Can HerbologyDiscover Cures for Tomorrow’s Diseases? · 9/19/2017 · Discover New Applications...
Transcript of Can HerbologyDiscover Cures for Tomorrow’s Diseases? · 9/19/2017 · Discover New Applications...
Can Herbology Discover Cures for Tomorrow’s Diseases?
Yeo Tiong ChiaCEOSarawak Biodiversity Centre
NationalInstituteofAllergyandInfectiousDiseasesDirectorAnthonyFauci,2016
RoyalCollegeofGeneralPractitioners,December9,2015.
$100
“Aftertwobountifulyears,thepharmaceuticalindustryexperiencedasharpdropinnewdrugapprovalsin2016.Thedecline,to22from45in2015..”-C&ENJan2017
SarawakBiodiversityCentre
VisionEnrichingLiveswith
BreakthroughInnovationsinBiodiversity
MissionToDecodeBiodiversityfortheBenefitof Mankind
ActivityBioprospecting
Sarawak’sForestEcosystemMixDipterocarpForestKerangasForestMangroveForestMontaneForestRiverineForestPeatSwampforestBeachForestShrubland
TraditionalKnowledge
Aknowledgethathasarichsourceofinformation;plantsusedasherbsinmedicinalapplications
Why traditional knowledge?
If you walking on a jungle trail, what do you see-
Antidote
Food
Sweet
Stopbleeding
This is what a traditional knowledge practitioner would see…..
Flavour
1)DocumentandConserveTraditionalKnowledge,DiscoverNewApplicationsandGenerateBenefit
PriorInformedConsent
Documentation
TKDatabase
BenefitSharing
LocationsofSBCTraditionalKnowledgeDocumentationProgramme
No.ofTKConsultativeMeetingSites 64
No.ofTKDocumentationWorkshopSites
78
No.ofIndigenousCommunities 16/28
No.ofPlantsdocumented 5,817
No.ofplantspecies(identified) 1,701
Consultativemeeting
OngoingDocumentationUpdated as of 19 September 2017
TraditionalKnowledgeDocumentation:SummaryofPlantCollection(2001– 2017)
COMMUNITY NO.OFPLANTS
Bidayuh (9sites) 1,167
Iban (23sites) 1,279
Kelabit (3sites) 478
Lun Bawang (6sites) 583
Penan (6sites) 1,094
Kayan (3sites) 185
Kenyah (5sites) 259
Melanau (5sites) 215
Bidayuh (Selako)(1site) 112
Kedayan (MixedwithIban &Lun Bawang – 1site)
62
Tabun (1site) 51
Bisaya (1site) 30
Punan (1site) 39
Malay(7sites) 156
Beketan (1site) 19
Sa’ban (1site) 65
1952752148
147
12295
9795
57
71
62
4759
42
1511
Documented Uses of PlantsMedicinal Use
Food
Ritual
Craft
Building Materials
Shampoo
Poison
Antidote
Drink
Fragrance
Flavour
Dye
Repellent
Figures as at 19 September 2017
CollectionTKDocumentation
Sorting
2)NaturalProductLibrary
Leaves
Stems
Fruits
Roots Wholeplant
Preparation
Extraction of Plant Samples
OvendryingGrinding
Extraction
DryingPlantExtracts
2Patentsgranted1Patentfiled1GIgranted2Trademark(5classes)
Natural Products Library 10ChemicallyCharacterisedCompounds
21ScentTracks
3types
Asat03.07.2017
Genomes
NaturalProductLibraryfordiscovery
Scents
607strains
Strain:20,519Extract:28,358
24,623extracts
433 E-OilTypes
Dataof2,000extracts
1Metagenome7bacterialgenomes3fungigenomes
2planttranscriptomes
• Localname:Segera (Iban),Puyau(Penan),Rukang (Lun Bawang),Kelabuno (Kelabit)
• Location:• Pulong TauNationalPark&
Ba’Kelalan• AlsofoundinPa’Ukat,Pa’Lungan,
Bario ,SBC,BRC
• Usage:Theroot(verysmallportion)isusedtotreatstomachachebyLun BawangCommunityatBakelalan.Therootisboiledwithwateranddrinktheconcoction.
Pre-clinicalinOhioStateUniversityPublicationbyUniversityofMarburgonEbolavirus
Scientificname:Aglaiastellatopilosa
Family:Meliaceae
• Localname:Baku’Bayung• Community:Lun Bawang• Scientificname:Globba atrosanguinea• Family:Zingiberaceae• Usage:
Usedascharm.Thefloweringstemisthrowntowardsthebackoftheadmiredpersontoattracthim/her.
• Localname:Tubu’Pulang• Community:Kelabit• Scientificname:Hanguana
malayana• Family:Zingiberaceae• Usage:
Totreatringworm.Fruitisslicedintohalfandappliedoninfectedarea
3)RapidScreeningCollaboration
CONFIDENTIAL 22
• Muscodor sp.forresearchonitsactivityonitseffectivenessasbiocontrolagentofGanodermadisease
• Silvestrol compoundtodetermineitseffectivenessatkillingnasopharyngealcancercells.
• Naturalproductbiosyntheticcapabilitiesbygenomesequencingandfermentationprocessofarareactinomycete strain
EffectivenessofCostus speciosus intreatingurologicaldisorders
NaturalcompoundsfromtheSarawak’sbiodiversityforneurologicaldiseasesdisorders.
Biologicalresourcesandindustrialbiomasswasteforvariousindustrialapplicationssuchasbiofuelsandnaturalchemicals
Microalgaeforfuel,food,feedandfunctionalmaterials
EvaluationofplantmaterialsfromSarawakonitssuitabilitytobeusedasingredientsforcosmetics,skincare,haircareandbiotechindustrialapplication
ScreeningofplantsforMethicillin-ResistantStaphylococcusaureus (MRSA)inhibition
TransesterificationandFattyAcidMethylEster(FAME)ProfileAnalysisforVariousSpeciesofMicroalgaeand/orYeastOil
Screeningofnewrubberdegradingbacteria
Anti-wormandanti-microbialactiveextractsinanimalhealthapplication
• PurificationandstructuralelucidationofbioactivecompoundsusingspectroscopicmethodswithDepartmentofPharmacy
• Screeningofpotentialcontrollinghighbloodsugar,anti-agingandwhitening(cosmetics)fromnaturalproductswiththeDepartmentofChemistry
Newnaturalingredientsasfoodandflavouring agents
Scientifictrainingandscreeningforrareactinomycetes fromSarawak’sbiodiversity
Silvestrol
Video:LitSara Story
ThankYou