst. of Technology Annie Chen (MVP) Dartmouth Univ. Ryan Pei Yin Chen (DSRB) Iowa State Univ. Lisa Cucolo (CBP) Williams College Erica Dhuey (CB) Univ. of California-San Diego Julie Fink (CBP) Wheaton College Shawn Foley (GGR) Univ. of Pennsylvania Robert French (GTV) Univ. of Georgia

Join us in welcoming the incoming class of 2013!

Save the date for the 2013 CAMB Symposium

The 17th Annual CAMB Symposium is scheduled for

October 11, 2013

in the Perelman Quadrangle. Please put this date on your calendars!

This year, Dr. Sandra Schmid (UT Southwestern) will deliver the keynote address.

More information about the research in her lab can be found at: http://www.utsouthwestern.edu/labs/schmid/.

We look forward to seeing all of the exciting research our students will share this year.

The CAMB Annual Symposium is a full day (8:30am –6:00pm) of science and social interaction for CAMB faculty and students.

Talks will be presented by two faculty and six students, as well as the keynote speaker.

All students one year past prelim and older are ex-pected to present posters. A panel of faculty judges will award prizes to the top posters at the end of the day.

ANNOUNCEMENTS AND AWARDS

2

2012-13 GRADUATES

4

STUDENT PUBLICATIONS 6

2013-14 ADMISSIONS 10

2013 FALL COURSE LIST 11

NEW CAMB FACULTY 12

Inside this issue:

Summer 2013

U N I V E R S I T Y O F P E N N S Y L V A N I A

Cell and Molecular Biology Graduate Group Newsletter

Dr. Sandra Schmid, Professor and Chair, Department of Cell Biology, UT Southwestern

Allison Jamieson-Lucy, Iryna Shakhmantsir, Ewa Stypulkowski, Sue Lee, Yang Li, Allison Cote

Graduate, Dan Feng

Mi Kwon (CBP) Univ. of Pennsylvania Lillian Lim (DSRB) Univ. of California-Berkley Mei Lin (CB) Peking Univ. Devin McDougald (GTV) Univ. of Southern Mississippi Somdutta Mukherjee (DSRB) Univ. of Maryland-College Park Christopher Natale (DSRB) Pennsylvania State Univ. Michael Peel (GTV) Villanova Univ.

Julianne Rieders (GTV) Bryn Mawr College Jonathan Rumley (GGR) Wingate Univ. Samantha Russell (DSRB) Univ. of Maryland-Baltimore Brenda Salantes (GTV) Mills College Danielle Sanchez (DSRB) Boston College Alexandra Stanley (DSRB) Univ. of California-San Diego Camille Syrett (DSRB) Allegheny College

Frances Taschuk (MVP) Swarthmore College David Walter (CB) Queens Univ. Rebecca Windmueller (DSRB) Univ. of Wisconsin Caiyue Xu (CB) Peking Univ. Stephen Zhao (CB) Rutgers Univ. Seth Zost (MVP) Univ. of Pennsylvania

2013 FALL ORIENTATION August 26-30, 2013

Dr. Shelley L. Berger and Dr. Virginia Man-Yee Lee, have been elected as new members to the American Academy of Arts and Sciences. Dr. Shelley Berger was named Fellow of the American Association for the Advancement of Science. Dr. Dustin Brisson was named a 2013 Investigator in the Pathogenesis of Infectious Disease by the Burroughs Wellcome Fund. Andria Culbert (GTV) received the Outstanding Poster Award at the Gordon Research Conference: Cartilage Biology and Pathology. Les Diablerets, Switzerland.

Dr. Ishmail Abdus-Saboor (GGR) was awarded the Tom Kadesch Prize in Genetic Research. Dr. David Artis has received the AAI-BD Biosciences Investigator Award for outstanding, early-career research contributions to the field of immunology from the American Association of Immunologists (AAI). Dr. Artis is also the recipient of the Stanley N. Cohen Biomedical Research Award. Dr. Lauren Bayne (GTV) and Dr. Stephan Kadauke (GTV)received the Saul Winegrad Award for Outstanding Dissertation.

Dr. Olena Jacenko has been awarded the Vet Medicine Class of 2016 Lecture Teaching Award. Brian Johnson (GGR) was awarded the 2013 UNCF-Merck Graduate Science Research Fellowship. Dr. Carl H. June has been selected to receive the 2012 Philadelphia Award. Dr. Carl H. June was also honored as a recipient of the American Society of Hematology’s 2012 Ernest Beutler Lecture and Prize. Dr. Mitchell Lazar was elected to serve as a council member, at-large of The Endocrine Society.


Incoming class of 2013, Continued

Announcements and Awards

Katy Ong, Rebecca Rivard, Jingwen Zeng

36th Street to Hamilton Walk

“GAIN-OF-

FUNCTION ALK2

MUTATION

ENHANCES

CHONDROCYTE

DIFFERENTIATION

AND PROMOTES

HETEROTOPIC

ENDOCHONDRAL

OSSIFICATION.”

-A. CULBERT

Dr. Amita Sehgal received a Senior Scholar Award from the Ellison Medical Foundation. Dr. James Shorter is the recipient of the Michael S. Brown New Investigator Award. Dr. Meera Sundaram received the Jane Glick Graduate Student Teaching Award. Dr. Robert H. Vonderheide is the recipient of the William Osler Patient Oriented Research Award.

Dr. Nicola Mason and Dr. Yvonne Paterson, are the co-recipients of the inaugural One Health Award. Dr. Daniel Rader has been awarded the American Heart Association’s (AHA) Clinical Research Prize. Ali Rosenberg (DSRB) won the 2012 Nachmias Thieman Award. Dr. Anil K. Rustgi is the recipient of the Arthur Asbury Outstanding Faculty Mentor Award.

Joseph Zinski (DSRB) won the 1st place award for his talk at the Mid-Atlantic Society for Developmental Biology meeting at the College of William & Mary, Williamsburg, Virginia.

Announcements and Awards

Summer 2013

Spring blooms in the James G. Kaskey Memorial Garden

2013 PhD Admissions Student Leaders: Mike Convente, Tanya Corman,

Hilary DeBardeleben, Jason Diaz, Dan Feng, David Frederick, Erin Graf, Sudil Mahendra, Ian Silverman.

We couldn’t do it without you!

A great big Thank You to all the students who helped make our 2013 PhD Admissions Season a success!

2012 Holiday Party

Qi Fu, Jamie Knox, Xiu Li Sim, Melissa Ducommun, Rianne Esquivel, Michael Herriges

Alexandra Bryson, April Giles, Kristel Emmer

Rachel Leibman, Jason Diaz, Mike Hogan

Jacqueline Avila Advisor: Dr. Joseph Kissil “The Role of Notch1in K-Ras Induced Pancreatic Ductal Adenocarcinoma”

Lauren Bayne Advisor: Dr. Robert Vonderheide “Inflammatory Networks and T Cell Immunosurveillance in Pancreatic Cancer”

Becky Brisson Advisor: Dr. Elisabeth Barton “Synergy Between Insulin-like Growth Factor-I (IGF-I) E-Peptides and IGF-I Signaling Alters Growth in Skeletal Muscle”

Alexander Brown Advisor: Dr. Douglas Epstein “The Function of Hedgehog and WNT Signaling Pathways in Otic Development”

George Buchlis Advisor: Dr. Katherine High “Advances and Challenges in Human AAV-Mediated Gene Transfer: Immunological Insights from a Mouse Model of Human Glycosylation”

Emily Charlson Advisors: Dr. Frederic Bushman and Dr. Ronald Collman “The Human Respiratory Tract Microbiome in Health and Disease”

Sarah Clark Advisor: Dr. Jeffrey Weiser “Evasion of Host Recognition by Phase Variation in Haemophilus influenzae”

Alison Dell Advisor: Dr. Jonathan Raper “cAMP Promotes Retinal Midline Crossing at the Zebrafish Optic Chiasm”

Dan Feng Advisor: Dr. Mitchell Lazar “Epigenomic and Transcriptional Regulation of Hepatic Metabolism by REV-ERB and HDAC3”

Jamie Fox Advisor: Dr. Andrei Thomas-Tikhonenko “Novel Mechanisms of MicroRNA-mediated Regulation of Key TGFß Effector CTGF in Glioblastoma Multiforme”

Erin Graf Advisor: Dr. Una O’Doherty “Clinical Measures of HIV Provide Insight into Determinants of Reservoir Size”

Jennifer Grier Advisor: Dr. Jordan Orange “A Role for CD16 in Natural Killer Cell-mediated Spontaneous Cytotoxicity Identified via a Human Immunodeficiency-causing Germline Mutation”

Derek Johnson Advisor: Dr. Youhai Chen “The Role of TIPE2 in the Regulation of Inflammation and Tumorigenesis”

Stephan Kadauke Advisor: Dr. Gerd Blobel “Tissue-specific Epigenetic Bookmarking to Preserve Transcriptional Programs Through Mitosis”

Jacob Lazarus Advisor: Dr. Erika Holzbaur “Cytoplasmic Dynein and Dynactin Coordinate Microtubule Dynamics at the Growing Plus End”

Eric Lee Advisor: Dr. Alan Diehl “FBXO4 Opposes Cyclin D1 Accumulation and the Tumorigenic Potential of BRAFV600E in Melanoma”

Grace Lin Advisor: Dr. Christopher Chen “Integrins and Forces in Mesenchymal Stem Cell Differentiation”

Chao Lu Advisor: Dr. Craig Thompson “Epigenetic Basis for the Oncogenic Potential of IDH Mutations”

Daniel Lysko Advisor: Dr. Jeffrey Golden “Elucidating the Role of SDF1 Signaling During Cortical Interneuron Migration”

Amar Majmundar Advisor: Dr. Celeste Simon “O2- and HIF1alpha-Dependent Regulation of Skeletal Muscle Progenitor Differentiation and Skeletal Muscle Regeneration”

Congratulations to our 2012—2013 Graduates!


Derek Johnson and Jennifer Grier

Andy Edmondson and son

“TISSUE-SPECIFIC

EPIGENETIC

BOOKMARKING

TO PRESERVE

TRANSCRIPTIONAL

PROGRAMS

THROUGH

MITOSIS” -S. KADAUKE

Ashley Mentlik Advisor: Dr. Jordan Orange “Lytic Granule Convergence to the Microtubule Organizing Center in Natural Killer Cells”

Mayumi Miller Advisor: Dr. Edward Morrisey “WNT2 and WNT7B Cooperative Signaling in Lung Development”

Natalie Miller Advisor: Dr. David Roos “Toxoplasma gondii Diversity—From Seroprevalence in Multiple Host Species to Genotyping Analysis of Field Isolates”

Melanie Millholland Advisor: Dr. Doron Greenbaum “Host-Apicomplexan Parasite Interactions: Leveraging Biological Discovery into Antiparasitic Drug Development”

Samuel Minot Advisor: Dr. Frederic Bushman “Evolution and Dynamics of the Human Gut Virome”

Karen Ocwieja Advisor: Dr. Frederic Bushman “Patterns of HIV Integration and Splicing: Windows on Mechanism”

Michael O’Donnell Advisor: Dr. Greg Bashaw “Signal Transduction Mechanisms in Commissural Axon Guidance: The Role of Intracellular Tyrosine Kinases in NetrinDCC/Frazzled Axon Attraction”

Matthew Pace Advisor: Dr. Una O’Doherty “HIV Gag Expression During Latent Infection: Is the Reservoir Really Invisible”

Tatyana Panchenko Advisor: Dr. Ben Black “Centromeric Chromatin: Structure, Function and Epigenetic Inheritance”

Nicholas Parrish Advisor: Dr. Beatrice Hahn “Phenotypic Characteristics of Transmitted/FounderHIV-1”

Gregory Peterfreund Advisors: Dr. Frederic Bushman and Dr. Jun Zhu “Bacterial and Microeukaryotic Succession in the Gut Microbiome”

2012—2013 Graduates!

Alanna Strong Advisor: Dr. Daniel Rader “Sortilin as a Novel Regulator of Plasma Cholesterol, Very-low Density Lipoprotein Secretion and LDL Catabolism”

Austin Thiel Advisor: Dr. Xianxin Hua “The Central Role of Menin and Wild-Type MLL in MLL-AF9-Induced Leukemia”

Alexander Valvezan Advisor: Dr. Peter Klein “Novel Roles for the Tumor Suppressor APC Through Regulation of GSK-3”

Patrick Ward Advisors: Dr. Garret FitzGerald and Dr. Craig Thompson “The Common Feature of Cancer-Associated IDH1 and IDH2 Mutations is a Neomorphic Enzyme Activity Converting α -Ketoglutarate to the Oncometabolite 2-Hydroxyglutarate”

Jamie Weaver Advisor: Dr. Marisa Bartolomei “Interrelated Roles of Repressive Chromatin Modifiers in Genomic Imprinting”

Jason Wojcechowskyj Advisor: Dr. Robert Doms “HIV-induced Cellular Reprogramming: Insights from Phosphoproteomics”

Gabrielle Wong Advisor: Dr. Anil Rustgi “Periostin and its Role in Promoting Invasion in the Tumor Microenvironment of Esophageal Cancer”

Summer 2013

Erin Graf celebrating graduation with family and friends.

“INFLAMMATORY

NETWORKS AND T CELL

IMMUNOSURVEILLANCE

IN PANCREATIC

CANCER” -L. BAYNE

Waihay Wong Advisor: Dr. Celeste Simon “Hypoxic Regulation of MYC and Epidermal Barrier Development”

Te-Lang Brian Wu Advisor: Dr. Hildegund Ertl “Adaptive Immune Responses to Adeno-Associated Virus (AAV) Vector-Mediated Gene Transfer”

Jie Xu Advisor: Dr. Sara Cherry “Discovering Novel Intrinsic Antiviral Responses to Arboviruses: From Transcription to Intestinal Innate Immunity”

2012—2013 Graduates!

Student Publications Chakkalakal, S. A., D. Zhang, A.L. Culbert, M.R. Convente, R.J. Caron, A.C. Wright, A.D.A. Maidment, F.S. Kaplan, and E.M. Shore (2012). An Acvr1 R206H knock-in mouse has fibrodysplasia ossificans progressiva. J. Bone Min. Res. 27(8), 1746-1756

Chen-Plotkin AS, Unger TL, Gallagher MD, Bill E, Kwong LK, Volpicelli-Daley L, Busch JI, Akle S, Grossman M, Van Deerlin V, Trojanowski JQ, Lee VM (2012) TMEM106B, the risk gene for frontotemporal dementia, is regulated by the miR-132/212 cluster and affects progranulin pathways. J Neuroscience 32(33):11213-27

Clark SE, Eichelberger KR, Weiser JN. Evasion of killing by human antibody and complement through multiple variations in the surface oligosaccharide of Haemophilus influenzae. Mol Microbiol. 2013 May;88(3):603-18. doi: 10.1111/mmi.12214. Epub 2013 Apr 12. PMID: 23577840

Clark SE, Weiser JN. Microbial modulation of host immunity with the small molecule phosphorylcholine. Infect Immun. 2013 Feb;81(2):392-401. doi: 10.1128/IAI.01168-12. Epub 2012 Dec 10. Review. PMID: 23230294

Cocka LJ and Bates P. (2012) Identification of Alternatively Translated Tetherin Isoforms with Differing Antiviral and Signaling Activities. PLoS Pathogens Sep; 8(9):e1002931. doi: 10.1371/journal.ppat.1002931. Epub 2012 Sep 27. PMID: 23028328

Culbert, A.L., S.A. Chakkalakal, M.R. Convente, V.Y. Lounev, F.S. Kaplan, and E.M. Shore (2013). Fibrodysplasia (Myositis) Ossificans Progressiva, Chapter 26. Genetics of Bone Biology and Skeletal Disease. pp 375-393. Editors: R.V. Thakker, M.P. Whyte, J.A. Eisman, and T. Igarashi.

Degenhardt K, Singh MK, Aghajanian H, Massera D, Wang Q, Li J, Li L, Choi C, Yzaguirre AD, Francey LJ, Gallant E, Krantz ID, Gruber PJ, Epstein JA. Semaphorin 3d signaling defects are associated with anomalous pulmonary venous connections. Nat Med. 2013 May 12. doi: 10.1038/nm.3185. [Epub ahead of print]



David Weiner and Ting Yang

“IDENTIFICATION

OF

ALTERNATIVELY

TRANSLATED

TETHERIN

ISOFORMS WITH

DIFFERING

ANTIVIRAL AND

SIGNALING

ACTIVITIES”

-L. COCKA

Dan Kessler, Konrad Hochedlinger, and Chris Lengner

at the 2012 CAMB Symposium

Dan Lysko and Alex Valvezan (and wife) at graduation

Dey S, Tameire F, Koumenis C. PERK-ing up autophagy during MYC-induced tumorigenesis. Autophagy. 2013 Apr;9(4):612-4

Durzyńska J, Philippou A, Brisson BK, Nguyen-McCarty M, Barton ER. The pro-forms of insulin-like growth factor I (IGF-I) are predominant in skeletal muscle and alter IGF-I receptor activation. Endocrinology. 2013 Mar;154(3):1215-24. doi: 10.1210/en.2012-1992. Epub 2013 Feb 13

Fleetwood MR, Ho Y, Cooke NE, Liebhaber SA. DNase I Hypersensitive Site II of the Human Growth Hormone Locus Control Region Mediates an Essential and Distinct Long-range Enhancer Function. J Biol Chem 287:25454-65, 2012. PMCID:340815

Fox JL, Dews M, Minn AJ, Thomas-Tikhonenko A. Targeting of TGFβ signature and its essential component CTGF by miR-18 correlates with improved survival in glioblastoma. RNA. 2013 Feb;19(2):177-90

Haines KM, Vande Burgt NH, Francica JR, Kaletsky RL and Bates P. (2012) Chinese hamster ovary cell lines selected for resistance to ebolavirus glycoprotein mediated infection are defective for NPC1 expression. Virology Oct 10;432(1):20-8

Hart LS, Cunningham JT, Datta T, Dey S, Tameire F, Lehman SL, Qiu B, Zhang H, Cerniglia G, Bi M, Li Y, Gao Y, Liu H, Li C, Maity A, Thomas-Tikhonenko A, Perl AE, Koong A, Fuchs SY, Diehl JA, Mills IG, Ruggero D, Koumenis C. ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J Clin Invest. 2012 Dec 3;122(12):4621-34. doi: 10.1172/JCI62973. Epub 2012 Nov 12

Hasson, D.*, T. Panchenko*, K.J. Salimian*, M.U. Salman, N. Sekulic, A. Alonso, P.E. Warburton, and B.E. Black. 2013. The octamer is the major form of CENP-A nucleosomes at human centromeres. Nature Structural & Molecular Biology, Online ahead of print. (*contributed equally and listed in alphabetical order)

Christopher B. Hergott, Mithun Mitra, Jianhui Guo, Tiyun Wu, Jennifer T. Miller, Yasumasa Iwatani, Robert J. Gorelick, Judith G. Levin. Zinc finger function of HIV-1 nucleocapsid protein is required for removal of 5’-terminal genomic RNA fragments: A paradigm for RNA removal reactions in HIV-1 reverse transcription. Virus Research, Volume 171, Issue 2, February 2013, Pages 346-355, ISSN 0168-1702, 10.1016/j.virusres.2012.08.013

Huang J, Nguyen-McCarty M, Hexner EO, Danet-Desnoyers G, Klein PS. Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways. Nat Med. 2012 Dec;18(12):1778-85. doi: 10.1038/nm.2984. Epub 2012 Nov 11. PubMed PMID: 23142822; PubMed Central PMCID: PMC3518679

Kague E*, Gallagher M*, Burke S, Parsons M, Franz-Odendaal T, Fisher S (2012) Skeletogenic fate of zebrafish cranial and trunk neural crest. PLoS ONE 7(11):e47394. *Denotes equal contributions

Kim, Y.-J., H.-J. Lee, A. Y. Zhang, B. Schmidt, T. M. Kim, T. S. K. Eisinger-Mathason, D. L. Karl, M. S. Nakazawa, P. J. Park, M. C. Simon, and S. S. Yoon (2012) Overcoming evasive resistance from vascular endothelial growth factor A inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia inducible factor 1α. Int. J. Cancer 132:29-41

Lee SI, Conrad T, Jones SM, Lagziel A, Starost MF, Belyantseva IA, Friedman TB, Morell RJ. A null mutation of mouse Kcna10 causes significant vestibular and mild hearing dysfunction. Hear Res. 2013 Mar 22;300C:1-9. doi: 10.1016/j.heares.2013.02.009


Student Publications, Continued

Summer 2013

Ron Collman with Emily Charlson and family at graduation

“TARGETING OF

TGFΒ SIGNATURE

AND ITS ESSENTIAL

COMPONENT CTGF

BY MIR-18

CORRELATES WITH

IMPROVED

SURVIVAL IN

GLIOBLASTOMA”

-J. FOX

Students at the 2012 Holiday Party

Top l-r: Ali Rosenberg, Rachel Kadzik and friends Bottom l-r: Cierra Casson, Richard Jimenez, Ciara Gimblet, Luis Cocka

Li ML and Greenberg RA: Links between genome integrity and BRCA1 tumor suppressor function. Trends in Biochem Sci 37(10): 418-24, 2012

Lijek RS, Luque SL, Liu Q, Parker D, Bae T, Weiser JN. Protection from the acquisition of Staphylococcus aureus nasal carriage by cross-reactive antibody to a pneumococcal dehydrogenase. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13823-8. doi: 10.1073/pnas.1208075109. Epub 2012 Aug 6. PMID: 22869727

Jianhong Lu, Yonggang Qu, Yuliang Liu, Rakesh Jambusaria, Ziying Han, Gordon Ruthel, Bruce Freedman, and Ronald N. Harty. Host IQGAP1 and Ebola Virus VP40 Interactions Facilitate VLP Egress J. Virol. published ahead of print 1 May 2013 , doi:10.1128/JVI.00470-13

MacMillan, A.L., Kohli, R. and Ross, S.R. (2013) APOBEC3 inhibition of MMTV infection: the role of cytidine deamination versus inhibition of reverse transcription. J. Virol.87:4808-4817 (J.Virol. Spotlight)

Massey HC, Jr., Ranjit N, Stoltzfus JD, Lok JB (2013) Strongyloides stercoralis daf-2 encodes a divergent ortholog of DAF-2 in Caenorhabditis elegans. Int J Parasitol pii: S0020-7519(13)00067-2. doi: 10.1016/j.ijpara.2013.01.008

Morton EA, Lamitina T.: C. elegans HSF-1 is an essential nuclear protein that forms stress granule-like structures following heat shock. Aging Cell 12(1):112-20 February 2013

Mucaj, V., J. E. S. Shay, and M. C. Simon (2012) Effects of hypoxia and HIFs on cancer metabolism. Int. J. Hem. 95:464-470

G Nayak, S Lee, R Yousaf, S Edelmann, C Trincot, C Van Itallie, G Sinha, M Rafeeq, S Jones, I Belyantseva, J Anderson, A Forge, G Frolenkov, S Riazuddin (2013). Tricellulin is essential for associating bicellular and tricellular tight junctions and for survival of cochlear hair cells, Journal of Clinical Investigation (in press)

O’Donnell, M., and Bashaw, G.J. (2013). Src Inhibits Midline Axon Crossing Independent of Frazzled/DCC Receptor Tyrosine Phosphorylation. Journal of Neuroscience 33(1):305-14

O’Donnell, M., and Bashaw, G.J. (2013). Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits. Development (In press)

Parker ZF, Iyer SS, Wilen CB, Parrish NF, Chikere KC, Lee FH, Didigu CA, Berro R, Klasse PJ, Lee B, Moore JP, Shaw GM, Hahn BH, Doms RW. 2013. Transmitted/Founder and Chronic HIV-1 Envelope Proteins are Distinguished by Differential Utilization of CCR5. J. Virol 87 (5): 2401-2411. doi:10.1128/JVI.02964-12

Platt, JM, Ryvkin, P, Wanat, JJ, Donahue, G, Rickets, MD, Barrett, SP, Waters, HJ, Song, S, Chavez, A, Abdallah, KO, Master, SR, Wang, LS and Johnson, FB. (2013). Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence. Genes and Development (in press)

Qing, G., B. Li, A. Vu, N. Skuli, Z. Walton, X. Liu, P. A. Mayes, D. R. Wise, C. B. Thompson, J. M. Maris, M. D. Hogarty, and M. C. Simon (2012) ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation. Cancer Cell 22:631-644




2012 Symposium Eunsun Kim, Stella Hur,

Amber Riblett, Barzin Nabet, Jessica Grindheim

2012 Symposium Barzin Nabet, Amber Riblett,

Zahra Parker, Mike Nakazawa, Chuka Didigu

“DISTINCT

FUNCTIONAL

DOMAINS OF THE

ABELSON TYROSINE

KINASE CONTROL

AXON GUIDANCE

RESPONSES TO

NETRIN AND SLIT

TO REGULATE THE

ASSEMBLY OF

NEURAL CIRCUITS.”

-M. O’DONNELL

Riazuddin S, Belyantseva IA, Giese AP, Lee K, Indzhykulian AA, Nandamuri SP, Yousaf R, Sinha GP, Lee S, Terrell D, Hegde RS, Ali RA, Anwar S, Andrade-Elizondo PB, Sirmaci A, Parise LV, Basit S, Wali A, Ayub M, Ansar M, Ahmad W, Khan SN, Akram J, Tekin M, Riazuddin S, Cook T, Buschbeck EK, Frolenkov GI,Leal SM, Friedman TB, Ahmed ZM. Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48.Nat Genet. 2012 Nov;44(11):1265-71. doi: 10.1038/ng.2426. Epub 2012 Sep 30

Shay, J. E. S. and M. C. Simon (2012) Hypoxia-inducible factors: crosstalk between inflammation and metabolism. Semin. Cell Dev. Biol. 23:389-394

Silverman IM, Li F, Gregory BD. Genomic era analyses of RNA secondary structure and RNA-binding proteins reveal their significance to post-transcriptional regulation in plants. Plant Sci. 2013 May;205-206:55-62

Skuli, N., A. J. Majmundar, B. L. Krock, R. C. Mesquita, L. K. Mathew, Z. L. Quinn, A. Runge, L. Liu, M. N. Kim, J. Liang, S. Schenkel, A. G. Yodh, B. Keith, M. C. Simon (2012) Endothelial HIF-2a regulates murine pathological angiogenesis and revascularization processes. J. Clin. Invest. 122:1427-1243

Stoltzfus JD, Minot S, Berriman M, Nolan TJ, and Lok JB (2012) RNAseq analysis of the parasitic nematode Strongyloides stercoralis reveals divergent regulation of canonical dauer pathways. PLoS Negl Trop Dis 6(10): e1854. doi:10.1371/journal.pntd.0001854

Sundararaman SA, et al., Plasmodium falciparum-like parasites infecting wild apes in southern Cameroon do not represent a recurrent source of human malaria. PNAS 2013 110 (17) 7020-7025

Tang J, Cho NW, Cui G, Manion EM, Shanbhag NM, Botuyan MV, Mer G, Greenberg RA: Acetylation limits 53BP1 accumulation at DNA double-strand breaks to promote homologous recombination. Nat Struct Mol Biol 20: 317-25, 2013

Villanueva A*, Alsinet C*, Yanger K*, Hoshida Y, Zong Y, Toffanin S, Rodriguez-Carunchio L, Solé M, Thung S, Stanger BZ, Llovet JM. Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice. Gastroenterology. 2012 Dec;143(6):1660-1669.e7. doi: 10.1053/j.gastro.2012.09.002. Epub 2012 Sep 11 *co-first author*

Wang Y, Tian Y, Morley MP, Lu MM, Demayo FJ, Olson EN, Morrisey EE. Development and regeneration of Sox2+ endoderm progenitors are regulated by a Hdac1/2-Bmp4/Rb1 regulatory pathway. Dev Cell. 2013 Feb 25;24(4):345-58

Wang, X.*, Helfer, C.M.*, Pancholi, N., Bradner, J.E., You, J. Recruitment of Brd4 to the human papillomavirus type 16 DNA replication complex is essential for replication of viral DNA. J Virol 2013, 87, 3871-3884

Wise, D. R., P. S. Ward, J. Shay, J. R. Cross, J. J. Gruber, U. M. Sachdeva, J. Platt, R. G. DeMatteo, M. C. Simon, and C. B. Thompson (2012) Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. Proc. Natl. Acad. Sci. USA 108:19611-19616

Yanger K, Zong Y, Maggs LR, Shapira SN, Maddipati R, Aiello NM, Thung SN, Wells RG, Greenbaum LE, Stanger BZ. Robust cellular reprogramming occurs spontaneously during liver regeneration. Genes Dev. 2013 Apr 1;27(7):719-24. doi: 10.1101/gad.207803.112. Epub 2013 Mar 21. *cover*


Summer 2013

David Shen, Jennifer Myers, Katie Sheehan, Thomas Porturas

Paul Bates, Dennis Kolson Rachel Blomberg, Scott Dooley, April Giles, Rachel Leibman, Friend

Schedule of Faculty Interview Times

MD/PhD Friday Interviews November 8 & 22, and January 10

11:00—11:30 11:45—12:15 12:30—1:00 2:00—2:30 2:45—3:15 3:30—4:00

PhD Friday Interviews January 17 & 31, and February 21

10:00—10:30 10:45—11:15 2:15—2:45 3:00—3:30


2013-14 Admissions

Mark Your Calendars!

DSRB students celebrate the end of prelims.

January 2014 S U N M O N T U E W E D T H U F R I S A T

1 2 3 4

5 6 7 8 9 10 11

12 13 14 15 16 17 18

19 20 21 22 23 24 25

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MD/PhD Recruiting

PhD Recruiting

PhD Recruiting

February 2014 S U N M O N T U E W E D T H U F R I S A T

1

2 3 4 5 6 7 8

9 10 11 12 13 14 15

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23 24 25 26 27 28 1

PhD Recruiting

November 2013 S U N M O N T U E W E D T H U F R I S A T

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3 4 5 6 7 8 9

10 11 12 13 14 15 16

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MD/PhD Recruiting

MD/PhD Recruiting

Summer 2013

Fall 2013 CAMB Course List

Class Instructor (s) Day: Time

BIOM 600 Cell Biology & Biochemistry J. Weisel MWF: 10:30am-12pm

CAMB 518-301 Current Topics in Ion Channels C. Deutsch TR: 9:30-10:30am

CAMB 530-301 The Cell Cycle, Genome Integrity and Cancer

A. Diehl and E. Brown W: 1-3pm

CAMB 532-401 Human Physiology K. Foskett and T. Lamitina MWF: 9-10:30am

CAMB 542-401 Topics in Molecular Medicine (TIMM) B. Stanger and R. Kohli W: 3:30-5:15pm

CAMB 542-402 Topics in Molecular Medicine (TIMM) M. Atchison and N. Mason W: 5-7pm

CAMB 547-001 Fundamental Virology N. Fraser and M. Weitzman TR: 1-2:30pm

CAMB 548-001 Bacteriology J. Zhu and F. Bushman MWF: 1:15-2:15

CAMB 549-001 Parasites and Parasitism J. Lok and C. Hunter MF: 2:30-3:30pm W: 1:30-2:30pm

CAMB 605 (301-304) CAMB First Year Seminar J. Seykora T: 1-4pm

CAMB 608-301 Regulation of Eukaryotic Gene Expression

Z. Zhou, S. Liebhaber and D. Epstein T: 3-5pm

CAMB 609-401 Vaccines and Immune Therapeutics D. Weiner WR: 2:30-5pm

CAMB 610-301 Molecular Basis of Gene Therapy J. Wilson MWF: 1-2pm

CAMB 617-301 Emerging Infectious Diseases S. Hensley, H. Shen, and P. Bates MW: 10-11:30am

CAMB 620-301 Thematic Concepts in Developmental Biology

S. DiNardo and N. Speck T: 10am-12pm

CAMB 698-301 Elective Tutorials in Cell Biology J. Burkhardt See instructor

CAMB 701-301 Tumor Microenvironment S. Ryeom, D. Feldser, and E. Puré R 11am-1pm

CAMB students - please remember to discuss your course choices

with your program advisor and communicate with your coordinator so that she

can register you properly

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View from 36th and Spruce

Dedicated to the search for new knowledge

U N I V E R S I T Y O F P E N N S Y L V A N I A

Photos in this issue of the newsletter include images from

recent CAMB events, and around the University of Pennsylvania.

Hui Hu (GTV)

Brendan Keating (GGR)

Minghong Ma (CBP)

Michael Milone (GTV)

Hiroshi Nakagawa (CB)

Katalin Susztak (GGR)

Montserrat Alguerra (CBP)

Stewart Anderson (DSRB)

Maya Capelson (DSRB)

David Feldser (CB)

Benjamin Garcia (GGR)

Hakon Hakonarson (GGR)

Benjamin Voight (GGR)

Matthew Weitzman (MVP)

Gary Wu (CBP)

Rugang Zhang (CB)

New Cell and Molecular Biology Graduate Group Faculty

WELCOME OUR

NEW CAMB

FACULTY, AND

VISIT THEIR WEB

PAGES FOR

MORE

INFORMATION!

Cell and Molecular Biology Graduate Group Newsletter · Mi Kwon (CBP) Univ. of Pennsylvania ......

Documents

Transcript of Cell and Molecular Biology Graduate Group Newsletter · Mi Kwon (CBP) Univ. of Pennsylvania ......