Bayesian Modeling of Incidence and Progression of Disease from ...
Canadian Study of Health and Aging The Incidence and Progression of Dementia 1996 Follow-Up Study.
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Canadian Study of Health and Aging The Incidence and Progression of Dementia 1996 Follow-Up Study 1996 Follow-Up Study
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Transcript of Canadian Study of Health and Aging The Incidence and Progression of Dementia 1996 Follow-Up Study.
Canadian Study of Health and Aging Canadian Study of Health and Aging
The Incidence and Progression of Dementia
1996 Follow-Up Study1996 Follow-Up Study
Canadian Study of Health and Aging Canadian Study of Health and Aging
Annual Numbers of New Cases of DementiaCanada, 1991
19,770
25,840
14,540
65 - 74
85+
75 - 84
All Ages: 60,150
Source: Neurology 2000; 55: 66-73
Canadian Study of Health and Aging Canadian Study of Health and Aging
Age-Specific Incidence of Dementia in Canada, per thousand (whole population)
0
20
40
60
80
100
65-69 70-74 75-79 80-84 85+
Women Men
Source: Neurology 2000; 55: 66-73
Canadian Study of Health and Aging Canadian Study of Health and Aging
0
20
40
60
80
100
120
65-69 70-74 75-79 80-84 85+ 90+
CSHA
RochesterTurku
Bordeaux
New York
Mannheim
Rotterdam
Kungsholmen
Age-Specific Incidence of Dementia, per thousand (whole population) in selected studies
Canadian Study of Health and Aging Canadian Study of Health and Aging
Estimates of the incidence of Alzheimer’s disease from selected studies
0
10
20
30
40
50
60
70
80
90
100
65- 70 - 75 - 80 - 85 - 90 - 95+
Per thousand
Age
All levels of Severity. Jorm’s Meta analysis
CSHA
Moderate + severeJorm’s meta analysis
USA estimate
EurodemGao’s meta analysis
Canadian Study of Health and Aging Canadian Study of Health and Aging
The Progression of Dementia• Primitive reflexes return as dementia progresses; they show Primitive reflexes return as dementia progresses; they show
a logarithmic association with declining 3MS scoresa logarithmic association with declining 3MS scores (Hogan (Hogan & Ebly, 1995)& Ebly, 1995)
• Mortality among people with probable AD is 2.5 times Mortality among people with probable AD is 2.5 times higher than among non-demented peoplehigher than among non-demented people (Hogan et al., 1994) (Hogan et al., 1994)
• There are physiologic changes as dementia progresses; There are physiologic changes as dementia progresses; these are similar for AD and vascular dementia these are similar for AD and vascular dementia (Hogan et al., (Hogan et al., 1996) 1996)
• The rate of functional decline rises with the severity of The rate of functional decline rises with the severity of dementia dementia (Mitnitski et al., 1999)(Mitnitski et al., 1999)
