Cadius Health - Improving lives through Circadian Science

CADIUS HEALTH All Rights Reserved. CONFIDENTIAL 10.01.2015!

!EFFECTIVE PERSONAL HEALTH MANAGEMENT

Establishing life-long patterns for healthy living!through science and technology!

We have radically simplified effective personal health management through new circadian science!


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Americans are grossly overweight. This is the single largest cause of health problems and costs.

Over 50% of population at levels of risk for key health

indicators: BMI, Hypertension, Cholesterol

and Fitness.

60% of the US population struggles

with weight loss issues.!

30% are Obese.!

$ 60.9B 39% of overweight

adults seeking solutions!

Represents a $60.9 B market!

CADIUS HEALTH All Rights Reserved. CONFIDENTIAL 10.09.2015! 3

Calorie Counting Meal Plans Paid Coaching

There are NO effective solutions that deliver sustained weight management


Results are not sustained, as people just simply fall back into their old HABITS

90% of people who go on a diet, gain the weight back within 2 years.

90% gain weight

back


The time we choose to consume calories is the single easiest thing to change and is now proven to have the

single most significant impact on health

Eat all day, anytime!

Restricted feeding times!

Mice offered a high-fat, high-sugar diet lose their natural feeding rhythm and get fat. !

Mice fed this same diet but forced to maintain their natural circadian rhythm maintain normal weight - even with the same higher caloric intake.!


We now have the science to reverse obesity. We know which habits to change and how to

change them.

RESEARCH World-renowned researchers studying Circadian Rhythm

make a novel discovery.

EVIDENCE Effects of circadian rhythms in

metabolically important organs can positively affect physiology and

metabolism.

BREAKTHROUGH Altering feeding and fasting rhythms can profoundly change health and weight, even without altering caloric intake.

RESULT Chronic disruption of circadian rhythm can increase incidences of chronic diseases like obesity, diabetes, heart disease, cancer and depression

Our subjects lost 3.8% average weight in 3-month pilot trial, measured after 1 year.


Introducing the Cadius App and Program

AppDemo: ask us for the app demo link

The first diet app driven by circadian rhythm science. Tracks with time-stamps from the photos the user takes of the foods and drinks they consume through the course of the day. Gradually learns people’s habits and routines and gently guides them to a healthier eating window that restores their natural metabolic rhythms. Almost zero impact on lifestyle NO calorie counting NO journaling NO food restrictions


Consumer Model The initial free consumer facing application is focussed on meal schedules, as this will simply deliver tangible results quickly. Free trial version used as proof of concept and anecdotal efficacy to drive sales for enterprise health and wellness model. After a 30 day trial period, we will prove our effectiveness and ask for a subscription to a greatly expanded and accelerated offering:

Paid subscription delivers:

Sleep patterns tracked and

analyzed

Review of

photos with professional

analysis

Expert

personalized advice

Exercise Options Advice

Medication Reminders

Metrics

and device Integration

BMI BP

BloodSugar Weight etc.


Enterprise Model

With the results of more extensive clinical trials expanding on the recently published pilot trial, Cadius will pursue reimbursement from health plans and payments from large self-insured corporations.

Primary Care MD

125,000 Primary care Physicians in US

Increasing focus on preventative care

Adopting mobile apps for efficient patient interaction

Driven by clinical data

Nutritionists

70,000 Nutritionists in US

Seeking better engagement tool with clients

Photo storage and feedback mechanism provides a more useful and accurate food consumption tracker versus food logs and diaries

Corporate Wellness

55 Million Employees with access to Wellness programs

Self-insured or covered by major plans

Employers pushing for preventative care


Management Team

Satchin Panda, Ph.D. Co-founder Chief Science Officer

World renowned circadian rhythms researcher.

Associate Professor at the Salk Institute

Inventor, Cadius Technology

Shubhroz Gill, Ph.D. Co-Founder

Ph.D. with Dr. Satchin Panda

Inventor, Cadius technology

Thesis work: Circadian rhythms in humans, mice and fruit flies

John Barrett CEO

Extensive leadership and business-building experience

Co-founder and CEO of CoAlign Innovations- Acquired by Stryker in 2014.

Leadership positions at Abbott Labs and Baxter

David Shantz Chief Marketing Officer

Co-Founder and marketing lead for multiple funded ventures.

Extensive background in product development and marketing for launching new ventures for consumer and enterprise mobile and web applications


Advisory Board

Dan Zigmond

Ex-VP of Data, Hampton Creek Foods

Previously head of data science for Google Maps, You Tube, etc.

Advising on data science

Tara Wright

Digital Content Manager, Stanford GSB

Editor, web producer, writer

Founder, Dump Your Frump, women’s lifestyle blog

Advising on user experience and social media


Marketing: Customer Acquisition

User Generated Content: My week in food shared to Social graph

(see shared week in food infograhpic RIGHT)

FRIENDS AND FAMILY: driving referrals where people can sign up 3 friends with the third group member free

Channel Marketing with partners and affiliates using associated products and services.

PR: based on the unique story behind the science


Milestones

2014 2015 2016 2017

  Scientific Paper

  Application Dev. A B C !

  SALK Mouse Study

  Pilot Human Study

  Consumer Direct !

  Enterprise Market !Research App development and back

end data collection system completed for

use in clinical trials

Database of 25,000 photos with USDA coding

Build up clinical credibility Sell with evidence based data. Achieve reimbursement to drive utilization and revenue $100/month for a 3 month intervention

MVP through two revs of usability optimization Backend management systems and infrastructure

  Expanded Trial !


Use of Funds

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$1M Seed round Development of consumer app and launch $250K Pattern recognition process and infrastructure $200k Support for clinical trials $200K (300 patient trial) Marketing/PR $200k Legal $40K Salk fees $45K Series A planned in late Q116, early Q216 $5-7M


Media Coverage We have seen over $300k worth of media coverage in 2015 for the recent paper authored by Founder Satchin Panda through Salk Institute. See Media Report


Appendix Slides!

Cadius Health - Improving lives through Circadian Science

Healthcare

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