Calculations &Dilutions (2)

7/23/2019 Calculations &Dilutions (2)

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DR.DHAVAL.S.PATEL

CALCULATION OF DRUG DOSES AND

DILUTIONS



■ Factor infuencing the dose o a drug:

• Patient Factors: 1. Age

2. Weight 3. !"# $%&'()e (&e( *. Se+ ,. Se-e&it# !' the "i$e($e %"e& t&e(t/et 0. St(t%$ !' &e( !& he(ti) '%)ti! . Se)ie$ (" &()e

4. He&e"it(&# i5%e)e 6geeti)$7 8. F!!" 19. P$#)h!!gi)( '()t!&$

•Drugs actors: 1. Che/i)( (t%&e !' the "&%g

2. O &ee(te" %$e !' "&%g$ 6i7 T!e&()e6ii7 Re$i$t()e

3. C!)%&&et ("/ii$t&(ti! !' the !the& "&%g$. *. Ti/ig R(te ;R!%te !' ("/ii$t&(ti! !' "&%g$



■ Expression o Doses :

< For adults: • S!i" "&%g$ i /g !& g/=>g="(# i "(i# "i-i"e" "!$e$

• Li?%i" i /iiite& 6/7 !& ite& • i!!gi)( &e(&(ti!$6e.g. i$%i7 i I.U.=>g=h&$ • Ae&!$! i %@="(#

■ D!$e )()%(ti!$ '!& pediatrics patients:

6(7 ! the ($i$ !' Age: 6i7 Young’s ormula: Chi"B$ "!$eA"%t "!$e

6ii7 Dilling ‘s ormula:

Chi" $ "!$eA"%t "!$e 67 O ($i$ !' Weight: 6i !lar"’s ormula: Chi"B$ "!$eA"%t "!$e Chi"B$ "!$eA"%t "!$e

)!ti.



637O the ($i$ !' SA: • Chi"B$ "!$e: A"%t $ "!$e SA i$ )()%(te" # %$ig :

Du#ois ormula:

Re("# /("e )h(&t$= $i"e &%e !/!g&(/$ '!& SA:

Age $deal

%eight&"g

'(A& ) o adult

dose

Ne !& 3 0.22 12

3 /!th$ 6 0.33 18

1 #&$ 10 0.45 28

, #&$ 20 0.8 48

8 #&$ 30 1.0 60

12 #&$ 40 1.3 78

1* #&$ 50 1.5 90

Age $deal

%eight&"g

) o adult

dose

Ne !& 3 0.22 12

3 /!th$ 6 0.33 18

1 #&$ 10 0.45 28

, #&$ 20 0.8 48

8 #&$ 30 1.0 60

12 #&$ 40 1.3 78

1* #&$ 50 1.5 90



* For elderl+ patients &, -. +rs/ : • N! J+e" &%e$ !& '!&/%(e '!& "ete&/iig the "!$e ie"e&#

(tiet$.

• D!$e /(# e &e"%)e" t! 2=3 !' the ("%t "!$e . ▪ Sh!%" ($e" ! -(&i!%$ '()t!&$:

617 T#e$ !' "&%g eig("/ii$te&e". 627 Age &e(te" "e)ie i &e(!& >i"e#

'%)ti!.

For patients o renal ailure:

• D!$e A"%t "!$e

☻6N!&/( )&e(tiie )e(&()e '!& ( 9 >g he(th# /( i$ 0..102. ml3min7



►(trength o ormulations and drug dilutions:

&0 Percentage: 1K $!%ti! /e($ 1g !' $!%te i 199 / 619/g=/7

&2 W34: '!& $!i"$ i i?%i" t#e !' '!&/%(ti!$ /e($ %/e& !' g&(/$ !' ()ti-e $%$t()e i 199 / !'i?%i" &!"%)t. e.g. ,K "e+t&!$e )!t(i$ , g/ "e+t&!$e i 199 / !'i'%$i!.

&5 W3W: '!& $!i"$ i $!i" t#e !' &e(&(ti!$ /e($ %/e& !' g&(/$ !' th(t )!$tit%et i 199 g !''!&/%(ti!$ e.g. 3K '&(/#)eti !it/et )!t(i 3g !' '&(/#)eti i199g !'

!it/et.

&6 434: '!& i?%i"$ i i?%i" t#e !' &e(&(ti!$/e($ the -!%/e !' )!$tit%et 6i /7 i 199 / !' t!t(

'!&/%(ti!. e.g. 9K eth# ()!h! )!t(i$ 9 / eth# ()!h! i (

t!t( !' 199 /( %e!%$ $!%ti!



☻Assignment: 1. A 19 #e(& !" !# i$ &e$)&ie" $#&% i$!i(i" '!& t%e&)%!$i$.i' the "%&(ti!

!' t&e(t/et i$ 09 "(#$ h! /(# !tte$ !' i$!i(i" i e

&e?%i&e" Weight 2* >g D!$e i )hi"&e , /g=>g="(#. E()h !tte )!t(i$ 199 /g=, / "&%g. !tte )(()it# 199 /

2. A "i(eti) (tiet &e?%i&e$ i$%i (t the &(te !' 9.1 U=>g=h&.Set % i$%i "&i (" )()%(te the &(te !' i'%$i!.

Weight 49>g I$%i i$ (-(i(e ($ *9 U=/ i , / -i(.

3. eti! the $te$ t! &e(&e :

19 / !' 1,K N(C $!%ti!. 19 / !' i$!t!i) $(ie $!%ti!.

*.C()%(te the "(i# "!$e !' (/i>()i '!& , #e(&$ !" 'e/(e !e$e(tiet 89 >g h(-ig S.)&e(tiie 2., /g=" $%@e&ig '&!/ &e( (&e)h#/("i$e($e.

Calculations &Dilutions (2)

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