calcium role in Blood clotting
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Transcript of calcium role in Blood clotting
WHAT IS BLOOD CLOTTING?Blood clotting or coagulation is an important process that prevents excessive bleeding when a blood vessel is injured.
WHAT ARE CLOTTING FACTORS?The clotting factors are the group of chemicals that are constant circulation in the blood or present in tissues of the blood vessels. These compound are responsible for the formation of a blood clot. The are activated by cofactors (e.g calcium ).
List of pathways:There are two pathways: Intrinsic pathway Extrinsic pathway
Names of blood clotting factors:
CALCIUM AND ITS ROLE IN COAGULATION OF BLOOD
CALCIUMACTS AS A COFACTOR
DURING BLOOD CLOTTING
Aggregation of platelets by calcium:Activates protein kinase C
Activates phospholipase A
Modifies glycoprotein
Binds to fibrinogen
Cross linked with glycoprotein
Causes aggregation of platelets
Activation of factors by calcium Calcium are involved in factors like 2,7,9,10
FACTOR IINAME: prothrombinSOURCE: liverPATHWAY: extrinsic and intrinsic pathwayACTIVATOR: prothrombin activatorACTIONS: prothrombin is converted into thrombin which then activated fibrinogen into fibrin
FACTOR VIIName: anti-hemophilic factor Source: endothelium lining blood vessel and plateletsPathway: intrinsic Activator: thrombinActions: works with factor 8 and CALCIUM to activate factor 9
FACTOR X NAME: Stuart factorSOURCE: liver PATHWAY: bothACTIVATOR: factor 6 + factor 8 + factor 7+ calciumACTIONS: works with the platelets phospholipids to convert prothrombin into thrombin. this reaction is made faster by activated factor 5
FACTOR XINAME: plasma thromboplastin SOURCE: liver PATHWAY: intrinsicACTIVATOR: factor 11ACTION: works with calcium to activate factor 8deficiency: hemophilic c
Role of calcium in the activation of cofactors:
Calcium is required for the activation of factors like 2,7,9,10 Calcium are required cofactors for prothrombin activation
enzyme complexes to function. This is called tenase and converts prothrombin to thrombin.
Calcium mediates the binding of tenase enzyme complexes to the phospholipid surfaces expressed by platelets, which in turn activates prothrombin to produce thrombin which produces fibrin to fibrinogen.
Calcium acts as a catalyst for this reaction Calcium speeds up the reaction to occur within time factors
involved in the coagulation Calcium is involved to synthesize anticoagulant protein C
EXAMPLE
STARTING WITH THE MINOR INJURY
WHEN BLOOD VESSEL GOT DAMAGED
BLOOD CELLS ESCAPE FROM THE WOUND
BLOOD CELLS CARRIES OXYGEN
PLATELETS COMES FROM WHITE BLOOD CELLS
CLOTTING FACTOR HELPS TO CLOT
PLATELET ADHERE TO THE SURFACE
PLATELET PLUG STOPS THE EXTERNAL BLEEDING
BEGINNING OF CLOTTING PROCESS
CLOTTING FACTOR ACTIVITY INCREASES
FIBRIN ATTACH AND SEALS THE WOUND
BLOOD VESSEL SEALS AFTER SEVERAL DAYS
calcium deficiencies: Inhibit proper blood
coagulation. This may be caused by a
nutritional deficiencies Acute problems in which the
calcium is allocated elsewhere in the blood