Cancer Survivorship Research & Funding at NIHdepts.washington.edu/bcpt/docs/2013-3-26 FHCRC...
Transcript of Cancer Survivorship Research & Funding at NIHdepts.washington.edu/bcpt/docs/2013-3-26 FHCRC...
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Cancer Survivorship Research
& Funding at NIH
Catherine Alfano Deputy Director, Office of Cancer Survivorship,
National Cancer Institute
FHCRC
March 26, 2013
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The Dream of Yesterday National Cancer Act of 1971
“Make the Conquest of Cancer a National Crusade”
President Richard Nixon signs National Cancer Act on December 23, 1971
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Visibility of Cancer Survivorship at the
International Level
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Definitional Issue: Who is a Cancer Survivor?
(NCCS, 1986)
• Philosophically, anyone who has been diagnosed with cancer is a survivor— from the time of diagnosis and for the balance of life
• Differentiate types of survivors:
• Active treatment
• Disease-free long-term survivors (≥5 yrs post-dx);
• Those living with CA as a chronic disease
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Drivers of Survivorship Research
• Earlier detection & better treatment ↑ survival
– Adults: 5-year survival 67%
– Children: 10-year survival > 75%
• Cancer for many has become a chronic illness
• Cancer is a family illness
– Effects extend to workplace, society
• ↑# survivors = ↑ attention to chronic, late effects
of cancer/treatment
– Physical, psychological, social, economic, existential
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Chronic Effects of Cancer Treatment
Physical, Psychosocial, & Economic:
• Fatigue
• Pain, neuropathy
• Cognition problems
• Lymphedema
• Sexual impairment
• Incontinence
• Depression & anxiety
• Uncertainty
• Altered body image
• Relationship changes
• Health/life insurance problems
• Concerns re: Job lock/loss,
financial burden
…And some positive changes: sense of purpose or meaning,
appreciation of life
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Cancer Survivors at
Risk for Late Effects
• Disease recurrence/ new cancers
(>756K multiple CA; 16% of new diagnoses)*
• Cardiovascular disease
• Endocrine dysregulation
• Obesity
• Diabetes
• Osteoporosis
• Upper/lower quadrant mobility & functional limitations
• Functional decline disability
* Mariotto et al., CEBP 2007
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Oeffinger et al, N Engl J Med, 2006
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1.0
0 5 10 15 20 25 30
Yrs. From Original Cancer Diagnosis
Cu
mu
lative
In
cid
en
ce Grade 1-5
Grade 3-5
Incidence of Chronic Health Conditions in 10,397
Adult Survivors of Childhood Cancer
Mean age of 26.6 years (18-48 years)
By 30 years post cancer:
• 73% survivors with at least one
chronic health condition
• 42% with a Grade 3-5 (severe,
life-threatening, death)
• 39% had >2 chronic health
conditions
Survivors – 8.2 times more likely to
have a severe or life threatening
condition compared to siblings
Childhood Cancer Survivor Study
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% with Limitations:
Survivors vs. General Population
0
10
20
30
40
50
60
General
Survivors
Hewitt, Rowland, Yancik. J Gerontol. 58:82, 2003
Psych
Problems
1+
ADL/IADL
1+
Functional
Work
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“[Survivors] have special psychological, physical, and health care counseling needs
that we are only beginning to understand…the [OCS] will support the much needed
research that will help cancer survivors deal with the problems they face even after
their cancer is cured.” President Clinton, October 27, 1996, at the Rose Garden
ceremony to formally announce the launch of the OCS.
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Office of Cancer Survivorship Goals
• The ultimate goal of the OCS is to enhance the length and quality of survival of all cancer survivors
• To provide a focus for the support of research that will lead to a clearer understanding of, and the ultimate prevention of, or reduction in, adverse physical, psychosocial, and economic outcomes associated with cancer and its treatment.
• To educate professionals who deal with cancer survivors about issues and practices critical to the optimal well-being of their patients. This educational commitment extends to cancer survivors and their families.
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Men Women Both sexes
World 13514 15288 28802
More developed regions 7756 7505 15261
Less developed regions 5758 7782 13540
WHO Africa region (AFRO) 431 725 1156
WHO Americas region (PAHO) 3345 3496 6841
WHO East Mediterranean region (EMRO) 381 526 907
WHO Europe region (EURO) 4378 4516 8894
WHO South-East Asia region (SEARO) 1123 2020 3143
WHO Western Pacific region (WPRO) 3852 3998 7850
IARC membership (22 countries) 7799 7933 15732
United States of America 2137 2059 4196
China 2187 2416 4603
India 620 1084 1704
European Union (EU-27) 3404 3213 6617
Estimated Prevalence in 2008 (thousands)
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Estimations and modeling provided by Angela Mariotto, PhD, based on: Mariotto AB, Yabroff KR, Shao Y, Feuer EJ, Brown ML.
Projections of the cost of cancer care in the United States: 2010-2020. J Natl Cancer Inst. 2011 Jan 19;103(2):117-28. Epub 2011 Jan 12.
Estimated Number of Cancer Survivors in the
United States From 1975 to 2012
0
2,000,000
4,000,000
6,000,000
8,000,000
10,000,000
12,000,000
14,000,000
16,000,000
Nu
mb
er
Year
13.7M
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Estimated Number of Persons Alive in the U.S. Who Were Diagnosed With Cancer, by Site (N = 13.7 M) (as of January 1, 2012)
Female Breast 22%
Prostate 20%
Colorectal 9% Gynecologic
(cervix, corpus uterus, ovary)
8%
Hematologic (Hodgkin, Non-
Hodgkin, Leukemia) 8%
Urinary Bladder, Kidney,
Renal Pelvis 7%
Melanoma 7%
Thyroid 4%
Lung 3%
Other 13%
Estimations and modeling provided by Angela Mariotto, PhD, based on: Mariotto AB, Yabroff KR, Shao Y, Feuer EJ, Brown ML.
Projections of the cost of cancer care in the United States: 2010-2020. J Natl Cancer Inst. 2011 Jan 19;103(2):117-28. Epub 2011 Jan 12.
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-
500,000
1,000,000
1,500,000
2,000,000
2,500,000
<1 1-<5 5-<10 10-<15 15-<20 20-<25 25+
Nu
mb
er
Years from Diagnosis
Males
Females
Estimated number of cancer survivors in the United States as of
January 1, 2012 by time since diagnosis and sex source: de Moor et al, CEBP, in press March 2013
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Estimated Number of Persons Alive in the U.S. Who Were Diagnosed
With Cancer, by Current Age (as of January 1, 2012) (Invasive/1st Primary Cases Only, N = 13.7 M survivors)
0-19 Years 1%
20-29 Years 1%
30-39 Years 3%
40-49 Years 7%
50-59 Years 17%
60-69 Years 26%
70-79 Years 25%
80+ Years 20%
Estimations and modeling provided by Angela Mariotto, PhD, based on: Mariotto AB, Yabroff KR, Shao Y, Feuer EJ, Brown ML.
Projections of the cost of cancer care in the United States: 2010-2020. J Natl Cancer Inst. 2011 Jan 19;103(2):117-28. Epub 2011 Jan 12.
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FY 13 Funding Priorities in
Cancer Survivorship
• Understanding the Chronic & Late Effects
of Cancer/Treatment
• Cancer & Aging
• Translation of Survivorship Science into
Care
• Interventions & Models of Care to Improve
Post-Treatment Health, QOL, &
Functioning
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FY 13 Funding Priorities in
Cancer Survivorship
• Understanding the Chronic & Late Effects
of Cancer/Treatment
• Cancer & Aging
• Translation of Survivorship Science into
Care
• Interventions & Models of Care to Improve
Post-Treatment Health, QOL, &
Functioning
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Grants Targeting Late Effects:
FY 2007 & 2010 (Grants may have more than 1 focus)
0 20 40 60 80 100 120
Psychological Distress
Fatigue or sleep
Pain
Sexual Function
Neurocognitive Function
Recurrence
Cardiac Toxicity
Weight/Obesity
Lymphedema
Endocrine Function
Reproductive Factors
Menopausal Symptoms
Second Cancers
Bone Density
FY2007
FY2010
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Chronic & Late Effects Priorities
• Cohort! PAR-11-167
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PAR-11-167: Cohorts with n=10,000 Expires 11/9/13
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Chronic & Late Effects Priorities
• Cohort! PAR-11-167
• Leverage large extant databases to ask
novel Qs:
– SEER-Medicare, SEER-MHOS, MEPS, NHIS,
CCSS
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Link to surveys: appliedresearch.cancer.gov
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Chronic & Late Effects Priorities
• Cohort! PAR-11-167
• Leverage large extant databases to ask
novel Qs:
– SEER-Medicare, SEER-MHOS, MEPS, NHIS,
CCSS
• Working to include common data elements
in clinical trials to monitor survivorship
outcomes
– Socio-demographics, comorbidity, PA,
smoking, depression, social isolation, QOL
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Focus on Cardio-toxicity
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FY 13 Funding Priorities in
Cancer Survivorship
• Understanding the Chronic & Late Effects
of Cancer/Treatment
• Cancer & Aging
• Translation of Survivorship Science into
Care
• Interventions & Models of Care to Improve
Post-Treatment Health, QOL, &
Functioning
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Projected Increase in US Cancer
Survivors by 2020
Cancer Epidemiol Biomarkers Prev; 20(10) October 2011
0
2,000,000
4,000,000
6,000,000
8,000,000
10,000,000
12,000,000
14,000,000
16,000,000
18,000,000
20,000,000
2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020
Nu
mb
er
of
cases
Year
65+
<65
47% ↑
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Baby Boomers and Expectations
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What a Difference a Generation Makes
THEN COMING SOON…
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Aging & Cancer Priorities
• Older adult survivors
– Needs
– Interventions
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FY 2010 NIH Survivorship Research Grants by
Survivor Population Studied (N=273; Grants may have
more than 1 focus)
0 10 20 30 40 50 60
Spanish-Speaking
Rural Survivors
Family Members/Caregivers
Health Disparity Populations
Cancer Survivors >5 Yrs Post-Dx
Older Adult (>65 Yrs Dx)
Young Adult (20-45 Yrs Dx)
Adolescent Survivors (14-19 Yrs Dx)
Pediatric Survivors (<19 Yrs Dx)
9
5
42
33
55
30
28
25
46
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Aging Survivors- We are NOT ready!
• Many unanswered questions:
– Efficacy of cancer treatments?
– Terrain of recovery?
– Who is in need of what intervention when?
– Who will manage complicated care for
survivors with multiple comorbidities?
– How & at what cost?
– How can we avoid overwhelming the
healthcare system?
• Given PCP, ONC, & NSG shortages?
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Aging & Cancer Priorities
• Older adult survivors
– Needs
– Interventions
• Understanding the Mechanisms driving
“accelerated aging” in survivors using
systems science
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Cancer & Cancer Treatment
Pathophysiological Processes
Comorbid Conditions
Cognitive/Functional Decline
Organ System Failure
Death
Pathophysiological Processes
Comorbid Conditions
Cognitive/Functional Decline
Organ System Failure
Death
Cancer
Survivor
“Healthy”
Adult
Time
Hypothesized Aging Trajectories A
ge
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Underlying Intracellular
Processes
•Oxidative Stress (ROS, DNA damage)
•Genomic Stability (Telomere, telomerase, sirtuins)
Pathophysiologic Processes
•Endocrine dysregulation (insulin, leptin, adiponectin, glucose metabolism)
•Impaired cardiorespiratory fitness
•Inflammation
•Circadian disruption
•Change in vasculature
•Nerve/tissue damage
•Change in bone turnover markers
•Estrogen deficiency
•Cardiac Tissue damage
•Fatigue
•Functional decline
Comorbid Conditions
• Depression
•Anxiety
•Sleep disorders
•Neuropathy
•Lymphedema
•Cardiovascular Disease
•Chronic Pain
•Osteoporosis
•Obesity
•Diabetes
•Cognitive Impairment
•Functional Impairment
•Premature menopause
• Chronic Arthralgias
Cognitive/
Functional Demise
Organ System Failure
Death
Spirituality Health Behaviors
Productivity Financial Resources
Social Factors
Personal Control/
Self-Management
Life Satisfaction
Stress
“Healthy” Adult Rate of Acceleration
Healthcare System Factors
Cancer Survivor Rate of Acceleration
Cancer & Cancer Treatment
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Obesity Ex: Embrace Complexity!
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Aging & Cancer Priorities
• Older adult survivors
– Needs
– Interventions
• Understanding the Mechanisms driving
“accelerated aging” in survivors using
systems science
• DHHS interest in Multiple Chronic
Conditions
– Feb 13 workshop to develop research agenda
– Interest in self-management of health after CA
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HHS Initiative Highlights Need for Self-Management
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FY 13 Funding Priorities in
Cancer Survivorship
• Understanding the Chronic & Late Effects
of Cancer/Treatment
• Cancer & Aging
• Translation of Survivorship Science into
Care
• Interventions & Models of Care to Improve
Post-Treatment Health, QOL, &
Functioning
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Translational Science Priorities
• Biennial 2012 meeting mapping
translational science onto survivorship
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T3
T1
T2
T4
T0 Technology
Knowledge Integration
Multi-level Analysis
Collaboration (Researchers,
Survivors, Stakeholders)
The Translational Science Process for Survivorship
Modified from Lam et al; CEBP 2013; (22); 181-8
Survivor Population Health &
Disease Burden
Scientific Discovery
Promising Applications & Interventions
Evidence Based Recommendations ,
Guidelines or Policies
Programs in Practice, Organization, &
Community Settings
Describe Health Outcomes & Determinants
Mechanisms; Preclinical Studies; Phase I & II trials
Efficacy (Phase III Trials)
Implementation & Dissemination
Effectiveness in Populations
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Translational Science Priorities
• Biennial 2012 meeting mapping
translational science onto survivorship
• Stimulate research along the T0-T4
process
– Targeted funding announcements
– Portfolio Analysis by T0-T4
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Stimulating Translational Survivorship
Research; e.g, PAR 12-228 & PAR 12-229
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Translational Science Priorities
• Biennial 2012 meeting mapping
translational science onto survivorship
• Stimulate research along the T0-T4
process
– Targeted funding announcements
– Portfolio Analysis by T0-T4
• Collaboration with NCI Implementation
Science group
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Dissemination & Implementation
Research PAR-13-054; 13-055; 13-056
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FY 13 Funding Priorities in
Cancer Survivorship
• Understanding the Chronic & Late Effects
of Cancer/Treatment
• Cancer & Aging
• Translation of Survivorship Science into
Care
• Interventions & Models of Care to Improve
Post-Treatment Health, QOL, &
Functioning
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Interventions &
Models of Care Priorities
• Test models of survivorship care planning:
PA 12-274 & PA 12-275
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Selected Recommendations from the
President’s Cancer Panel & IOM Reports
• When treatment ends, all survivors
should receive a summary record that
includes important disease
characteristics and treatments received.
• In addition, they should be provided with
a follow-up care plan incorporating
available evidence-based standards of
care.
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Care Planning
• ASCO, ACOS CoC recommendations, &
LiveSTRONG Essential Elements meeting call
for implementation of care planning
• 2 scientific meetings and IOM report call for
evaluation of care planning
• Lack of evidence base for implementation and
evaluation
• Comparative approaches needed to evaluate
impact of care planning on patient, provider,
payor, and systems factors & evaluate best
practices for implementation
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Test models of survivorship care
planning: PA 12-274 & PA 12-275
Purpose: stimulate research to evaluate the effect of care planning on cancer
survivors' health and psychosocial outcomes; self-management of late
effects and adherence to cancer screening and health behavior guidelines;
utilization of follow-up care; organizational-level factors influencing the
implementation of care planning; and associated costs
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Interventions &
Models of Care Priorities
• Test models of survivorship care planning:
PA 12-274 & PA 12-275
• Integrate cancer rehabilitation into
survivorship care
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0
2
4
6
8
10
12
14
16
18
20
1977 1982 1987 1992 1997 2002 2007 2012 2017 2022
Nu
mb
er i
n M
illi
on
s
Year
15+ years
10-<15 years
5-<10 years
1-<5 years
<1
Estimated and projected number of cancer survivors in the
United States from 1977-2022 by years since diagnosis Source: de Moor et al, CEBP, in press March 2013
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Time for a new model of
survivorship care
• Dramatic ↑ in # survivors
– Especially in older adults
• Multiple comorbidities
– Many will die of comorbid conditions
• Chronic effects of tx; At risk for late effects
– physical & emotional issues not being met
• Need to prevent spiral into disability
• Need to promote healthy behaviors
• Shortage of providers
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Why a comprehensive rehab model?
Joint focus on optimizing functional status & QOL
Address pre-existing or tx-related comorbidities
Reduce risk of death from comorbid conditions
Treat chronic effects of tx; Reduce risk for late
effects
Evaluates sum total problems & coordinates tx
Promotion of self-management and healthy
behaviors prevents further problems; ↓risk of
recurrence
Prevents spiral into disability; preserve work, roles
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Interventions &
Models of Care Priorities
• Test models of survivorship care planning:
PA 12-274 & PA 12-275
• Integrate cancer rehabilitation into
survivorship care
• Address barriers to adoption of evidence-
based findings into care
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Research Evidence Care
• Takes a coordinated approach: having
enough of the right kind of evidence…
• Need value added & “costs” at multiple
levels (survivor, family, provider, healthcare system)
– September meeting will explore how to create
research synergies between behavioral
interventionists and health services/health
economics researchers
• Implementation Science collaboration
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Interventions &
Models of Care Priorities
• Test models of survivorship care planning:
PA 12-274 & PA 12-275
• Integrate cancer rehabilitation into
survivorship care
• Address barriers to adoption of evidence-
based findings into care
• Improve adherence to survivorship care
recommendations & interventions
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Adherence to Care & Interventions
• NIH-wide adherence network: Need to study
adherence using a multi-level lens:
– Provider adherence to guidelines/care standards
– Survivor adherence to
• cancer treatment; surveillance; healthy behavior recs, follow-
up care, other interventions
– Study personnel adherence to study protocol
– Family, clinic, or organization-level adherence
• Need to make care goals “person-centered”
– Identification of care goals should be a collaborative
process (survivor, provider, family)
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Thanks!.. Contact: [email protected]