Case 1 History: A 53 year-old woman presented with a frontal-parietal lobe intra-axial tumor.
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Diagnostic Challenge Pathology for Neurosurgery & Neurology Residents Department of Pathology University of Oklahoma Health Sciences Center, Oklahoma City, OK, U.S.A. Case 1 History: A 53 year-old woman presented with a frontal-parietal lobe intra-axial tumor. Contributor: Kar-Ming Fung, M.D., Ph.D., [email protected] Last updataded: 1/9/2009
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Diagnostic Challenge Pathology for Neurosurgery & Neurology Residents Department of Pathology University of Oklahoma Health Sciences Center, Oklahoma City, OK, U.S.A. Case 1 History: A 53 year-old woman presented with a frontal-parietal lobe intra-axial tumor. - PowerPoint PPT Presentation
Transcript of Case 1 History: A 53 year-old woman presented with a frontal-parietal lobe intra-axial tumor.
Diagnostic ChallengePathology for Neurosurgery & Neurology
ResidentsDepartment of Pathology
University of Oklahoma Health Sciences Center,Oklahoma City, OK, U.S.A.
Case 1History: A 53 year-old woman presented with a frontal-parietal lobe intra-axial tumor.
Contributor: Kar-Ming Fung, M.D., Ph.D., [email protected] Last updataded: 1/9/2009
Cytologic PreparationFrozen Section
A B
Paraffin Section Paraffin Section
C D
Thyroid transcription factor-1 (TTF-1)
Gross cystic disease fluid protein-15 (GCDFP-15)
E F
What is your diagnosis?
Diagnosis: Metastatic adenocarcinoma of breast origin.Discussion: • The cells are highly pleomorphic with large nuclei
and nucleoli (Panel A and B). The cytologic features are best appreciated in the cytologic preparation (Panel B).
• The tumor cells form solid sheets. In between the tumor cells are small glands that contain mucin (arrow in the panel on the right).
• The glandular structure are well demonstrated in permanent sections (Panel C). There are also necrosis (Panel D).
• Putting all of these together, the features are most consistent with a metastatic adenocarcarcinoma.
• The patient has a history of breast carcinoma. The positive immunoreactivity of GCDFP-15 confirmed the breast origin. Breast carcinoma are usually negative for TTF-1.
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