Can Mushrooms Help Prevent Breast Cancer?

by Natalie on April 17, 2012

Mushrooms are often overshadowed by other glamorous superfoods, but its mushrooms who are among the most powerful.Mushrooms have been used in many cultures to treat and prevent illness for centuries. In the western world, they are just now starting to get some attention.

In research, mushrooms have shown to have powerful anti-oxidant activity, anti-inflammatory activity, and immune boosting activity. Most importantly, studies of women with high mushroom intakes have shown lower rates of breast cancer. This may be of particular importance to post-menopausal women, as mushrooms can help maintain healthy estrogen levels. In research, some mushroom types have been able to shut off the enzyme that creates estrogen, leading to healthier hormone levels.

Mushrooms may also be helpful during breast cancer treatment. A 7 year study done at the National Institutes of Health looked at the effect of Turkey Tail mushroom on patients with active breast cancer. The study showed that turkey tail helped improve the immunity of the women without any adverse side effects. This is a huge benefit for women undergoing breast cancer treatment.

The Most Powerful Breast Cancer Fighting Mushrooms

In research studies, the following mushrooms have suggested a protective effect against breast cancer. I have also provided you with additional health information in the brief paragraph that follows each mushroom.

1. ShiitakeLentinan, a component extracted from shiitake mushrooms, is an approved anti-cancer drug in Japan. Lentinan is the most well known anti-cancer component in the shiitake but others exist. Shiitakes have also proven beneficial at treating other diseases and illnesses including HIV, and herpes.

2. MaitakeMaitakes are high in 1,6 Beta Glucan, a type of polysaccharide (complex carbohydrate). Research has shown strong anti-tumor activity of maitake mushrooms in animal and test tube studies. Some older studies showed that an extract of maitake reduced tumor growth by 86% in mice implanted with cancer cells. Maitakes have shown to be protective against a wide variety of cancers.

3. OysterIn rodent studies, oyster mushrooms have shown to inhibit tumor growth, and stop carcinogens from initiating cancer. An interesting non-cancer related health fact is that oyster mushrooms naturally produce Lovastatin, a drug that is commonly used to treat high blood cholesterol.

Ways To Use Mushrooms in Meals

Add to stir-fries and/or soups

Saute lightly in oil and serve as a side dish

Brush with oil and grill

Are White Button Mushrooms Healthy?

Interestingly, white button, portabella and crimini mushrooms all belong to the same family. In some studies, these mushrooms have shown to be protective against breast cancer. BUT there is one caveat and that is why I dont have them listed as the most powerful. White button mushrooms and their family members are also know to contain carcinogenic compounds called hydrazines. The effect of these toxins are largely unknown, and at this time it is still considered safe to eat these mushrooms is small amounts. Avoid eating these mushrooms raw; heat may decrease the amount of toxins present.

Oyster Mushroom Pleurotus Ostreatus Suppresses Breast and Colon Cancer

Author Bridget Greenwood

A study from the International Journal of Oncology investigated the links between eating medicinal mushroom and the risk of cancer. Can extracts of Pleurotus ostreatuscommonly known as the oyster mushroom, which are often found growing on dead logsaffect the growth of breast and colon cancer cells?Cancer is a major public health issue. Breast cancer in women and colon cancer in men are the most common fatal cancers. New treatments are being developed all the time, but its currently difficult to cure malignant tumors, and the side effects of treatments like chemotherapy and radiation can severely affect quality of life.

Cancer prevention is therefore an important strategy. Changing our lifestyles and diets are the best things we can do to reduce our risk of developing cancers. And natural productsfoods such as medicinal mushrooms (like Pleurotus ostreatus)are being investigated because of their low toxicity.

A Jedinak and D Silva, from the Cancer Research Laboratory, Methodist Research Unit, Indianapolis, USA, investigated the biologically active compounds in Pleurotus ostreatus.Can oyster mushrooms (Pleurotus ostreatus) prevent breast and colon cancer?

Medicinal mushrooms have been used in traditional Chinese medicine for thousands of years. Their therapeutic effects have now been scientifically proven. Pleurotus ostreatus has strong antitumor and antioxidative properties. But how does it inhibit breast and colon cancer cells?

Methanol extracts were prepared from ground Pleurotus ostreatus. Human breast cancer and human colon cancer cell lines were treated with various concentrations of mushroom extracts to test for cell proliferation.

Pleurotus ostreatus suppressed the proliferation of highly invasive breast cancer cells, and also highly-invasive colon cancer cells. The normal breast and colon cells were not affected.

So should we add oyster mushrooms to our shopping lists? Yes! The study concluded with promising news. Oyster mushrooms (Pleurotus ostreatus) have potential therapeutic and preventive effects on both breast and colon cancer.

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Sources:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796484/The Mighty Oyster Mushroom: The Workhorse of Gourmet Fungi

Posted: 01/25/2013 4:39 pm EST Updated: 03/27/2013 5:12 am EDT

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Oyster Mushrooms: Pleurotus ostreatus, P. columbinus, P. citrinopileatus, and P. djamor. Of all mushrooms commonly consumed, oyster mushrooms in the genus Pleurotus stand out as exceptional allies for improving human and environmental health. These mushrooms enjoy a terrific reputation as the easiest to cultivate, richly nutritious and medicinally supportive. Oyster mushrooms are also renowned for their ability to degrade environmental toxins, particularly hydrocarbon-based contaminants. Their role as guardians of the biosphere becomes clear as new research into their complex biochemistry proves their potential to combat hunger, improve immunity and clean up polluted lands.

For now, I am focusing on oyster mushrooms' important human health-oriented properties. For those interested in exploring their bioremediative -- mycoremediation -- properties, please see Mycelium Running: How Mushrooms Can Help Save the World.

Oyster mushrooms are native to both deciduous hardwood and conifer tree species. Recognized as wood decomposers, they are ubiquitous in forestlands around the world. Fruiting both in the spring and fall, oyster mushrooms, particularly Pleurotus ostreatus and its close relatives, attract cultivators and entrepreneurs for their numerous advantages and unique ecological interactions. Most significantly, nearly all oyster mushrooms are primary saprophytes, meaning they do not require a composted substrate. They grow readily on dead wood, straw, grasses (wheat, rye, rice, fescues, corn, bamboo), cotton, cacti, Scotch broom, hemp, coffee wastes, paper products, and practically any other dried cellulosic plant material.

LaDena Stamets holding oyster mushrooms (P. ostreatus) growing from recycled money (hemp/cotton).Cultivators of button mushrooms (Agaricus bisporus, aka portobello, crimini and meadow mushrooms) noted long ago that nematodes (tiny worms that feed on living plant and fungal tissue) -- the bane of their industry -- are not an issue with oyster mushrooms. This fact led Barron and Thorn (1986) to discover that oyster mushroom (P. ostreatus) mycelium is carnivorous -- it eats nematodes. It exudes extracellular toxins that stun the worm, whereupon the mycelium invades its body through its orifices. This may lead gardeners and farmers to one day control these root-crop damaging worms without resorting to toxic pesticides. One U.S. patent (#6,048,714), still in effect, has been issued to Bryan Hiromoto (2000) for products with nematicidal activity based on oyster and other mushrooms.

Following on this discovery of nematode-predating activity, oyster mushroom mycelium was also found to be one of the most adept, of more than 100 tested, at consuming bacteria (Pseudomonas and Agrobacterium) in order to get nitrogen and protein (Barron 1988). This makes sense, considering that in 1950 one of the first antibiotics isolated from mushrooms, pleuromutilin, was found after observing that Pleurotus ostreatus inhibited a wide range of Gram-negative bacteria, including Salmonella and Pseudomonas. More recently, using in-contact antibacterial tests, we verified that exudates from oyster mushroom (Pleurotus ostreatus) mycelium strongly inhibited Escherichia coli and staph (Staphylococcus aureus). Viable cell counts were reduced from more than 100,000,000/ml of water to less than 1,000/ml within 24-72 hours when a 1:1 mixture of exudate and bacterially enriched water were combined (Stamets, 2005).

From dead plant matter to nematodes to bacteria, never underestimate the cleverness of mushrooms to find new food!

Walls of Pleurotus eryngii, the King Oyster. Photo courtesy of Roel Dreve.

Used by permission Global Roel Media B.V. / Mushroom Business.Oyster mushrooms come in many species and forms, but by far the most popularly marketed are Pleurotus ostreatus and Pleurotus pulmonarius. In Asia, Pleurotus nebrodensis and P. eryngii are gaining market share since these thick-fleshed and short-gilled mushrooms have a shelf life that exceeds most species by several weeks. Oyster mushrooms are rich in protein (up to 30 percent by dry weight), plentiful in B vitamins, have no cholesterol, and have significant levels of the cholesterol-lowering molecule lovastatin -- up to 2.8 percent by dry weight (Stamets, 2005; Alarcon, 2003). Because of their native lovastatin content, oyster mushrooms have been studied for their benefits in helping modulate blood cholesterol levels.

Encouraged by preliminary evidence of cholesterol modulation by Dr. Nina Gunde-Cimmeran (1993, 1995, 1999), the National Institutes of Health, through their National Center for Complementary and Alternative Medicine (NCCAM), funded a 2004 study of the effect of oyster mushrooms on anti-retroviral-induced hyperlipidemia in HIV patients. Supervised by Dr. Donald Abrams of the University of California San Francisco General Hospital, the study showed potential benefit from ingesting a tea made from wood grown, freeze dried oyster mushrooms. Although the study did not achieve statistical significance -- in part since all the patients did not complete the specified regimen -- the trends suggested benefit in reducing triglycerides and LDL cholesterol. Some of the patients complained that the simple hot water soup did not taste good and stopped consuming it. Interestingly, in a subsequent analysis of our wood-grown mushrooms -- which were used in this clinical study -- vs. straw grown, the straw grown oyster mushrooms had about 5 percent more sugar, which could have affected palatability.

While oyster mushrooms remain an excellent source of natural lovastatin, their medicinal attributes extend well beyond cardiovascular health. In the International Journal of Oncology, Jedinaki and Silva (2008) idenitified two molecular mechanisms from alcohol extracts of oyster mushrooms that "specifically inhibits growth of colon and breast cancer cells without significant effect on normal cells, and has a potential therapeutic/preventive effect on breast and colon cancer." Moreover, in the same cell culture tests, these alcohol-soluble extracts of oyster mushrooms out-performed similarly prepared extracts from button (Agaricus bisporus), shiitake (Lentinula edodes) and enoki (Flammulina velutipes) mushrooms -- three species more extensively studied for their immune-supporting properties. These mushroom extracts up-regulate genes coding for p53 and p21 proteins, which in turn stop tumors from growing and support tumor regression. Additionally, the non-alcohol soluble beta glucan and glycoprotein complexes found in oyster and other medicinal mushrooms alert the immune system's natural killer and cytotoxic T cells, improving the body's natural anti-cancer responses. For cancer researchers interested in mushroom use in complementary therapies, the possibility that oyster mushroom consumption can improve cancer treatment using distinctly different but synergistically powerful pathways should be cause for serious consideration. Many more mushrooms are likely to activate and up-regulate these genes for coding cancer-limiting proteins.

Although oyster mushrooms have been studied extensively and support health in a number of ways, it is also extremely important to always cook oyster mushrooms! Oyster mushrooms contain a novel, heat-labile, hemolytic protein called "ostreolysin," which can be toxic unless the mushrooms are cooked at temperatures exceeding 140 degrees Fahrenheit. This compound is found in developing and mature oyster mushrooms yet is absent in the mycelium. Nevertheless, this is another good reason -- among many -- that all mushrooms, with the exception of truffles, should be cooked to best take advantage of their beneficial nutritional properties while deactivating heat-sensitive toxins.

Now that the line between "gourmet" and "medicinal" mushrooms is sufficiently blurred, what does this mean to you? Clearly, consuming the right mushrooms can enhance health. Oyster mushrooms reign supreme in their multifaceted talents for benefiting humanity.

Financial Disclosure: Paul Stamets, author of Growing Gourmet & Medicinal Mushrooms and educator of mushroom cultivators world-wide, is also the Founder of Fungi Perfecti, LLC -- a company that supplies mushroom related products including whole, encapsulated powders, and extracts of mushrooms.References Used for This BlogAbrams, D.I., P. Couey, S.B. Shade, F. Aweeka, & P. Stamets., 2011. "Antihyperlipidemic effects of Pleurotus ostreatus (oyster mushrooms) in HIV-infected individuals with antiretroviral-induced hypercholesterolemia." University of California, San Francisco, Aids Research Institute, The Osher Center for Integrative Medicine, San Francisco. BMC Complementary and Alternative Medicine 11:60 doi:10.1186/1472-6882-11-60.Alarcon, J., S. Aguila, P. Arancibia-Avila, O. Fuentes, E. Zamorano-Ponce, and M. Hernandez., 2003. "Production and purification of statins from Pleurotus ostreatus (Basidiomycetes) strains" Naturforsch. 58c, 62-64.Barron, G.L., and R.G. Thorn, 1986. "Destruction of nematodes by species of Pleurotus." Can. J. Bot. 55: 3054-3062.Barron, G.L., 1988. "Microcolonies of bacteria as a nutrient source for lignicolous and other fungi" Can. J. Bot. 66: 2505-2510.Gunde-Cimerman N, Friedrich J, Cimerman A, Beni ki N. "Screening fungi for the production ofan inhibitor of HMG-CoA reductase--production of mevinolin by the fungi of the genusPleurotus." FEMS Microbiol Lett 1993; 111: 203-6.Gunde-Cimerman NG., Cimerman A., 1995. "Pleurotus fruiting bodies contain the inhibitor of 3-hydroxy-3-methylglutaryl-Coenzyme A Reductase- Lovastatin." Experimental Mycology 19: 1-6.Gunde-Cimerman, NG., 1999. "Medicinal value of the genus Pleurotus (Fr.) P.Karst. (Agricales S.R., Basidiomycetes)" International Journal of MedicinalMushrooms. 1(1): 69-80.Hiromoto, B., 2000. "Composition Having Nematicidal Activity." U.S. Patent #6,048,714. Kwok, O.C.H., Plattner, R., Weisleder, D., Wicklow, D.T., 1992. A nematicidal toxin from Pleurotus ostreatus NRRL 3526." J. Chem. Ecol. 18: 127-136.Jedinak, A. and D. Sliva, 2008. "Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway." International Journal of Oncology 33(6): 1307-1313.Novak, R., and D.M. Shlaes, 2011. "The pleuromutilin antibiotics: a new class for human use" Curr. Opin. Investig. Drugs. 11(2): 182-91. Sepcic, K. and R. Frange, 2010. "Cytolytic and toxic effects of ostreolysin, a protein from the oyster mushroom (Pleurotus ostreatus)" Comp. Bio. Nat. Pro. Vol. 2 - Efficacy, Safety & Clinical Evaluation (Pt-1).Stamets, P., 2005. "Notes on nutritional properties of culinary-medicinal mushrooms." International Journal of Medicinal Mushrooms, 7(1&2): 109-116.Stamets, P., 2005. Mycelium Running: How Mushrooms Can Help Save the World. Ten Speed Press, Berkeley, CA.Vidic, I., Berne, S., Drobne, D., Macek, P., Frangez, R., Turk, T., Strus, J., Sepcic, K., 2005. "Temporal and spatial expression of ostreolysin during development of the oyster mushroom (Pleurotus ostreatus)." Mycological Research. 109 (Pt 3):377-82.For more by Paul Stamets, click here.For more on natural health, click here.