Caenorhabditis elegans as a model - Instituto de la · PDF fileCaenorhabditis elegans as a...

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Caenorhabditis elegans as a model Aprox 40% genes are homologues to human Different cell types, tissues and organs (intestine, nervous system, epithelial cells) Easy to growth and manipulate Short life cycle Many genetic pathways are conserved [email protected] Manuel Muñoz

Transcript of Caenorhabditis elegans as a model - Instituto de la · PDF fileCaenorhabditis elegans as a...

Page 1: Caenorhabditis elegans as a model - Instituto de la  · PDF fileCaenorhabditis elegans as a model ! ... Modelode’galactosemia’tipoIII ... Grasa.pptx Author: James C. Hombria

Caenorhabditis elegans as a model

§  Aprox 40% genes are homologues to human §  Different cell types, tissues and organs (intestine, nervous system, epithelial cells) §  Easy to growth and manipulate §  Short life cycle § Many genetic pathways are conserved

[email protected]

Manuel  Muñoz  

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Genética  de  la  longevidad  

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Wild  type  Old  animal  (20  days)  

sul-­‐2(pv17)  Old  animal  (20  days)  

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Wild  type   Parkinson  

1. Parkinson Model

Mobility  assays  

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Parkinson    

Parkinson;  STX64  

Adult 3º día

Mobility  assays  

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Modelos  que  usamos  de  forma  habitual    

1.  Envejecimiento  2.  Modelo  de  Diabetes  3.  Modelo  de  Ovario  poliquístico  4.  Modelo  de  Alzheimer  5.  Modelo  de  Parkinson  6.  Modelo  de  Corea  de  Huntington  7.  Modelo  de  obesidad  8.  Modelo  para  ensayos  de  compuestos  

antiproliferativo  o  proapoptótico  9.  Modelo  de  galactosemia  tipo  III  10. Modelo  de  ictiosis  ligada  al  cromosoma  X  

11.  Podemos  estudiar  otros  modelos  a  solicitud  del  interesado.  

Empresas  que  nos  han  contratado    Biosearch  Life  LandsteinerGenmed  Bionaturis  Hojiblanca  ResBioagro  Puleva  Biotech  

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[email protected]  Manuel  Muñoz