Cardiac Arrhythmias. Types of cardiac arrhythmias: Bradyarrhythmias Tachyarrhythmias...
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Transcript of Cardiac Arrhythmias. Types of cardiac arrhythmias: Bradyarrhythmias Tachyarrhythmias...
![Page 1: Cardiac Arrhythmias. Types of cardiac arrhythmias: Bradyarrhythmias Tachyarrhythmias Bradyarrhythmias: treat with atropine, pacing Tachyarrhythmias can.](https://reader036.fdocuments.us/reader036/viewer/2022082816/56649d825503460f94a67353/html5/thumbnails/1.jpg)
Cardiac Arrhythmias
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Types of cardiac arrhythmias:
•Bradyarrhythmias
•Tachyarrhythmias
•Bradyarrhythmias: treat with atropine, pacing
•Tachyarrhythmias can occur due to:
Enhanced automaticity
Afterdepolarization and triggered activity
Re-entry
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Tachyarrhythmias:
•Enhanced automaticity:
In tissues undergoing spontaneous depolarization
-stimulation, hypokalemia, mechanical stretch of cardiac muscle
Automatic behaviour in tissues that normally lack spontaneous pacemaker activity e.g. ventricular ischaemia depolarizes ventricular cells and can cause abnormal rhythm
•Afterdepolarization:
EAD: when APD is markedly prolonged
Occur in phase 3
May be due to inwards Na+ or Ca2+ current
Excessive prolongation of APD- torsades de pointes syndrome
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EAD
DAD
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Torsades de pointes: polymorphic ventricular tachycardia along with prolonged QT interval
DAD: precipitating conditions are intracellular or sarcoplasmic Ca2+ overload, adrenergic stress, digitalis intoxication, heart failure
If afterdepolarizations reach a threshold, an AP is genererated which is called ‘triggered beat’
DAD occur when the HR is fast, EAD occur when the HR is slow
•Re-entry: when a cardiac impulse travels in a path such as to return to and reactivate its original site and self perpetuate rapid reactivation independent of normal sinus node conduction
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Requirements for re-entry rhythm:
slowing or conduction failure due to either an anatomic or functional barrier
Anatomic barrier- Wolff-Parkinson-White syndrome
Functional barrier- ischaemia, differences in refractoriness
Presence of an anatomically defined circuit
Heterogenecity in refractoriness among regions in the circuit
Slow conduction in one part of the circuit
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•What are channels? – they are macromolecular complexes consisting of a pore forming subunit, subunits and accessory proteins
•They are:
Transmembrane proteins
Consist of a voltage sensitive domain
A selectivity filter
A conducting pore and,
An inactivating particle
•In response to changes in membrane voltage, the channel changes conformation so as to allow or prevent the flow of ions through it along their concentration gradient
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Na+
K+ (Transient)
Ca2+
K+ (delayed rectifier)
Ca2+
Na+K+ATPase
K+
Na+
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Na+ channel blocker
K+ channel blocker
-blocker, CCB
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Ca2+ channel blocker & -blocker
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How can drugs slow the cardiac rhythm?
Decreasing phase 4 slope
Increase in threshold potential for excitation
Increase in maximum diastolic potential
Increase in APD
•Fast response tissues
•Slow response tissues
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Na+ channel blocker:
•Na+ channel block depends on:
HR
Membrane potential
Drug specific physiochemical characteristic- recovery
•Blockade of Na+ channels results in:
Threshold for excitability is increased (more current)
Increase in pacing and defibrillation threshold
Decrease conduction velocity in fast response tissues
Increase QRS interval
Some drugs tend to prolong PR interval- flecainide (possibly Ca2+ channel blockade)
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•Some sodium channel blockers shorten the PR interval (quinidine; vagolytic effect)
•APD unaffected or shortened
•Increase in threshold for excitation also decreases automaticity
•Can also inhibit DAD/EAD
•Delays conduction so can block re-entry
•In some cases, it can exacerbate re-entry by delaying conduction
•Shift voltage dependence of recovery of sodium channels from inactivated state to more negative potentials and so increases refractoriness
•Net effect- whether it will suppress or exacerbate re-entry arrhythmia depends on its effect on both factors- conduction velocity and refractoriness
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•Most Na+ channel blockers bind to either open or inactivated state and have very little affinity for channels in closed state, drug binds to channels during systole & dissociates during diastole
•ADRs:
Decrease in conduction rate in atrial flutter- slows rate of flutter and increases HR due to decrease in AV blockade
Especially common with quinidine due to its vagolytic property; also seen with flecainide and propafenone
Cases of ventricular tachycardia due to re-entrant rhythm following MI may worsen due to slowing of conduction rate
Slowing of conduction allows the re-entrant rhythm to persist within the circuit so that complicated arrhythmias can occur
Several Na+ channel blockers have been reported to exacerbate neuromuscular paralysis by d-tubocurarine
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•K+ Channel blockers:
Prolong APD (QT interval) and reduces automaticity
Increase in APD also increases refractoriness
Effective in treating re-entrant arrhythmias
Reduce energy requirement for defibrillation
Inhibit ventricular arrhythmias in cases of myocardial ischemia
Many K+ channel blockers also have blocking activity also like sotalol
Disproportionate prolongation of APD can result in torsaides de pointes, specially when basal HR is slow
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•CCBs:
Major effect on nodal tissues
Verapamil, diltiazem and bepridil cause slowing of HR, nifedipine and other dihydropyridines reflexly increase HR
Decrease AV nodal conduction so PR interval increases
AV nodal block occurs due to decremental conduction and increase in AV nodal refractoriness
DAD leading to ventricular tachycardia respond to verapamil
Verapamil and diltiazem are recommended for treatment of PSVT
Bepridil increases APD in many tissues and can exert antiarrhythmic action in atria and ventricles but it use is associated with increased incidence of torsades de pointes- rarely used