Case of the month December 2006 Irish Setter, m, 4y.
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Transcript of Case of the month December 2006 Irish Setter, m, 4y.
Case of the month
December 2006
Irish Setter, m, 4y
For more than two years irregular seizure attacks of about 1 min duration. One week ago cluster of 2 h duration. Since then the dog is in lateral recumbency, unable to get up.
History
Referral to the Neurology division of the Vetsuisse Faculty Berne
Results of neurologic examination
• Lateral recumbency, severe tetraparesis• Generalized missing proprioception• Menace response and palpebral reflex bilaterally
reduced
Localisation diffuse, intracranial
MRI
FSE T2 transverse
MRI of the brain
dorsal
right
dorsal
right
dorsal
right
FLAIR DOR
MRI of the brain
rostral
right
rostral
right
rostral
right
rostral
right
rostral
right
plain contrast enhanced
MRI of the brain
FE 3D MPR (T1) dorrostral
right
rostral
right
rostral
right
rostral
right
Findings
In T2 and FLAIR there is a symmetric increase in signal intensity of the gray matter from the areas rostral to the lateral ventricles going caudally to the gyrus dentatus (yellow arrows). The T1-weighted images are unremarkable, there is no contrast uptake.
The distribution of the lesions is typical for polioencephalomalacia. The etiology of this rare condition is unclear. A toxic/metabolic genesis is assumed. It is progressive and cannot be improved by any known therapy. Prognosis is infaust.
Symmetric changes either of white or gray matter or both usually are caused by toxic/metabolic conditions. These include hypooxygenism, hepatoencephalopathy or renal failure, storage diseases and intoxications. Some of them show a typical distribution; e.g. hypooxygenism typically leads to signal enhancement of the basal ganglia. However, the available veterinary medical database of these conditions is still small.
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