Cancers of the Reproductive System Review Session
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Cancers of the Reproductive System Review Session November 19, 2012
description
Cancers of the Reproductive System Review Session . November 19, 2012. Ashkan Afshin, MD, MPH ScD Candidate, Department of Epidemiology ScD Candidate, Department of Global Health & Population Harvard School of Public Health Kresge Building, Room 913 677 Huntington Avenue - PowerPoint PPT Presentation
Transcript of Cancers of the Reproductive System Review Session
Cancers of the Reproductive System
Review Session
November 19, 2012
Ashkan Afshin, MD, MPHScD Candidate, Department of EpidemiologyScD Candidate, Department of Global Health & PopulationHarvard School of Public HealthKresge Building, Room 913677 Huntington AvenueBoston, Massachusetts 02115Phone: (949) 235-6137Email: [email protected]
Review Sessions
Format:
• Q & A (20 min)• Discussing the questions received by email (10 min)
Questions
Please send your questions or suggestions to:
Text Message: (949) 235-6137 Email: [email protected]
Midterm Exam
Midterm Exam
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7080
9010
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Midterm Exam
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50 60 70 80 90 100Midterm
Stages of Tumor Development
Weinberg RA. How cancer arises. Sci Am. 1996 Sep;275(3):62-70.
AB C
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Stages of Tumor Development
Weinberg RA. How cancer arises. Sci Am. 1996 Sep;275(3):62-70.
Genetic Abnormalities in Cancer Cells
Genetic Abnormalities in Cancer Cells
A. Oncogenes
HER2 → Breast Cancer
B. Tumor Suppressor:
BRCA→ Breast Cancer
New cases of cancer in the US
American Cancer Society. Cancer Facts & Figures 2012. Atlanta: American Cancer Society.
New cases of cancer in the US
American Cancer Society. Cancer Facts & Figures 2012. Atlanta: American Cancer Society.
New cases of cancer in the US
American Cancer Society. Cancer Facts & Figures 2012. Atlanta: American Cancer Society.
True or False?
• Testicular cancer is the most common form of cancer in men 16-34
• Positive family history of the testicular cancer increases the risk of the cancer
• Testicular cancers is more common in African American males.
• Carcinoma in situ can sometimes progress to invasive cancer
• Obese men show highest risk of testicular cancer
True or False?
Testicular cancer is the most common form of cancer in men 16-34
Positive family history of the testicular cancer increases the risk of the cancer Testicular cancers is more common in African American males.
Carcinoma in situ can sometimes progress to invasive cancerObese men show highest risk of testicular cancer
Race & Prostate Cancer
World J Urol (2012) 30:195–200
Mortality
Mortality
Incidence
Incidence
Race & Prostate Cancer
World J Urol (2012) 30:195–200
Mortality
Mortality
Incidence
Incidence
Diet & Prostate Cancer Risk
Dietary Factor Direction of Effect Calcium Processed Meat Intake Fish Intake Vitamin D Tomatoes
Giovannucci et al. Int. J. Cancer: 121, 1571–1578 (2007)Wilson et al. J Natl Cancer Inst. 2011;103(11):876-84.Chan et al. J Clin Oncol 23:8152-8160
Diet & Prostate Cancer Risk
Dietary Factor Direction of Effect Calcium (fatal & adv disease) Processed Meat Intake
Fish intake (fatal disease) Vitamin D
Tomatoes
Giovannucci et al. Int. J. Cancer: 121, 1571–1578 (2007)Wilson et al. J Natl Cancer Inst. 2011;103(11):876-84.Chan et al. J Clin Oncol 23:8152-8160
Other Risk Factors for Prostate Cancer
Risk Factor Direction of effect Height BMI
Other Risk Factors for Prostate Cancer
Risk Factor Direction of Effect Height (fatal disease) BMI (adv/fatal disease)
Breast Cancer Risk Factors
• True or False?– Nulliparity– Early menarche– Early menopause– Postmenopausal hormone use– Older forms of birth control pills – Premenopausal obesity – Alcohol use
Breast Cancer Risk Factors
• True or False?NulliparityEarly menarche
Early menopausePostmenopausal hormone useOlder forms of birth control pills
Premenopausal obesity Alcohol use
Race/Ethnicity and Breast Cancer
American Cancer Society. Breast Cancer Facts & Figures 2011-2012. Atlanta: American Cancer Society.
American Cancer Society. Breast Cancer Facts & Figures 2011-2012. Atlanta: American Cancer Society.
Race/Ethnicity and Breast Cancer
American Cancer Society. Global Cancer Facts & Figures 2nd Edition. Atlanta: American Cancer Society; 2011.
Endometrial Cancer Risk Factors• True or False:
– Nulliparity, – Early menarche– Late Menopause– Obesity– Prior breast cancer treatment with tamoxifen – Polycystic ovarian syndrome (PCOS)
Endometrial Cancer Risk Factors• True or False:
Nulliparity, Early menarche Late Menopause Obesity Prior breast cancer treatment with tamoxifen Polycystic ovarian syndrome (PCOS)
Obesity
• Obesity is not a risk factor for: – Breast Cancer – Ovarian Cancer – Testicular Cancer – Prostate Cancer
Obesity
• Obesity is not a risk factor for: – Breast Cancer – Ovarian Cancer – Testicular Cancer – Prostate Cancer
