CAROTID DEBATE High-Grade Asymptomatic...
Transcript of CAROTID DEBATE High-Grade Asymptomatic...
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Todd W GenslerMD
April 28, 2018
CAROTID DEBATE
High-Grade Asymptomatic Disease
Should Be Repaired Selectively;
Medical Management is NOT Enough
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DISCLOSURES
• I have no financial disclosures
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Philip A Davenport, MD, PhD
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Stroke Statistics
• About 795,000 Americans each year suffer a new or recurrent stroke. That means, on average, a stroke occurs every 40 seconds.
• Stroke kills more than 129,000 people a year. That's about 1 of every 18 deaths. It is the 5th leading cause of death.
• On average, every 4 minutes someone dies of stroke.
• Americans paid about $95 billion in 2015 for stroke-related medical costs and disability.
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PREVALENCE OF ASX DZ
• It is now estimated that some 6% of Americans over 65 harbor an asymptomatic carotid artery stenosis >50%
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Nat’l History of Asymptomatic Disease
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• Carotid stenosis >70% significantly increases stroke risk irrespective of the fact that 70% of this cohort were on statin medications
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• A total of 1121 patients with asymptomatic carotid stenosis of 50% to 99% in relation to the bulb diameter (European Carotid Surgery Trial [ECST] method) underwent six monthly clinical assessments and carotid duplexes for up to 8 years (mean follow-up, 4 years).
• Regression occurred in 43 (3.8%), no change in 856 (76.4%), and progression in 222 (19.8%) patients.
• For the entire cohort, the 8-year cumulative ipsilateral cerebral ischemic stroke rate was zero in patients with regression, 9% if the stenosis was unchanged, and 16% if there was progression (average annual stroke rates of 0%, 1.1%, and 2.0%, respectively)
• For patients with baseline stenosis 70% to 99%, in the absence of progression (n = 349), the 8-year cumulative ipsilateral cerebral ischemic stroke rate was 12%. In the presence of progression (n = 77), it was 21% (average annual stroke rates of 1.5% and 2.6%, respectively)
PROGRESSION IS
BAD!!!!
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ASX TRIALS
• VA Cooperative Study Group
• Asx Carotid Atherosclerosis Trial (ACAS)
• Asx Carotid Surgery Trial (ACST)
• Asymptomatic Carotid Stenosis and Risk of Stroke (ACSRS)
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ACST (asymptomatic carotid surgery trial)
• 3120 asx pts w/ >60% stenosis by U/S
• Randomized b/t immed CEA and indefinite deferral of any CEA and were followed for up to 5 yrs
• Net five year risk for stroke or periop death in CEA pts was reduced by nearly half
• Absolute risk reduction over 5 yrs greater for men than for women (8.2 vs 4.08)
• 80% of patients were on statins in latter yrs of study
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CRITICAL STENOSIS,
VULNERABLE PLAQUE,
PRIOR C/L TIA/CVA IS
BAD
ADDITIVE EFFECT IS
WORSE
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3 or more ulcers adds 5% risk to microemboli (greater than equal 2/hr)
TCD HITS & MULTIPLE ULCERS
ARE BAD
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DateWE HAVE TO FIND THIS
PLAQUE BEFORE IT FINDS
OUR PATIENT’S BRAIN
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GUIDELINNES
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• While awaiting data from CREST-2, ECST-2, ACST-2, and ACTRIS and the development of validated algorithms for patient selection, the presence of one or more clinical and/or imaging features such as silent infarction on CT/MRI, stenosis progression, large plaque area, large juxta-luminal black area (JBA) on computerized plaque analysis, plaque echolucency, intra-plaque haemorrhage on MRI, impaired cerebral vascular reserve (CVR), and spontaneous embolisation on transcranial Doppler (TCD) monitoring, might be useful for selecting “higher-risk stroke” patients for revascularisation
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RECOMMENDATIONS FOR ASX CAROTID STENOSIS
• HIGH GRADE LESIONS (80-99%)
• PROGRESSION OF DISEASE
• VULNERABLE PLAQUE
– GSM <15
– PLAQUE AREA >80
– JUXTA-LUMINAL BLACK AREA > 8 cm²
• CONTRALATERAL CVA or OCCLUSION (↓ CV RESERVE)
• MULTIPLE TCD “HITS”
• MULTIPLE ULCERATIONS
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???BIAS???
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Roadster 2 Exclusion Criteria
• EXCLUSION CRITERIA:
• Each potential patient must be screened to ensure that they do not meet any of the following exclusion criteria. This screening is to be based on known medical history and data available at the time of eligibility determination and enrollment.
• Patient has an alternative source of cerebral embolus, including but not limited to:
– Patient has chronic atrial fibrillation.
– Patient has had any episode of paroxysmal atrial fibrillation within the past 6 months, or history of paroxysmal atrial fibrillation requiring chronic anticoagulation.
– Knowledge of cardiac sources of emboli. e.g. left ventricular aneurysm, intracardiac filling defect, cardiomyopathy, aortic or mitral prosthetic heart valve, calcific aortic stenosis, endocarditis, mitral stenosis, atrial septal defect, atrial septal aneurysm, or left atrial myxoma).
– Recently (<60 days) implanted heart valve (either surgically or endovascularly), which is a known source of emboli as confirmed on echocardiogram.
– Abnormal angiographic findings: ipsilateral intracranial or extracranial arterial stenosis (as determined by angiography or CTA/MRA ≤ 6 months prior to index procedure) greater in severity than the lesion to be treated, cerebral aneurysm > 5 mm, AVM (arteriovenous malformation) of the cerebral vasculature, or other abnormal angiographic findings.
• Patient has a history of spontaneous intracranial hemorrhage within the past 12 months, or has had a recent (<7 days) stroke of sufficient size (on CT or MRI) to place him or her at risk of hemorrhagic conversion during the procedure.
• Patient had hemorrhagic transformation of an ischemic stroke within the past 60 days.
• Patient with a history of major stroke attributable to either carotid artery (CVA or retinal embolus) with major neurologicaldeficit (NIHSS ≥ 5 OR mRS ≥ 3) likely to confound study endpoints within 1 month of index procedure.
• Patient has an intracranial tumor.
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Exclusion Criteria Roadster 2• Patient has an evolving stroke.
• Patient has neurologic illnesses within the past two years characterized by fleeting or fixed neurologic deficit which cannot bedistinguished from TIA or stroke, including but not limited to: moderate to severe dementia, partial or secondarily generalized seizures, complicated or classic migraine, tumor or other space-occupying brain lesions, subdural hematoma, cerebral contusion or other post-traumatic lesions, intracranial infection, demyelinating disease, or intracranial hemorrhage).
• Patient has had a TIA or amaurosis fugax within 48 hrs prior to the procedure.
• Patient has an isolated hemisphere.
• Patient had or will have CABG, endovascular stent procedure, valve intervention or vascular surgery within 30 days before or after the intervention.
• Myocardial Infarction within 72 hours prior to the intervention.
• Presence of a previous placed intravascular stent in target vessel or ipsilateral CCA or significant CCA inflow lesion.
• Occlusion or [Thrombolysis In Myocardial Infarction Trial (TIMI 0)] "string sign" >1cm of the ipsilateral common or internal carotid artery.
• An intraluminal filling defect (defined as an endoluminal lucency surrounded by contrast, seen in multiple angiographic projections, in the absence of angiographic evidence of calcification) whether or not it is associated with an ulcerated target lesion.
• Ostium of Common Carotid Artery (CCA) requires revascularization.
• Patient has an open stoma in the neck.
• Female patients who are pregnant or may become pregnant.
• Patient has history of intolerance or allergic reaction to any of the study medications or stent materials (refer to stent IFU), including aspirin (ASA), ticlopidine, clopidogrel, statin or contrast media (that can't be pre medicated). Patients must be able to tolerate statins and a combination of ASA and ticlopidine or ASA and clopidogrel.
• Patient must have a life expectancy <3 years without contingencies related to other medical, surgical, or interventional procedures as per the Wallaert Score and patients with primary, recurrent or metastatic malignancy who do not have independent assessment of life expectancy performed by the treating oncologist or an appropriate specialist other than the physician performing TCAR.
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Best method TCD microemboli
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Abbott says this is best risk stratifier
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1.0% in vascular surgeons
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All asx carotid pts should be on intensive lipid lowering Rx
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Published in Circulation
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How often do stent fx occur?
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Peaks yrs 2-3 and does not increase w time
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<5% benefit
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Asymptomatic Disease—Consensus Guidelines
• Class 1--Selection of asymptomatic patients for carotid revascularization should be guided by an assessment of comorbid conditions, life expectancy, and other individual factors and should include a thorough discussion of the risks and benefits of the procedure with an understanding of patient preferences. (Level C)
• Class IIa--It is reasonable to perform CEA in asymptomatic patients who have more than 70% stenosis of the internal carotid artery if the risk of perioperative stroke, MI, and death is low (Level A)
• Class IIb--Prophylactic CAS might be considered in highly selected patients with asymptomatic carotid stenosis (minimum 60% by angiography, 70% by validated Doppler ultrasound), but its effectiveness compared with medical therapy alone in this situation is not well established (Level B)
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• Click to edit Master text styles
– Second level
• Third level– Fourth level
» Fifth level
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• Click to edit Master text styles
– Second level
• Third level– Fourth level
» Fifth level
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Where Do We Draw the Line?
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Event Rates in Patients With ASX Carotid Artery Stenosis Managed Without Revascularization
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