Calcium Metabolism, Vitamin D, Parathyroid Hormone and Calcitonin

Shibani Hegde-080201024Riddhi Joshi-080201027

Calcium-Importance

• Key role played by calcium in:1.Skeletal muscle contraction2.Cardiac muscle contraction3.Smooth muscles contraction4.Blood clotting5.Transmission of nerve impulses

Distribution of Calcium in the Body

% distribution of total body calcium

• 1. ECF - 0.1%

• 2. Intracellular – 1%

• 3. Bones – Rest (Serve as Reservoirs)

• Calcium Distribution in ECF

Calcium Exchange Between Different Tissue Compartments

1000

Bone And Its Relation to Extracellular Calcium

• Bone = matrix (collagen + ground substance) + salts (mostly hydroxyapetite, some amorphous)

• Exchangeable calcium – readily mobilizable salts like calcium phosphate and other amorphous salts