CALIFORNIA TUMOR TISSUE REGISTRYheterogeneous right adrenal mass with calcification and central...
Transcript of CALIFORNIA TUMOR TISSUE REGISTRYheterogeneous right adrenal mass with calcification and central...
CALIFORNIA TUMOR TISSUE REGISTRY
"Endocrine Pathology"
Study Cases, Subscription A
November 2006
California Tumor Tissue Registry c/o: Department of Pathology and Human Anatomy
Loma Linda University School of Medicine 11021 Campus Avenue, AH 335 Loma Linda, Calltornla 92350
(909) 558-4788 FAX: (909) 558-(1188
E-mail: [email protected]
I'ID'f
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Target audience: Ptacticing pathologists aod pathology residents.
Goal: To acquaint the participant with the' histologic features of a variety of benign alid
mal.ignant ntQpla.'<IIIS and tumor-like conditions:
Objectives: The participant will be able to retQgnize morphologic features of a variety of benign
and malignant neoplasms and tumor-like cOnditions and relate those processes to pertinentreferenoes in the medical literature.
Edutational method• and media: Review of represenlative glass slides with associated histories. Feedback on consensus diagnoses from participating pathologists. Listing of selected refe-rences from the medical literature.
Priocinal faculty: Donald R. Chase, MD
CME Cred.it: Lorna Linda University School of Medicine designates·this continuing medical
education activity for up to 2 houn; of Category I of the Physician' s· Recognition Award of the American Medical Association.
CME credit is offered for the subscription year only.
Acereditatioo: Lorna Linda University School of Medicine is accredited by the Aceredilation
Council for Continuing Medical Education (ACCME) to sponsor continuing medical education for physicians.
Study Cases, November 2006, Subscription A
Contributor: Lorna Linda Pathology Group (mm) Lorna Linda, CA
Tissue from: Adrenal glands
Clinical Abstract:
Case No. 1 - November 2006 A
Accession #29173
A 42 year old man had worsening symptoms of Cushing's syndrome. A full work-up showed no localized masses. A bilateral adrenalectomy was performed.
Gross Pathology: The left adrenal specimen weighed 27 grams and contained a 7.0 x 4.5 x 2.0 em adrenal gland
with a slightly nodular, dark red cortex and a red-tao medulla. The right adrenal gland specimen weighed 32 grams and contained a 6.5 x 3.2 x 2.5 ~m adrenal gland with a slightly nodular purple-tan cortex.
Contributor: Xuedong Wang, M.D. Case No. 2 - November 2006 A Pasadena, CA
Tissue from: Adrenal gland Accession #29472
Clinical Abstract: Multiple medical problems developed in this 33 year old woman during the late stages of her
pregnancy. She was admitted at 36 weeks' gestation because of fetal demise. During work-up, a mass was noted in her right adrenal gland and very high norepinephrine levels were found.
Gross Pathology: The 120 gram, 7.5 x 6.5 x 4.8 em adrenal gland was largely replaced by a yellow-gray mass
with areas of necrosis.
Study Cases, November 2006, Subscription A 3
Contributor: Loma Linda Pathology Group (mrd) Loma Linda, CA
Tissue from: Right adrenal gland
Clinical Abstra.ct:
Case No.3 - November 2006 A
Aecession #29239
A pregnant 21 year old woman was discovered to have elevated serum and urine cortisol levels. A mass was found in her right adrenal gland.
Gross Pathology: The specimen consisted of a I 08 gram, 7.0 x 6.0 x 4.5 em, well-circumscribed orange-colored
mass.
Contributor: Lester Thompson, M.D. Case No. 4 - November 2006 A Woodland Hills, CA
Tissue from: Left adrenal gland Accession #30274
Clinical Abstract: A 63 year old woman had a history of hypertension, which recently had become postural. She
presented to the emergency department with epistaxis. During work-up she became diaphoretic and complained of chest pain. A CT scan showed a left adrenal mass.
Gross Pathology: The resected mass was 2 em in diameter and had a yellow-red cut surface with areas of
degeneration and hemorrhage.
4 Study Cases, November 2006, Subscription A
Contributor: Loma LiDda Pathology Group (bl) Loma LiDda, CA
Tissue from: Thyroid
Clinical Abstract:
Case No. 5 - November 2006 A
Accession #29237
While pregnant, this 30 year old woman was noted to have a thyroid mass. A needle aspiration biopsy was negative and the mass was watched for two years until it increased in size. At that time, a subtotal thyroidectomy was perfonned.
Gross Pathology: The left lobe of the thyroid was replaced by a 4.9 x 3.4 x 2.5 em friable red-tan mass.
Contributor: Phillip Gordon, M.D. Case No. 6 - November 2006 A Winter Haven, FL
Tissue from: Thyroid Accession #30193
Clinical Abstract: A 35 year old woman presented with a fullness in the left side of her neck. A thyroidectomy
was performed.
Gross Pathology: The left lobe was 8.4 grams and 3.5 x 3 x 1.3 em.
Srudy Cases, November 2006, Subscription A s
Contributor: Robert James, M.D. Case No. 7 - November 2006 A Ventu.ra, CA
Tissue from: Thyroid Accession #30293
Clinical Abstract: This 60 year old woman had a goiter and cervicallympliadenopathy. A total thyroidectomy
was performed. After surgery, her blood calcitonin level was 1550pglmL (reference range for females, post-calcium stimulation: 35 pglmL or less).
Gross Pathology: The markedly irregular thyroid gland had a 9 x 5 x 5 em right lobe and a4.5 x 2 x 2 em left
lobe. The right lobe contained an 8.5 em diametc:r rubbery, pale tan tumor.
Contri"utor: Scott Silveira, M.D. Case No. 8 - November 2006 A Dearbom,MI
Tissue from: Thyroid Accession #29543
Clinical Abstract: For three years, this 38 year old woman had been known ro have a .right sided thyroid nodule
and for one year she had been on medication for hypothyroidism. After symptoms of recurrent laryngeal nerve involvement we.re noted, she underwent aright h.emithyroidectomy.
Gross Pathology: The 56 gram, 7.0 x 4.5 x 3.0 em thyroid lobe was replaced by a firrn, homogeneous pale yellow
tumor.
Special Studies: AEI/AE3: TTF-1: Thyroglobulin:
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positive positive negative
Study Cases, November 2006, Subscrip1:ion A
Contributor: Lorna Linda Pathology Group (mp) Lorna Linda, CA
Tissue from: Adrenal
Clinical Abstract:
Case No. 9 - November 2006 A
Accession 1#30619
Angiography showed this 52 year old woman to have a thrombus involving her inferior vena cava and extending into her right hepatic vein. Additional radiographic findings included a heterogeneous right adrenal mass with calcification and central necrosis.
Gross Pathology: The 1,168 gram specimen included the right lobe of the liver with an attached 12.0 x 11.5 x 9.0
em well-circumscribed gray-tan mass. The heterogeneous cut surface consisted of multiple pink, yellow and gray-tan nodules up to 3 em in diameter, with areas of residual yellow adrenal cortex. There were large areas of necrosis.
Special Studies: Positive: ]llegative:
Synaptophysin, calretinin EMA, S-100, HMB-45
Contributor: Peter Morris, M.D. Santa Barbara, CA
T~ue from: Thyroid
Clinical Abstract:
Case No. tO - November 2006 A
Accession #30389
After a 6-month course of treatment for thyroiditis, this 18 year old woman was referred for thyroidectomy because of the presence of three thyroid nodules.
Gross Pathology: The right lobe of thyroid weighed 64 grams and was 6.5 x 6 x 3.3 em. The cut surfaces showed
innumerable pale tan-white nodules ranging from 0.3 to 2.5 em in greatest diameter. There were no areas of calcification, hemorrhage or cystic degeneration.
Special Studies: Abnormal cells negative: Abnormal cells negative, with
positive staining of background lymphocytes:
Abnorm.-tl cells positive:
Study Cases, November 2006, Subscription A
TIF-1, AE1/AE3, CAM5.2, CK8, CD45
CD3, CD43, CD20 CDJO
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CALIFORNIA TUMOR T ISSUE REGISTRY
ENDOCRINE PATHOLOGY
Minutes- Subscription A
November, 2006
SUGGESTED READING (General Topics from Recent Literature):
Pediatric Salivary Gland Malignancies. Shapiro N Land Bhattacharyya N ., Otolaryngol NaM Neck Surg 2006; 134:63 I -634.
Implications oflntratubular Seminoma. Berney OM, Lee A, et at. Hum Patlto/2006; 37:458-461. Higb.(irade Pelvic Urothclial Carcinoma of the Renal Pelvis. Clinicopathologic Study of 108 cases With Emphasis 011
Unusual Morphologic Variants. Perez-Montiel 0, Wakely PB JR, et al. Mod Patho/2006; 19:494-503. Special Stains for Upper Gl Biopsies Not That Helpful. Wright Cl and Kelly JK. Am J Surg Patho/2006; 30:357-361. Ovarian Krukenberg Tumors. K.Jyokawa T, YoUIIg RH, Scully RE, et at. Am JSurg Palho/2006; 30:277-299.
California Tumor Tissue Registry c/o: Department of Pathology and Human Anatomy
Lorna Linda University School of Medicine 11021 Campus Avenue, AH 335 Lorna Linda, California 92350
(909) 558-4788 FAX: (909) 558-0188
E-mail: [email protected] Web site & Case of the Month: www.cttr.org
FILE DIAGNOSES
(Preferably submitted on website at www.cttr.org. Click "subscriptions", then submit answers".)
CTTR Subscription A
Case 1: .
Case2:
Case3:
Case4.:
CaseS:
Case6:
Adrenal cortical ~yperplasia, nodular T-93000, M-83700
Phe~hromocytoma, adrenal gland T-930QO, M-87000
Adrenal cortical adenoma T-93000, M-81400
Pheochromocytoma, adrenal T-93000, M-87000
Papillary carcinoma, thyroid T-96200, M-80503
Tall cell/columnar papillary carcinoma, thyroid T-96000, M-45810
Case 7:
CaseS:
Medullary carci.noma, thyroid T -96000, M-851 03
November, 2006
Sclerosing mucoepidermoid carcinoma with eo~inophilia, thyroid T-96000, M-84303
ca.~_ejl;
Adrenal cortical carcinoma T,93 100, M-83703
Case 10: Nodular sclerosing Hodgkin's lymphoma, thyroid
T-96100, M-96563
Case No. I, Accession No. 29173 November 2006
~ - Adrenal cortical hyperplasia, nodular Bt!dwin PJrk (Kaiser Pqmanente) - Adteoal conical hyperplasia (4) Chico - Nodular adrenal cortical hyperplasia l,a Jolla IScrjovs ·Hcallhl - Adrenal cortical hyperplasia with atypia Lone Beach - Adrenal cortical hyperplasia (S) Mooterey ICommunjlY Hospital oflhc Monterey Peni!l!l!lol - Acquired hyperplasia Qllis.!l!l!!! - Adrenal hyperplasia Ommre (]{ajser Pe!maocnlel - Multinodular adrenal cortical hyperplasia Ognoe <O!JD•• County Medical Gmuo) - Adrenal cortical hyperplasia Onngc CUCI Medical Centa:l - Cortical hyperplasia Oxnard 1St. John's Rcojonal Medical Center) -Adrenal cortical hyperplasia Sacrnmcnto IUC Davjs Resjdent<l • Primary pigmented nodular adrenocortical disease Son Dieoo IUCSDl - Diffuse adrenocortical hyperplasia Sonia Barl!ara - Adrenal cortical byperpt.sia SIQ!a Roy - Nodular adrenal hyperplasia (J) Woo!!lan!l Hills ISuda's Soldiers\ - Adrenal cortical hyperplasia (pituitary, ectatle) (I); Adrenal cortical hyperplasia ( I ) Arkansas (!Jnjvcrsily of Arkansas Cor Medical Scjepces) - Adrenocortical nodular hyperplasia, adrenal Florida. AmerjQ3!h - Adtcoal hc:monbage florida IJacbon Memorial Hospjtn!l - Adrenal gland hyperplasia floric!a /Munroe Re•ionul Medical Center) - Micrunodular hyperplasia Florida ITa!l&hassce Po!bology As:socjatesl - Adrenal conical hyperplasia f!orida<W'mtq Haven Hospilall - Adn:oocortical hyperplasia Georgia IWcllgar KennC$!one Hospjlall - Primary pigmented nodular adenocortical disease Illinois IM!l&Ncal Memorial Hospjl!l!\ - Cortical nodule/adenoma ( l ); Adrenal cortical hyperplasia (Cushing syndrome) ( I) Illinois £Heartland Rcojona! Medical Coo!erl - Adrenul cortical hyperplasia lm!iana (HoW!I!'d Regjopa! Medical Center! - Adrenocortical hyperplasia M•swhwcns !Berlcsbln: Medical Center) - Bilateral adrenal hyperplasia M•'W•usetts !Tufts. New England Medical Center Resjdenls) - Pigmented nodular hypcrpii!Sia Michigan !O!!kwood Ho:;pjtaJ) • Adrenal hyperplasia (I); Diffuse hyperplasia ( I) lleb!asb <Ctd@ton !Jnjvmirtl - Adrenal conical hyperplasia New York CNgssau Uniymity Medical CenwrJ - Nodular cortical hyperplasio, adrenal, functional New York !SUNX Stony Brook! - Cortical adrenal hyperplasia North CaroUna (Mounlajo Area Pathology! - Adrenal cortical hyperplasia (1); Nodular hyperplasia (2) PmnsyMoja !Conemau&h Memorial Medical Center! - Adrcttal hyperpt.sia Pennsylyanla (Lehigh Valley Hosoitoll - Diffuse cortical hyperplasia Pcnnsylvnnjn <Magee Women's liospitall - Adrcnocortienl hyperplasia J>ennsylyanja (ML Nj!tAny Medical Center! - Macronodular adrenal hyperplasia with hypercortisolism Pamsylyonjo CPcnnsylnnia Hospj!AI Residents) - Adrenal hyperplasia Texas (The Melhodist HO§l1itall - Adrenocortical hyperplasia Texas. HoUSJoo - Nodular adrenocortical hyperplasia Icm l..ubb9ck - Nodular bype<plasia We!! Yiroinja (Greenbrier Valley Medical Center> - Adrenal nodular hyperplasia West Virginjo /Wetzel Coyoty tlospjtall - Cortical hyperplasia Conada IPosoua Hospital! - Cortical hyperplasia Clnada !Shcrbruoke llnjycrsity HQSpjtaJl - Nodular hyperplasia of the adrenal gland Gcnnanv llpstitut fur Paihologie UKEJ - Adrenal conical hyperplasia !long Kong (Pamela Youde Nethersole Eastern Hosoitall - Adrenal cortical hyperplasia O.w !Hamad Medjcol Corpornllon\ - Adrenal cortical hyperplasia Saudi Arabja £King l'ahot! Natlooa! Guard Hospilllll - Adrenal hyperplasia The Ncthcdands, Ams!elvcen - Adrenal cortical hyperplasia United Kin8dom IOxfor!l Study Gmuol - Adrenal diffuse cortical hyperplasia
Case I - Diagnosis: Adrenal cortical hyperplasia, nodular
T-93000, M-83700 Directors nott: "'The process also shows focal pigmentation in a minority oCihc slides." drc.
ClTR. November 2006 "Minutes" (Sub$<ription 1\) J
Case l - References: Kohler 0. Anding K, nnd Bohm N. Primary Pigmented Nodular Adrenocortical Dy.plasia. Pathol, ReseOJ'cl~ & Practice 1998;
194(3):201-204. Wu HH, Cramer HM, Kho J, eta!. Fine Needle Aspiration Cytology ofBenigo Adrenal Cortical Nodules. A Compllrision of
Cytologic F'mdings with Those of Primary nnd Metastatic Adrenal Maligoaneies. Acta Cytologlca 1998; 42(6): 1352-1358. Endo Hand Olea T. Jwcta-Adrmal COrtical Cell Ne:m or Nodular Fonnali011 in the Younger Oencralion- \YIIat Does It Mean?
l'athol, Research & Practice 1998; 194(11):765-772. Tcrzolo M, Boccuzzi A, Ali A, et at. Cushing's Syndrome Due to ACTH-lndcpende<~t Bilateral Adrenooortlcnl Maeronodular
Hyperplasia. J of Endocrine lnvost l991; 20(5):270-275. Jalali M and Krishnamunhy $. COmparision oflmmunomarkers for the Identification of Adrenooorlical Cells in Cytology
Specimens. Diog Cytopatlu>l2005; 33(2):78-82.
Case No. 2, Accession No. 29472
Alameda - Pheochroonocyloma Baldwin PorldKaiser l' crmaneptel • Phcochromocytoma(4) Olico - Pheochromocytoma La Jolla !Scripps Health) - Pheochromocytoma Lon• Beach - Pheochromocytoma (5) Monterey <Community HospitaJ.oflhe Monterey pcnjnsu1al - Phoochromocytomu l2l!k!!Ylll - Pheochromocytoma Qrange (){•i:ter Pqmancntcl - Pheochrotoocytoma Onmoe CQrangc COunty Medical GroUP) - Pheochromocytoma Orange CUC! Medical Center\ - Pheochromocytoma Oxnanj !St. John's Regional Medical Center! - Pheochromocytoma (2) Sacramento IUC Davjs Residen!Sl - Pheochromocytoma San Djego I!!CSDl - Pheochromocytoma Santa l!arbata - Pheochromocytoma Santa Rosa - PheochromocytOma (3) Woodland l·lills ISuda's Soldiers\ - Pheochromocytoma (2) Arkansas (University of Arkansas for Medical Scjcnces\ - Phcochromocytomn. adrenal Florida. Amqjpath - Medullary hyperplasia Florida !Jackson Mem9ria] Hosnitall - Pheochromocytoma Florida (Munroe Rcgjonal Medical Center\ - Pheochromocytoma flortdaffi!!ahassce Pathology Assocjn!es) - Pheochmmocytomn Florida CWintcr ffayen Uospital\ - Pheochromocytoma Gcomia IWclls!ar Kenncstono Hospila!\ - Pheochromocytoma Illinois !MacNeal Memorial Hospitatl - Pheochromocytoma (2) Illinois CHc!lCl!and Rcaion!!l Medical Center\ - Pheochromocytoma Indian• (1-!oward Regjona] Medical Center) - Phoochromoeytoma Massachusetts CBcrksttjre Medical Center) - Phoocbromocytoma M!I.<S!Gbuset!S fTuiW-Ncw Ens land Medical Center Residents\ • Pheochromocytoma MichjRI!J C<la!;wooc! Hospital\ - PheochromocytOma (2) Nebruka CCreishton Unjyec;ityl - Pheochromocytoma New York <Nassau linjyersity MediCAl Center! - Pheochromocytoma New York CSUNY Stony Brookl - l'hcoehromocytoma No!!h Carolina(MounWo Area Pathology) • Pheochromocytoma (3) Pennsylyania !Conemaugh Memorial Me!ljca! Center) • Pbeochromocytoma Pennsylyania CLehigh Valley Hospital> - Pheochromocytoma Pcoosylynnja (Magee Women's Bosnilall - Phoochromocytoma Pennsylyania IML Njuany Medical Center> - PheochromOcytoma, adrenal gland Pennsylvania (Peposvlyania Hospi!Al R.,;dentsl - l'hoochromocytoma Texas Obe Methodist HQSI)i!all • Pheochromocytoma Iexa'!, Houston • Pheochromocytoma Texa.<. Lubbock - Phcochromocytomn West Vjr2jnia (Gn;enbder Valley Mcdjeal Center\ - Pheochromocytoma West Vjminia CWet:t.el Counw HospHall - Pheochromocytoma C4Mda CJ>a.wua RospjWl - Pheochromocytoma Can&da CShcrbrookc Uojvcr.;ity Hospilal\ - Pheochromocytoma
November 2006
4 CTTR. Noven>ber 2006 .;Minulfs" (Subscription A)
GC!l!13!lv !ln5titut fur Pi,tbologie UK!ll - Pheochromocytoma Hong Kons (paroela YoydeNethcrsolc Epm H9!fpilal) - Pheochromocytoma Oatar (Hamad Medjcal ComoratiQO) - l'bcochromoeytoma Saudi Ar!bia !King Fabod National Oyard Rosnitall - Pheochromocytoma The Netbq!apds. Amsldyeen - Pheochromocytoma of the adrenal gland United Kinadom COxford Study Grpuo> - Adrenal pheochromocytoma
Cas• 2- Dlunosis: Pheochromocytoma, adrenal gland
T-93000, M-87000
Case 2 - References: Plouin PF and Gimeocz-Roqueplo AP. The Genetic Basis of PbcochromoeytomL Who to Sa= and How? Nat Clln Pract
Endocrlnol Metab 2006; 2(2):60-61 . Orodski S, lung C, Kertes P, ol al. PhMOchromocytoma in PregnWJcy. lnttm Med 12006; 36(9):604-606. Ouller U, Turck J, EubiiJlkS S, et al. Detecting Pheochromocytoma. D<fining tho Most Sensitive Test A 1m Surg 2006; 243(1 ): I 02-
107. Dahia PL. lfao K, Rogus J. et al. Novd Phcochromocytoma Susceptibility l..oci ldenlif"Jed by lottgJativc Geoomies. Omcor Ru
2005; 6$(21):9651-9658. -llanda U Kbullar U and Mohon H. Pigmeoted PhcocbromocytomtL Report of a case with Diagnosis by Fine Needle Aspiration.
Acta C)!to/2005; 49(4):421-423.
Case No. 3, Accession No. 29239 November 2006
A]ameda - Adrenal cortJcnl neoplasm !)aldwin Park CKaiser Pcnnanentel - Cortical adenoma (adrennl) (4) lJlli;!! - Adrenal cortical adeoolllll !.a Jolla CScrioos Heal!hl - Adrenal eortical neoplasm, tavor adenoma Long Jleach - Adrcoal cortical adenoma (5) Monterey <Community HoSJ>ital of the Monterey Peojnsulal - Adrenal cortical carcinoma (2); Adrenocortical adenoma (2) ~ - Cortical adenoma Orange !K ajyr Pcrmanentcl - Ad~ conical adenoma Orange <Orange County Medical Groypl - Adrenal cortical adenoma Omnge IUC! Medical Center! - Cortical adenoma Oxnard 1St lobo's Reclooa! Medical Center! -Adrenal cortical adenoma Saqamq]IO 0/C Dayjs Resjdcn!>l - Cortical adenoma San Diego IUCSOl - Adrenocortical adenoma Santa BarbllrJl - Adrenal cortical adenoma Santa Rosa - Invasive adenoma of adrenal gland ( I); Adrenal cortical adenoma (2) Woo<lland Hms ISuda's Soldiers) - Adrenal cortical adenoma (2) 1\rbosa;; IUnivqsity ofAd<llllS8S for M<dical Scicru;esl - Adrcoocortical adenoma, adrenal florida. Amsripath - Adn:oal adenoma flori<fa !Jackson Memorjal Hospi!8Jl - Adrenal cortical adenoma f lorida <Munroe Regionnl Medical Ceoterl - Cortical adenoma florida !Tallahassee Pathology Asroc!arcsl - Adrenal adenoma florida CWjntcr Haveo HO!!pitaD - Adrenocortical adenoma Georgia IWei!S!¥ Kenocsrone HospiJu!) - Cortical adenoma !!Unois <MacNeal Memorial liosni!8)) - Cortical adenoma (2) !llloois <Heart]and Reajonal Mediql Center! - Adrenal cortical neoplasm, favor adenoma !ndiaoa <Hol!l!!d RcgipoaJ Medical Ceo]&rl - Adrenal cortical adenoma MB.'-<aCbUSC!JS merkshire Medical CCQ!tC) - Adrenocortical adenoma MIISSachugr[S Crufts-New England Medical Cen!er Residents\ - Adrenal cortical adenoma Michiaan COakwooc! HosojlaJ\ - Adrenal cortical adenoma (2) Nebra<b <Creishton Unjvrnjlyl - Adrenal cortical adeooma New Yodc !Nassau Univenity Medical Center) - Cortical adenoma New York ISl/NY Siony Orookl - Cortical adrcnnl ndenoma North Carolina (Mount4in Area Pathology! - Adrenal cortical neoplasm (3) Peonsv!I'Mja CConernaugh Memorial Medical Ccn!crl - Adrenal corticaladcooma
Cri'R, November 2006 "Mintrtc:s• (Subscription A} 5
Pcnnsvlynnja (Lehigh Valley Hospjtall • Cortical adenoma vs. foeal nodular hyperplasia Pmnsylvaoja (Magee Women's Hospjta!l • Adcnocortical adenoma Pcnnsvlunia(Mt. Ninaoy Mec!ical Center) • Adlenoeortical adenoma Pennsylvania CPennsyhaoia HospjJal Rqidcotsl • Adreoal adenoma Tgn Obe Mdbsxlist Hospital) ... Adrenocortical adenoma Texas. Houston - Adrenal adenoma IexM. Lubbock - Cortical adenoma \Vc:o.1 yjrajoia <Greenbrier Valley MedjcAI Center) .. Adrenal cortical adenoma West Virginia CWetzel County Hosnltnll - Cortical adenoma Cann!la ll'osgua Hosoi!all - Cortic.~l adenoma Can!!da ISberbmoke University Ho:mjtall • Adenoma (fascicular bone) GennMv Clnstitut fur Patholooic !JKEl - Adrenal cortical adenoma Hona Kons CParnola Youde Nethersole Eascm H<»yital\ - Adncnal eorticnladcnoma Oatar fHama4 Medical Cnrponuionl • Adrenal cortical adenoma Sauc!j Ambia CKin2 Fahad NatiOMI Guard Hosnita!l • Adncnal cortical adenoma The N!:thcrl8!!ds. Amstelyeq! - Adrenal cortical adenoma United Kjnsdom <Oxford Study Group) • Adrenal cortical adenoma
Co•e 3- Diagnosis: Adrenal cortical adenoma
T·93000, M-81400
Case 3 - References: Ghorab Z, lorda M, Ganjei P, et al. Melan A (A103) is Expressed in Adrenocortical Neoplasms But Not In Renal Cell and
Hepatocellular Carcinomas. Appllmmunohisto & Molecular Morpho/2003: 11(4 ):330.333. Zhllllg Pl, Gcncga EM. Tomaszewski JE, ct al. The RoleofCalretinin, lnhibio. Melan-A. BSL-2 and C-Kit in Oilfereotialing
Adrenal Cortical and MeduUary Tumors. An lmmunobiSIOCbemical Study. 2003; Modern Potho/2003; 16(6):591-597. Sasano H, Suzuki T and Moriya T. Oiseeming Malignancy in Resected Adrenoeortical Neoplasms. Endocrlnt Potho/2001;
12(4):397-406. Stojadinovic A, Brennan MF, Hoos A, ct al. Adrenocortical Adenoma and Carcinoma Histopathological and Molecular
Comparative Analysis. Modern Patho/2003; 16(8):742-751. Erickson LA, Lloyd RV, Hartman R, et al. Cystic Adrenal Neoplasms. Canctr· 2004; 101(7):1537·1544.
Case No. 4, Accession No. 30274
Alamq!a - Pheochromocytoma Baldwjn Pad< (Kaiser Penmancntcl • Cortical adenoma (adrenal) (4) QUsQ - PheochromocytOma La Jolla CScnoos Health! - Pheochromocytoma !.ono Qeach - Malignant pheoehromoeytoma {S) Montqey CCommunitv Hospital of the MontereY Peninsula) .. Pheochromocytoma Q.Qkl.crul - Adrenal carcinoma Ornnso O<aiscr Pcrmancntel - Phe<>chromoeytoma Omnoe IOcange County Medical Group) • Pheoehromoeytoma Orange CUCI Medical Cenrerl - Pheochromocytoma Oxnard ISL John's Regional Medical Center> - PheocbromoeytOma {2) Slmmen!O fUC Davis Residco!S) • Pheochromocytoma San Ojqo ruq;m - Pheochromocytoma Santa Bltbara - Pbeoehromocytoma Sontn RoS!l • Pheochromocytoma (3) W90dland Hms CSuda' s Soldiers) - Pheochromocytoma (2) ArkanS!I.:i fUnivcrsity of Arkansas lb r Medical Sciences! - Pheochromocytoma. adrenal florida Amerinath • Pheochromocytoma Florjda (Jackson Memorial Hosi2W!!} • Phcoehromocytoma Florida (Munroe Regional Medical Ccmer) • Nodular adrenal medullruy hyperplasia Floddg Cipllahassee-Pathology Assocjatesl - Pheochromocytoma floric!a C\Vintcr Haven Hosoita!) - Phcoehromocytoma Gco!!!i& !WeiiS!l!r Kenncstonc RospjtaD • Pboochromocytoma
November 2006
Illinois (MacNeal Memorial HosnitaD • Neuroeodocrineturnor(l): Adrenal cortical adenoma (Conn's syndrome){!)
6 C1TR. Novm>ber 2006 "Minutes" (SUbscription A)
Illinois <Heartland Regiopal Meciical Center) - Pheochromocytoma lndiw <Howard RegjonaJ Medical Center> - Phc:ocbromocytoma ~!Jnarhysens CBcrkshin; Medjcal Center> • Pheochromocytoma M'""thusctts ITyfts..N;w England Medjcal Csntg Residents> - PheochromocytOma Micbhll!!! CQakwood Hospila!l - PheochromOCytoma (2) Nebraska !Crei•hton Up!yersitvl - Pheochromocyll>ma New York <Nassau llniyc[$jty Medical <&otcr> - Pheochromocytoma New York <SUNY Stony Brook! - Pheochromocytoma Nonh Carolina !Moun!Ajn Area Patl!o!ogy) - Phcochromocytoma (3) Pennsylyanja !Conqnau!!h Memorial Medical Center> - PheochromocytOma PenosvlvBI!i•IUbi•h valley Hosnitall - Phc:ocbromocytoma Pcnnsylyanja CMagee Women's Hospital) .. Pheochromocytoma l'ennsylvani• CMtNitww Medical Center! - Pheochromocytoma, adrenal gland Pennsylvania <Pennsvlyonio HospicaJ Residents) - Pheochromocytoma Tex;s !The Mcthodistliospilall - Pheochromocytoma Tg'$ HoUSion ... Phcoehromocyt.oma Tem Lubl!ock - Phcochromoc:ytoma West virginia fGreenbri<t Valley Medical Ccoterl - Phc:ocbromocytoma West Yirgjnia I'Wctzel County 1-Jospitall .. Phcochromocytoml\ CBOada CPasoua HOSTJjlol\ - Pheochromocytoma Canoda ISherbrooke University Hosoitall - Pheochromocytoma Gqmuw (lnstiM fur PaJhologie UKEl - Pheochro!OOC)1oma HOQ8 Kong CPamc;la Youde Ne!lte!1!01e Eastern Hospi1all - Phcochromocytoma Ol!lr !Hamad Medical C0!!!0!1!!ionl - Phcochromocytoma Saudi Arabi• <King Fabad National Guard Hospital> - Phc:ochromoeyll>ma The Ncthedands Amstolycco - Adrenal pheocbromoeyll>ma l)nlied Kingdom !Oxford Study Grougl - Adrenal pheochromocytoma
Case 4 - Diagn0$is: Pheochromocytoma. adrenal
T-93000, M-87000
Case 4 - References: Din<.~ BK. Franks ME, Bebarl A, et al. Pl!rlinl Adrenalectomy. Tite National Cancer lnstiMe 13xperience. Uro/2005: 66(1):19-23. A marL, Servais A, Gimcncz.-Roqueplo AP, et Ill. Year of Diagnosis, Featurts nt Presentation, and Risk oi'Recurreocc in Patients
with Pbc:ocbromocytoma or Sc:crelins, l'4f18Ntglioma. J Clin Endocrinol Me tab 2005; 90( 4 ):21 1 0.2116. Elder E£. Elder G and l..aiSSOO C. Pbeoc:bromocytoma and Functional Paraganglioma Syndrome.. No longer the 10% Tumor. J Sutg
Oocvi200S; 89(3):193-201. Naya X, Ichikawa T, Su~lci H, ctal. Efficocy and Sa!c:ty of Laparoscnpic Surgery for Pheochromocytoma. lnt J Uro/2005;
12(2):128-133. Westphal SA. Diagnosis of a Pbeocbromoeytoma. Am J Med Sc/2005; 329(1 ): tS-21.
Case No. S, Accession No. 29237 November 2006
~ - PaplUary th)'l'Oid careinoma Ba!dwjn l)ark(J(Wser Pemmnentcl .. Papillary cnrcinoma (4) ~ - Papillary thyroid careinoma 4 JO)Ia (Scripps Heahbl - Papillary thyroid carcinoma Lon& Jls!T - Papillary carcinoma of !be thyn>id (S) Monterey !Community Hosnjta! of the Mommy Peninsula) - Papillary thyn>id can:inoma !l!ildlll.!l - Papillary careinoma Omoac CKniser Pennnnenjel ~ Papillary t.hyroid carcinoma OrMae f'Or;mge County Medical Group) - Pepillary carcinoma Or!noe fUCl Me<lica! Center) - Papillary lh)'l'Oid carcinoma Oxnard (SL John's BcsionaJ Medical Center! -Papillary ca:einoma ofthy.oid (2) SacrJmq!to CUC Davjs Resick:ntsl - Papillll)' can:innma of !he lhyn>id San Ojcgo CUCSDl - Well-<liff"""'tiated papillll)' thyn>id carcinoma SantaBarbara - Papillary carcinoma Santa Rosa - Papillary carcinoma of!hyroid (3)
C'ITR. Novanber2006 "Minutes" (Subscripcion A) 7
Wondi!U!d Hl!ls CSuda's Soldiers) - Papillllt)' thyroid carcinomo (2) • Ar1uy!sM OJnh•er.;itv of Arkanw for Mcdjcal Sciences> - Papillary thyroid c.arcinoma, thyroid florida. Amcrioa!h - Papillary thyroid carcinoma Florida CIA£ls!!!n Memorial Hospjlllll - ~illary thyroid carcinoma Florida (Muome Regional Medical Center\ - Papillary careinoma flori4a ITa!labessee Pa!hology Ass9cja!C$) - Papillary carcinoma ofll>e thyroid Florida CWjntcr Ha~n Hospital) - Papillary can:inoma Georgia CWcllstar Kennestonc Hospjloll - PapUJruy thyroid can:inoma ll!jnois (MacNeal Memorial Hosoitall • Papillary carcinoma, thyroid l!ljoojs CHeartland Re&ional Medical Ccpterl - Papillary carcinoma !ndjana <Howard Reeional Medical Center! - Papillary careiooma, thyr<>id Ma:!S!!Cbusctts £Berkshire Medical Center! - Papillary carcinoma Massachusetts ITufts-New Enoland Medjcal Center Residents) • Papillary carcinoma, thyroid Michjgan !O!!lswoo<i Hosnilllll - Papillary carcinoma (2) Nebmk& !Crcigllton Uojversityl - Papillary thyroid carcinoma New Xort <Nassau Univqsitv Medical Ccntql • Papillary thyroid careinoma New York !SUNY Stony Brook) - ~illary thyroid can:inoma, panly sclctotie North Carolina CMoontam Area Pa!holo1rtl - Papillary thyroid carcinoma (3) Pennsylyania <Conemaugh Memorial Medical Center> - Papillary can:inona ofth)Toid J'eonsvlynni• <Lchieb Valley Hospital> - Papillary careinoroa Pcnnsylyania <Mngee Women's Howitol> .. Papillary carcinoma Pennsyll'lllli• !ML Njttany Medical (;eOJ'!) • Papillary careinoma, thyroid g!Wld f>coosyJya.nia CPennsvlvap'ja Hosnjtnl Rgsjdcots) · Papillary carcinoma Texas CThe Methodist Hosnitall - Papillary thyroid carcinoma Texas Houston - Papillary thyroid carcinoma Tex..,. Lubbocls - Papillary carcinoma of thyroid Wcs Virginia C<Jrecnbrier Valley M<dlcal Center! - Adenocarcinoma, papillary WCSJ Yirgjnja (Wetzel County Hospjta!l • Papillary carcinoma Canada CPasoua HQS'!illlll - Papillary cateinoma and Hashimoto's disease Canada CShabrookc Univqsjty Hospjtall - ~illary carcinoma Gennanx Onstil1lt fur Pathologjc UKID - Papillary tarcinoma Hons Kons <Pamela Youde Nethersole Eastern Hospital) • Papillary ean:inoma ofth~Toid O!!W fHamad Medical Comorationl - Papillary thyroid carcinoma Saudj Arubia CKing faha!l National Guard tlospjl!!ll - Papillary thyroid carcinoma '!be Ntthcdwu!s. Amslclvccn - Papillary thyroid carcinoma Unl!ed Kjnodom (Oxford Study Groyp) - Thyroid papillary can:inoma
Case 5 - Diagnosis: Papillary C3l'Cinoma, thyroid
T-96200, M-80503
Case S - References: Mehmood RK, Basha SJ and Ghan:eb E. A Case of Papillary Careinoma Arising in Ectopic Thyroid Ttssu<: within a Branchial Cyst
with Neck Node Metastasis. Ear Nos• Thr«U J 2006; 85(10):675-676. Haas SN. Management ofl'apillary Microcarclnoma of the Thyroid. SD Med 2006; 59(10}:425-427. Wang Z, Qiu S, Eltork)' MA, et al. HlslUpathologic and Immunohistochemical Characterization of a Prinuory Pupillary Thyroid
Carcinoma in tbe Lateral Cervical Lymph Node. &p Mol Patho/2006. Collin! P Moltavelli F. Pellegrinelli A, Cl a!. Papillary Carcinoma of the Tioyroid Glllltd of Childhood and Adolescence.
Morphologic Subtypes, Biologic Behavior and Prognosis. A Clinieopathologic Study of 42 Sporwlic Cases Treated at a Single Institution During a 3().Ycar Period. Am J Surg Padwl '1006; 30(11):142().1426.
Oionigi G. Dionigi R, Banalena L. 01 a!. Surgery of Lymph Nodes In Papillary Thyroid cancer. E:sper Rtrv AlllfCQJKW Tiler 2006; 6(9): 1217-1229.
Case No. 6, Accession No. 30193 November 2006
AlamedA - Papillary thyroid eareinoma, IIIII cell variant Ba!dwjo J>art <Kaiser Pcrmanentel - Papillary careinoma ("tall cell" variant) (4)
8
~ - Columnar cell corcinoma (columnar wriant of papillary carcinoma) l.alolla CScrinns Health) - Papillary thyroid carcinoma, columnar cell variant l,ong Beach - Papillary carcinoma, tall cell variant (~) Mootgey <eommunity Hosnital of the Monterey Penigsulal - Papillary lh)TOid careinoma, tall cell variant (2); Folticular adenoma
(I); Columnar cell c:arcinoma {I) ~-Adenoma
Omgge CKojsq PennansDJc\ - Papillary thyroid carcinoma, !All-cell variant Oragge !Orange County Medical Group) - Tall cell variant of papillary carcinoma Oranoe !tiC! Medical Cemcrl - Papillary thyroid, columnar variant Oxnard !St. J9hn's Reojognl Medicn! Center) ·Papillary carcinoma, tall cell variant (I); follicular adenoma vs. tall cell variant (I) Saaa!nento OJC Davis Residents) • Tall cell carcinoma of tile thyroid s.o Diego cucsm - Papillary thyroid carcinoma. columnar cell variant Santa Barbnra • Thyroid hypetpl"-'ia &mta Rosn - Papillary carcinoma of tull cell variant (2); Papillary thyroid CArcinoma, cncopsulated ( I) Woodland Hills CSuda's Soldjers) - Papillary carcinoma, columnar wriant (2) M!n:s!:; CUgjversity of Arlsansas for Mc;dical Scicnc:csl - Papillary thyroid carcinoma. tall cell wri11111, tb)TOid florida. Ameripatb • Tall cell papillary carcinoma • florida Oaclsson MemoriAl HospjtaJl · Columnar variant or papillary thyroid carcinoma florida <Munroe Rcgion!!l Medical Center> - Papillary carcinoma, taU cell variant FJorida iD!!eh•ssce Palhg!ogy AS5"QA1§l - Papilla.ycartinomaofthe thyroid Florida !Winter Haven HospjtaD - Columnar variant papillary cnrcinoma Georgia !Well:.w Kenneslone HOMil!!!\ - Papillary thyroid carcinoma, columnar variant Illinois !MacNeal Memorial Hosnilall- Papillary carcinoma, thyroid (I); Thyroid papillary carcinoma, tall cell wriant {I) Jlljnois !Heartland Regional Medical Center) - Follicular adenoma with papillary areas Indiana fHownrd Regional Medlen! Cco1cr\ - Tall cell varian~ papillary thyroid carcinoma Massachusens<Berkshire Mcdjcal Center\ - Papillary carcinoma, variant tall cell Mossl!fhusetq qufts..New En&lan<l Mc!lical Center Residents\ - Papillary c:arcinoma, colwnnar type thyroid/medullary carcinoma Miehi!!l!!l. !Qnkwood Homjta!\ - Papillary carcinoma, tall cell variant (2) Nebraska !Crejsh.ton linjycr!jiM - Papillary thyroid carcino!IUI, tall/columnar cell variant New Vorl: lN•ssm University Medical Center) • Papillary thyroid carcinoma, columnar-tall cell type
New York ISVNY Stony Brook) - Tall cell wrian~ papillary thyroid carcinoma North Carolina (Mountain Area Patholosyl - Papillary thyroid carcinoma (2); Papillary thyroid carcinoma, tall cell type (I} Pennsylyanla !Conemaugh Memorial M¢jcal Center) - Papillary carcinoma of thyroid, columnar variant Pc:on.wlvanjp Q&bigh ¥alley HOSDitAl) - Papillary carcinoma. call ceU variant hnnsvlvan!a fM...,., WOroeo's Hospila!> • Papillary carcinoma, taU cell wriant Pcogsytvanjn !Mt. Njttany Medical Center\ • Columnar cell carcinoma (a variant of papillary carcinoma), thyroid gland Pennsylvanja CPennsyiYAAja HospitAl Residents) .. Columnar cell cw-cinomn Texas !The Mctboc!iS! Ho:mital\ - Papillary tllyroid carcinoma (columnar cell variant) TCI!!t< Ho\Lll()n - Follicular adenoma with papillary hyperplasia Texas. Lubbock - l'apillury carcinoma, tall cell variant We:.1 Virginia !Greenbrier v alley Mcdjcal Center) - Follicular varinnt of papillary carcinoma West Y'trgjnja (Wetz<:l Counsv HOS!!ilall - Papillary carcinoma Canada !Pasqua Hosoi!l!)\ · Papillary carcinoma, columnar cell type Canada IShc;rbrogke tlnjycrsitv Homilnl\ - Papillary carcinoma, lall cell variant Geananv Onsthut fur Pathologic \IKEl ·· Papillary carcinoma, columnar cell variant Hong Kong IPan!ela YoudeNctbenlole East<m HospjtaD - Papillaryca..:inomaoftbyroicl. tall cell wriant Oa!ar !Hamgd Mc!lical Cgrponuionl - Columnar cell varian~ papillary carcinoma Saudi Arabia CKing Fahad National Gu8!!l HQMitall • Papillary thyroid carcinoma The Nethedands. Amstelvecn - Columnar cell carcinoma of the thyroid United Kin&dom !Oxford Study Gmuol - Thyroid, tall cell wriant papillary con:inoma, lymphocytic thyroiditis
CITR, November 2006 .. Minutes" (Subscription A) 9
Case 6- Diagnosis: Tall celVcolumnar papillary carcinoma, thyroid
T-96000, M-45810
Case 6 • References: Euscbi v. Damiani S, Ellis 10, et al. Breast Tumor Resembling lhe Tall Cell Varillllt of Papillary Thyroid Carcinoma. Report of5
Cases. AmJ Surg Pathol2003; 27(8):1 114-1118. Gupta S. SodhMi P, Join S, e< at. Morphologic Spectrum of Papillary Carcinoma of the Th)'I'Oid. Rok of Cytology in IdentifYing the
Variants. Acta Cyto/2004; 48(6):79$-800. Yiagan LR, Dehner LP, Huettner PC, et al. Columnar Cell Variant of Papillary Thyroid Carcinoma. Report of a Case with Cytologic
Findings. Acta Cyto/2004; 48(1):73-77. Solomon A, Gupta PK, LiVolsi VA, ct at. Distinguishing Tall Cell Variant ofl'apillwy Thryoid Carcinoma from Usual Variant of
PapiUarylbyroid Carcinoma in Cytologic Specimens. Diagn Cytopatlw/; 2002; 27(3):143-148. Nair M, Kapita K. Karole AK, ct at. Papillary Carcinoma of the 'Thyroid and its Variants. A Cytohistologieal Correlation. Diagn
Cytopolho/2001; 24(3):167-173.
Case No. 7, Accession No. 30293
Alameda - Medullary carcinoma Baldwin Parle fKaiscr Pcrmllllcntcl • Medullary carcinoma ( 4) ~ • Medullary carcinoma Lil Jolla CScrjpps Hcalthl - Medullary thyroid carcinoma !.cmg Beacll - Medullary carcinoma (S) Monterey{Communjty Hosoital oftheMonterev Peninsula) • Medullary carcinoma Oakland - Medullary carcinoma Osanoe CK•iw Pqmansntcl - Medullary carcinoma Qrungc {Or!!llae County Medical Grounl • Medullary CftrCinoma Omnge OJCI Medjcnl Centerl • Medullary carcinoma Oxn!l!'d CSl John's Regional Medical Center\ - Medullary carcinoma (2) Sacramento C!JC P!lyjs Residents) - Medullary carcinoma San Diego (UCSQl • Medullary carci.noma Santa Barbara • Carcinoma Santa Ro5a • Medullwy carcinoma (3) Wooslland Hills CSuda's So!diml • Medullary carcinoma (2) Ar!sansas OJniveaitv ofA!kansa< for Mc!lical ScjenMl - Medullary carcinoma, thyroid florida: Ameripath - Medullary carcinoma florida <Jackson Memorial Hosoitall • Medullary carcinoma, poorly differentiated florida <Munroe RegjonaJ MedjcaJ Center - Medullary weinoma florida <Ta)!aha•m Pathology AsSQCjprul - Medullary carcinoma of the thyroid florida (Winter Hayen Rosoitall - Medullary carcinoma Georgia (Wcllstar Krope:Ftone Ho.mitall - Medu.JJary eercinoma lllinojs <MacNeal Memorial Hospj(Ail - Medullary carcinoma, thyroid (2) Illinois CHcartland &•ional Medical Center) • Medullary car~:inoma Indiana CHownrd Rcajnnal Medical CcnJer) • Medullary carcinoma Massachusetts <DcrkShjl'f Mes!ica! Center) - Medullary carcinoma Massacbusens Cl\lfls-New England Medical Center Residents> • Medullary earclno.ma, thyroid Miobi21lll <Otlswoo<l Hosoitall - Medullary carcinoma, squamous variant (I): Medullary carcinoma ( I) Nebraska <Ctcig!JJoo 1/nivqsityl - Medullwy carcinoma New York <Na'S'" Universirv Medigl Center) - Medullary carcinoma New York CSVNY Stony Brook) • Medullary carcinoma. thyroid J'!orth Carolina CMoyntain Area l'niholoay) - Medullary thyroid carcinoma (3) Pennsylvania CConcroaugh Memorial Medical Center) • Medullary carcinoma of thyroid PennsyiVllllia ().e!Jish Valley Hosoital) - Medullary carcinoma PennsviYl!Di• <Magoe Women's Hospj(Ail - Medullary carcinoma Pcnnsvlvaoia (ML J'!jttany Medical Cguql • Medullary carcinoma, tb)'I'Oid gland Pennsyl·vania CPennsylyania Hospital Rgjdentsl - Medullary carcinoma Texa< <The Methodjs! HospiJII!l - Medullary thyroid carcinoma Texas Houston • Medullary thyroid carcinoma Tex!L'l Lubbock • Medullary carcinoma
November 2006
10 CTTR, Novcmba 2006 "Mim!!es" (SUI»<riptioo A)
WCSJ virginia IG!CC!lbricr Valley Medjsa! Center) - Medullaty can:inolllll West yjrgjnia QVetzeJ Coyntv HosnjtBU - Medullary carci.noma Canoda !Pasqua Ho1ohal\ - Medullary carcinoma Cana!la (Shcrbrookc Unjvcrsitv Hosojtall • Medullary CIIJ'Cinoma f1!2!Jl!!Av Onstitut fur Patholosie UKEl • Medullary can:inoma Hooa Kong <Pamela Youdc Ne!herljole Eastern Hospital\ · Medullary c:on:inoma of thyroid O.W Oianmd Medical Co!!lO!ll!ionl - Medullaty carcinoma S.1udj Arabja <Kino faha4 National Guard Hospital\ • Me<lullary carcinoma The Netherlands. AmS)clvccn · Medullary carcinoma of the thyroid Unite<! Kingdom IOxfqrd Study Grounl - Thyroid. medullary carcinonlO
Case 7- Diagnosis: Medullary carcinoma, thyroid
T ·96000, M -85 I 03
Ca.w 7 · References: Bockbom M. Sheu SY, Frilling A. ct al. ParagangJioma-LikeMedullaty 'lluyoid Carcinoma. A Rare Entity. Thyroid 200S;
IS(I2):1363-1367. Brauckhoff M, Lon:nz K, Ukkat J, ct al. Medullary Thyroid Carcinoma. Scandin J o[SW'g 2004; 93(4):249-260. KhuranA R, Agarwal A, Bajpai VK, ct al. Unraveling the Amyloid ll.1$ocinted with Human Medullary Thyroid Carcinoma.
l.':ndocrino/2004; 14S( 12):5465-S470. Ensinger C, Prommegger R, Kcndlcr D, et al. Hcr2JNcu Expression inC-Cell Hyperplasia and Medullary Thyroid Carcinomas.
Alllicczncer ~ 2003; 23(38):2241·2243. Tlbmi H. Medullary Thyroid Carcinoma and Multiple Endocrine Neoplasia Type2. Endocrine Patho/2003; 14(2):123-131.
Cast: No. 8, Accession No. 29543 November 2006
6lilmedJ! • Sclerosing mucoepidermoid carcinoma with eosinophilia Bllldwjn Park (Kajser Pennanentel • Poorly-diffe<enliated carcinoma (2); Poorly difTi:rontiated carcinoma with squamous features
(2) ~ - Sclerosing mucoepidermoid carcinoma with eosinophilia !,a Jolla (Sqipos Heal(hl • Sclerosing mucoepidermoid carcinoma with eosinophilia loos Beach - Metastatic poorly difTerentialfd squamous cell carcinoma, lung primary (S) Mootcrev CCommonjty Hosoi!J!! of the Montmv Pcnjruulal - Anaplestie carcinoma (2): Sclerosing mucoepidermoid carcinoma
with eosinophilia (2) ~ .. Neuroendocrine vs. insular carcinoma O!JnRC CKN:;er PcanMcnlel • Mucocpidennoid carcinoma Oranoe lOran•• COuntY Medical Omupl • Lymphocytic thyroiditis Omnse IUC£ Medical Centfrl • Poorly differentiated squamous cell carcinoma OxnAI!! CSL John's Rcsional Me<lica! Center) · Sclerosing mucoepidermoid carcinoma with eosinophilia (2) SI!Cramcnto (UC Dayls Residents) • Metastatic squamous cell carcinoma of lung SM Djego CUCSDl - Sclausiog mucoepidermoid thyroid carcinoma with eosinophilic San!l B8rl!am • Carcinoma Santa Rosa • Mucoepidermoid carcinoma wilh eosinophilia associated with Hashimoto tllyroiditis (2); Sclerosing mucoepidermoid
carcinoma with eosinophilic (I) WOO<!Innd Hills ISudfs Soldiers) • Mucoepidermoid carcinoma with eosinophilia (2) ArkJlll!!;M CUnivcr.sitv ofArtansa~ for McdicaJ Sciences> - SeJerosing muoocpi9ennoid carc.inoma with cosi_nophilia, thyruid florida, A!l!CriQ!!lh • Squamous carcinoma Floric!aiJackson Memorial Hosnitall • Squamous mucoepidermoid carcinoma witll eosinophilia arising in liashimoto's thyroiditis P!oric!a (Munroe Reajonal Medical Center! • Papillary carcinoma, sclerosing variant florida ITallahas;oee Pa!holosv Ass!leiatcsl • Medullary carcinoma of the thyroid Florida CWintcr Hayen Hosnitall • Sclerosing mucoopidennoid carcinoma Goorgjo IWcllstar KepneS)One HD>pj\a!l • PTCA witll squamous diffCJ<:ntintion ll!joojs <MacNeal Memorial H2S!!itall - Mucoepidermoid carcinoma. thyroid (I); Muooepidcrmal carcinoma. rule out metastatic
carcinoma (I) ll!inojs CHean!and R£Ci9!la! Medical Ccntql • Sclerosing mucoepidermoid carcinoma with eosinophilia lndi:w. <Howan! Bcajonal Medical Center) • Mucoepidcnnoid c:on:inoma M!I$$!1Chusetts ffi,>cksbjre Medical Center\ - Sclcrosina mucoepidermoid carcinoma with eosinophilia Mj1S3!1Chusetts ITuO&:New llns!and Mc4jca! Center Rcsjd<'D!Sl • Sclt:ro$ing mucpepidcrmoid carcinoma with cosinophiliu
crrR, November 2006 "MinlltOS" (Subocription A) II
Mjehigan (Oakwood Hospital! - Sclerosing mucoepidermoid carcinoma with eosinophilia (2) Nebraska CCrejghton llniversity) · Hashimoto•s thyroiditis with squamous metaplasia vs. pure squamous cell carcinoma New York CNassau University Medical Center) • Mueoepithelioma New York CSUNY Stony Brook) - Muooepidermoid carcinoma with eosinophilia North Carolina (Mountain Area Pathology\ • Muoocpidennoid carcinoma, sclerosing variwll (2); Muooepidennoid carcinoma (I) Pennsvlvania (Conemaugh Memorial Me<lica! Center) • Sclerosing mucoepidermoid tumo1 of thyroid Pennsylvania (Lehigh Valley Hosnitall . ~lcrosing mucoepidermoid carcinoma wi·th eosinophilia Pcnnsvlvania fMagee Women•s ijof'pitnl) - Medtilhuy carcinoma Pennsylvania <Mt. Nittany Medical Center) - Primary thyroid mucoepidermoid carcinoma Pennsvlvania <Pennsylvania Hospital Residents> - Sclerosing mucoepidennoid carcinoma with eosinophilia Texas llbe Me!hodist tlosrita!) • Sclerosing mucocpidennoid carcinoma with eosinophilia Texa').. Houston .. Sclerosing mucoepidennoid carcinoma with eosinophilia Iexas. Lubbock • Follicular carcinoma West Virginia <Grecnbrjer Valley Medical Center\ • Sclerosing anaplastic carcinoma West Virginia <Wetzel County Hospital) • Thymoma Canada <Pasqua Hospital) • Squamous cell carcinoma Canada CShed>ro9ke University ~lospitall • Ectopic thymoma (2); Papillary carcinoma with squamous metaplasia (2) C'rermany lln>1itut fur Pathologic UKfl) - Sclerosing mucocpidcr:moid carcinoma with eosinophilia Hong Kong<Pwnela Youdc Nethersole Eqstem Uosritall - P"oorly·diffcrcntiated carcinoma, thyroid Qatar <Hamad Medical Comoration) • Sclerosing mucoepidermoid carcinoma with eosinophilia {6); Metastatic squamous cell
carcinoma (2) . Saudi Arabia <King Fab!l!fN!!ljonal Guan! Hospital\ • Ha.mimoto's thyroiditis, fi)>rous type The Netherlands. Amstclvccn • Anaplastic carcinoma· of !be thyroid with squamous differentiation United Kingdom <Oxford Study Gmunl • Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia
Case 8 · Diognosis: Sclerosing mucoepidermoid carcinoma with eosinophilia, thyroid
T-96000, ~-84303
Case 8 -References: Geisinger KR. Stetfee Ctl, McQeeRS, eta! .. The Cytomorphologic Features of Sclerosing Mucoepidermoid Carcinoma ofU>e
'l)lyroid Gland with Eosinophilia. Am J Clin Patho/1998; 109(3):294-301. Sim Sl, RoN, Ordonez NG, ct a!. Sclerosing Mucoepidermoid CarciJ>oma wiO> Eosinophilia of the Thyroid. Report of Two
Patients, One with Distant Metastasis, and Review of the Literature. Hum Palhol !997; 28(9): 1091-1096. Bondes0n Land Bondeson AG. Cytologic Felllllres in Fine-Needle Aspirates from a Sclerosing Mucoepidermoid Tbyr0id
Carcinoma with Eosinophilia. Diagn CytOpalho/1996; 15( 4):30 1·305. Chan 11<. A!bores-Saavedra J, .Battifo.ra H, ct aL S~lcrosing Muooepidermoid Thyroid Carcinoma with Eosinophilia. A Distinctive
Low-Grade Malignancy Arising from the Metapla.o;tie Follicles of Hashimoto's Thyroiditis. Am J Surg Patlw/ 1991 ; 15(5):438· 448.
Soares J, Limbert E and Sobrinbo·Simocs M. Diffuse Sclerosing Variant ofPapill:uy Thyroid Carcinoma. A Clinicopathologic Study of 10 Cases. Pathol Res f'racl t989; 185(2):200-206.
Case No. 9, Accession No. 30619
Alameda • Adrenal cortical carcinoma Baldwjn l'w-k !Kaiser Permanentc) • Adrenalcorlical carcinoma (3); Maligrum! ph·eodtromOC)iOma (I) Chico - Adrenal cortical carcinoma ta Jolla <Scripps Health! - Adrenal cortical carcinoma Lone Beach • Neuroendocrine carcinoma, high grade (5) Monterey CCQmmyoity Hosnita).ofthe Monterey PcninsuJal · AdcnocorticaJ carcinoma Oakland • Pheochromocytoma Orange O<aiser Permanentel • Adrenal cortical carcinoma Orange<Qrange €ounw Medjcal Grouol · Adrenal cortical c·axcinoma Orange /UCI Medical Ccnte.rl • Adrenal corfica! carcinoma Oxnard !St. Jobn's Regional Medical Center! -Adrenal cortical carcinoma (2) Sacramento !UC Davi~ Resident~) - Cortica1 carcinoma San Diego /UCSDl - Adrenocortieal carcinoma Snnta Barbara • Adrenal cortical carcinoma
November 2006
Santa Rosa - Adrenal cortical carcinoma with rhabdoid features(!); Adrenocortical carcinoma (I); Adrenal coiticaladcnocarcinoma
12 CITR. November 2006 "Minutes" (Subscription A)
(I) Wpodland Hills !SUllo's Soldiasl - Adrenal corti<:al carcinoma (2) Arbnsas CUniversitv or Arknnll!S for Medical Scjences) • Adrenal cortical carcinoma. adrenal florida, A!neripath - Adrenal carcinoma tlori!la Oacl<son Memorjal Hosnil3ll - Adrcnlll cortical cQI()inoma Florida {Munroe Reoional Medjclll Caller) • Adrenal cortical carcinoma florida Cfal!!!ha.<see Pathology Associates) - Adrenal cortical carcinoma Flods!a £Winter Haven Hospjlall - Adrenocortical carcinoma Geomja CWellsrar Kcnncstope Ho;;pitall • Adrenal cortical carcinoma lt!jnojs rMoeNeal Memorial Hospjtall - Adrenal corticlll carcinoma (2) lt!inojs fHgutland Regional Mediclll <&nterl • Adrenal cortical carcinoma lnd!Ma <Howard Regiopo! Medjcal Center) • Adrenocortical cQI()inoma Ma.<wchusetlS merk.<hjre Medical Center> • Adrenocortical carcinoma MR.<sru;husctts ffiJ!Is-New Enoland Meclical Center Residents) - Adrenocortical carcinoma Michj&ao <Oakwood Hospjhlll • Adrenal cortical carcinoma (2) Ndmh CCtei&hton Unjymi1Yl • Adrenal cortical carcinoma New York <Namw Unlvmitv Medical Centql . Pbcocbromoeytoma New York !SUNY Stony Brookl - Myxoid cortical adrenal carcinoma North Carolina <Mountojn Art• Pathology) - Adrenal corticnl.cnrcinoma (3) Pennsvlyania (Conemaugh Memorial Medical Center) - Adrenal cortical carcinoma Pennsylvania CLcltillh Valley Hosnilall - Adrenal cortical carcinoma Ptnnsylvania<Magee Women•s Hospital) - Adrenocortical carcinoma. Pmp:.-ylyaaia !ML Nittany Mo!!jcal Caltcrl • Malignant composite pbeocbromocytorna, adrenal gland Pennsvlrania IPcnnsvlvania Hospital Residents) - Malignant pheochromocytoma Texas !The Methodist Hgsl!.ili!} - Adrenocortical carcinoma TexM· Houston • Adrenocortical carcinoma TeJSM. L.ubbock - Adrenal corticaL carcinoma Wes! virginia !Greenbrier yallcy Medical CentciJ - Adrenal CW"Cinoma West virginia (Wc:tzx:l Coupty Hoopjtal) • Adrenal cortical carcinoma Canada <Pasaua Hospi!Jil • Adrenal cortical careinoma Canm !Shqbmoke Unjvqsitv Ho;;pj!Jil - Adrenal eortical carcinoma Germany Clnstitut fur Patbologie UK.El • Adrenal cortical carcinoma Hong Kong !pamela Yoyde Ne!her.oolc !las!erp HospjWl • MalignMttumor, favor adrenal cortical carcinoma O!ltar CHamru! Medical Corpomtjonl - Adrenocortical carcinoma Saud! AT8bia CKino Fahad National Guard llgspjlall - Adrenocortical carcinoma The NeJber!ands. AmstcLvcen • Adrenal corticaL carcinoma Unitec! Kjn&dom /Oxford $tydy Grouol - Adrcoal cortical caJcinoma
Ca~ 9 • Diagnosis: Adrenal corticAl carcinoma
T-93100ff·56000, M-83703
Case 9 - References: Stojadinovic A, Brennan MA, Haas A. et a!. Adrenocortical Adenoma and Carcinoma. llistopathoLogical and Molecular
Comparative Analysis. Mod Pmlw/2003; 16(8):742-751. Allolio Band Fassnacht M. Clinical Review. Adrenocortical Carcinoma. C~nical Updal<:. J o[Ciin Endo & Metabo/ 2006;
91(6):2027-2037. Sasooo U. Suzuki T and Moriya T. Disccmln& Malignancy in Rc:scctod Adrenocortical Neoplasms. 6ndo Patho/200L; L2(4):397·
406. ~
~-alis C, Fassnacht M, Willen berg HS, ct aL. Dendritic Cells os Potcotial Adjuvam ror Immunotherapy in Adrenocortical Carcinoma. C/in Endocrino/2006; 65(2):215-222.
Rod&en SE, Evans DB, Lee IE, et al. Adrenocortical Carcinoma. Surg Oncol Clln N Am 2006;. LS(3):S3S-SS3.
Cue No. 10, Accession No. 30389 November 2006
~ - Hodgkin's lymphoma Baldwin Pwl< CKru:;erPerm!l!!cntcl - Hodgkin's lymphoma (nodular sclerosing) (2); ~lodgkin's lymphoma (2) ~ • Hodgkin's lymphoma. nodular sclerosing type 4 Jolla !Sqipns l·lealthl - liodgkin's lymphoma
C1TR. November 2006 --Minutes" (Subscription A) I)
Lon• Beach • Hodgkin's lymphoma, nodu.Jar sc.lerosing type (5) • Monterey (Community Hosnital of the Monterey Peninsula) · Classical Hodgkin's lymphoma, nodular sclerosing type Oakland · Hodgkin's disease(NS) Orange (Kaiser Permancntcl · Hodgkin's disease Orange (Qmnge County Medical Grounl • Hodgkin' s disease Oran•e (UCI Medical Center) · Hodgkin's disease (nodular sclerosing type) Oxnard (St. John's Regional Medical Cen!¢rl • Hodgkin's disease, nodular scleros.ing (2) Sacramento IIJC Davis Residents> • Hodgkin's lymphoma, nodular sclerosing S;m Diego IUCSDl • Nodular sclerosing Hodgkin's lymphoma Santa Bamara • Hodgkin's disease Santa Rosa - Hbdgkin' s lymphoma (3) Woo<ltand Hills (Suda's Soldiers) · Hodgkin's lymphoma vs. diffuse large B-cell with RS-like cells (I); Hodgkin's lymphoma (I) Arkansas (University of Arkansas for Medical Sciences) • Hodgkin's lymphoma, thyroid Florida. Ameripath • Hodgkin's lymphoma Plnrida llackson Memorial H(!spi]all • Hodgkin's disease Florida (Munroe Regional Medical. Center) • Hodgkin's disease F!ori!laiiallah•¥£ Pillhology Associates) · Hodgkin's lymphoma Florida (Winlcr Haven Hospi!Jl!) • liodgkin's disease Georgia <Wcllstar; Kennestone HospitaJl - ALCL vs. HD · lllinojs <MacNeal Memorial Hosoitall • Hodgkin's lymphoma(2) Illinois CHcartland Regional Meclical Genter) • Hodgkin's lymphoma, nodular sclerosis Indiana <Howard Regional Medical Center\ • Hodgkin's disease Massachusetts ffierksbirc Medical eentei\ . Hodgkin's lymphoma Massacbuseus ffufts-New Ens land Medical Center Re>identsl · Hodgkin' s lymphoma. thyroid Michigan <oakwood Hosoitall • Hodgkin's lymphoma, classic lype (2) Nebrnska(Crcigbton University) · Hodgkin's lymphoma, nodular sclerosis type New york (Na.<sau University Medical Center) · Hodgkin's lymphoma: New Yorls (SUNY Stony Brook) • Hodgkin's lymphoma, nodular sclerosing variEUlt North Carolina (Moun!!ljn Area PaJhology.) • Hodgkin's lymphoma (3) Penn.wlvania <Conemaugh Memorial Medica! Center> - Anaplastic large cell lymphoma Pennsv!vaqia <Lehigh Valley HoSpitall · Hodgkin's lymphoma, nodular sclerosing type PcnnsvlvanialMagee Women's Hosnitall . Hodgkints lymphoma Pennsylvania {Mt. Nittany Medical Center! · Hodgkin's lymphoma Pennsylvania <Pennsylvania Ro>pital ResidCOlts) • Nodular sclerosing Hodgkin's Texas (The Me!hodist Hoseital) • Anaplastic large cell lymphoma Texas; Houston · Hodgkin's lympbO)ma. NS type I exa.s. Lubbock· · Hodgkin's lymphoma, nodular sclerosis WeSt Viminja <Greenbtier Valley Medical Center) • Anapl.,iic large cell lymphoma West Virginia (Wetz.el County Hospjtnll · Hodgkin's disease, nodular sclerosis Canada <Pasqua Hospital) • Hodgkih's disease Clinada <Sherl>rooke University Hospital\ • Hodgkin's lymphoma Germany ()nstitut fur Palhnlosie lJKEl • Hodgkin's lymphoma Hong Kong (pii!Dcla Youde Nethefliole Eas!em H9spitall - ~lodgkin's l)mphoma, nodular sclerosis Oatpr Mamad Medical Comorationl • Hodgkin's lymphoma Saudi Arabia {King Fahad National Guar4 Hospital) • Hodgkin's lymphoma The Netherlands. Amstelveen · Hodgkin's lymphoma of the thyroid United Kinodem (Oxford Studv Grouel - Thyroid, nodular sclerosing Hodgkin's lymphoma
Case 10 ·Diagnosis: Nodular sclerosing Hodgkin's lymphoma, thyroid
T-96100, M-96563
Case I 0 • References: Wang SA, Rabemrullah A, Faquin WE, et at. Hodgkin' s Lymphoma of the Thyroid. A Clinicopathologic Study of Five Cases and
&eview of' the Literature. Mod Patho/2005; 1&(12):1577-1584. Aco>1a·Ortega J; MoJltalban-Romero S, Garcia-Solano J, ct a!. Simultaneous Medullary Carcinoma of the Thyroid Gland and
Hodgkin's Lymphoma in Bilateral Lymph Nodes of the Neck. A Potential Pitfall in Fine-Needle Aspiration Cytology. Diagn Cytopatho/2004; 31(4):255-258.
Khurana KK, Stanley MW, Powers GN, et al. Aspiration Cytology of Malignant Neoplasms Associated with Granulomas and Granuloma-Like Fcaturcs. Diagno>1ic Dilemmas. Cancer 1998; 84(2):84-91.
Nakamura S, Mizul<ami K, Yokoyama K, ct a!. Thyroid Tumor as Jnitial Presentation of Hodgkin's Disease. A Case Report Including atll.mmunophenotypic Characterization. Acta Haematologica 1997; 98(4):214-216.
14 CITR: No"cmb<:r 2006 "Minutes" (Subscription A)
Weber AL. Rllllemtullah A 8l!d Ferry JA. Hodgl<in and Non-Hodgkin Lympboma of the Head and Neck. Clinical, Pathologic, and Imaging Ev•luation. Neurofmaging Clin N Am 2003; 13(3):371·392.
C'ITR. November 2006 "Minutes" (Subscription II) 15