Cardiometabolic Panel · Supplement with 500 mg - 4 g of L-carnitine per day. Omega-3 Coronary...
Transcript of Cardiometabolic Panel · Supplement with 500 mg - 4 g of L-carnitine per day. Omega-3 Coronary...
CardiometabolicPanel
Health Action Plan
May 9, 2019
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Table of Contents
Understand Your Genetics
How These Traits Affect You
Recommendations
Supplements
Diet
Lifestyle
Exercise
Further Testing
Traits
Inflammation
Insulin Resistance
Oxidative Stress
Coronary Artery Disease
Diabetes
Hypertension
Lipid Impairment with Lp(a)
Client Summary
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Understand Your GeneticsThis report is broken down into three main sections: TraitImpact, Recommendations and Trait Detail. Depending onthe number of traits being reviewed, your report willcontain multiple trait and recommendation detailsections. Terms and sections of the report are definedbelow.
DNA
DNA is a long, ladder-shaped molecule. The rungs of the ladder are madeof two amino acids pairing together, these are called bases. They alwayspair the same way, A (Adenine) with T (Thymine), and C (Cytosine) with G(Guanine). The body is constantly replicating DNA strands.
GENE
Genes are the basic units of heredity (passeddown from generation to generation). Theyare made of DNA and provide theinstructions for how our body works, whatwe look like, etc. Humans have between20,000 - 25,000 genes. We inherit half ofthem from our mother and half from ourfather.
SNP
A SNP is a Single Nucleotide Polymorphism. SNPsoccur when the amino acids making up the basepair do not come together in the same way as theoriginal DNA strand. For example, the originalstrand may have had an A but the replicatedstrand has a G. SNPs are common and many ofthem have no impact to the individual, however,some can change how our body works.
VARIANT
Variants are how SNPs are referred to in thisreport. When the amino acid in the copiedstrand is different from the original, it iscalled a variant - it varies from the original.Variants are not necessarily 'good' or 'bad'they are simply different from the original.The depiction of variants is shown as: +/+(both copies have different amino acids), +/-(one copy has a different amino acid), -/-(both copies have the same amino acid as theoriginal) or U (one copy is indeterminate).
Reading This Report
Trait Impact Traits Recommendations
This report focuses on traits. These aretypically groups of SNPs that have asimilar impact on the body’s function.We use a proprietary algorithm todetermine the impact a group of SNPsmay have on a specific function in thebody based on your individual testresults.
The traits in our reports aretypically grouped by body function,a symptom type, a disease, anutrient need, or a response toenvironment. Within the traitpages, you will see the SNPs thatare looked at for that trait, yourvariant type and recommendationsto optimize health and minimize riskbased on your individual results.
Your genes, and therefore yourSNPs, will not change during yourlife. However, this report focuseson SNPs whose impact can beinfluenced by external factors likediet, exercise, supplements, andlifestyle changes.
Disclaimer - The recommendations in this report have been carefully prepared and reviewed for you by your health and wellness provider, based on his or herreasoned medical judgment about your personal health needs. Be sure that you have shared with your health and wellness provider all relevant information aboutyour health, including any medications or dietary supplements you may be taking, and any medical conditions you may be experiencing, before you adopt any of theserecommendations. This test is performed via DNA sequencing. As with all genetic testing with the highest possible standards, the data generated during thelaboratory process will have a <99% sensitivity and specificity.
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How These Traits Affect YouThis page provides a high-level snapshot of the clinical significance of each trait within this panel. The results are intwo categories: traits that are ranked high, medium or low impact as well as traits for which there is an explicit result(i.e. categorical such as "yes" or "no"). At the end of this page are a summary of any non-reportable (NR) traits. Theresults for these traits are unable to be determined from the sample submitted. Recommendations are made for traitswith high or medium impact only.
Impact Traits Impact Learn More
1 Inflammation HIGH Page 19
2 Insulin Resistance HIGH Page 20
3 Oxidative Stress HIGH Page 22
4 Coronary Artery Disease MEDIUM Page 23
5 Diabetes MEDIUM Page 25
6 Hypertension MEDIUM Page 27
7 Lipid Impairment with Lp(a) MEDIUM Page 29
8 Metabolic Syndrome LOW
1 2 3 4 5 6 7 8
High
Medium
Low
Impact Traits
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SupplementsBelow is a list of recommended supplements curated specifically for you based on the Supplement sections foundwithin your report. Supplement recommendations are listed in order of importance based on your individual geneticresults. The traits generating each recommendation are listed just below them. These recommendations have beenreviewed by your healthcare provider. Please contact your provider if you have any questions.
Supplement Recommendation & Linked Traits Details Comments
Green Tea Extract (EGCG)
Diabetes, Hypertension, InsulinResistance, Lipid Impairment withLp(a)
Supplement with 300 - 400 mg of green teaextract per day.
Magnesium
Coronary Artery Disease, Diabetes,Hypertension, Insulin Resistance
Supplement with 300 - 500 mg ofmagnesium per day.
CoQ10
Coronary Artery Disease,Hypertension, Lipid Impairment withLp(a)
Supplement with 150 - 500 mg of CoQ10per day.
Curcumin
Inflammation, Insulin Resistance,Lipid Impairment with Lp(a)
Supplement with 250 - 2,000 mg of curcuminextract per day.
Garlic
Coronary Artery Disease, Diabetes,Hypertension
Supplement with 400 - 1,200 mg of garlicextract per day.
Vitamin D3
Diabetes, Inflammation, InsulinResistance
Supplement with 3,000 IUs of vitamin D3 perday.
Zinc
Coronary Artery Disease,Hypertension, Oxidative Stress
Supplement with 10 - 40 mg of zinc per day.
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Aloe Vera
Diabetes, Lipid Impairment withLp(a)
Supplement with 300 - 1,000 mg of an aloevera extract or drink 2 tablespoons of aloevera juice per day.
Berberine
Diabetes, Insulin Resistance
Supplement with 1,500 mg of berberine perday.
Ginger
Diabetes, Lipid Impairment withLp(a)
Supplement with 400 - 3,000 mg of driedginger extract per day.
L-Carnitine
Coronary Artery Disease, LipidImpairment with Lp(a)
Supplement with 500 mg - 4 g of L-carnitineper day.
Omega-3
Coronary Artery Disease, Diabetes
Supplement with 2 - 5 g of omega-3 fattyacid supplement that contains essential fattyacids DHA and EPA.
Vitamin C
Lipid Impairment with Lp(a),Oxidative Stress
Supplement with 500 - 1,000 mg of vitaminC per day.
B-Vitamin Complex
Coronary Artery Disease
Supplement with 50 mg of a vitamin B-complex per day.
Betaine Hydrochloride(HCl)
Inflammation
Supplement with 1 - 2 g of betainehydrochloride (HCl) with meals for at least 6months.
Biotin (Vitamin B7)
Diabetes
Supplement with 8 - 16 mg of biotin per day.
Chromium
Diabetes
Supplement with 200 - 800 mcg ofchromium per day with meals.
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Cinnamon
Diabetes
Supplement with 250 mg of cinnamon perday.
Citrus Bioflavanoids andTocotrienols
Lipid Impairment with Lp(a)
Supplement with a combination of 270 mg ofcitrus bioflavanoids and 30 mg oftocotrienols per day.
Fenugreek
Diabetes
Supplement with 90 mg of fenugreek perday.
Folate
Inflammation
Supplement with 400 - 800 mcg of methyl-folate per day.
Grape Polyphenols
Hypertension
Supplement with grape polyphenols fromgrape seed extract at doses ranging from 150mg - 1,000 mg per day.
L-Arginine
Hypertension
Supplement with 500 mg - 4 g of L-arginineper day.
Multivitamin
Inflammation
Supplement with a multivitamin that includesactivated B vitamins.
Probiotics
Lipid Impairment with Lp(a)
Supplement with a 10 - 50 billion CFUprobiotic per day.
Quercetin
Hypertension
Supplement with 500 - 1,000 mg ofquercetin daily.
Resistant Starch
Insulin Resistance
Supplement with 40 g of resistant starch perday.
Resveratrol
Insulin Resistance
Supplement with 150 - 2,000 mg ofresveratrol per day.
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Thiamine (Vitamin B1)
Diabetes
Supplement with 30 - 100 mg up to 3 timesper day.
Vanadium
Diabetes
Supplement with 100 mg of vanadium perday.
Vitamin E
Oxidative Stress
Supplement with 100 - 400 IUs of vitamin Eper day.
Vitamin K1
Insulin Resistance
Supplement with 500 mcg of vitamin K1 perday.
Vitamin K2 (Menaquinone)
Diabetes
Supplement with 100 - 200 mcg of vitmainK2 per day.
Note - If you are taking any medications, consult with your practitioner before starting any new supplements as they may have adverseeffects with your medications.
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DietBelow is a list of dietary recommendations curated specifically for you based on the Diet sections found within yourreport. Diet recommendations are listed in order of importance based on your individual genetic results. The traitsgenerating each recommendation are listed just below them. These recommendations have been reviewed by yourhealthcare provider. Please contact your provider if you have any questions.
Diet Recommendation & Linked Traits Details Comments
Dark Chocolate (70-99%)
Coronary Artery Disease, Diabetes,Hypertension, Insulin Resistance,Lipid Impairment with Lp(a)
Eat approximately 1 oz of dark chocolate perday.
Mediterranean Diet
Coronary Artery Disease, Diabetes,Hypertension, Inflammation, InsulinResistance
Adopt a Mediterranean-style diet thatincludes a variety of antioxidant-rich foods,heart healthy fats, and complexcarbohydrates.
Dietary Fiber
Diabetes, Inflammation, InsulinResistance
Increase dietary fiber intake to recommended25 g for females and 30 g for males.
Almonds
Coronary Artery Disease, InsulinResistance
Eat approximately 1 oz of almonds per day.
Apple Cider Vinegar
Diabetes, Insulin Resistance
Consume 2 to 4 tsp of apple cider vinegarprior to eating.
Calorie Restriction
Insulin Resistance, Oxidative Stress
Reduce overall calorie intake to create acalorie deficit.
Cinnamon
Diabetes, Insulin Resistance
Add 1 to 2 tsp of cinnamon to your diet perday.
Fruits and Vegetables
Inflammation, Oxidative Stress
Include fruits and vegetables at every meal toincrease levels of antioxidants in the body,especially strawberries, blueberries, broccoli,sprouts, and green leafy vegetables.
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Low Glycemic Index Foods
Diabetes, Insulin Resistance
Choose low-glycemic index foods to avoidblood sugar spikes.
Nut Consumption
Coronary Artery Disease,Inflammation
Consume a variety of nuts including almonds,walnuts, macadamia nuts, and brazil nuts.
Olive Oil
Coronary Artery Disease,Hypertension
Choose olive oil as the main source of fat inthe diet by replacing vegetable cooking oilswith olive oil and using olive oil-baseddressings.
Add Spices to Food
Diabetes
Add spices such as red pepper, cayenne, orturmeric each day to snacks and meals.
Anti-Inflammatory Diet
Inflammation
Consume a diet rich in anti-inflammatoryfoods.
Choose ComplexCarbohydrates
Diabetes
Replace foods that are heavy in sugar orrefined carohydrates with complexcarbohydrates.
Consume Legumes
Coronary Artery Disease
Include 1 cup of legumes per day orapproximately 6 cups per week into the diet.
Eat Small, Healthy Snacks
Diabetes
Eat small healthy snacks that are rich incomplex carbohydrates and protein.
Eggs
Lipid Impairment with Lp(a)
Include 1 whole egg in the daily diet.
Flax Seeds
Hypertension
Add 2 tbsp of flaxseeds to your daily diet.
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Folate Rich Foods
Lipid Impairment with Lp(a)
Consume a diet rich in folate.
Limit Coffee Intake
Diabetes
Drink no more than 3 cups of coffee per day.
Limit Fructose andFructans
Hypertension
Avoid fructose or limit fructose to no morethan 75 g per day.
Limit Sweetened Beverages
Hypertension
Limit or eliminate sugar-sweetenedbeverages and fruit juices to no more than 12oz daily.
Magnesium Rich foods
Coronary Artery Disease
Consume a diet rich in magnesium.
Monounsaturated FattyAcids (MUFAs)
Insulin Resistance
Consume a diet rich in monounsaturatedfatty acids, sources include avocados andolive oil.
Plant-Based Diet
Coronary Artery Disease
Consume a diet that is focused on whole,unprocessed plant-based foods and wholegrains.
Potassium Rich Foods
Hypertension
Consume a diet rich in potassium.
Protein Intake
Diabetes
Focus on high quality protein sources.
Reduce Sodium (Salt)Intake
Hypertension
Reduce sodium intake or adhere to a low-saltdiet limiting sodium to 1,500 mg per day.
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LifestyleBelow is a list of lifestyle recommendations curated specifically for you based on the Lifestyle sections found withinyour report. Lifestyle recommendations are listed in order of importance based on your individual genetic results.The traits generating each recommendation are listed just below them. These recommendations have beenreviewed by your healthcare provider. Please contact your provider if you have any questions.
Lifestyle Recommendation & Linked Traits Details Comments
Intermittent Fasting
Diabetes, Inflammation, InsulinResistance, Lipid Impairment withLp(a)
Try intermittent fasting (fasting for 14+ hoursdaily) or alternate day fasting (fasting for 24hours every other day).
Meditation
Coronary Artery Disease, Diabetes,Hypertension, Insulin Resistance
Engage in 10 to 20 minutes of mindfulnessmeditation 2 or more times per week.
Adequate Sleep
Coronary Artery Disease, Diabetes,Hypertension
Aim for the recommended 7 to 8 hours ofsleep each night.
Heat Therapy
Coronary Artery Disease, Diabetes
Aim for 20 to 30 minutes per day of heattherapy treatments such as sauna, infrared,and hot tub sessions.
Eat Larger Meals Earlier inthe Day
Insulin Resistance
Eat larger meals earlier in the day, preferablybefore 4 pm.
Limit Alcohol
Lipid Impairment with Lp(a)
Avoid alcohol or limit alcohol to no morethan 1 drink per day for women and 2 drinksper day for men.
Reduce Sedentary Behavior
Coronary Artery Disease
Reduce sedentary behavior. Try toincorporate small bouts (~ 5 minutes) ofstanding or moving throughout the day.
Reduce Stress
Oxidative Stress
Engage in enjoyable hobbies such asgardening, sports, or other leisure activitiesto help reduce stress.
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9 Sleep Consistency
Inflammation
Stick to a consistent sleep routinue thatconsists of going to sleep and waking up atapproximately the same time each day.
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ExerciseBelow is a list of exercise recommendations curated specifically for you based on the Exercise sections found withinyour report. Exercise recommendations are listed in order of importance based on your individual genetic results.The traits generating each recommendation are listed just below them. These recommendations have beenreviewed by your healthcare provider. Please contact your provider if you have any questions.
Exercise Recommendation & Linked Traits Details Comments
Aerobic Activity
Coronary Artery Disease, Diabetes,Hypertension, Insulin Resistance,Oxidative Stress
Aim for 20 to 30 minutes of aerobic physicalactivity most days of the week.
Yoga
Diabetes, Hypertension, OxidativeStress
Incorporate at least 1 to 2 yoga sessions intoyour weekly excercise routine.
Resistance Training
Coronary Artery Disease, Diabetes
Engage in resistance training that targets allmajor muscle groups 2 to 3 times per week.
Dancing
Hypertension
Incorporate 45 to 60 minutes of danceseveral times per week into your normalexercise routine.
Walk Hills
Diabetes
Incorporate walking hills into your exerciseroutine 3 times per week.
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Further TestingBelow is a list of further testing recommendations curated specifically for you based on the Further Testing sectionsfound within your report. Further Testing recommendations are listed in order of importance based on yourindividual genetic results. The traits generating each recommendation are listed just below them. Theserecommendations have been reviewed by your healthcare provider. Please contact your provider if you have anyquestions.
Further Testing Recommendation& Linked Traits
Details Comments
C-Reactive Protein (CRP) orhsCRP
Coronary Artery Disease,Inflammation, Lipid Impairment withLp(a)
Test levels of C-Reactive Protein (CRP) orhsCRP
Fasting Insulin
Coronary Artery Disease, Diabetes,Insulin Resistance
Test fasting insulin levels
Fibrinogen
Coronary Artery Disease,Inflammation, Lipid Impairment withLp(a)
Test fibrinogen levels in the body
Post-Meal Glucose
Coronary Artery Disease, Diabetes,Insulin Resistance
Test post-meal glucose levels
Fasting Glucose
Diabetes, Insulin Resistance
Test fasting glucose levels
Hemoglobin A1C (HbA1c)
Diabetes, Insulin Resistance
Measure Hemoglobin A1C levels
Lp(a)
Coronary Artery Disease, LipidImpairment with Lp(a)
Test Lipoprotein a (Lpa) Levels
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Magnesium
Coronary Artery Disease,Hypertension
Test magnesium levels
ApoB Test
Diabetes
Test ApoB (Apolipoprotein B)
Coenzyme Q10
Coronary Artery Disease
Test serum CoQ10 levels
Electrolyte Levels
Hypertension
Test for electrolyte levels
Erythrocyte SedimentationRate (ESR)
Inflammation
Test erythrocyte sedimentation rate (ESR) inblood
Folate Testing
Inflammation
Test folate levels
HOMA-IR
Insulin Resistance
Calculate HOMA-IR
Home Blood Pressure Cuff
Hypertension
Use a home blood pressure cuff to monitoryour daily blood pressure
Homocysteine Levels
Inflammation
Check blood homocysteine levels
IL-6 Testing
Inflammation
Test for levels of IL-6
Markers of Oxidative Stress
Oxidative Stress
Test markers of oxidative stress
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Potassium
Hypertension
Test serum potassium levels
TNF-alpha
Inflammation
Test for TNF-alpha
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Trait Details
Appendix 1
Cardiometabolic Panel
May 9, 2019
Demo ClientKit #1234ABCD5678
InflammationPeople with similar genetic markers may be more likely to experience increased levels of inflammation, which is thebody’s natural response to an injury, wound, or infection.
Gene SNP Variant Impact
TNF-α rs1800629 +/+ High
IL6 rs1800795 +/+ High
TNF-α rs1799724 +/- Medium
PTPN22 rs2476601 +/- Medium
IL-10 rs1800872 +/- Low
TNF-α rs1799964 -/- Low
IL23R rs2201841 +/- Low
IL-10 rs3024505 -/- Low
Recommendations
These recommendations are based on the genetic findings in the chart above.
SUPPLEMENT • Multivitamin • Betaine Hydrochloride (HCl)
• Vitamin D3 • Folate
• Curcumin
DIET • Anti-Inflammatory Diet • Dietary Fiber
• Mediterranean Diet • Nut Consumption
• Fruits and Vegetables
LIFESTYLE • Sleep Consistency • Intermittent Fasting
FURTHER TESTING • Homocysteine Levels • IL-6 Testing
• C-Reactive Protein (CRP) orhsCRP
• Erythrocyte SedimentationRate (ESR)
• Fibrinogen • Folate Testing
• TNF-alpha
Cardiometabolic Panel High Impact
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Insulin ResistancePeople with similar genetic markers may be at an increased risk for developing insulin resistance.
Gene SNP Variant Impact
IGF1 rs35767 +/+ High
NAT2 rs1208 +/+ High
PPARG rs13081389 +/+ High
SC4MOL rs17046216 +/- Medium
TCERG1L rs7077836 -/- Low
Recommendations
These recommendations are based on the genetic findings in the chart above.
Cardiometabolic Panel High Impact
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SUPPLEMENT • Vitamin D3 • Magnesium
• Berberine • Curcumin
• Vitamin K1 • Resistant Starch
• Resveratrol • Green Tea Extract (EGCG)
DIET • Almonds • Dark Chocolate (70-99%)
• Low Glycemic Index Foods • Cinnamon
• Apple Cider Vinegar • Monounsaturated Fatty Acids(MUFAs)
• Calorie Restriction • Dietary Fiber
• Mediterranean Diet
LIFESTYLE • Meditation • Intermittent Fasting
• Eat Larger Meals Earlier inthe Day
EXERCISE • Aerobic Activity
FURTHER TESTING • Fasting Glucose • Fasting Insulin
• Post-Meal Glucose • Hemoglobin A1C (HbA1c)
• HOMA-IR
Cardiometabolic Panel High Impact
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Oxidative StressPeople with similar genetic markers may experience higher levels of oxidative stress due in part to antioxidantdepletion.
Gene SNP Variant Impact
UGT rs1105879 +/+ High
CDKN rs10811661 +/+ High
GSTP1 rs1695 -/- Low
CYP1A1 rs1048943 -/- Low
LRRK2 rs34637584 -/- Low
SOD2 rs4880 +/- Low
Recommendations
These recommendations are based on the genetic findings in the chart above.
SUPPLEMENT • Zinc • Vitamin C
• Vitamin E
DIET • Calorie Restriction • Fruits and Vegetables
LIFESTYLE • Reduce Stress
EXERCISE • Aerobic Activity • Yoga
FURTHER TESTING • Markers of Oxidative Stress
Cardiometabolic Panel High Impact
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Coronary Artery DiseasePeople with similar genetic markers may be predisposed to Coronary Artery Disease (CAD).
Gene SNP Variant Impact
PPAP2B rs17114036 +/+ High
APOB rs515135 +/+ High
GUCY1A3 rs7692387 +/+ High
PHACTR1 rs9369640 +/- Medium
LDLR rs1122608 +/- Medium
MTHFR rs1801133 +/- Medium
IL6R rs4845625 +/- Medium
FLT1 rs9319428 +/- Medium
KCNK5 rs10947789 +/- Medium
KCNE2 rs9982601 +/- Medium
CDKN2B-AS1 rs1333049 +/- Medium
ZC3HC1 rs11556924 +/- Medium
VAMP5 rs1561198 +/- Medium
TEX41 rs2252641 +/- Medium
PLG rs4252120 -/- Low
APOA5 rs2075291 -/- Low
LPL rs264 -/- Low
SORT1 rs599839 -/- Low
SLC22A4 rs273909 -/- Low
PON1 rs662 -/- Low
HDAC9 rs2023938 -/- Low
CDKN2B-AS1 rs10757274 +/- Low
WDR12 rs6725887 -/- Low
ABO rs579459 -/- Low
FURIN rs17514846 -/- Low
Recommendations
These recommendations are based on the genetic findings in the chart above.
SUPPLEMENT • Garlic • Omega-3
• Zinc • CoQ10
• L-Carnitine • Magnesium
Cardiometabolic Panel Medium Impact
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• B-Vitamin Complex
DIET • Almonds • Dark Chocolate (70-99%)
• Olive Oil • Magnesium Rich foods
• Mediterranean Diet • Plant-Based Diet
• Consume Legumes • Nut Consumption
LIFESTYLE • Heat Therapy • Reduce Sedentary Behavior
• Adequate Sleep • Meditation
EXERCISE • Aerobic Activity • Resistance Training
FURTHER TESTING• Coenzyme Q10 • C-Reactive Protein (CRP) or
hsCRP
• Fasting Insulin • Fibrinogen
• Post-Meal Glucose • Magnesium
• Lp(a)
Cardiometabolic Panel Medium Impact
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DiabetesPeople with similar genetic markers may experience higher levels of blood sugar or greater irregularities with theirglucose levels. As a result, you may have an increased risk of developing type 2 diabetes.
Gene SNP Variant Impact
KFL14 rs972283 +/+ High
CDKN rs10811661 +/+ High
HHEX rs1111875 +/+ High
ZBED3 rs4457053 +/+ High
KCNQ1 rs2237892 +/+ High
PPARG rs13081389 +/+ High
HHEX rs7923837 +/+ High
IGF2BP2 rs4402960 +/- Medium
ADIPOQ rs266729 +/- Medium
CDKAL1 rs7756992 +/- Medium
KCNQ1 rs2237895 +/- Medium
CDKAL1 rs10946398 +/- Medium
ABCB11 rs478333 +/- Medium
LEPR rs1137101 +/- Medium
TCF7L2 rs7903146 +/- Medium
GCKR rs780094 +/- Medium
SLC30A8 rs13266634 +/- Medium
KCNQ1 rs231362 +/- Medium
TFAP2B rs987237 +/- Medium
GCK rs1799884 +/- Medium
TCF7L2 rs12255372 -/- Low
LIPC rs2070895 +/- Low
ARL15 rs4311394 -/- Low
NOTCH2 rs10923931 -/- Low
IGF2BP2 rs1470579 +/- Low
MC4R rs12970134 -/- Low
MTNR1B rs10830963 -/- Low
IRS1 rs2943641 -/- Low
G6PC2 rs16856187 -/- Low
Recommendations
These recommendations are based on the genetic findings in the chart above.
SUPPLEMENT • Garlic • Omega-3
Cardiometabolic Panel Medium Impact
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• Vitamin D3 • Magnesium
• Cinnamon • Thiamine (Vitamin B1)
• Berberine • Fenugreek
• Chromium • Aloe Vera
• Vitamin K2 (Menaquinone) • Biotin (Vitamin B7)
• Vanadium • Ginger
• Green Tea Extract (EGCG)
DIET • Limit Coffee Intake • Dark Chocolate (70-99%)
• Low Glycemic Index Foods • Cinnamon
• Apple Cider Vinegar • Dietary Fiber
• Protein Intake • Add Spices to Food
• Mediterranean Diet • Choose ComplexCarbohydrates
• Eat Small, Healthy Snacks
LIFESTYLE • Heat Therapy • Adequate Sleep
• Meditation • Intermittent Fasting
EXERCISE • Walk Hills • Aerobic Activity
• Yoga • Resistance Training
FURTHER TESTING • ApoB Test • Fasting Glucose
• Fasting Insulin • Post-Meal Glucose
• Hemoglobin A1C (HbA1c)
Cardiometabolic Panel Medium Impact
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HypertensionPeople with similar genetic markers may be predisposed to developing high blood pressure (hypertension).
Gene SNP Variant Impact
SULT1C3 rs6722745 +/+ High
ADD1 rs4961 +/- Medium
ALDH2 rs671 -/- Low
ACE rs4343 -/- Low
GALNT2 rs4846914 -/- Low
CYP11B2 rs1799998 -/- Low
AGT rs699 -/- Low
AGT rs4762 -/- Low
AGT rs5051 -/- Low
MTHFR rs1801133 -/- Low
NOS3 rs2070744 -/- Low
AGTR1 rs5186 -/- Low
Recommendations
These recommendations are based on the genetic findings in the chart above.
SUPPLEMENT • Garlic • Zinc
• CoQ10 • Quercetin
• L-Arginine • Magnesium
• Grape Polyphenols • Green Tea Extract (EGCG)
DIET • Dark Chocolate (70-99%) • Olive Oil
• Limit Sweetened Beverages • Potassium Rich Foods
• Reduce Sodium (Salt) Intake • Limit Fructose and Fructans
• Mediterranean Diet • Flax Seeds
LIFESTYLE • Adequate Sleep • Meditation
EXERCISE • Dancing • Aerobic Activity
Cardiometabolic Panel Medium Impact
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• Yoga
FURTHER TESTING • Electrolyte Levels • Potassium
• Magnesium • Home Blood Pressure Cuff
Cardiometabolic Panel Medium Impact
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Lipid Impairment with Lp(a)People with similar genetic markers may have elevated levels of cholesterol, cholesterol sub-types and/or triglycerides.
Gene SNP Variant Impact
FADS2 rs1535 +/+ High
CETP rs5882 +/+ High
APOB rs693 +/- Medium
LIPC rs8034802 +/- Medium
TCF7L2 rs7903146 +/- Medium
GCKR rs780094 +/- Medium
LPA rs10455872 -/- Low
APOA5 rs662799 -/- Low
APOA5 rs3135506 -/- Low
TCF7L2 rs12255372 -/- Low
APOE rs964184 NR Not Reportable
Recommendations
These recommendations are based on the genetic findings in the chart above.
SUPPLEMENT • CoQ10 • L-Carnitine
• Vitamin C • Probiotics
• Curcumin • Aloe Vera
• Citrus Bioflavanoids andTocotrienols • Ginger
• Green Tea Extract (EGCG)
DIET • Dark Chocolate (70-99%) • Folate Rich Foods
• Eggs
LIFESTYLE • Limit Alcohol • Intermittent Fasting
FURTHER TESTING • C-Reactive Protein (CRP) orhsCRP • Fibrinogen
Cardiometabolic Panel Medium Impact
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• Lp(a)
Cardiometabolic Panel Medium Impact
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Client Summary
Appendix 2
Cardiometabolic Panel
May 9, 2019
Demo ClientKit #1234ABCD5678
Client Summary Report: Cardiometabolic Panel
Below is a summary of the genetic data that we test for in this Health Action Plan. Recommendations are given for traits with Medium andHigh Impact.
Traits are listed in order of trait impact. Please look at the Trait Impact Summary Report for more information.
Trait Gene SNP/RSID Clinical SignificanceVariantType
SNPImpactScore
Comments
Inflammation TNF-α rs1800629Increased risk ofelevated inflammatoryresponse
+/+ High
Inflammation IL6 rs1800795Increased risk ofelevated circulatingIL-6 cytokines
+/+ High
Inflammation TNF-α rs1799724Increased risk ofelevated inflammatoryresponse
+/- Medium
Inflammation PTPN22 rs2476601Increased risk ofelevated inflammatoryresponse
+/- Medium
Inflammation IL-10 rs1800872Increased risk ofelevated inflammatoryresponse
+/- Low
Inflammation TNF-α rs1799964Increased risk ofelevated inflammatoryresponse
-/- Low
Inflammation IL23R rs2201841Increased risk ofelevated inflammatoryresponse
+/- Low
Inflammation IL-10 rs3024505Increased risk ofelevated inflammatoryresponse
-/- Low
Insulin Resistance IGF1 rs35767 Increased risk forinsulin resistance +/+ High
Insulin Resistance NAT2 rs1208 Increased risk forinsulin resistance +/+ High
Insulin Resistance PPARG rs13081389
Increased risk of T2DMdue to poorer insulinregulation and beta cellfunction
+/+ High
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Trait Gene SNP/RSID Clinical SignificanceVariantType
SNPImpactScore
Comments
Insulin Resistance SC4MOL rs17046216 Increased risk forinsulin resistance +/- Medium
Insulin Resistance TCERG1L rs7077836 Increased risk forinsulin resistance -/- Low
Oxidative Stress UGT rs1105879Increased risk forelevated levels ofoxidative stress
+/+ High
Oxidative Stress CDKN rs10811661Increased risk forelevated levels ofoxidative stress
+/+ High
Oxidative Stress GSTP1 rs1695Increased risk forelevated levels ofoxidative stress
-/- Low
Oxidative Stress CYP1A1 rs1048943Increased risk forelevated levels ofoxidative stress
-/- Low
Oxidative Stress LRRK2 rs34637584Increased risk forelevated levels ofoxidative stress
-/- Low
Oxidative Stress SOD2 rs4880Increased risk forelevated levels ofoxidative stress
+/- Low
Coronary ArteryDisease PPAP2B rs17114036 Increased risk for CAD +/+ High
Coronary ArteryDisease APOB rs515135
Increased risk forelevated LDLcholesterol and CADdevelopment
+/+ High
Coronary ArteryDisease GUCY1A3 rs7692387
Increased risk for CADand elevated bloodpressure
+/+ High
Coronary ArteryDisease PHACTR1 rs9369640 Increased risk for CAD +/- Medium
Coronary ArteryDisease LDLR rs1122608 Increased risk for CAD +/- Medium
Coronary ArteryDisease MTHFR rs1801133
Increased risk forpremature CADdevelopment
+/- Medium
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Trait Gene SNP/RSID Clinical SignificanceVariantType
SNPImpactScore
Comments
Coronary ArteryDisease IL6R rs4845625 Increased risk for CAD +/- Medium
Coronary ArteryDisease FLT1 rs9319428 Increased risk for CAD +/- Medium
Coronary ArteryDisease KCNK5 rs10947789 Increased risk for CAD +/- Medium
Coronary ArteryDisease KCNE2 rs9982601 Increased risk for CAD +/- Medium
Coronary ArteryDisease CDKN2B-AS1 rs1333049 Increased risk for CAD +/- Medium
Coronary ArteryDisease ZC3HC1 rs11556924
Increased risk for CADand elevated bloodpressure
+/- Medium
Coronary ArteryDisease VAMP5 rs1561198 Increased risk for CAD +/- Medium
Coronary ArteryDisease TEX41 rs2252641 Increased risk for CAD +/- Medium
Coronary ArteryDisease PLG rs4252120 Increased risk for CAD -/- Low
Coronary ArteryDisease APOA5 rs2075291
Increased risk forelevated triglyceridesand CAD
-/- Low
Coronary ArteryDisease LPL rs264 Increased risk for CAD -/- Low
Coronary ArteryDisease SORT1 rs599839 Increased risk for CAD -/- Low
Coronary ArteryDisease SLC22A4 rs273909 Increased risk for CAD -/- Low
Coronary ArteryDisease PON1 rs662
Increased risk forhypertension, ischemicstroke, and CAD
-/- Low
Coronary ArteryDisease HDAC9 rs2023938 Increased risk for CAD -/- Low
Coronary ArteryDisease CDKN2B-AS1 rs10757274 Increased risk for CAD +/- Low
Coronary ArteryDisease WDR12 rs6725887 Increased risk for CAD -/- Low
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Trait Gene SNP/RSID Clinical SignificanceVariantType
SNPImpactScore
Comments
Coronary ArteryDisease ABO rs579459 Increased risk for CAD -/- Low
Coronary ArteryDisease FURIN rs17514846 Increased risk for CAD -/- Low
Diabetes KFL14 rs972283 Increased risk of T2DM +/+ High
Diabetes CDKN rs10811661 Increased risk of T2DM +/+ High
Diabetes HHEX rs1111875 Increased risk of T2DM +/+ High
Diabetes ZBED3 rs4457053 Increased risk of T2DM +/+ High
Diabetes KCNQ1 rs2237892Increased risk ofdiabetes and impairedrenal function
+/+ High
Diabetes PPARG rs13081389 Increased risk of T2DM +/+ High
Diabetes HHEX rs7923837 Increased risk of T2DM +/+ High
Diabetes IGF2BP2 rs4402960 Increased risk fordiabetic nephropathy +/- Medium
Diabetes ADIPOQ rs266729 Increased risk of T2DM +/- Medium
Diabetes CDKAL1 rs7756992 Increased risk of T2DM +/- Medium
Diabetes KCNQ1 rs2237895Increased risk ofdiabetes and impairedrenal function
+/- Medium
Diabetes CDKAL1 rs10946398 Increased risk of T2DM +/- Medium
Diabetes ABCB11 rs478333Increased fastingglucose and impairedinsulin secretion
+/- Medium
Diabetes LEPR rs1137101 Increased risk of T2DM +/- Medium
Diabetes TCF7L2 rs7903146 Increased risk of T2DM +/- Medium
Diabetes GCKR rs780094Increased fastingglucose and impairedinsulin secretion
+/- Medium
Diabetes SLC30A8 rs13266634 Increased risk of T2DM +/- Medium
Diabetes KCNQ1 rs231362Increased risk ofdiabetes and impairedrenal function
+/- Medium
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Trait Gene SNP/RSID Clinical SignificanceVariantType
SNPImpactScore
Comments
Diabetes TFAP2B rs987237Increased risk ofobesity andprogression to T2DM
+/- Medium
Diabetes GCK rs1799884Increased fastingglucose and impairedinsulin secretion
+/- Medium
Diabetes TCF7L2 rs12255372 Increased risk of T2DM -/- Low
Diabetes LIPC rs2070895
Increased risk forprogression to T2DMin people with impairedfasting glucose
+/- Low
Diabetes ARL15 rs4311394
Increased risk of T2DMand may also increaserisk of coronary arterydisease
-/- Low
Diabetes NOTCH2 rs10923931 Increased risk of T2DM -/- Low
Diabetes IGF2BP2 rs1470579 Increased risk of T2DM +/- Low
Diabetes MC4R rs12970134 Increased risk of T2DM -/- Low
Diabetes MTNR1B rs10830963Increased fastingglucose and impairedinsulin secretion
-/- Low
Diabetes IRS1 rs2943641 Increased risk of T2DM -/- Low
Diabetes G6PC2 rs16856187Increased fastingglucose and impairedinsulin secretion
-/- Low
Hypertension SULT1C3 rs6722745 Increased risk for HTN +/+ High
Hypertension ADD1 rs4961 Increased risk for HTN +/- Medium
Hypertension ALDH2 rs671 Increased risk for HTN -/- Low
Hypertension ACE rs4343Increased risk for HTNdue to interaction withACE activity
-/- Low
Hypertension GALNT2 rs4846914 Increased risk for HTN -/- Low
Hypertension CYP11B2 rs1799998 Increased risk for HTN -/- Low
Hypertension AGT rs699 Increased risk for HTN -/- Low
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Trait Gene SNP/RSID Clinical SignificanceVariantType
SNPImpactScore
Comments
Hypertension AGT rs4762 Increased risk for HTN -/- Low
Hypertension AGT rs5051 Increased risk for HTN -/- Low
Hypertension MTHFR rs1801133Increased risk of strokeif they havehypertension
-/- Low
Hypertension NOS3 rs2070744 Increased risk for HTN -/- Low
Hypertension AGTR1 rs5186 Increased risk for HTN -/- Low
Lipid Impairmentwith Lp(a) FADS2 rs1535
Increased risk forimpaired phospholipidmetabolism
+/+ High
Lipid Impairmentwith Lp(a) CETP rs5882 Increased risk for lower
HDL +/+ High
Lipid Impairmentwith Lp(a) APOB rs693
Increased risk forelevated LDL andtriglycerides
+/- Medium
Lipid Impairmentwith Lp(a) LIPC rs8034802 Increased risk of HDL
impairment +/- Medium
Lipid Impairmentwith Lp(a) TCF7L2 rs7903146 Increased risk for
elevated triglycerides +/- Medium
Lipid Impairmentwith Lp(a) GCKR rs780094 Increased risk for
elevated triglycerides +/- Medium
Lipid Impairmentwith Lp(a) LPA rs10455872
Increased Lp(a)lipoprotein andincreased CAD risk
-/- Low
Lipid Impairmentwith Lp(a) APOA5 rs662799
Increased risk forelevated LDL andtriglycerides and lowerHDL
-/- Low
Lipid Impairmentwith Lp(a) APOA5 rs3135506 Increased risk of lipid
impairment -/- Low
Lipid Impairmentwith Lp(a) TCF7L2 rs12255372 Increased risk for
elevated triglycerides -/- Low
Lipid Impairmentwith Lp(a) APOE rs964184 Increased risk of
hyperlipidemia NR NotReportable
MetabolicSyndrome FTO rs9939609 Increased risk for
developing MetS +/+ High
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Trait Gene SNP/RSID Clinical SignificanceVariantType
SNPImpactScore
Comments
MetabolicSyndrome TCF7L2 rs7903146 Increased risk for MetS +/- Medium
MetabolicSyndrome APOA5 rs662799
Increased risk fordeveloping MetSespecially with theaddition of certainenvironment riskfactors combined (poordiet, smoking, etc).
-/- Low
MetabolicSyndrome MTNR1B rs10830963
Increased risk for MetSwith night-timedisturbances (trafficnoise, light)
-/- Low
MetabolicSyndrome LPL rs328 Increased risk for MetS -/- Low
MetabolicSyndrome ADRB3 rs4994 Increased risk for MetS -/- Low
MetabolicSyndrome APOA5 rs651821 Increased risk for MetS -/- Low
MetabolicSyndrome MC4R rs17782313
Increased risk forhigher body weight andbody fat
-/- Low
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Report Key
Gene: Basic unit of heredity that is made of DNA and acts as instructions to make all body proteins. Humans have between 20,000 -25,000 genes, half of which come from one’s mother and the other half from one’s father
SNP/RSID: A SNP is also called a Single Nucleotide Polymorphism. DNA consists of 4 main building blocks (Adenine (A), Thymine (T),Guanine (G), and Cytosine (C)). In certain locations within DNA, one person may have an A, whereas another may have a G. This differencein the base pair is often called a variant. This variant is a SNP. The rs number is a unique identifier used by researchers and databases torefer to specific SNPs. It stands for Reference SNP cluster ID.
Clinical Significance: The clinical or practical importance of a given SNP. Having a risk variant (+) for a particular SNP, increases one’spredisposition to this clinical significance.
Variant Type: Genetic variants are the differences that make each person unique. In this report, variant refers to Single NucleotidePolymorphisms (SNPs). + is the risk allele and - is the non-risk allele. Variants are not necessarily “good” or “bad,” rather genetic variantsare simply the differences in the forms of the genes present in the body.
Variant Type Definition
+/+ Both risk alleles present
+/- One risk allele present
-/- No risk allele present
+/U or -/U Indeterminable allele
NR Not Reportable, unable to determine variantspresent in the sample
Impact: The potential impact based on research of a variant type.
Impact Definition
High (H) Likely a large clinical impact.
Moderate (M) Likely a slightly elevated clinical impact
Low (L) Likely a low clinical impact
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