C24 - SAFETY REPORT

1)-OATS: oats works as tiny sponges that soak up cholesterol and carry it out of thebloodstream. Oat soluble fibers mix with cholesterol -based bile acids in the intestinesand prevents and prevents them from being absorbed. The oat fiber then carries out ofthe body. ln response the liver pulls cholesterol out of the blood stream to replace thesebile acids, cholesterol levels then drop.

Safety: Oats are not a commonly allergenic food, are not included in the list of 20 foodsthat most frequently contain pesticide residues, and are also not known to containgoitrogens, oxalates, or purines. Oats are often classified, however, as a member of the"gluten grains." This qroupinq of qrains has traditionallv included wheat. oats. barlev,and rve, and it has been traditionallv avoided in wheat-sensitive conditions. Theconclusion that oats should be qrouped toqether with wheat and svstematically avoidedin a wheat-free diet is not supported bv some research studies. However. most publichealth orqanizations continue to place wheat and oats toqether in a cateqorv called"qluten qrains" and recommend elimination of oats alonq with wheat for wheat-sensitiveindividuals.

2)-VITAMIN 86: Vitamin 86 is required for the proper functioning of more than 60different enzymes and is involved in the formation of body proteins and structuralcompounds, neurotransmitters, red blood cells, and prostaglandins. Vitamin 86 is alsocrit ical in maintaining hormonal balance and proper immune function.

Safety: Vitamin 86 is stored primarily in skeletal muscle. Although this vitamin is watersoluble, megadoses of vitamin 86 may be toxic. Symptoms of toxicity are mainlyneurological and include weakness and numbness and t ingl ing of peripheral nerves.These symptoms are thought to be related to excess levels of the vitamin coenzyme,pyridoxal phosphate, which inhibits neurotransmitter synthesis by negative feedbackinhibition. A standard dose of 150m9 has been suggested by the Food and NutritionBoard of the lnstitute of Medicine is 100 mg daily for adults. . Concerns reqardinqneuropathv in humans have become evident onlv when doses qreater than 1q per davwere qiven. but the C24 contains onlv traces and is used onlv once a month. then thereare no side effects.

3) - VITAMIN 812: Vitamin 812's primary functions are in the formation of red bloodcells and the maintenance of a healthy nervous system. 812 is necessary for the rapidsynthesis of DNA during cell division.l'f 812 deficiency occurs, DNA production isdisrupted and abnormal cells called megaloblasts occur. 812 is also important inmaintaining the nervous system. Nerves are surrounded by an insulating fatty sheathcomprised of a complex protein called myelin. 812 plays a vital role in the metabolism offatty acids essential for the maintenance of myelin. Prolonged B12 deficiency can lead tonerve degeneration and irreversible neurological damage.

Safety: No toxicity levels have been reported for vitamin B-12, and no toxicity symptomshave been identified in scientific research studies. Even long-term studies, in whichsubjects have taken 1,000 micrograms of the vitamin on a daily basis for five years, haverevealed no toxicity effects.

4)-VITAMIN E: vitamin E is a family of fat-soluble vitamins that are active throughout thebody. Some members of the vitamin E family are called tocopherols. These membersinclude alpha tocopherol, beta tocopherol, gamma tocopherol, and delta tocopherol.Vitamin E may help prevent or delay coronary heart disease by limiting the oxidation ofLDL-cholesterol. Vitamin E also may help prevent the formation of blood clots, whichcould lead to a heart attack. Observational studies have associated lower rates of heartdisease with higher vitamin E intake. A study of approximately 90,000 nurses suggestedthat the incidence of heart disease was 30% to 40o/o lower among nurses with thehighest intake of vitamin E from diet and supplements. Vitamin E helps prevent oxidativestress by working together with a group of nutrients that prevent oxygen molecules frombecoming too reactive.

Safety: The oral median lethal dose found in several species is 2 g/kg, and adverseeffects usuallyare observed atdoses greaterthan 1 g/kg, which is equivalentto 200-500mg/kg in humans. However, vitamin E has been shown to have few adverse effects,even at high dosages (up to 3200 mg/day). Adults have taken relatively large amounts ofvitamin E (400 to 800 mg/day of da-tocopherol)for months to years without anyapparent harm

5)-BlOTlN: Biotin is a water-soluble vitamin, generally classified as a B-complex vitamin.Biotin is required by all organisms. ln its physiologically active form biotin is attached atthe active site of four important enzymes, known as carboxylases. Each carboxylasecatalyzes an essential metabolic reaction. Biotin is involved in the metabolism of bothsugar and fat. In sugar metabolism, biotin helps move sugar from its initial stages ofprocessing on to its conversion into usable chemical energy. For this reason, musclecramps and pains related to physical exertion, which may be the result of the body'sinability to use sugar efficiently as fuel, may signal a biotin deficiency. The role of biotinin fat metabolism is discussed below under the heading "Synthesis of Fat (Fatty Acids)."

Safety: Reports of biotin toxicity have not surfaced in the research literature, despite theuse of biotin over extended periods of time in doses as high as 60 milligrams per day.For this reason, in its 1998 recommendations for intake of B-complex vitamins, theInstitute of Medicine at the National Academv of Sciences chose not to set a tolerableupper l imit (UL)for intake of biotin.

6) - Galcium Disodium EDTA: binds to lead and aid's in i ts el imination from the bodyvia urine.

Safety: The recommended dose now is 3 grams.

7) - Coenzyme Q10: Coenzyme Q10, also known as ubiquinone, and called CoQ10 orQ10 for short, is an important player in the generation of energy in humans; it is also apowerfulantioxidant. Humans natural ly manufacture CoQ10 in the body, and it is alsopresent in small amounts in some foods - unsaturated oils, fish, meats and nuts. Aspeople age, however, they produce less CoQ10.

Safety: Side effects are uncommon, even at high doses. Rarely, coenzyme Qro c?rlcause nausea, diarrhea, upset stomach, or appetite loss.

8)-ZINC: Zinc is an essential mineralthat is found in every cel l in our body. l t st imulatesthe activity of about 100 enzymes, substances that promote biochemical reactions inyour body. Among its many functions, zinc helps maintain a healthy immune system.

Safety: Zinc toxicity has been reported in the research literature, and in 2000 theNational Academy of Sciences set a tolerable upper limit (Ul) of 40 milligrams for dailyintake of zinc. (This limit applies to all individuals age 19 and over.) A metallic, bittertaste in the mouth can be indicative of zinc toxicity. However zinc is present in tracesamount in flush C24 so that there are no side effects excepted.

9)-PAPAYA FRUIT EXTRACT : Papaya offer not only the luscious taste, but is richsource of antioxidant nutrients such as carotenes, vitamin C and flavonoids; the Bvitamins, folate and pantothenic acid; and the minerals, potassium and magnesium; andfiber. Together, these nutrients promote the health of the cardiovascular system and alsoprovide protection against colon cancer. In addition, papaya contains the digestiveenzyme, papain, which is used like bromelain. Papayas is also involved in the protectionagainst heart disease, colon cancer and also help with the symptoms of those sufferingfrom irritable bowel syndrome, In addition, vitamin C and vitamin A, which is made in thebody from the beta-carotene in papaya, are both needed for the proper function of ahealthy immune system.

SAFETY : Papaya is not a common allergenic food, is not included in the list of the 20that most frequently contain pesticides residues, and is also not known to containgoitrogens, oxalates or purines.

1O)-PUMKIN SEED EXTRACT : Recent medical research has announced the healthbenefits provided by using pumpkin seed extract. These benefits include regulatingcholesterol levels and aiding in the prevention and treatment of bladder and prostateproblems. Two studies have found that eating pumpkin seeds can help prevent the mostcommon type of kidney stone, called a calcium oxalate stone. Pumpkin (Cucurbita pepo)seeds appear to reduce levels of substances that promote stone formation in the urineand increase levels of substances that inhibit stone formation.

SAFETY : There are no known side effects or reports of toxicity regarding pumpkinseeds.

11)-LEMON FRUIT EXTRACT: The medicinalvalue of the lemon is as fol lows: l t is anantiseptic, or is an agent that prevents sepsis [the presence of pathogenic bacteria] orputrefaction [decomposition of tissue]. lt is also anti-scorbutic, a term meaning a remedywhich will prevent disease and assist in cleansing the system of impurities. Due to thedigestive qualities of lemon juice, symptoms of indigestion such as heartburn, bloatingand belching are relieved. By drinking lemon juice regularly, the bowels are aided ineliminating waste more efficiently thus controlling constipation and diarrhea. Like manyof the fruits and vegetables found in the world's 125 healthiest foods, lemons containunique flavonoid compounds that have antioxidant and anti-cancer properties.

SAFETY : There are no side effects or toxicity reports concerning lemon fruits, it belonqsto one of the healthiest qroup of food products.

12)-FOLIC AGID: One of folate's key functions as a vitamin is to allow for completedevelopment of red blood cells. These cells help carry oxygen around the body. lnaddition to its support of red blood cell formation, folate also helps maintain healthycirculation of the blood throughout the body by preventing build-up of a substance calledhomocysteine.

SAFETY: At very high doses greater than 1,000-2,000 micrograms, folate intake cantrigger the same kinds of nervous system-related symptoms that it is ordinarily used toprevent. These symptoms include insomnia, malaise, irritability, and intestinaldysfunction. Primarily for these reasons, the Institute of Medicine at the NationalAcademy of Sciences set a tolerable upper limit (UL) in 1998 of 1 ,000 mcg for men andwomen 19 years and older. This UL was only designed to apply to "synthetic folate"defined as the forms obtained from supplements and/or fortified foods. the folic acidcontained in teh flush C24 is obtained from spinach and therefor is not concerned by theprevious UL.

13)-CAROTENE: Until late in the 20th Century, the functions of carotenoids, includingalpha-carotene, were discussed only in terms of their potential vitamin A activity. Alphaand Beta carotene are one of approximately 50 carotenoids of the known 600, that arecalled "provitamin A" compounds because the body can convert them into retinol, anactive form of vitamin A. carotenoids including alpha-carotene have received atremendous amount of attention as potential anti-cancer and anti-aging compounds.Alpha-carotene is a powerful antioxidant, protecting the cells of the body from damagecaused by free radicals. In addition to their antioxidant and immune-enhancing activity,carotenoids including alpha-carotene have shown the ability to stimulate cell to cellcommunication. Researchers now believe that poor communication between cells maybe one of the causes of the overgrowth of cells, a condition which eventually leads tocancer. By promoting proper communication between cells, carotenoids may play a rolein cancer prevention.

SAFETY : High intake of carotenoid-containing foods or supplements is not associatedwith any toxic side effects. As a result, the Institute of Medicine at the National Academyof Sciences did not establish a Tolerable Upper Intake Level (UL) for carotenoids when itreviewed these comoounds in 2000.

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