Caries diagnosis. Etiology of dental caries four factors are necessary to produce dental caries to...
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Transcript of Caries diagnosis. Etiology of dental caries four factors are necessary to produce dental caries to...
Caries Caries diagnosisdiagnosis
Etiology of dental Etiology of dental cariescaries
four factors are necessaryfour factors are necessary
to produce dental cariesto produce dental caries
Dental plaque Dental plaque A suitableA suitable
carbohydrate carbohydrate
(mainly sugar)(mainly sugar) Tooth surfaceTooth surface Time Time
How does it happenHow does it happen ????
Plaque bacteria fermentationPlaque bacteria fermentation
(sugars, sucrose & glucose(sugars, sucrose & glucose(( of carbohydrates of carbohydrates
Produce acidProduce acid
plaque pH within 1-3 minutesplaque pH within 1-3 minutes
& Plaque remains acidic for some & Plaque remains acidic for some
time taking time taking (30-60 min)(30-60 min) to neutralize to neutralize
Repeated falls in pHRepeated falls in pH
(in time) (in time) may result may result
in demineralization of in demineralization of susceptible tooth susceptible tooth
surface surface
Initiation of carious Initiation of carious processprocess
Things to be Things to be consideredconsidered
Dental caries should be Dental caries should be diagnosed and managed as a diagnosed and managed as a
dynamic diseasedynamic disease of enamel and of enamel and dentin with alternating dentin with alternating demineralization and demineralization and
remineralizationremineralization
less than 5.5 pH of oral fluidsless than 5.5 pH of oral fluids loss of Ca & ph loss of Ca & ph
fromfrom
E crystals on E crystals on thethe
surface and surface and sub-sub-
surface layers surface layers
large microporous large microporous areas developareas develop
"white "white spots"spots"
caries spreads more rapidly in caries spreads more rapidly in dentin than in enameldentin than in enamel
Continue loss ofContinue loss of tooth structuretooth structure
cavitationcavitation
In the In the pastpast
““Drill and fillDrill and fill”” approach approach
Symptomatic & failed to Symptomatic & failed to deal with etiological deal with etiological
factorsfactors
## Subsurface Subsurface demineralization precedes demineralization precedes cavitation of tooth surfacecavitation of tooth surface
Intact non restored Intact non restored teeth are superior to teeth are superior to
restored teethrestored teeth
************
What is the difference between What is the difference between lesion detection and diagnosislesion detection and diagnosis?? ??
Detecting mineral loss resulting fromDetecting mineral loss resulting from
carious process is only the first stepcarious process is only the first stepInformation is importantInformation is important
arrestedarrested
activeactive
Diagnosis adds the dimension of Diagnosis adds the dimension of lesionlesion
activity to detectionactivity to detection
Is the lesionIs the lesionor
objectives ofobjectives of caries diagnosis caries diagnosis
Identify lesions that require Identify lesions that require surgical treatment surgical treatment (restorative (restorative treatment).treatment).
Lesions that require Lesions that require nonsurgical nonsurgical treatment.treatment.
Those personsThose persons who are at who are at high high riskrisk for developing carious for developing carious lesions.lesions.
Is the patient at Is the patient at high high
risk for cariesrisk for caries?? ??
Diagnosis should not only Diagnosis should not only bebe
to search for cavitation but to to search for cavitation but to predict caries progression predict caries progression
Early diagnosisEarly diagnosis
Knowing which patients are at Knowing which patients are at high riskhigh risk for developing caries for developing caries
Implementation of Implementation of specific specific preventive strategiespreventive strategies
that may prevent cariesthat may prevent caries
Early diagnosisEarly diagnosis
If patient atIf patient at low risk for carieslow risk for caries
Preventive measures may be Preventive measures may be limited to oral hygiene limited to oral hygiene
ButButEarly diagnosisEarly diagnosis
How to diagnose How to diagnose a carious lesions ??a carious lesions ??
(Assessment tools)(Assessment tools) Patient historyPatient history Clinical examinationClinical examination Nutritional analysis Nutritional analysis Salivary analysisSalivary analysis Radiographic assessment Radiographic assessment
Patient historyPatient history
Age, gender, fluoride exposure, Age, gender, fluoride exposure, smoking habits, medications, smoking habits, medications, dietary habits, economic and dietary habits, economic and educational status, and general educational status, and general health health
can assist in diagnosis of can assist in diagnosis of caries caries
&&
identification of high-identification of high-riskrisk
patientspatients
e.ge.g..
smoking, alcoholsmoking, alcohol consumption, use of consumption, use of medication , & sucrose intakemedication , & sucrose intake
risk for caries risk for caries developmentdevelopment
Children and elderly adultsChildren and elderly adults Lower economic statusLower economic status Lower education Lower education fluoride exposurefluoride exposure Poor general healthPoor general health
caries caries riskrisk
A past history of caries A past history of caries experience is the best experience is the best
predictor of future caries predictor of future caries activityactivity
Clinical examination Clinical examination ((visual & tactile)visual & tactile)
Salivary functioningSalivary functioning
(adequate or inadequate)(adequate or inadequate) Plaque accumulationPlaque accumulation Inflammation of soft tissueInflammation of soft tissue Poor oral hygienePoor oral hygiene Cavitated lesionsCavitated lesions Existing restorationsExisting restorations
Risk to caries Risk to caries developmentdevelopment
The more factors present The more factors present
The greater the The greater the riskrisk
Assessing individual tooth Assessing individual tooth surfaces for cavitationsurfaces for cavitation Noncavitated lesions Noncavitated lesions (preventive (preventive
treatment indicated)treatment indicated)
important
If cavitation occurred If cavitation occurred (restorative treatment (restorative treatment indicated)indicated)
Visual assessmentVisual assessment of of discoloration.discoloration.
translucency or opacitytranslucency or opacity
How to assessHow to assess? ?
Proper cleaning & drying of teeth together with adequate illumination
Tactile assessmentTactile assessment
Determining the roughness or Determining the roughness or
softness of the tooth surfacesoftness of the tooth surface
Probing of the suspected lesionProbing of the suspected lesion
Penetration and resistance to Penetration and resistance to removal of explorer tip removal of explorer tip (a (a ““catchcatch””) )
evidence ofevidence of
demineralizationdemineralization
??
It may not be necessarly decayIt may not be necessarly decay It could be the local anatomicIt could be the local anatomic
features of the toothfeatures of the tooth Sharpness of the explorerSharpness of the explorer Force of application Force of application
ButButButBut
There is no There is no needneed to apply too to apply too much pressure much pressure on an on an explorerexplorer
There is no There is no needneed to apply too to apply too much pressure much pressure on an on an explorerexplorer
noncavitated incipientnoncavitated incipient lesions lesions could cause cavitation could cause cavitation
The use of sharp dental
explorer
alsoalso entrance of bacteria entrance of bacteria
lesion lesion susceptibilitysusceptibility
Nutritional analysisNutritional analysisFrequent exposure to sucrose e.g. Frequent exposure to sucrose e.g.
candycandy
(cariogenic MS organisms)(cariogenic MS organisms)
plaque developmentplaque development
caries activitycaries activity
ButBut not all patients with high not all patients with high sugar intake will develop caries.sugar intake will develop caries.
HoweverHowever, its unusual to find a , its unusual to find a patient with multiple carious patient with multiple carious lesions who does not have a high lesions who does not have a high sugar intake. sugar intake.
Salivary analysisSalivary analysis
Secretion rate Secretion rate Buffering capacityBuffering capacity Number of both mutans Number of both mutans
streptococci (MS) and streptococci (MS) and lactobacillilactobacilli
Helps to identify high patientsHelps to identify high patients
Salivary rate (salivary flow)Salivary rate (salivary flow):: High level of salivary flow High level of salivary flow
cariostatic effect cariostatic effect
Xerostomia or dry mouth Xerostomia or dry mouth
favorable favorable environmentenvironment
for caries for caries developmentdevelopment
Buffering and remineralization
Antidepressants, tranquilizers & diureticsRadiation therapy
With reduced salivary flowWith reduced salivary flow
Less Less ““washingwashing”” action allowing action allowing acidacid
& plaque to accumulate& plaque to accumulate
Buffering capacity:Buffering capacity:
Saliva is a buffer solutionSaliva is a buffer solution Helps to neutralize acid produced Helps to neutralize acid produced
by bacteriaby bacteria
saliva contains calcium and saliva contains calcium and phosphorous phosphorous
remineralizationremineralization
Mutans streptococci & Mutans streptococci & lactobacilli:lactobacilli:
High S.mutans countHigh S.mutans count
high risk high risk
Low S.mutans countLow S.mutans count
low risklow risk
Thick plaque on tooth surfaceThick plaque on tooth surface
enhance carious enhance carious processprocess
How? How? By shielding the bacteria from the By shielding the bacteria from the
buffering effects of saliva at tooth-buffering effects of saliva at tooth-plaque interface plaque interface
By preventing remineralization By preventing remineralization
At chairsideAt chairside
several Kits are available several Kits are available (e.g. Patient (e.g. Patient
Check-up Kit from GC)Check-up Kit from GC) that can be that can be
used to test for: used to test for: • Salivary flow rateSalivary flow rate• Buffering capacity &Buffering capacity &• Mutans streptococci & lactobacilliMutans streptococci & lactobacilli
Salivary flowSalivary flow
Patient chews Patient chews paraffin waxparaffin wax to to stimulatestimulate
saliva, then pt spits into a saliva, then pt spits into a measuringmeasuring
Cylinder (mL /min)Cylinder (mL /min)
Buffering capacityLitmus paper dipped in the pt’s saliva& color compared with manufacturer’s Chart to read the pt’s buffering capacity
To estimate the number ofTo estimate the number of S.mutans & lactobacilli S.mutans & lactobacilli
The number of S.mutans & The number of S.mutans & lactobacillilactobacilli
can be estimated in reference to can be estimated in reference to the the
manufacturermanufacturer’’s charts chartS.mutans lactobacilli
radiographic assessmentradiographic assessment
Radiographs shows carious Radiographs shows carious lesions that are not visible lesions that are not visible clinicallyclinically butbut they tend to they tend to under estimate the under estimate the histologic extent of the histologic extent of the carious lesioncarious lesion
Detection of Detection of occlusal caries in occlusal caries in dentindentin although enamel caries although enamel caries cannot be seen cannot be seen “hidden” caries
Diagnosis of Diagnosis of proximal cariesproximal caries in both in both E & DE & D
Bite-wing Bite-wing radiographsradiographs
What kind of x-ray?
Conventional radiography
Proximal lesions develops slowlyProximal lesions develops slowly
it may take more than a year it may take more than a year before it becomes evident on before it becomes evident on
radiograph radiograph
““white chalkywhite chalky”” appearance appearance
RadiographicallyRadiographically
A small A small radiolucent notchradiolucent notch is is evident below the contact area in evident below the contact area in enamelenamel
Advanced proximal caries
Very advanced
Approximately 60 % of teeth Approximately 60 % of teeth with radiographic proximal with radiographic proximal lesions in the outer half of lesions in the outer half of
dentin dentin
are likely to beare likely to be
Noncavitated Noncavitated And should be And should be remineralized and not restoredremineralized and not restored
Caries in dentin
with sound enamel “hidden” or
“occult’’ caries
bite-wing radiographs cannotbite-wing radiographs cannot be used solely for complete be used solely for complete caries diagnosis without caries diagnosis without additional clinical additional clinical
examinationexaminationand historyand historyWhy??
Overlaps & false-positive diagnosis
•Positioning mistakes of the cone
•Curvature of the dental arch
Prior caries activityPrior caries activity Frequent sucrose intakeFrequent sucrose intake Minimal exposure to fluorideMinimal exposure to fluoride Young or old ageYoung or old age Decrease in salivary functioningDecrease in salivary functioning High number of cariogenic High number of cariogenic
bacteriabacteria Presence of existing carious lesion Presence of existing carious lesion
patient ispatient is at high risk to cariesat high risk to caries
If a patient presents with many If a patient presents with many cavitated lesions & were skillfully cavitated lesions & were skillfully
restoredrestored Is the patient still at risk of caries??Is the patient still at risk of caries??
The answer is The answer is yesyesBiological environment that causedBiological environment that caused
caries was not changedcaries was not changed
A A change in diet change in diet or or oral oral hygiene habitshygiene habits in in
combination with optimal combination with optimal fluoridationfluoridation may may stop the stop the
progressionprogression of a lesion of a lesion and possibly allow its and possibly allow its
remineralization. remineralization.
““RiskRisk”” is the probability that some is the probability that some harmful event will occurharmful event will occur
““Caries riskCaries risk””
Is probability that an individual will Is probability that an individual will develop carious lesion during a develop carious lesion during a
specified period specified period
CariogramCariogram ItIt’’s a s a computer programcomputer program that serves as that serves as
a new risk assessment modela new risk assessment model It It assesses and graphically illusratesassesses and graphically illusrates
the caries risk for a patientthe caries risk for a patient It is expressed as the It is expressed as the ““chance to avoid chance to avoid
new cariesnew caries”” in the coming year in the coming year It can demonstrate It can demonstrate how and to what how and to what
extentextent the various caries-causing the various caries-causing factors may affect this factors may affect this ““chancechance””
The original purpose of the The original purpose of the program was educational but it program was educational but it
helps the dentist in making helps the dentist in making correct decisions.correct decisions.
Illustrate the chance to avoid Illustrate the chance to avoid cariescaries
Illustrate the interaction of caries-Illustrate the interaction of caries-related factors related factors
Express caries risk graphicallyExpress caries risk graphically Recommend preventive actionRecommend preventive action Motivate patient in clinical settingMotivate patient in clinical setting Provide an educational programProvide an educational program
The aims of the cariogram are to:The aims of the cariogram are to:
How does it worksHow does it works????
1-1- Patient examined & data Patient examined & data collectedcollected
Factors of direct relevance to cariesFactors of direct relevance to caries
(Bacteria, diet )(Bacteria, diet ) Indirect factors (susceptibility-Indirect factors (susceptibility-
related factors) related factors)
2- 2- factors are given a score from factors are given a score from 0-30-3 or or (0-2 for some factors)(0-2 for some factors) & &
entered into computer programentered into computer program
Score Score ““00”” is the most favorable values is the most favorable values &&
maximum score maximum score ““33”” (or (or ““22””)) indicates indicates high ,unfavorable risk valuehigh ,unfavorable risk value
1.1. Red Red ““bacteriabacteria””
2.2. Dark blue Dark blue ““dietdiet””
3.3. Light blue Light blue ““susceptibilitysusceptibility””
4.4. Yellow Yellow ““circumstancescircumstances””
The four sectors are mapped The four sectors are mapped outout
and what is left is theand what is left is the
5.5. Green Green ““chance to avoid carieschance to avoid caries””
The The pie-circle diagrampie-circle diagram is divided into 5 is divided into 5
sectorssectors
High risk High risk
low chance low chance
small green small green sectorsector
““Chance to avoid cariesChance to avoid caries”” & & caries risk are inversely relatedcaries risk are inversely related
Low risk Low risk
high chance high chance
large green large green sectorsector
Risk assessment needs Risk assessment needs
both clinical skill and both clinical skill and experienceexperience
Patient should realize that caries
risk status can change and that the dentist can detect
this change
Advanced diagnostic toolsAdvanced diagnostic tools11--Intraoral cameraIntraoral camera
22--Digital radiographDigital radiograph
33--Laser based deviseLaser based devise
44--Fibroptic trans-illuminationFibroptic trans-illumination
55--Electric caries monitorElectric caries monitor
66--dye penetrationdye penetration
11--Intra oral cameraIntra oral camera--Camera placed inside oral cavity to Camera placed inside oral cavity to
displaydisplayIntra oral images on a computerIntra oral images on a computer
--Has improved visual access to dental Has improved visual access to dental cavitycavity
--Improved lighteningImproved lightening--Improved magnificationImproved magnification
--Demonstrate the pt needs for treatmentDemonstrate the pt needs for treatment
22--Digital radiographyDigital radiography--Image recorded with non film Image recorded with non film
receptorreceptor
--The film replaced by flat electronic The film replaced by flat electronic pad or sensorpad or sensor
--Images sent to computer displayed Images sent to computer displayed on monitor screenon monitor screen
AdvantagesAdvantages11--Lower exposure of radiation for the ptLower exposure of radiation for the pt
22--Absence of dark roomAbsence of dark room
33--Convenience of image enhancement, Convenience of image enhancement, magnification and color codingmagnification and color coding
44--Diagnosis of initial caries lesion adequatelyDiagnosis of initial caries lesion adequately
DisadvantagesDisadvantages11--Under estimate the size of the Under estimate the size of the
lesionlesion
22--High false positive results in High false positive results in occlusal caries detectionocclusal caries detection
Radiographic Radiographic classification for classification for proximal cariesproximal caries
00--Sound surfaceSound surface11--lesion in outer half of enamellesion in outer half of enamel22--lesion in inner half of enamellesion in inner half of enamel
33--lesion in outer half of dentinlesion in outer half of dentin44--lesion in inner half of dentinlesion in inner half of dentin
Value of classificationValue of classificationTo dictate the line of treatmentTo dictate the line of treatment
Score 1,2 and possibly 3 treated Score 1,2 and possibly 3 treated with mineralizationwith mineralization
Other scores treated by cavity and Other scores treated by cavity and restorationrestoration
Laser-based device Laser-based device [DIAGNODENT][DIAGNODENT]
--Laser light passed via optical fiber to the Laser light passed via optical fiber to the area of decayarea of decay
--the decayed area fluorescencethe decayed area fluorescence
--The fluorescence passes back to the probeThe fluorescence passes back to the probe
--The decay displayed and indicated both The decay displayed and indicated both visually and audiblyvisually and audibly
AdvantagesAdvantages11--No sharp probe of the teethNo sharp probe of the teeth
22--lesse exposure to radiationlesse exposure to radiation33--Great for children and anxious patientGreat for children and anxious patient
44--Catching decay in early stages so Catching decay in early stages so minimalminimalTreatment is necessaryTreatment is necessary
55--Visual and acoustic measurementVisual and acoustic measurement66--Results are documentedResults are documented
33--Fibroptic Fibroptic transillumination[FOTI]transillumination[FOTI]
--Works under principle that caries has Works under principle that caries has lowerlowerIndex of light transmissionIndex of light transmission
--area of caries appears as darkened area of caries appears as darkened shadowshadow
--Initially designed for detection of Initially designed for detection of proximal cariesproximal caries
Consists ofConsists of::--halogen lamphalogen lamp
--Rheostat to produce light of Rheostat to produce light of variable intensityvariable intensity
--And two attachmentsAnd two attachments--Mouth mirrorMouth mirror
--Fibroptic probe 0.5mm diameterFibroptic probe 0.5mm diameter
Produce narrow beam of light for Produce narrow beam of light for transilluminationtransillumination
Displayed in computer screen for Displayed in computer screen for diagnosisdiagnosis
AdvantagesAdvantages11--No hazards of radiationNo hazards of radiation
22--Simple and comfortableSimple and comfortable
33--Lesion can not diagnose by Lesion can not diagnose by radiation diagnosed by this radiation diagnosed by this methodmethod
44--Not time consumingNot time consuming
DisadvantagesDisadvantages11--Permanent records are difficult to Permanent records are difficult to
maintainmaintain
22--Subjected to observer variationSubjected to observer variation
33--Difficult to place probe in certain Difficult to place probe in certain areasareas
44--Electrical caries monitor [ECM]Electrical caries monitor [ECM]--Based on difference of electrical Based on difference of electrical
conductivityconductivity
Between sound and carious dental tissuesBetween sound and carious dental tissues
--Works effectively for detection of occlusal Works effectively for detection of occlusal cariescaries
--Resistance should be recorded in absence Resistance should be recorded in absence of salivaof saliva
--High measurements indicates well High measurements indicates well mineralizationmineralization
--Low measurements indicates Low measurements indicates demineralized tissuesdemineralized tissues
--Has potential to monitor lesion Has potential to monitor lesion progressionprogression
7-Dye Penetration Method7-Dye Penetration Method
coloring by a dye may coloring by a dye may differentiate between several differentiate between several objects which have a similar objects which have a similar appearance appearance
Dye penetration
observation of the coloring can be: observation of the coloring can be:
qualitativequalitative or or quantitativequantitative
Intensity of colorPresence or absence
In caries diagnosisIn caries diagnosisqualitative examination is qualitative examination is
sufficientsufficient observation of colored dye observation of colored dye signifies presence of cariessignifies presence of caries
Dyes should fulfill the Dyes should fulfill the following criteria :following criteria :
1)1) Dyes should be absolutely safe for Dyes should be absolutely safe for intra oral use intra oral use3)3) Dyes should be easily removed and Dyes should be easily removed and not lead to permanent staining not lead to permanent staining
DDyes for carious dentinyes for carious dentinCarious dentin is divided into two Carious dentin is divided into two layers:layers: Outer decalcified layer (infected)Outer decalcified layer (infected) soft and cannot be soft and cannot be remineralizedremineralized Inner decalcified layerInner decalcified layer (affected)(affected) hard and can be remineralized hard and can be remineralized
0.5% Basic Fuchsin in 0.5% Basic Fuchsin in propylene glycolpropylene glycol
Denatured collagen Denatured collagen is stainedis stained
while the inner while the inner zone remains unstained zone remains unstained
Basic Fuchsin dye was considered Basic Fuchsin dye was considered to be to be carcinogeniccarcinogenic
replaced byreplaced byAcid Red and Methylene BlueAcid Red and Methylene Blue
Methylene blue is alsoMethylene blue is alsoslightly toxic slightly toxic
soso
Acid red is preferredAcid red is preferred
Management of cariesManagement of cariesBy two measuresBy two measures-:-:
a-Preventive:-a-Preventive:-To prevent occurans To prevent occurans of cariesof caries
B-control & treatment:-B-control & treatment:-To stop To stop progress of active lesion and progress of active lesion and restore itrestore it
Caries preventionCaries prevention11--By the patientBy the patient
a-Low intake of carbohydratesa-Low intake of carbohydrates
B-Removal of plaque by brushing & flossingB-Removal of plaque by brushing & flossing
C-Use fluoridated tooth pastC-Use fluoridated tooth past
d-Maintenance of good healthd-Maintenance of good health
e-Stimulation of circulation of gengival e-Stimulation of circulation of gengival tissuestissues
22--By the dentistBy the dentist-:-:a-Periodic cleaning of teetha-Periodic cleaning of teeth
B-application of fluorideB-application of fluoride
C-Fissure sealant in pits & fissuresC-Fissure sealant in pits & fissures
D-Educating & motivating the D-Educating & motivating the patientpatient
E-repairing early lesionsE-repairing early lesions
Treatment of early cariesTreatment of early cariesa-fluoride exposurea-fluoride exposure-:-:
Action of fluorideAction of fluoride--Precipitated into tooth structurePrecipitated into tooth structure
--remineralizationremineralization--Inhibit enzyme productionInhibit enzyme production
--Decrease surface energy of enamel Decrease surface energy of enamel leads to decrease retention of micro leads to decrease retention of micro organismsorganisms
B-Anti microbial agent:-B-Anti microbial agent:-((chemoprophylaxischemoprophylaxis))
- -fluoridefluoride--chlorhexidine:-is chlorhexidine:-is
antiseptic ,bactericidal, fungicidalantiseptic ,bactericidal, fungicidal--Triclosan:- is broad spectrum anti Triclosan:- is broad spectrum anti
microbial agentmicrobial agent - -antibioticsantibiotics
C-Oral hygieneC-Oral hygiene-:-:
Removal of the plaque byRemoval of the plaque by-:-:--Dental flossingDental flossing
--dental brushingdental brushing
--rinsingrinsing
D-Xylitol gumsD-Xylitol gums--Reduces streptoccocus mutans by Reduces streptoccocus mutans by
Altering their metabolic pathwaysAltering their metabolic pathways
--Enhance demineralizationEnhance demineralization
--Arrest dental cariesArrest dental caries
Used as chewing gum for 5-30 Used as chewing gum for 5-30 minutesminutes
E-shewing sugar free gumE-shewing sugar free gum--Reduces acidogenicity of plaque Reduces acidogenicity of plaque
by stimulation of salivary flowby stimulation of salivary flow
--Buffering of the phBuffering of the ph
‘‘Iodine penetration method’Iodine penetration method’ measuring enamel porosity of the measuring enamel porosity of the incipient carious lesions incipient carious lesions how??how??* * potassium iodide applied on a well-potassium iodide applied on a well- defined area of enamel defined area of enamel* excess removed* excess removed* iodine remaining in micropores is * iodine remaining in micropores is estimated estimated indicates permeability of indicates permeability of enamel enamel
complicated procedurecomplicated procedure
In spite of the modern In spite of the modern diagnostic aids caries diagnostic aids caries detection remain an detection remain an
inexact scienceinexact science
Early detection of Early detection of Digital radiographyDigital radiography Quantitative light-induced Quantitative light-induced
fluorescencefluorescence Electrical conductivityElectrical conductivity UltrasonographyUltrasonography