C ARGENTINA ARG-1 - IAEA9 COUNTRY: ARGENTINA ARG-2 [1] INSTITUTE: Fundación Escuela de Medicina...

7

COUNTRY: ARGENTINA ARG-1 [1] INSTITUTE: Comisión Nacional de Energia Atómica (CNEA)

Avenida del Libertador 8250 1429 Buenos Aires

TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:

+54 11 4379 8250 [email protected] +54 11 4480 0615

[2] PERSON IN CHARGE: POSITION:

Mr. Carmelo Rocco Head of the Facility

OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION

Mr. Roberto Strangls, in charge of Operation Mr. Eduardo Haro, in charge of Maintenance Mr. Guillermo Casale, in charge of Radiochemistry

[3] TYPE OF CYCLOTRON: Isochronous, negative ion

YEAR OF: (I) INSTALLATION: 1994

MANUFACTURER: The Cyclotron Corporation

(II) UPGRADE: Beam current increase

MODEL: CP - 42 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 25/42 Yes No Maximum beam available (µA) 150 Typical beam employed (µA) 100 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production h/week for research

h/week for maintenance

h/week for applications

29 22 - 7 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 18F, 123I, 18FDG, 123I iodide and other compounds [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s and how often? Yes No

[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?

Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for

agricultural applications such as plant biochemistry/research? Yes No

[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No

8

18F RADIONUCLIDE PRODUCTION

Production Typical production yield (GBq)

% Isotopic enrichment

18O used

Target Volume Usage/year Do you recycle 18OH2?

18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F

18F RADIOPHARMACEUTICALS PRODUCED Name (list)

Yield on batch (GBq)

Frequency of production

Used on site Distribution/ sales

Price/GBq if available

18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No

11C RADIOPHARMACEUTICALS PRODUCED Name (list)





Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No

13N RADIOPHARMACEUTICALS PRODUCED Name (list)

Typical yield on batch (GBq)


Nuclear reaction used Distribution/ sales


Yes No Yes No Yes No

15O RADIOPHARMACEUTICALS PRODUCED Name (list)

Typical yield on batch (GBq) Frequency of production Nuclear reaction used


OTHER ISOTOPES PRODUCED Name (list)





64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 55 weekly Yes No Yes No US$ 310 211At Yes No Yes No

COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced) The production of high purity 123I is a project that was carried out under the IAEA’s Technical Co-operation Programme (ARG/4/085). The IAEA supported the CNEA efforts to set up required facilities including different system provision of expert and personnel training.

9

COUNTRY: ARGENTINA ARG-2 [1] INSTITUTE: Fundación Escuela de Medicina Nuclear

Garibaldi 405, CP 5500 Mendoza 1429


+54 261 4201 615 (1ext. 564; 2ext. 562; 3 ext. 508) [email protected] +54 261 4203 288


Ing. Enrique R. Noya1 Electronic Engineer – Head of Operation and Maintenance


Dr. Fernando Spigatin2, Head of Radiochemical Laboratory Ing. Norma Acosta3, Head of Radiological Security

[3] TYPE OF CYCLOTRON: Negative ion hospital cyclotron

YEAR OF: (I) INSTALLATION 1997

MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS:

This cyclotron is not self-shielded. This is installed inside a bunker. All the support equipment is located in different rooms. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




10 8 2 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 15O, 11C [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 1 Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



10




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 20 >97 0.330 100

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






18FDG 10 5/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No












Ammonia 4 6/week p+ H20 Yes No Yes No Yes No









64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)

11

COUNTRY: AUSTRALIA AUL-1 [1] INSTITUTE: Austin and Repatriation Medical Centre

Studley Road Heidelberg, VIC 3084


+61 3 9496 3995 [email protected] +61 3 9496 5892


Dr. Henri Tochon-Danguy Senior Radiochemist


Dr. John Sachinidis, Radiochemist Dr. Uwe Ackermann, Radiochemist Mr. Stan Poniger, Cyclotron/Robotic Engineer

[3] TYPE OF CYCLOTRON: Negative ion accelerator


MANUFACTURER: IBA, s.a. (II) UPGRADE: 1996 (new sources) MODEL: Cyclone 10/5 2001 (remote start-up & control) [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10 5 Yes No Maximum beam available (µA) 50 20 Typical beam employed (µA) 25 8 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




18 16 1 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 16 Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 124I, 18F-MPPF, 18F – A 85380, 18F- Thymidine analogue [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 6 Positron emission tomography (PET) – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



12




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 40 97 0.6 100

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






18FDG 24 7/week Yes No Yes No 18F MISO 2 1/week Yes No Yes No Yes No Yes No Yes No Yes No






Flumazenil 4 1/week Yes No Yes No SCH23390 4 1/week Yes No Yes No AG 957 2 1/month Yes No Yes No Yes No Yes No






Ammonia 4 1/month 16O[p, ά] 13N Yes No Yes No Yes No




O2 4/min 1/week 14N[d, n] 15O Water 1/min 1/week 14N[d, n] 15O








13

COUNTRY: AUSTRALIA AUL-2 [1] INSTITUTE: Australian Nuclear Science & Technology Organization (ANSTO)

Radiopharmaceutical Division New Illawarra Road


+61 2 9717 9079 [email protected]


Dr. S. Carr Director, Radiopharmaceuticals


D. Arnott

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: IBA, s.a. (II) UPGRADE: 1997 MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




140 90 60 10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?



Yes No




14




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F





























15

COUNTRY: AUSTRALIA AUL-3 [1] INSTITUTE: Peter MacCallum Cancer Institute

12 Cathedral Place East Melbourne 3002, Victoria


+61 3 9656 1852 [email protected] +61 3 9656 1826


Dr. Rodney J. Hicks Associate Professor/Director, PET Centre


Mr. Peter Eu, Radiochemist

[3] TYPE OF CYCLOTRON: Superconducting YEAR OF: (I) INSTALLATION 1998 MANUFACTURER: Oxford (II) UPGRADE: MODEL: 12 MeV [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 12 Yes No Maximum beam available (µA) 80 Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




13 12 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 18F-AZA, 18F-LT [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 18F, Wesley Private Hospital/ 2-3 times/week

Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 2 Positron emission tomography (PET) – Clinical 2 – Small animal 1

(Jan. 2002 delivery)

– Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



16




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 55 95 5 500

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






18FDG 6.5 1-2/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No























17

COUNTRY: AUSTRIA AUS-1 [1] INSTITUTE: ARGOS Zyklotron

Betriebs-Ges.m.b.H. LKH Klagenfurt, PET-Zentrum NMSE St. Veiter Str. 47, A-9026 Klagenfurt


+43 (0) 463 500 705 +43 (0) 463 500 705 14


Dr. Michael W. Nader Chemist


Stefan Weber, Leading Technician

[3] TYPE OF CYCLOTRON: PT YEAR OF: (I) INSTALLATION 1999 MANUFACTURER: GE Medical Systems (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 8.5 Yes No Maximum beam available (µA) 75 60 Typical beam employed (µA) 35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




25 25 3 2 22 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) Isotope production [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): (18F) FLT, 124I, 86Y [9] Do you supply radionuclides to other institutions?



Yes No




18




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 120 95-96

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






FDG 65 Yes No Yes No DOPA Yes No Yes No MISO 30 Yes No Yes No Fluoride 150 Yes No Yes No






Methionin Yes No Yes No Cholin Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia Yes No Yes No Yes No











19

COUNTRY: AUSTRIA AUS-2 [1] INSTITUTE: Österreichisches Forschungszentrum Seibersdorf

Department of Radiopharmaka A-2444 Seibersdorf


+43 0 50 550 3470 [email protected] +43 0 50 550 3473


Dr. Peter Angelberger Department Head


Dr. Herbert Kvaternik, Deputy

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1999 MANUFACTURER: GE Uppsala (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.4 Yes No Maximum beam available (µA) 75 60 Typical beam employed (µA) 40 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




15 10 4 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): Further 18F radiopharmaceuticals [9] Do you supply radionuclides to other institutions?



Yes No




20




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 130 95 250

Yes No

20Ne (d, α) 18F 20 16O (α, d) 18F






18FDG 65 5/week Yes No Yes No FDOPA 2 2/month Yes No Yes No Yes No Yes No Yes No Yes No























21

COUNTRY: BELGIUM BEL-1 [1] INSTITUTE: Erasme Hospital

PET/Biomedical Cyclotron Unit Brussels Free University 808, Route de Lennik


+32 2 555 4711 [email protected] +32 2 555 4701


Dr. Serge Goldman


Dr. Damhaut M. Monshus J. Van Naemen

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS:

1H 2H 3He 4He Dual Beams Beam energies (MeV) 30 Yes No Maximum beam available (µA) 100 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




9 2 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) 11( for PET) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



22

18



18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 65 > 94 1.3 150 - 200

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






18FDG 40 4 - 5 batch/week Yes No Yes No [18F] MPPF 20/year Yes No Yes No Yes No Yes No Yes No Yes No






Methionin ~ 9 8/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 3.7 6/week 16O (p, α) 13N Yes No Yes No Yes No




Water 3.7 only for research 16O( p, pn) 15O








23

COUNTRY: BELGIUM BEL-2 [1] INSTITUTE: Institute of Nuclear Sciences

University of Ghent Proeftuinstraat 86, B-9000 Gent


+32 9 264 6616 [email protected] +32 9 264 6699


Professor Dr. Karel Strijckmans Professor


[3] TYPE OF CYCLOTRON: Isochronous YEAR OF: (I) INSTALLATION 1977 MANUFACTURER: CGR-MeV (France) (II) UPGRADE: 1982 MODEL: 520 [4] CYCLOTRON CHARACTERISTICS:

1H 2H 3He 4He Dual Beams Beam energies (MeV) 2.5 – 24 3 – 14.5 6 – 32 10 – 29 Yes No Maximum beam available (µA) 100 100 60 60 Typical beam employed (µA) 20 5 - - [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




20-30 10 10-20 <1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: <1 Activation analysis: <1 Other (specify) PIXE 10-20 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Tracers 1

207Bi 0.4 MBq Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No En = 7MeV [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?



Yes No




24




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 15 97 0.8 50

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






18FDG 4 3-4/week Yes No Yes No seronotin receptor antagonist

Yes No Yes No

Yes No Yes No Yes No Yes No






PK 11195 4 <1/week Yes No Yes No CAMPRAL 4 <2/week Yes No Yes No new research molecules

Yes No Yes No

Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED

Name (list)







Typical yield on line (GBq)

Frequency of production Nuclear reaction used


O2 4 GBq min-1 <1/week 14N(d, n) 15O CO2 4 GBq min-1 <1/week 14N(d, n) 15O CO 2 GBq min-1 <1/week 14N(d, n) 15O






81Rb 81mKr 0.6 2/week Yes No Yes No 48V <1/week Yes No Yes No 114In <1/week Yes No Yes No 75Se <1/week Yes No Yes No 74As <1/week Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No


25

COUNTRY: BELGIUM BEL-3 [1] INSTITUTE: MDS Nordion S.A.

Zone Industrielle B-6220 Fleurus


+32 10 829 211 +32 10 829 696


Dr. Claude Pirarat Manager, Radiochemical Production


[3] TYPE OF CYCLOTRON: Isochronous Cyclotron H-


MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS:

1H 2H 3He 4He Dual Beams Beam energies (MeV) 15 - 30 Yes No Maximum beam available (µA) 400 Typical beam employed (µA) 400 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




160 160 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Bulk 201Tl – Europe, North and South America, 123I, 201Tl – Europe (OEM manufacturing)

Yes No


Yes No




26




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG Yes No Yes No 123I 100 – 250 4/week Yes No Yes No 201Tl 150 - 300 5/week Yes No Yes No Yes No Yes No























27

COUNTRY: BELGIUM BEL-4 [1] INSTITUTE: Universite catholique de Louvain

Centre de Recherches du Cyclotron 2, Chemin du Cyclotron, B-1348 Louvain-la-Neuve


+32 10 472 998 [email protected] +32 10 452 183


Mr. Guido Ryckewaert Director


Mr. Daniel Labar – Head of Radiochemistry

[3] TYPE OF CYCLOTRON: Compact H- YEAR OF: (I) INSTALLATION 1987 MANUFACTURER: UCL/IBA, s.a. (II) UPGRADE: MODEL: Prototype

Cyclone 30

[4] CYCLOTRON CHARACTERISTICS:

1H 2H 3He 4He Dual Beams Beam energies (MeV) 15 – 30 Yes No Maximum beam available (µA) 350 Typical beam employed (µA) 50/300 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




30 - 4 15 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: 15 Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 2 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



28




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 80 95 2 200

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






18FDG 40 daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Acetate 5 monthly Yes No Yes No Methionine 5 weekly Yes No Yes No Flumazenil 5 monthly Yes No Yes No Yes No Yes No






NH4OH 5 weekly 16O(p, α)13N Yes No Yes No Yes No




Water 10 2/week 16O (p, pn)15O






64Cu Yes No Yes No 67Ga Yes No Yes No 86Y 1 weekly Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No


29

COUNTRY: BELGIUM BEL-5 [1] INSTITUTE: Universite catholique de Louvain

Centre de Recherches du Cyclotron 2, Chemin du Cyclotron, B-1348 Louvain-la-Neuve


+32 10 472 998 [email protected] +32 10 452 183


Mr. Guido Ryckewaert Director


Mr. Daniel Labar – Head of Radiochemistry

[3] TYPE OF CYCLOTRON: Isochronous multiparticle variable energy

YEAR OF: (I) INSTALLATION 1969-1972

MANUFACTURER: Thomson – CSF. (II) UPGRADE: MODEL: Cyclone [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 20 – 85 10 – 55 15 – 145 20 - 110 Yes No Maximum beam available (µA) 30 20 5 20 Typical beam employed (µA) 20 10 5 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




150 8 - 4 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? To two centres, sporadically. Yes No


Yes No




30




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F

Yes No

20Ne (d, α) 18F 16O (α, d) 18F



























28Mg 20 MBq Al (100%) Yes No Yes No 52Fe 0,2 – 2 MBq Mn (100%) Yes No Yes No 94,95,96Tc 0,1 – 0,01 MBq Mo (nat) Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No


31

COUNTRY: BELGIUM BEL-6 [1] INSTITUTE: Universite de Liege

Centre de Recherches du Cyclotron Sart Tilman, B-4000 Liege


+32 4 366 2360 [email protected] +32 4 366 2946


Dr. A. Luxen Director


C. Brihaye, Senior Radiochemist G. Del Fiore, Senor Radiochemist C. Lemaire, Senior Radiochemist A. Plenevaux, Senior Radiochemist, Aerts/Pharmacist

[3] TYPE OF CYCLOTRON: H-/D- YEAR OF: (I) INSTALLATION 1999 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 50 35 Typical beam employed (µA) 50 35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




30 10 20 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) PET/30 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): Several radiopharmaceuticals specific for receptoe and gene expression imaging. [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



32




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 4 Ci 95 2 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 75 250/year Yes No Yes No FTyrosine 11 12/year Yes No Yes No FDopa 11 12/year Yes No Yes No Yes No Yes No
















Water 0.37 4000/year








33

COUNTRY: BELGIUM BEL-7 [1] INSTITUTE: University of Leuven (KUL)

Department of Nuclear Medicine, U.Z. Gasthuisberg Herestraat 49 B-3000 Leuven


+32 16 34 3715 [email protected] +32 16 34 3759


Luc Mortelmans, MD, PhD. Head of Nuclear Medicine

OTHER SENIOR STAFF: NAME/POSITION

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 10/5 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10 5 Yes No Maximum beam available (µA) 70 50 Typical beam employed (µA) 45 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




5 4 0 1 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 0 Gamma camera 3 Single photon tomography (SPET) 3 Positron emission tomography (PET) 2 – Clinical 0 – Small animal 0 – Plant biochemistry 0 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



34




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F #1 — 20 GBq

#2 — 70 GBq 97 #1 — 0,5 mL

#2 — 2 mL Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 350 GBq 1-2/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Methionine 2 1/week Yes No Yes No Acetate 2 0,5/week Yes No Yes No Yes No Yes No Yes No Yes No






13N H3 2 3/week 16O(p,x) Yes No Yes No Yes No




H215O 2 2-3/week 14N(d,n)








35

COUNTRY: BELGIUM BEL-8 [1] INSTITUTE: Vrije Universiteit Brussels

Eenheid Cyclotron Laarbeeklaan 103, B-1090 Brussels


+32 2 4774 864 or +32 2 477 4860 [email protected] [email protected] +32 2 477 4855


Professor A. Hermanne Head, Cyclotron Department


Professor P. Van den Winkel Professor J. Mertens

[3] TYPE OF CYCLOTRON: AVR YEAR OF: (I) INSTALLATION 1983 MANUFACTURER: CGR France (II) UPGRADE: MODEL: 560 [4] CYCLOTRON CHARACTERISTICS: All beams are extracted with an electrostatic deflector – average 50%.

1H 2H 3He 4He Dual Beams Beam energies (MeV) 5-42 10-22 20-50 20-43 Yes No Maximum beam available (µA) 100 100 10 20 Typical beam employed (µA) 2-30 8 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




2 3 2 10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: 7 Proton therapy: Physics: 3 Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No En > 25 MeV. Thin targets

neutron TOF spectroscopy [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): Neurotensin analogues; 18F peptides and aromatic amino acids; Pd- 103 for research labelling and rodent studies;

188Rh 186Rh [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? RUG , SCK Yes No

[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site? In academic hospitals – Nuclear Medicine

Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera > 3 Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical From June 2001 – Small animal collaboration with RUG – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for


[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience Yes No

36




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 16 95 0.45 40 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






















OTHER ISOTOPES PRODUCED

Name (list)





64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 37 2-4 /week Yes No Yes No Stopped in 1996 211At Yes No Yes No

COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced) Additional labelled compounds: 77Br, 56Co, 123I , 111In, 206Tl neurotensin analogues, 123I peptides and aromatic amino acids

37

COUNTRY: BRAZIL BRA-1 [1] INSTITUTE: Instituto de Engenharia Nuclear (IEN)

Caixa Postal 68550, Cidade Universitária S/N – Ilha do Fundão 21945-970 – Rio de Janeiro – RJ


+55 21 560-4113 ext. 2184 [email protected]


Dr. Julio Cezar Suita Head, Radiopharmaceutical Division


Ana Maria Silveíra Braghirolli José Antônio Dias Furlaneto Jackson Louis Queiroz de Britto Migual Ângelo Valle Bastos

[3] TYPE OF CYCLOTRON: Isochronous YEAR OF: (I) INSTALLATION 1975 MANUFACTURER: The Cyclotron

Corporation (II) UPGRADE:

MODEL: CV-28 [4] CYCLOTRON CHARACTERISTICS: Variable energy and multiparticle 1H 2H 3He 4He Dual Beams Beam energies (MeV) 24 14 36 28 Yes No Maximum beam available (µA) 50 75 30 25 Typical beam employed (µA) 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




32 20 4 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Occasionally Mössbauer sources? (specify which & quantity) Yes No Occasionally X ray sources? (specify which & quantity) Yes No Occasionally Intense neutron beam? (specify average En = ?) 17 MeV Yes No Occasionally [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): n-isopropyl para-iodine anphetamine labelled with 123I [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for agricultural

applications such as plant biochemistry/research? Yes No


38




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (ml)

18O2 (l) 18O (p, n) 18F 11 96 0.3 30 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F



























64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 15 3/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced) Meta – iodinebenzilguanine labelled with 123I has also been produced.

39

COUNTRY: BRAZIL BRA-2 [1] INSTITUTE: Instituto de Pesquisas Energéticas e Nucleares – IPEN/CNEN-SP

Travesa , R, 400, Cidade Universitária CEP – 05508-900, São Paulo, SP


+55 11 3816 9275/ 9265 [email protected] +55 11 3816 9263


Dr. Wanderley de Lima Head, Cyclotron Laboratory


Dra. C. Pagano G. da Silva, Head – Radioisotope Department Uylton Matsoda Valdir Sciani

[3] TYPE OF CYCLOTRON: Fixed field, fixed frequency


MANUFACTURER: TBA, S.A. (II) UPGRADE: MODEL: Cyclone - 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 Yes No Maximum beam available (µA) 500 Typical beam employed (µA) 200 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




20 18 - 2 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 201Tl, 111In [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Hospitals and medical centers/ weekly

Yes No


Yes No




40




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 37 94 2 200 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






FDG 500 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No





















64Cu Yes No Yes No 67Ga 50 1/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 20 1/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced) As of June 2001, MIBG 123I, HEPPURAN 123I and radiopharmaceutical for neuroreceptors are produced.

41

COUNTRY: BRAZIL BRA-3 [1] INSTITUTE: Instituto de Pesquisas Energeticas e Nucleares - IPEN - CNEN/SP

Travessa R. 400, Cidade Universitaria CEP 05508 – 900, São Paulo, SP


+55 11 3816 9185/9000 [email protected] +55 11 3816 9257


Dr. C. Pagano G. da Silva Head, Radioisotope Department


Dr. Wanderley de Lima, Head – Cyclotron Laboratory

[3] TYPE OF CYCLOTRON: Isochronous compact, variable


MANUFACTURER: The Cyclotron Corp. (II) UPGRADE: MODEL: CV-28 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 2-14 4-14 6-36 8-28 Yes No Maximum beam available (µA) 200 300 135 90 Typical beam employed (µA) 10-20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




1.7 0.5 0.2 1.0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: 0.5 Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 0.5 Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No 0.5 Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?



Yes No




42




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F




























COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced) All the radiopharmaceuticals are produced with the Cyclone – 30.

43

COUNTRY: CANADA CAN-1 [1] INSTITUTE: Clark Institute of Psychiatry

250 College Street Toronto, ON M5T 1R8


+1 416 979 4651 +1 416 979 4656


Dr. Sylvain Houle Head, PET Centre

OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION

Allan A. Wilson Jean Da Silva

[3] TYPE OF CYCLOTRON: Fixed energy isochronous


MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 8.5 Yes No Maximum beam available (µA) 15-60 20-25 Typical beam employed (µA) 10-40 10-12 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




20-25 20-22 2-3 (additional 1-week maintenance/year

[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



44




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18F-FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






11C-raclopride Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No










15O-water








45

COUNTRY: CANADA CAN-2 [1] INSTITUTE: Cross Cancer Center

University of Alberta Edmonton, Alberta


+1 403 492 2905


Dr. Steve McQuarrie


[3] TYPE OF CYCLOTRON: TR19, (p,d) YEAR OF: (I) INSTALLATION October, 2001 MANUFACTURER: EBCO. (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 200 µA beam 1H 2H 3He 4He Dual Beams Beam energies (MeV) 19 9 Yes No Maximum beam available (µA) 200 100 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No



[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron usefor education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No

46




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F


















Yes No Yes No











47

COUNTRY: CANADA CAN-3 [1] INSTITUTE: Hamilton Health Sciences Corporation

Department of Nuclear Medicine Mc Master Site, 1200 Main Street West, Room 1 P 6 Hamilton, ON L8N3Z5


+1 905 521 2100 ext. 76893/73025 [email protected] +1 905 546 1125

[2] PERSON IN CHARGE: TITLE/POSITION:

Dr. Raman Chirakal Radiochemist


Jia Juen Chen

[3] TYPE OF CYCLOTRON: RDS 112 YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: Negative ion cyclotron 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




5 3 2 1 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 3 Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) Research - 2 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Ottawa Heart Institute, 1/week Yes No


Yes No




48




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 18.5 94 0.8 14 200 10

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






FDG 10 6/week Yes No Yes No J6 – F MT 1.12 1/week Yes No Yes No J6 - FDOPA 0.3 2/month Yes No Yes No Yes No Yes No






ACETATE 0.3 2/month Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






AMMONIA 0.8 4/week 16O(p, α) 13N Yes No Yes No Yes No




WATER 5.6 9/month







COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)

49

COUNTRY: CANADA CAN-4 [1] INSTITUTE: Montreal Neurological Institute

McGill University 3801, University Street Montreal, Quebec H3A2BA


+1 514 398 8526 [email protected] +1 514 398 8540


Prof. Mirko Diksic


Dean Jolly

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1993 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 100 60 Typical beam employed (µA) 30-40 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




20-30 20-30 2-3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 2 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for agricultural



50




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18F-FDG Yes No Yes No 18F-DOPA Yes No Yes No






11C-RO Yes No Yes No Deprenyl Yes No Yes No α-methyl- L-trypotophan

Yes No Yes No

Bensotropine Yes No Yes No PK-11195 Yes No Yes No

















51

COUNTRY: CANADA CAN-5 [1] INSTITUTE: TRIUMF

4004 Westbrook Mall Vancouver, BC V6T 2A3


+1 604 222 1047 [email protected] +1 604 222 1074


Dr. Stefan K. Zeisler Manager, Applied Technology Groups


Mr. R. Van Den Elzen

[3] TYPE OF CYCLOTRON: H- / sector-focused YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: EBCO (II) UPGRADE: 1995 MODEL: TR30 [4] CYCLOTRON CHARACTERISTICS 1H 2H 3He 4He Dual Beams Beam energies (MeV) 30 Yes No Maximum beam available (µA) 1200 Typical beam employed (µA) 1000 [5] CYCLOTRON OPERATION:

Total hours (h)/ week h/week for radionuclide production

h/week for research



168 148 - 20 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?



Yes No




52




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F



























64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd ~7/week Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 3/week Yes No Yes No 201Tl ~5/week Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced) Yields and prices of commercial products are confidential and cannot be reported.

53




+1 604 222 1047 [email protected] +1 604 222 1074


Dr. Stefan K. Zeisler Manager, Applied Technology Group



[3] TYPE OF CYCLOTRON: 520 MeV H-/ sector-focused


MANUFACTURER: TRIUMF (II) UPGRADE: 1997 MODEL: [4] CYCLOTRON CHARACTERISTICS: Isotope production beam line only 1H 2H 3He 4He Dual Beams Beam energies (MeV) 500 Yes No Maximum beam available (µA) 100 Typical beam employed (µA) 70 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




144 4 months/year [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?



Yes No




54




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F




























COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 82 Sr/ 82Rb, Mo(p, spall) — ~ 8 targets/year

55




+1 604 222 1047 [email protected] +1 604 222 1074


Dr. Stefan K. Zeisler Manager, Applied Technology Group



[3] TYPE OF CYCLOTRON: H-/sector-focused YEAR OF: (I) INSTALLATION 1980 MANUFACTURER: The Cyclotron

Corporation (II) UPGRADE: 1991

MODEL: CP42 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 42 Yes No Maximum beam available (µA) 200 Typical beam employed (µA) 180 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




168 158 1 9 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? University of British Columbia, Botany Department, 1-2 times/week

Yes No


Yes No




56




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F


















13N – NO3 7 1/week 16O(p, α) Yes No Yes No Yes No









64Cu Yes No Yes No 67Ga 5/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 1/month Yes No Yes No 123I 3/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Yields and prices of commercial products are confidential and cannot be reported.

57

COUNTRY: CANADA CAN-8 [1] INSTITUTE: UBC/TRIUMF PET Programme



+1 604 222 1047 [email protected] +1 604 222 1074


Dr. Thomas Ruth PET Director/Senior Research Scientist


Ken Buckley, PET Project Engineer

[3] TYPE OF CYCLOTRON: Negative ion, sector focused


MANUFACTURER: EBCO (II) UPGRADE: MODEL: TR13 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 13 Yes No Maximum beam available (µA) 100 Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




25 15 10 4 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: 2 Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? University of Alberta - 18 F, 1 /week

Yes No


Yes No




58




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F F 2 – 18.5

F -26 >90 0.5 500 50 1

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






18FDG 3.7 1/week Yes No Yes No 18F SETOPERONE 1.8 1/week Yes No Yes No 18F DOPA 0.8 3/week Yes No Yes No Yes No Yes No






Raclopride 1.1 3/week Yes No Yes No Schering 1.1 3/week Yes No Yes No Methylphenidate 1.1 3/week Yes No Yes No Pk 11195 1.1 3/week Yes No Yes No






NOX 3.0 3/week 16O (p, α ) Yes No Yes No Yes No










COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 11C PMP, 1.1 GBq, 1/week

59

COUNTRY: CANADA CAN-9 [1] INSTITUTE: University of Ottawa Heart Institute

TELEPHONE NO.:

E-MAIL ADDRESS: FAX NO.:

+1 613 761 5296


Dr. Rob Beanlands Director, Cardiac PET Centre


Dr. Gunter Firnau Dr. Rob deKemp

[3] TYPE OF CYCLOTRON: RDS-111 YEAR OF: (I) INSTALLATION 2001 MANUFACTURER: CTF, Inc. (II) UPGRADE: MODEL: RDS-111 [4] CYCLOTRON CHARACTERISTICS: Protons only, 11 MeV 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 30-40 [5] CYCLOTRON OPERATION:

Total hours (h)/week h/week for radionuclide production

h/week for research



10 8 2 0.5 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) Target research [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Ottawa General Hospital — FDG, 2/week

Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence (Ottawa General Hospital) — ADAC 1 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical — ECAT – ART 1 ECAT – MR 1 – Small animal (in next phase) – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



60




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 37 96 1.1 ~300 -

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






FDG 22.2 1/day Yes No Yes No Fluoronovadrenalin

Yes No Yes No







Acetate 3.7 1/day Yes No Yes No HED 3.7 2/week Yes No Yes No Ligand for β-receptor

Yes No Yes No


Name (list)





Ammonia ~ 5 daily 16O (p, α ) 13N Yes No Yes No Yes No




Water 3.7 1/week 15N(p, n) 15O






64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc only target

research Yes No Yes No

103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I only target

research Yes No Yes No

201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) – The Ottawa Heart Institute PET Centre is dedicated to the development of cardiac PET imaging. – We are not working on oncology problems. – Basic research in the Heart Institute will be combined with PET imaging (e.g. Angiotensin II receptor ligand). – Target development for 124I and 94mTc.

61

COUNTRY: CHINA, PEOPLE'S REPUBLIC CPR-1 [1] INSTITUTE: China Institute of Atomic Energy

P.O. Box 275 (99) Beijing 102413


+86 01 69358090 +86 01 69357195


Dr. Li Da Kang


Zhao Gui Zhi; Zhao Zhen Lu Shen de Heng Xu Shu He

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1995 MANUFACTURER: IBA sa (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 Yes No Maximum beam available (µA) Typical beam employed (µA) 100-220 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




4 days/week 4 days/week 1 day/week [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 123I, 186Re [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 57Co to USA 1 per month Yes No


Yes No




62




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F

Yes No

Ne (d, α) 18F 16O (α, x) 18F





























63

COUNTRY: CHINA, PEOPLE'S REPUBLIC OF CPR-2 [1] INSTITUTE: Guangdong Province People's Hospital

96 Dong Chuan Road Guangzhou 5 10 100


+11 86 20 8382 7812 +11 86 20 8382 5453


Dr. Tang Au-Wu


[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 1999 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11.1 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 38.5 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




18 12 2 2 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




64




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 1.2 260

Yes No

Ne (d,α) 18F 16O (α , d) 18F






FDG 30 4/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No












AMMONIA 4 1/week 16O (p , α ) 13N Yes No Yes No Yes No




Water 22 3/month 15N (p , n ) 15O








65

COUNTRY: CHINA, PEOPLE’S REPUBLIC OF CPR-3 [1] INSTITUTE: Hong Kong Sanatorium & Hospital, Ltd.

Department of Radiology & Radiotherapy 2 Village Road, Happy Valley Hong Kong


+11 852 2835 8989 +11 852 2835 8825


Dr. C.L. Ho Director, Department of Nuclear Medicine and PET


Dr. David W.C. Young, Deputy Director Mr. Steve H.Q. Sitt, Manager Dr. M.K. Cheung, Radiochemist

[3] TYPE OF CYCLOTRON: - YEAR OF: (I) INSTALLATION 1998 MANUFACTURER: CTI, Inc. (II) UPGRADE: - MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




6 5 – 18F; 1 – 11C 1 6 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 15O-oxygen; 18F-Fluoroestradiol, 18F-choline, 18F-fluoro-α-methyltyrosine, 18F-DOPA [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



66




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F ~ 37 95 1100

Yes No

Ne(d, α) 18F 16O (α, x) 18F






18FDG ~ 15 5 batches/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Acetate ~ 3.7 1-2/week Yes No Yes No Choline ~ 3.7 1/month Yes No Yes No Methionine ~ 3.7 1/ month Yes No Yes No Yes No Yes No






Ammonia ~ 1.8 1/month O(p, α) 13N Yes No Yes No Yes No











67

COUNTRY: CHINA, PEOPLE'S REPUBLIC OF CPR-4 [1] INSTITUTE: Institute of Applied Chemistry

Beijing Normal University Bejing Cyclotron Produced Radiopharmaceutical Laboratory 100875 Beijing


+86-01-6220 7786 or 8396 [email protected] +86-01-62200567


Professor Bo Li Liu Dean


Huang Zheng Xing Professor Liu Zheng Hao Zhang Hui Xing Chen Ru Yi

[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1997 MANUFACTURER: TCC (II) UPGRADE: MODEL: CS-22 [4] CYCLOTRON CHARACTERISTICS: Our CS-22 will be used to produce radiopharmaceuticals in 2002. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 22 11 29 Yes No Maximum beam available (µA) 50 50 50 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18 F, 67 Ga, 111In, 18 FDG, 18F - DOPA [9] Do you supply radionuclides to other institutions?



Yes No




68




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 95 0.3

Yes No

Ne (d, α) 18F 16O (α , d) 18F






18FDG Yes No Yes No 18F - DOPA Yes No Yes No Yes No Yes No Yes No Yes No























69

COUNTRY: CHINA, PEOPLE'S REPUBLIC OF CPR-5 [1] INSTITUTE: Institute of Applied Chemistry

Beijing Normal University Bejing Cyclotron Produced Radiopharmaceutical Laboratory 100875 Beijing


+86 01 6220 7786 or 8396 [email protected] +86 01 6220 0567


Professor Bo Li Liu Dean of Radiochemistry


Huang Zheng Xing Professor Liu Zheng Hao Zhang Hui Xing Chen Ru Yi

[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1986 MANUFACTURER: TCC (II) UPGRADE: MODEL: CS-30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 26 15 30 Yes No Maximum beam available (µA) 200 200 100 Typical beam employed (µA) 110 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




70




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α , d) 18F





























71

COUNTRY: CHINA, PEOPLE'S REPUBLIC OF CPR-6 [1] INSTITUTE: Peking Union Medical College Hospital

Nuclear Medicine Department PET Centre Beijing 100730


+86 10 652 33129 +86 10 652 33129


Dr. Chien Chou


[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 1998 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 35-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




4 – 8 2 - 3 1 - 2 1 - 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence EXACT HR + Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



72




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 14.8 - 29.6 > 94 1.1 Yes

No Ne (d, α) 18F 16O (α , d) 18F






18FDG 7.4 – 11.1 2-3/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






















COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 18F-F–Ethyl–tyrosine: not in clinical trial yet.

73

COUNTRY: CHINA, PEOPLE'S REPUBLIC OF CPR-7 [1] INSTITUTE: Shanghai Institute of Nuclear Research

P.O. Box 800-204 201800 Shanghai


+86 21 5955 3634 [email protected] +86 21 5955 2509


Professor Wang Yongxian Director


Cao Benhong Gao Wenzhao Yuyi

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1996 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) 400 Typical beam employed (µA) 150 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




50 50 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




74




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α ,d) 18F






18FDG 5500 - 7400 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No





















64Cu Yes No Yes No 67Ga 12950 - 14800 1/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 14800- 16650 2/week Yes No Yes No 211At Yes No Yes No


75

COUNTRY: CHINA, PEOPLE'S REPUBLIC OF CPR-8 [1] INSTITUTE: The PLA General Hospital

28 Fuxing Road Beijing 100853


+86 10 6693 9424 [email protected] or [email protected] +86 10 681 31142


Professor Jia-he Tian


Jinming Zhang

[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 1999 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




8 4 1 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




76




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 37 1.1 150

Yes No

Ne (d,α) 18F 16O (α ,d) 18F






FDG 18.5 2-4/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Acetate 3.7 1-2/week Yes No Yes No Methioine 2 0-1/week Yes No Yes No RACLOPRIDE 2 0-1/week Yes No Yes No Yes No Yes No






AMMONIA 1.5 2/week 16O(p, α ) 13N Yes No Yes No Yes No




WATER 74 0-1/week 15N(p, n ) 15O








77

COUNTRY: CHINA, PEOPLE'S REPUBLIC OF CPR-9 [1] INSTITUTE: Zibo Wanjie Hospital

Boshan, Zibo Shandong


+86 533 4650 000 8730 +86 533 4650 830


Dr. Sun Qiyin


Wang Ming Fang Zhao Jun Wang Changqing Li Jiamin

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1995 MANUFACTURER: GE (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 Yes No Maximum beam available (µA) Typical beam employed (µA) 20-30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




6 5 7 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C, 15O, 82Rb [9] Do you supply radionuclides to other institutions?


[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried

out on-site? Yes No




78




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F





























79

COUNTRY: CZECH REPUBLIC CZR-1 [1] INSTITUTE: Nuclear Physics Institute

Rez near Prague 25068 Rez


+420 2 6617 3613 [email protected] +420 2 20941130


Ing. Jan Stursa, MSc. Head of the Cyclotron Division


J. Kucera, Deputy Head J. Lacman, Control System M. Cihak, Beam Dynamics

[3] TYPE OF CYCLOTRON: Isochronous YEAR OF: (I) INSTALLATION 1977 First beam MANUFACTURER: JINR Dubna, Russia (II) UPGRADE: 1992 Axial injection MODEL: U-120M 1997 H-, D- Beams, [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10-38 10-20 17-53 20-40 Yes No Maximum beam available (µA) 30 25 3 3 Typical beam employed (µA) 20 3 3 3 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




62.5 53 6.5 1 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) - Stent

activation 1

[7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) = 15 MeV Yes No 2 [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 86Y, 123I [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) Clinical Small animal Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



80




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 60 95 1.5 750

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






18FDG 25 12/week Yes No Yes No 335 USD Yes No Yes No Yes No Yes No Yes No Yes No





















64Cu Yes No Yes No 67Ga 4 1-2/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 4 1/week Yes No Yes No 211At 1 1/month Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 81Rb/81mKr – radionuclide generator: not used on site; distribution – yes.

81

COUNTRY: CZECH REPUBLIC CZR-2 [1] INSTITUTE: Nuclear Research Institute Rez plc

250 68 Rez


+42 02 572 16 982 or +42 02 570 90 616 mailto:[email protected] or ami@ ujv.cz +4202 572 15 949


Ing. Michal Antos Head, Department of PET Radiopharmaceuticals


Ing. Karel Mudra, Cyclone Operator Ing. Petr Kopecky, Vice Director – Division of Radiopharmaceuticals

[3] TYPE OF CYCLOTRON: IBA cyclone YEAR OF: (I) INSTALLATION 1999 MANUFACTURER: IBA Belgium (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 80 40 Typical beam employed (µA) 33 20 [5] CYCLOTRON OPERATION:


h/week for research



Not periodically operated 5 3 6 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 18F -5 GBq/year Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 18F- FDG, - DOPA 15O-H2O-O2 [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 Clinical Small animal Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



82




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 150/2hrs >95 2000 100

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






18FDG 60 Not periodically Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
















Water 14 Under testing and tuning 14N(d,n)15O







COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) We are in a registrationm process. We do not produce FDG for routine commercial purpose. The data provided here is from testing and tuning runs.

83

COUNTRY: DENMARK DEN-1 [1] INSTITUTE: PET Centre, Aarhus University Hospital

Nørrebrogade 44 DK-8000 Aarhus C


+45 89 49 3034 [email protected] +45 89 49 3020


Professor Albert Gjedde


Dirk Bender, Head of Radiochemistry Søren B. Hansen, Chief Physicist

[3] TYPE OF CYCLOTRON: Negative ion, self-shielded


MANUFACTURER: GEMS (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 8 Yes No Maximum beam available (µA) 60 60 Typical beam employed (µA) 25-40 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




40 36 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify)

PET – Radiotracer 36

[7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




84




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 60

(40A,60min) 95 0.8 150

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






18FDG 6-8 3/week Yes No Yes No FMISO 1-2 1/week Yes No Yes No FDOPA 0.6 1/week Yes No Yes No Yes No Yes No






Raclopride 1-2 4/week Yes No Yes No PK - 11195 2 1/week Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 4-6 6x/week 16O (p, α ) 13N Yes No Yes No Yes No




Water 6 10/week 14N (d, n ) 15O Oxygen 10 5/week 14N (d, n ) 15O







COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Fluoride, Way – 100635, NMSP, NS2381, NS 2456, CO. In all, more than 50 different radiotracers are currently available at the Aarhus PET – Centre.

85

COUNTRY: DENMARK DEN-2 [1] INSTITUTE: University Hospital of Copenhagen

Cyclotron and PET Unit, KF 3982 Blegdamsvej 9, DK – 2100 Copenhagen


+45 3545 3915 [email protected] +45 3545 3898


Dr. Mikael Jensen Physicist-in-Chief


Holger Jensen, Physicist Nic Gillings, Chemist Jacob Madsen, Chemist

[3] TYPE OF CYCLOTRON: Negative ion, sector-focused


MANUFACTURER: Scandinotrix (II) UPGRADE: 1994 – Addition of positive ions and 4He

MODEL: MC 32-NI [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 32 16 - 32 Yes No Maximum beam available (µA) 100 80 30 Typical beam employed (µA) 20 10 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




30-40 25 5 2 0-8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: 1 Neutron therapy: Activation analysis: Other (specify) Space component tests [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C – FLB 457 [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 6 Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



86

18F RADIONUCLIDE PRODUCTION Production Typical

production yield (GBq)


18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 40 >95 1.2 200

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






18FDG 25 2-3/week Yes No Yes No ~600 Euro 18F -ALTANSERIN 4 1/week Yes No Yes No ~400 USD

per. patient dose













Ammonia 2 2-8/week 16O (p, α) 13N Yes No Yes No Yes No




Water on line 8 hours/week 14N (d, n ) 15O CO on line 14N (d, n ) 15O OO on line 14N (d, n ) 15O






64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 0.1 5/year Yes No Yes No 201Tl Yes No Yes No 211At 1 1/week Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) – The home of : gas phase Methyl iodine - 11C, 10C - carbon dioxide – Production of 81Rb/ 81mKr generators 16/week – 12 GBq/week.

87

COUNTRY: EGYPT EGY-1 [1] INSTITUTE: Atomic Energy Authority

AEA Post Office, Postal Code 13759 Cairo


+202 469 0840 +202 469 8414


Professor Dr. A.H. Azzam Supervisor


Professor Dr. M.N.H. Comasan Professor Dr. Z.A. Saleh Professor Dr. F.I. Asfour

[3] TYPE OF CYCLOTRON: AVE YEAR OF: (I) INSTALLATION 1997 MANUFACTURER: NIIEFA (II) UPGRADE: MODEL: MGC-20 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 5-18 3-10 8-24 6-20 Yes No Maximum beam available (µA) 200 50 Typical beam employed (µA) 45 17 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




The machine is under installation

[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 67Ga, 111In and 123I [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Planning to supply to radiomedical institutes.

Yes No


Yes No




88




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F



























64Cu Yes No Yes No 67Ga 2/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 1/week Yes No Yes No 123I 3/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No


89

COUNTRY: FINLAND FIN-1 [1] INSTITUTE: Laboratory of Radiochemistry

University of Helsinki, Department of Chemistry P.O. Box 55, 00014 University of Helsinki


+358 9191 50133 [email protected] +358 9191 50121


Dr. Kerttuli Helariutta , Senior Laboratory Manager


Martti Hakanen, Laboratory Manager

[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 1997 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 10/5 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10 5 Yes No Maximum beam available (µA) 80 40 Typical beam employed (µA) 10-20 Not yet used [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




~ 4.5 ~ 4 ~ 0.5 ~ 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: A couple of times Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No 57Co X ray sources? (specify which & quantity) Yes No 109Ag Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 124I, 64Cu , 86Y [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Hospitals (Helsinli, Tampere, Lahti, Kuojno) 1-3 times/week

Yes No


Yes No




90




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 1-5 0.4, 2.0

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






18FDG 1-3/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






















COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) We are still in the beginning of using Cyclotron. Probably this year, the production of radionuclides will increase significantly.

91

COUNTRY: FINLAND FIN-2 [1] INSTITUTE: Turku PET Centre

Turku University Central Hospital Kiinamyllynkatu 4-8 FIN-20520 Turku


+358 2 261 1860 [email protected] +358 2 261 2882


Mr. Hannu Sipilä Chemist


Mika Teräs, Hospital Physicist Kari Lindberg, Technician Kalevi Eklund, Technician

[3] TYPE OF CYCLOTRON: Positive ion 2H YEAR OF: (I) INSTALLATION 1992 MANUFACTURER: IBA, s.a. Belgium (II) UPGRADE: MODEL: Cyclone 3 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 3-7 Yes No Maximum beam available (µA) 60 Typical beam employed (µA) 5-35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




14 14 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: 14 Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 4 Positron emission tomography (PET) 2 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



92




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






















H2 O 0.2 – 1.4 4 days/week 14N (d, n) 15O CO 2.6 3 days/week O2 1.2 1 day/week








93

COUNTRY: FINLAND FIN-3 [1] INSTITUTE: Turku PET Centre

Accelerator Laboratory Äbo Akademi, Porthansgatan 3 FIN-20500 Turku


+358 2 2654 608 [email protected] +358 2 2654 912


Dr. Sven-Johan Heselius Director


Olof Solin; Jörgen Bergman; Jan-Olof Lill; Ulf Hällsten; Stefen Johansson; Erkki Stenvall; Per Olof Eriksson

[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1974 MANUFACTURER: D.V. Efremov

Institute (II) UPGRADE:

MODEL: MGC-20 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 3-20 6-10.5 9-28 12-21 Yes No Maximum beam available (µA) 30 30 20 20 Typical beam employed (µA) 300 300 80 80 [5] CYCLOTRON OPERATION:


h/week for research h/week for maintenance h/week for applications

42 32 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? ……. Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 2 Gamma camera 4 Single photon tomography (SPET) 4 Positron emission tomography (PET) 2 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



94




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F




























COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced ……………………….

95

COUNTRY: FINLAND FIN-4 [1] INSTITUTE: University of Jyväskylä

Department of Physics, P.O. Box 35 40351 Jyväskylä


+358 14 260 2350 [email protected] +358 14 260 2351


Professor Esko Liukkonen Professor


Pauli Heikkinen, in charge of Accelerator Physics Hannu Koivisto, in charge of Ion Sources Teuvo Poikolainen, Radiation Safety Officer

[3] TYPE OF CYCLOTRON: Isochronous YEAR OF: (I) INSTALLATION 1990-92 MANUFACTURER: JYFL, Scandinotrix (II) UPGRADE: 2000 for H- acceleration MODEL: [4] CYCLOTRON CHARACTERISTICS: E = q2 m 130 MeV 1H 2H 3He 4He Dual Beams Beam energies (MeV) 5-70 5-65 15 - 168 Yes No Maximum beam available (µA) 100 50 20 Typical beam employed (µA) 30-50 0.1 - 10 0.1 - 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




10 120 18 20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: 20 Proton therapy: Physics: 120 Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?



Yes No




96




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F




























COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced

97

COUNTRY: FRANCE FRA-1 [1] INSTITUTE: Centre Antoine Lacassagne

Laboratoire du Cyclotron 227, Avenue de la Lanterne 06200 Nice


+33 4 920 31070 [email protected] +33 4 920 31095


Dr. Pierre Mandrillon Head of Cyclotron Laboratory


Donadey Trimud Giusto

[3] TYPE OF CYCLOTRON: Compact isochronous - negative ion


MANUFACTURER: Centre Antoine Lacassagne

(II) UPGRADE:

MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 65 65 65 65 Yes No Maximum beam available (µA) 40 40 40 40 Typical beam employed (µA) 0.1 - 25 0.1 - 25 0.1 - 25 0.1 - 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




30 10 20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: 20 Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C [9] Do you supply radionuclides to other institutions?



Yes No




98




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 150 Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No























99

COUNTRY: FRANCE FRA-2 [1] INSTITUTE: Centre National de la Recherche Scientifique

Centre d'Etudes et de Recherches par Irradiation (CNRS-CERI), 3a rue de la Ferolerie


+33 2 3825 5410


Mr. G. Blondiaux Director, CERI


J. Briaud

[3] TYPE OF CYCLOTRON: Isochronous YEAR OF: (I) INSTALLATION 1974 MANUFACTURER: CGR MeV (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 5-35 5-25 10-60 10-50 Yes No Maximum beam available (µA) 70 40 40 Typical beam employed (µA) 40 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




64 6 26 8 24 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: 4 Proton therapy: Physics: 10 Neutron therapy: 24 Activation analysis: 12 Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) 15 MeV Yes No 1012n/cm2/s [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



100




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F



























64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No 81mKr 0.1 – 0.5 2/week Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Production of 211At ; industrial applications with thin and ultra thin layer activation; application in the field of waste management.

101

COUNTRY: FRANCE FRA-3 [1] INSTITUTE: Centro d'Exploration et de Recherche Medicales

par Emission de Positrons (CERMEP) Cyclotron Biomedical de Lyon 59 Boulevard Pinel, F-69003 Lyon


+33 4 726 88600 [email protected] +33 4 726 88610


Dr. D. Le Bars Head of Radiochemistry


G. Galy P. Lanai D. Comar

[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1987 MANUFACTURER: CGR-MeV (II) UPGRADE: MODEL: Cypris 325 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 8 Yes No Maximum beam available (µA) >50 >50 Typical beam employed (µA) 30 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




>15 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 18F-FDG one per/month to one per week.

Yes No


Yes No




102




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F





























103

COUNTRY: FRANCE FRA-4 [1] INSTITUTE: CERMEP - Hospital Neurocardiologique

59 Bd Pinel F - 69003 Lyon


+33 4 72 688600


Dr. Pujol


Dr. D. Le Bars Dr. L. Zimmer Dr. S. Guillouet

[3] TYPE OF CYCLOTRON: CYCLONE 18/9 YEAR OF: (I) INSTALLATION 1999 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 80 40 Typical beam employed (µA) 15-35 5 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




20-30 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




104




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 25-75 >95 0.5 50-100

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






18FDG 10 3/week Yes No Yes No DOPA 6 1/week Yes No Yes No MPPF 3 1/week Yes No Yes No Yes No Yes No






Methionine 2 1/week Yes No Yes No Flumazenil 2 1/week Yes No Yes No Raclopride 2 1/week Yes No Yes No MHED 2 1/month Yes No Yes No










Water 0.33 2/week 14N(d, n) 15O








105

COUNTRY: FRANCE FRA-5 [1] INSTITUTE: Service Hospitalier Frederic Joliot

C.E.A. Direction des Sciences du Vivant 4, Place du General Leclerc F-91406 Orsay


+33 1 698 67704 [email protected] +33 1 698 07768


Dr. C. Crouzel


F. Dolle D. Roeda M. Ponchant/C. Loch

[3] TYPE OF CYCLOTRON: Compact cyclotron (variable energy)


MANUFACTURER: CGR-MeV (II) UPGRADE: 1996, 1997 MODEL: 520 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 20 14.5 30 29 Yes No Maximum beam available (µA) Typical beam employed (µA) 30 30 15-20 15-20 [5] CYCLOTRON OPERATION:


h/week for research



25-30 25-30 6 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Supply of 18F-FDG to hospitals with the help of Cis-Bio (ORIS-Industry)

Yes No


Yes No




106




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG Yes No Yes No Dopa Yes No Yes No Oliganuclides Yes No Yes No Spiperone Yes No Yes No






Flumazenyl Yes No Yes No MQNB Yes No Yes No CGP Yes No Yes No Yes No Yes No










Water








107

COUNTRY: GERMANY GER-1 [1] INSTITUTE: Cyclotron Laboratory

Forschungszentrum Karlsruhe Technik und Umwelt Hauptabteilung Zyklotron P.O. Box 3640, 76021 Karlsruhe


+49 7247 82 2433 [email protected] +49 7247 82 3156


Dr. H. Schweickert Director, Cyclotron Laboratory


Dr. V. Bechtold, in charge of Radioisotope Production Dr. P. Fehsenfeld, RTM, Radionuclide Technique in Mechanical Engineering

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1984 MANUFACTURER: Cyclotron

Corporation (II) UPGRADE: Continuous

MODEL: CP 42 H- [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-40 Yes No Maximum beam available (µA) 200 Typical beam employed (µA) 100 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




140 50 70 when needed 20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) TLA [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? To hospitals and industry Yes No


Yes No




108




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 75-150 >95

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






18FDG 37 - 75 1/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No





















64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Planned Yes No Yes No 94mTc Planned Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 175 1/day Yes No Yes No 124I 3.7 1/week Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):

109

COUNTRY: GERMANY GER-2 [1] INSTITUTE: Cyclotron Laboratory

Forschungszentrum Karlsruhe Technik und Umwelt Hauptabteilung Zyklotron P.O. Box 3640, 76021 Karlsruhe


+49 7247 82 2433 [email protected] +49 7247 82 3156


Dr. H. Schweickert Director, Cyclotron Laboratory


Dr. V. Bechtold, in charge of Radioisotope Production Dr. P. Fehsenfeld, RTM, Radionuclide Technique in Mechanical Engineering

[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1964 MANUFACTURER: AEG (II) UPGRADE: Continuous MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 52 104 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 20 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




110




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F >95

Yes No

20Ne (d, α) 18F 16O (α, d) 18F



























64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At 1/week Yes No Yes No


111

COUNTRY: GERMANY GER-3 [1] INSTITUTE: Eberhard-Karls-University Tübingen

Interdisciplinary PET Centre Department of Nuclear Medicine Röntgenweg 15, D-72076 Tübingen


+49 7071 29 87443 [email protected] +49 7071 29 5264


Professor Dr. H.-Juergen Machulla


Professor R. Bares, Director of Nuclear Medicine

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1995 MANUFACTURER: GE (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8 Yes No Maximum beam available (µA) 75 Typical beam employed (µA) 35-55 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




15-20 10-15 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 2 Single photon tomography (SPET) 2 Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



112




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 75 95 1.6 1000

Yes No

20Ne (d, α) 18F 8 16O (α, d) 18F






18FDG 30 5/week Yes No Yes No FLT 10 3/week Yes No Yes No Yes No Yes No Yes No Yes No






Raclopride 2 2/week Yes No Yes No NMSP 4 1/week Yes No Yes No SCH 23390 3 1/week Yes No Yes No Methionin 8 1/month Yes No Yes No






Ammonia 3 1/month 16O(p, α ) 13N Yes No Yes No Yes No




Water 20 1/month 14N(d, n ) 15O






64Cu Yes No Yes No 67Ga Yes No Yes No 86Y 1 2/month Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No On request 123I Yes No Yes No 124I 0.4 1/month Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced): 11C CARFENTANIL 3 GBq 1/week, 11C METHYL PHENIDAT 4 GBq 1/week, 11C FLB 457 2GBq 1/week 124I mIBG 0.2GBq 1/3month

113

COUNTRY: GERMANY GER-4 [1] INSTITUTE: Euro-PET GmbH

Hugstetlerstrasse 55 D-79106 Freiburg


+49 761 270 9204 [email protected] +49 761 270 9200


Professor Dr. Peter Reuland

OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION NAME/POSITION

Dr. Ursula Sahm, Chief Chemist Kenneth Stalmo, Technician Bernd Morasch, Chemist Dagmar Hentschel, Engineer

[3] TYPE OF CYCLOTRON: Negative Ion YEAR OF: (I) INSTALLATION 1996 MANUFACTURER: GE. (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: ……. 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) 75 75 Typical beam employed (µA) 40 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




3 0.25 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C-carbon monoxide and carbon dioxide, 15O–water, carbon monoxide and oxygen. [9] Do you supply radionuclides to other institutions? To different institutions



Yes No




114




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 110 >95 1.2 1000

Yes No

20Ne (d, α) 18F 25 16O (α, d) 18F






18FDG 35-45 8-10/week Yes No Yes No Fluoride Yes No Yes No Yes No Yes No Yes No Yes No






(see comments) Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






13NH3 10-13 10/year Yes No Yes No Yes No




N213O 8-10 50/year







COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) We’ll produce 11C radiopharmaceuticals starting November 2001.

115

COUNTRY: GERMANY GER-5 [1] INSTITUTE: Forschungszentrum Rossendorf

Institut für Bioanorganische undRadiopharmazische Chemie P.O. Box 510119, 01314 Dresden


+49 351 260 3170 [email protected] +49 351 260 3232


Professor habil. Bernd Johannsen Director of the Institute


F. Wuest, Head of PET Tracer Department St. Preusche, Head of Cyclotron Unit

[3] TYPE OF CYCLOTRON: Negative Ion YEAR OF: (I) INSTALLATION 1996 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: Beam – beam on the targets. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 35 20 Possible for 1H, 2H,

but not used Typical beam employed (µA) 30 15-18 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




10-20 10-120 for PET routine and research

2-5

[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) RN production: 10-20

beam on the targets [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Solid target under construction [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Radiopharmaceutical company, daily

Yes No


Yes No




116




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 60-90 94-96 1.4 500

Yes No

20Ne (d, α) 18F 12-13 600ml Ne/F2 16O (α, d) 18F






18FDG 33-45 1/day Yes No Yes No Customer dependent

[F-18] 16 alpha-Fluoroertradiole

20 1/week Yes No Yes No

[F-12] Fluoro-Dopa

1.2 1/week Yes No Yes No

[F-JP]3-0-Methyl-F-Dopa

1.2 2/month Yes No Yes No






11C-NeN5652 8-9 on request Yes No Yes No on request Yes No Yes No Various research

products Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED

Name (list)





Ammonia 2 1/week 160(p,∝)13N Yes No Yes No




Water 5-6 2-5/week 14N(din)15O







COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced): Broad biomedical research programs using various radiotracers as well as radiochemical research have been carried out. Our internet home pages: http:/www.fz-rossendorf.de; http:/www.fz-rossendorf.de/FWB2; http:/www.fz-rossendorf.de/FWB/usercom/usucom1.html/3. 1-Forschungszentrum Rossendorf; 2-Radiopharmazeutische Chemie. 3-Cyclone 18/9 & 10/5 USU Community.

117

COUNTRY: GERMANY GER-6 [1] INSTITUTE: Forschungszentrum Rossendorf

Institut für Bioanorganische und Radiopharmazische Chemie P.O. Box 510119, 01314 Dresden


+49 351 260 3170 [email protected] +49 351 260 3232


Professor habil. Bernd Johannsen Director of the Institute


F. Wuest, Head of PET Tracer Department St. Preusche, Head of Cyclotron Unit

[3] TYPE OF CYCLOTRON: U-120 YEAR OF: (I) INSTALLATION 1958 MANUFACTURER: NIIEFA St.

Petersburg (II) UPGRADE: 1989

MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 7 14 28 Yes No Maximum beam available (µA) Typical beam employed (µA) 50 50 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




50 10 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? External application of radionuclides generally

Yes No


Yes No




118




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F





























119

COUNTRY: GERMANY GER-7 [1] INSTITUTE: German Cancer Research Centre (DKFZ)

Im Neuenheimer Feld 280 D-69120 Heidelberg


+49 6221 550 3 [email protected] +49 6221 422 572


Dr. Gerd Wolber, Head, Cyclotron Operation Group Professor Dr. Wolfhard Semmler, Head - Biophysics


Professor Dr. Michael Eisenhut, Head – Radiochemistry

[3] TYPE OF CYCLOTRON: Isochronous, negative ion


MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 32 NI [4] CYCLOTRON CHARACTERISTICS: Average magnetic field: 1.59 T; pole face diam.: 135 cm; accel. freq: 24.3 MHz; 2 Dees 90º;

dual cold cathode ion source; total weight: 53 tons; total power dissipation: 185 kva. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16-32 8-16 Yes No Maximum beam available (µA) 100 100 Typical beam employed (µA) 30 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




50 (aver), 1997-2000 25 15 2-5 45 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 1 Radiography: Materials science: 2-3 Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) Neutron dosimetry - 2 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 140 Pr Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No εn= 14MeV [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): see comments [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Dept. of Nuclear Medicine, Radiological Clinic of the University of Heidelberg; daily

Yes No


Yes No

Both [11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 – Clinical 1 – Small animal planned – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



120




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 50-70 >95 1 16 at 30

bar 300 1

Yes No

20Ne (d, α) 18F 20-30 16O (α, d) 18F






18FDG 15-20 1-2/day Yes No Yes No FLT 1.7 on demand Yes No Yes No

Yes No Yes No Others, see comments Yes No Yes No






Yes No Yes No Others, see comments Yes No Yes No Yes No Yes No Yes No Yes No










Water 5-6 2-3/week 14N(d, n) 15O






64Cu rare Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I in preparation Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 18F – DOPA, FU, FET, 2F-Throsine,Choline 11C – AIB, ethanole, doxorubicine, dacarbacine, acetate, choline In preparation : Iodinated compounds (124I, 121I) 140 Pr ( 20%β +,via 141Pr (p, 2n) 140 Nd is used for calibration of PET systems.

121

COUNTRY: GERMANY GER-8 [1] INSTITUTE: Institut für Molekulare, Radiopharmazie u. Nuklearmedizin

Universitaetsklinik der Ruhr-Universitaet Bochum Georgstrasse 11. D-32535 Bad Öynhausen


+49 5731 97 1308 [email protected]/[email protected]/[email protected] +49 5731 97 1819


Professor W. Burchert Director


Ms. Petra Hadjilazaros Mr. Harald Henneken

[3] TYPE OF CYCLOTRON: Negative Ion YEAR OF: (I) INSTALLATION 1994 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: d P 3He 4He Dual Beams Beam energies (MeV) 9 18 Yes No Maximum beam available (µA) 40 80 Typical beam employed (µA) 12 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




20 20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 15O-Water 11C-MHEO [9] Do you supply radionuclides to other institutions?



Yes No




122




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 25

50 95 0.6

1.6 400

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






18FDG 20 5-7/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Acetate 3.7 4/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 4.5 4/day 16O(p, α ) 13N Yes No Yes No Yes No




Water the first tests








123

COUNTRY: GERMANY GER-9 [1] INSTITUTE: Institut für Nuklearchemie

Forschungszentrum Jülich GmbH D-52425 Juelich


+49 2461 614141 [email protected] +49 2461 612535


Professor H.H. Coenen


Professor S.M. Qaim Dr. M. Holschbach

[3] TYPE OF CYCLOTRON: Fixed energy, two particle


MANUFACTURER: General Electric (II) UPGRADE: 1999 MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.4 Yes No Maximum beam available (µA) Typical beam employed (µA) 40 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical 2 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for


[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.?

(radiochemistry) Yes No

[16] Does your institute accept IAEA research fellows for training/experience? Yes No

124




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG Yes No Yes No Yes No Yes No






Flumazenil 3 2/week Yes No Yes No Raclopride 3 2/week Yes No Yes No Yes No Yes No Yes No Yes No










Water 15 daily 14N(d, n) 15O Butanol 5 daily 14N(d, n) 15O








125




+49 2461 614141 [email protected] +49 2461 612535




Professor S.M. Qaim Dr. J. Ermert Dr. K. Hamacher

[3] TYPE OF CYCLOTRON: Baby Cyclotron YEAR OF: (I) INSTALLATION 1987 MANUFACTURER: Japan Steel Works,

Ltd. (II) UPGRADE:

MODEL: BC 1710 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 10 Yes No Maximum beam available (µA) Typical beam employed (µA) 30 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical 2 – Small animal 1 – Plant biochemistry 1 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for


[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.?

(radiochemistry) Yes No

[16] Does your institute accept IAEA research fellows for training/experience? Yes No

126




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 60 96 1.5 200

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






18FDG 30 4/week Yes No Yes No CPFPX 15 1/week Yes No Yes No FET 15 occasionally Yes No Yes No






Methionine 1-3 occasionally Yes No Yes No Flumazenil 1-3 occasionally Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 1 occasionally 16O(p, α ) 13N Yes No Yes No Yes No











127




+49 2461 614141 [email protected] +49 2461 612535




Professor S. Qaim Dr. B. Scholten

[3] TYPE OF CYCLOTRON: Variable energy compact



(II) UPGRADE: 1986, 1991, 1997

MODEL: CV 28 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 6-22 4-14 18-36 10-28 Yes No Maximum beam available (µA) 30 20 10 20 Typical beam employed (µA) 30 20 10 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




56 12 16 7 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: 28 Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 86Y, 94mTc and 12yI to several clinics under co-operative research

Yes No


Yes No




128




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 35 95 50 5

Yes No

20Ne (d, α) 18F 15 16O (α, d) 18F



























64Cu Yes No Yes No 67Ga Yes No Yes No 86Y 2 on demand Yes No Yes No 94mTc 2 on demand Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 0.5 ½ weeks Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No


129

COUNTRY: GERMANY GER-12 [1] INSTITUTE: Institute for Medical Radiation Physics

Hufelandstrasse 55 D-45122 Essen


+49 201 723 4182 +49 201 723 5907


Professor Dr. A. Bochisch Director


G. Hudepohl, Technician/Engineer

[3] TYPE OF CYCLOTRON: Positive Ion, sector-focused



(II) UPGRADE:

MODEL: CV 28 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 24 14 36 28 Yes No Maximum beam available (µA) 100 100 50 50 Typical beam employed (µA) 100 100 50 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




40 20 10 5 Neutrons 5 patient treatment

[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: research 5 Radiography: Materials science: Proton therapy: Physics: research 5 Neutron therapy: 5 Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




130




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 16O (3He,p)18F

37

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






18FDG 18.5 3/week Yes No Yes No Yes No Yes No






11CO2 37 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No










O2 15/min 3/week 14N(din)15O CO2 15/min 3/week 14N(din)15O






64Cu Yes No Yes No 67Ga Yes No Yes No 86Y temporary Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 7.4 temporary Yes No Yes No 124I 3.7 temporary Yes No Yes No 201Tl Yes No Yes No 211At temporary Yes No Yes No


131

COUNTRY: GERMANY GER-13 [1] INSTITUTE: Institute of Radiology and Nuclear Medicine

Adickes-Allee 51-53 60322 Frankfurt am Main


+49 69 95961 626 +49 69 95961 630


Professor G. Hoer


Dr. W.T. Kranert

[3] TYPE OF CYCLOTRON: Negative ion H YEAR OF: (I) INSTALLATION 1998 MANUFACTURER: CTI. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




40 20 15 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) Nuclide production

for Nuclear Medicine [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 94mTc, 124I [9] Do you supply radionuclides to other

institutions? If yes and available, name of institution/s & how often? We can give addresses, after the cyclotron is established.

Yes No


Yes No




132




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 80 0.8

Yes No

20Ne (d, α) 18F 16O (α, d) 18F






18FDG 40 1/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






CO 5 1/week Yes No Yes No CO2 5 1/week Yes No Yes No Amino acids 5 1/week Yes No Yes No Yes No Yes No






Ammonia 5 2/week Yes No Yes No Yes No




Water 1/week







COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) The cyclotron is not established so far.

133

COUNTRY: GERMANY GER-14 [1] INSTITUTE: Max-Planck-Institut fuer Neurologische Forschung

Gleueler Strasse 50 D-50931 Koeln (Lindenthal)


+49 221 4726 220 +49 221 4726 298


Professor Wolf-Dieter Heiss Director


Professor Dr. Klaus Wienhard

[3] TYPE OF CYCLOTRON: Baby cyclotron YEAR OF: (I) INSTALLATION 1987 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 16 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 8.5 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 25 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




20 20 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other

institutions? If yes and available, name of institution/s & how often?

Yes No


Yes No




134




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 15 95 1.2 100

Yes No

20Ne (d, α) 18F 10 16O (α, d) 18F






18FDG 10 4/week Yes No Yes No Dopa 1 2/week Yes No Yes No Yes No Yes No Yes No Yes No






Methionine 12 3/week Yes No Yes No Raclopride 5 2/week Yes No Yes No Flumazenil 10 1/week Yes No Yes No MPHA 8 1/week Yes No Yes No










Water 6 25/week 14N(d,n) 15O CO 5 1/month 14N(din)15O O2 5 3/month 14N(din)15O







COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced): 124I – FIAU with 124I from outside.

135

COUNTRY: GERMANY GER-15 [1] INSTITUTE: Medizinische Hochschule Hannover (MHH)

Klinik für Nuklearmedizin Carl Neuberg-Strasse 1 D-30623 Hannover


+49 511 532 5606/3085 +49 511 532 2315


Dr. Helmeke Head of the Cyclotron Group


Mr. G.-J. Meyer

[3] TYPE OF CYCLOTRON: Isonochronous, variable energy

YEAR OF: (I) INSTALLATION 1976/1977

MANUFACTURER: Scanditronix (II) UPGRADE: MODEL: MC 35 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 7.5-35 3.8-18 5.6-47 7.5-35 Yes No Maximum beam available (µA) 65 65 30 30 Typical beam employed (µA) 40 35 - 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




14 (pure beam time) 11-12 2-3 0.5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 66Ga [9] Do you supply radionuclides to other institutions?



Yes No




136




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 31 80-94 1.5 500 Yes

No 20Ne (d, α) 18F 1-3 16O (α, d) 18F






18FDG 14 1/day Yes No Yes No Fluoride 1.3 30/year Yes No Yes No Dopa 0.3 30/year Yes No Yes No Yes No Yes No






Acetate 7-15 200/year Yes No Yes No Methionine 3.5 - 8.5 200/year Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 6-7 120/year 15O(p, α ) 13N Yes No Yes No Yes No




Water 4.4 220/year 14N (d, n ) 15O






64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At 0.02 1-2/week Yes No Yes No


137

COUNTRY: GERMANY GER-16 [1] INSTITUTE: Rheinisch-Westfaelische Technische Hochschule

Klinik fuer Nuklearmedizin, Universitaetsklinikum Pauwelsstrasse 30 D-52057 Aachen


+49 241 808 8741 [email protected]/ [email protected] +49 241 888 8520


Dr. Udalrich Büll


Dr. Berthold Müller

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1997 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




22 20 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F, 11C [9] Do you supply radionuclides to other

institutions?

If yes and available, name of institution/s & how often?

Yes No


Yes No




138




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






















Water 1 20/day 15N(p,n ) 15O








139

COUNTRY: GERMANY GER-17 [1] INSTITUTE: Technische Universität. München

Nuklearmedizinische Klinik u. Poliklinik Ismaningerstrasse 22 D-81675 München


+49 89 4140 4575 +49 89 4140 4841


Professor M. Schwaiger


Dr. I. Wolf Dr. G. Reidel M. Herz

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1992 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: Dual beam 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




33 26 5 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) Nuclear

Medicine [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): FLT, Epinephrine, Diprenorphine [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 3 Single photon tomography (SPET) 5 Positron emission tomography (PET) – Clinical 2 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



140




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 37 95-98 0.7 525 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 17 3/day Yes No Yes No 18F-PET 3.7 1/week Yes No Yes No 18F- 3.7 2/month Yes No Yes No 18F-FDPN 1.0 2/month Yes No Yes No






Acetate 3.7 1/week Yes No Yes No FM2 1.9 2/week Yes No Yes No Methionine 2.7 1/week Yes No Yes No HGD 1.9 1/week Yes No Yes No






Ammonia 1.5 36/week 15N(pin)15O Yes No Yes No Yes No




Water 0.8 36/week 15N(pin)15O








141

COUNTRY: GERMANY GER-18 [1] INSTITUTE: Universitätsklinikum Hamburg-Eppendorf

Klinik u. Poliklinik für Radiologie, Abteilung für Nuklaermedizin Bereich Zyklotron u. Radiopharmazie Luruper Chaussee 149 D-22761 Hamburg


+49 40 8998 2968 [email protected] +49 40 8998 2960


Dr. Bruno Nebeling Head


Uve Kirchner

[3] TYPE OF CYCLOTRON: Isochronous YEAR OF: (I) INSTALLATION 1968 MANUFACTURER: Philips (II) UPGRADE: MODEL: 140/IV [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 30 16 42 30 Yes No Maximum beam available (µA) 130(internal) Typical beam employed (µA) 20(external) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide





If yes and available, name of institution/s & how often? 5-7/week Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for agricultural



142




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 28 75-95 0.9 500 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F












McN 5652z 1-3 4/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No

















143

COUNTRY: GERMANY GER-19 [1] INSTITUTE: Universitätsklinikum Ulm

Abteilung Nukleamedizin Robert-Koch-Strasse 8 D-89081 Ulm


+49 731 500 24981 [email protected] +49 731 500 24979


Dr. Bernd Neumaier Head of PET Chemistry


Dr. Andreas Vogg, Radiochemist Christoph Solbach, Radiochemist Dr. Michaela Schmid, Chemist

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1994 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 40 20 Typical beam employed (µA) 30 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




20 16 3 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) 20 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Research, still not specified. [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Munich, Nuklearneclizimsche und Polikline, KRI & in cases of cyclotron maintenance

Yes No


Yes No

e.g. with FLP, FDOpa [11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 5 Single photon tomography (SPET) 2 Positron emission tomography (PET) – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for


[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience?

The candidate can only visit our cyclotron site, self-operation is impossible. Yes No

144




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 50 95 2 600 Yes

No 20Ne (d, α) 18F 6 21 16O (α, d) 18F






18FDG 22 4/week Yes No Yes No Dopa 0.8 2/week Yes No Yes No FLT 3 1/week Yes No Yes No Fluoride 6 1/week Yes No Yes No






Methionine 7 2/week Yes No Yes No Acetate 2.5 2/week Yes No Yes No Raclopride 4 2/week Yes No Yes No PK11195 1 0-1/week Yes No Yes No






Ammonic 16 0/week 16O(p,α) Yes No Yes No Yes No




Water 8 0/week 14N(din)







COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced): – 18F micliosides by electrophilic fluorination. 0.4GBq, occasionaly for research – 11C chlorine, 6GBq/batch, 0.1/week – 11C alpha-methyl-tryptophane, 1.5 GBq/batch, 0.1/week – 11C carfentanil, 4GBq/batch, 0-1/week – 11C flumazenile, 4GBq/batch, 0.1/week.

145

COUNTRY: GERMANY GER-20 [1] INSTITUTE: University of Frankfurt

Department of Nuclear Medicine Klinikum der Johann Wolfgang Goethe-Universität Theodor-Stern-Kai 7, Jaus 21 D D-60590 Frankfurt am Main


+49 69 6301 4330 [email protected] +49 69 6301 6805


Professor Dr. Frank Grünwald Chairman and Director


Professor Dr. Christian Menzel, Deputy Director

[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION MANUFACTURER: (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




146




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F




























COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced ……………………….

147

COUNTRY: GERMANY GER-21 [1] INSTITUTE: Westfaelische Wilhelms Universitaet

Klinik und Poliklinik fuer Nuklearmedizin Domagkestrasse 5 48189 Münster


+49 251 83 473 76 or 473 62 [email protected] +49 251 83 473 63


Professor Dr. O. Schober Director


Jörg Eckardt, Physicist Dr. Markus Knickmeier, Chemist





11 10 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 10 Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




148




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 40 97 1.1 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 20 Daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
















Water 2 weekly 15N(p,n) 15O








149

COUNTRY: GERMANY GER-22 [1] INSTITUTE: Zentralklinik Bad Berka GmbH

PET Centre Humbold Strasse 2A


+49 364 585 2200 [email protected] +49 364 585 3515


Professor Dr. Richard P. Baum Chairman, Clinic of Nuclear Med./Centre for PET


[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1997 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




Installation underway [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C, 13N, 15O, 18F [9] Do you supply radionuclides to other institutions?


[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals caried out on-site?

Yes No




150




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F





























151

COUNTRY: HUNGARY HUN-1 [1] INSTITUTE: Institute of Nuclear Research

of the Hungarian Academy of Sciences Bem ter 18/c, P.O. Box 51


+36 52 417 266 +36 52 416 181


F. Tarkanyi Head, Cyclotron Department


Dr. L. Trón, Head of PET Centre Z. Kormany P. Kovacs Z. Szucs

[3] TYPE OF CYCLOTRON: Compact isochronous YEAR OF: (I) INSTALLATION 1985 MANUFACTURER: NIIEFA Russia (II) UPGRADE: 1997 MODEL: MGC 20E [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 20 10 26 20 Yes No Maximum beam available (µA) 200 300 50 50 Typical beam employed (µA) 50 50 25 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




94 28 (56 every 2nd week) 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 13N-Ammonia, 15O-Water, 11C-Flumezinil, 111In-DTPA, 123I-mIBG, 123I-Imoazine [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Na123I-every 2 weeks; 67Ga-citric acid – every 2 weeks.

Yes No


Yes No




152




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F




























COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced): Neutron source (radiobiology, radiation hardness test, neutron activation, Thin Layer Activation (TLA), wear measurements, activation analysis (charged particle) Basic nuclear physics (in beam nuclear spectroscopy, astrophysical nuclear reactions)

153

COUNTRY: INDIA IND-1 [1] INSTITUTE: Radiation Medicine Centre

Bhabha Atomic Research Centre (BARC), Dept. of Atomic Energy Trombay, Mumbai 400 085


+91 22 550 5326 [email protected] +91 22 550 5326


Dr. A.M. Samuel Director, Bio-Medical Group, BARC, Mumbai Dr. N. Ramamoorthy Chief Executive, BRIT, Mumbai


Dr. B.N. Karkers, Head, MD & PDS Dr. M.R.A. Pillai, Head, Radiopharmaceuticals Division Dr. N. Nair, Head, Radiation Medicine Centre

[3] TYPE OF CYCLOTRON: Medical YEAR OF: (I) INSTALLATION 2001 MANUFACTURER: Wipro GE, Mumbai (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: Dual particle (16.5 MeV Proton and e MeV Deuteron) 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.5 Yes No Maximum beam available (µA) 80 80 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




10-12 10-12 Not yet decided [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions? If yes and available, name of

institution/s & how often? Planned to supply 18F to Nuclear Medicine Departments Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 4 Single photon tomography (SPET) 3 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



154




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F




























COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): This is the first facility to be set up in the country with expertise in accelerations, radiopharmaceuticals, radiation biology and nuclear medicine. It is anticipated that apart from the routine PET radiopharmaceuticals, research in the development of new PET labeled compounds will be initiated.

155

COUNTRY: INDIA IND-2 [1] INSTITUTE: Variable Energy Cyclotron Centre (VECC)

1/AF, Bidhan Nagar Calcutta - 700 064


+91 33 3371 230 +91 33 3346 871


Dr. B.C. Sinha Director


[3] TYPE OF CYCLOTRON: Sector-focused (pole diameter 224 cm)


MANUFACTURER: VEC Centre (II) UPGRADE: MODEL: (Individual design) [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 6.30 12.30 25.80 Yes No Maximum beam available (µA) 200 200 200 Typical beam employed (µA) 20 20 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




160 24 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 201Tl [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Regional Radiation Medicine Centre, Thakurpukur, Calcutta – weekly, Radiation Medicine Centre Mumbai - monthly

Yes No


Yes No




156




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F




























COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):

157

COUNTRY: INDONESIA INS-1 [1] INSTITUTE: National Atomic Energy Agency, BATAN

PPR-Batan Kawasan Puspiptek Serpong 15310


+21 756 3141 [email protected]


Mr. Silakhuddin Head, Cyclotron Division


Mr. Tonny Heryanto Budi Tarigan

[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: CTI, Inc. (II) UPGRADE: 1995 (modified to negative ion

by IBA) MODEL: CS 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 24-27 Yes No Maximum beam available (µA) 60 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




6 4 2 2 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): We would like to produce 123I. Unfortunately we have no experts and facility. [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Hospitals, 1-2/week Yes No


Yes No




158




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F



























64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 1/2week Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): We are planning to produce 18FDG in 2002.

159

COUNTRY: IRAN IRA-1 [1] INSTITUTE: Nuclear Research Centre for Agriculture

and Medicine (NRCAM) P.O. Box 31585-4395 Karaj


+98 261 313 0676 +98 261 411 105


Professor Hossein Afarideh


Satari; Partovi Rafii; Akbari; Shafiei

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1995 MANUFACTURER: IBA, Belgium (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 7-15 Yes No Maximum beam available (µA) Typical beam employed (µA) 500 150 175 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




20-25 12-17 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 81mKr - Rb generator, 18F - FDG , 123In [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? To all nuclear medicine centres - Once a week

Yes No


Yes No




160




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F



























64Cu Yes No Yes No 67Ga 0.1 0.5/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 0.5 0.5/week Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 0.037 1/week Yes No Yes No 211At Yes No Yes No


161

COUNTRY: ISRAEL ISR-1 [1] INSTITUTE: Hadassah Medical Organization

Ein Karem Il-91 120 Jerusalem


+972 2 6777 197 [email protected] +972 2 6438 506


Dr. Eyal Mishani Head of Cyclotron Unit


Mr. Desideriu Laky, Cyclotron Operator Ms. Iris Pauker Ben-David, Research Ms. Yulia Rozen, Research Mr. Daniel Wajnblum, Engineer

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1997 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 30 20 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




12 5 5 13 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F – FDG, DOPA, Uracil; 11C – Choline ; 15O - Water [9] Do you supply radionuclides to other institutions?



Yes No




162




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 52 97 2 400 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 25 1/day Yes No Yes No Dopa Yes No Yes No ML 01 Yes No Yes No ML 03 Yes No Yes No






Choline Yes No Yes No Deprenyl Yes No Yes No Methionine Yes No Yes No Yes No Yes No






Ammonia 8 16O(p,α ) 13N Yes No Yes No Yes No




Water 4 -8 1/week 14N (d, n ) 15O








163

COUNTRY: ISRAEL ISR-2 [1] INSTITUTE: Soreq NRC

81800 Yavne


+97 2 8943 4615 [email protected] +97 2 8943 4133


Engineer Yosef Shohet Head of Facility


Dr. M.B. Goldberg, Head, Steering Committee Dr. D. Berkovits, Chief Physicist Bs. Phrm. B. Hoch, Chief Radiochemist Mr. T. Arbel, Head of Operation Staff

[3] TYPE OF CYCLOTRON: Cyclone series YEAR OF: (I) INSTALLATION 2000 MANUFACTURER: IBA, Belgium (II) UPGRADE: MODEL: 10/5 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10 5 Yes No Maximum beam available (µA) 80 80 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




20-25 15-20 1-2 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 15-20 Radiography: Materials science: 1-2 Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C 66-68Ga 15F-DOPA [9] Do you supply radionuclides to other institutions?



Yes No




164




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 15000 94 2 600 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 50 1-2 Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No























165

COUNTRY: ITALY ITA-1 [1] INSTITUTE: Azienda Ospedaliera di Bologna

Policlinico S. Orsola - Malpighi Via Massarenti, 9 40138 Bologna


+39 051 636 3575 [email protected] +39 051 349 920


Professor Nino Monetti Professor of Nuclear Medicine


Dr. Mario Marengo, Medical Physicist, responsible for the Cyclotron Dr. Stefano Boschi, Chemist, responsible for Radiopharmacy

[3] TYPE OF CYCLOTRON: Pet trace YEAR OF: (I) INSTALLATION 2001 MANUFACTURER: GE (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8 Yes No Maximum beam available (µA) 75 60 Typical beam employed (µA) 40 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




25 20 4 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other

institutions?

If yes and available, name of institution/s & how often? Distribution is planned in the third quarter of 2002.

Yes No


Yes No




166




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 80 >94 1.1 500 Yes

No 20Ne (d,α) 18F 16O (α, d) 18F












CO2 100 weekly Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 20 weekly 16O(p, α) 13N Yes No Yes No Yes No




O2 70 weekly 14N(d,n ) 15O







COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): The cyclotron will start operation by end of 2001. Productivity and workload data are based on typical values reported by General Electric.

167

COUNTRY: ITALY ITA-2 [1] INSTITUTE: Azienda Ospedaliera 5. Maria Nuova

Servizio di Medicina Nucleare V. le Risorgimento 80, Reggio Emilia


+39 0522 296 284 [email protected] +39 0522 296 392


Dr. Diana Salvo Department Chief


[3] TYPE OF CYCLOTRON: Minitrace GE 10 Mev

YEAR OF: (I) INSTALLATION October 2001

MANUFACTURER: General Electric (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 9.6 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




15 13 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Maybe 11C [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? In 2002 Yes No


Yes No




168




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 37 95 0.8 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F





























169

COUNTRY: ITALY ITA-3 [1] INSTITUTE: CNR Institute of Clinical Physiology

Via Moruzzi, 1 I-56100 Pisa


+39 050 315 3384 [email protected] +39 050 315 2166


Piero A. Salvadori Head – PET/Cyclotron Facility


Luca Menichetti, Radiopharmacist Debora Petroni, Radiopharmacist Michela Poli, Pharmacist

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1996 MANUFACTURER: GE Medical Syst. (II) UPGRADE: 2001 MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 5 beam ports used (6 available); targets resident on beam ports, no beam transport lines. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.7 8.4 Yes No Maximum beam available (µA) 75 50 Typical beam employed (µA) 25 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 3 Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal planned – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



170




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 55 97 1 150 Yes

No 20Ne (d, α) 18F 11 16O (α, d) 18F






18FDG 11 1/day Yes No Yes No Fluoride 3.7 2/week Yes No Yes No Yes No Yes No Yes No Yes No






Methyl iodide 37 Development Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 2 1/day Yes No Yes No Yes No




O Development Water Development






64Cu Development Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Development Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Development Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): Additional activities planned for near future: - use of cyclotron for research in Boron neutro capture therapy - FDG manufacturing site - research in molecular imaging applied to genomic and proteonomic.

171

COUNTRY: ITALY ITA-4 [1] INSTITUTE: Consiglio Nazionale delle Ricerche

Institute Pascale (CNR) Via M. Semmola I-80131 Napoli


+39 81 5903 528/527 +39 81 5465 797


Professor Marco Salvatore


Antonello Green

[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 17 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 8.5 Yes No Maximum beam available (µA) 75 50 Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




40 15 25 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 15O - Water , 11C – CH3 I [9] Do you supply radionuclides to other institutions?



Yes No




172




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG Yes No Yes No Fluoride Yes No Yes No Yes No Yes No Yes No Yes No






Acetate Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No

















173

COUNTRY: ITALY ITA-5 [1] INSTITUTE: Istituto Naziónale per lo Studío e la Çura dei Tumori

Via G. Venezian 1 I-20133 Milano


+39 2 2390 2220 [email protected] +39 2 2367 874


Dr. Emilio Bombardieri Director, Nuclear Medicine Department


Dr. Flavio Crippa, Co-ordinator, Clinical PET Dr. Claudio Pascali, Co-ordinator, Radiopharmacy Eng. Vinicio De Sanctis, Responsible for the Cyclotron

[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1995 MANUFACTURER: Scanditronix (II) UPGRADE: MODEL: MC 17F [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 85 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 25 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




12 6 6 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) PET 35 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other

institutions?


Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 9-10

patients/day

– Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



174




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 4500 94-97 ~ 1 250 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 10-15 1/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Methionine 2 - 10 1/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No

















175

COUNTRY: ITALY ITA-6 [1] INSTITUTE: Istituto Scientifico H. San Raffaele

Servizio di Medicina Nucleare Via Olgettina, 60 I-20132 Milano




Professor Ferruccio Fazio


Mario Matarrese Francesco Perugini Sergio Todde

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1988 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: Negative hydrogen ions 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




27 20 5 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other

institutions?


Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 5 Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 3 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



176




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 26 > 94 0.65 500 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F












Methyl choline 3 2/week Yes No Yes No FE - CIT 1 2/week Yes No Yes No Raclopride 1.5 1/week Yes No Yes No Yes No Yes No










Water 370 MBq 3/week 15N (p, n ) 15O








177

COUNTRY: ITALY ITA-7 [1] INSTITUTE: Joint Research Centre (European Commission)

Institute for Health and Consumer Protection I-21020 Ispra (VA)


+39 0332 785 281 [email protected] +39 0332 789 385


Dr. Rien Stroosnijder Section Head


K. Abbas D. Gilliland U. Holzwarth M. Hoffman

[3] TYPE OF CYCLOTRON: Variable energy positive ion


MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-40 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 40 20 40 Yes No Maximum beam available (µA) 60 60 30 Typical beam employed (µA) 30 10 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18FDG in setting up phase. Several others for research purposes. In

[9] Do you supply radionuclides to other institutions? If yes and available, name of institution/s & how often? Commercial and research purposes.

Yes No


Yes No




178




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F In setting up

stage > 95 1 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG in set-up stage Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






















COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): Applications of cyclotron: Biomedical radioisotope production, for release testing of medical devices and biological studies. Very keen on training possibilities.

179

COUNTRY: ITALY ITA-8 [1] INSTITUTE: Ospedale Civile de Castelfranco Veneto

Reparto Medicina Nucleare Via Ospedale 18 – 31033 Castelfranco Veneto - TV


+39 423 732 326 +39 423 732 426


Dr. Franca Chierichetti Physician – responsible for the PET Centre


Dr. Alberto Fini, Radiochemist, responsible for Cyclotron & Radiopharmacy

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1994 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS:

1H 2H 3He 4He Dual Beams Beam energies (MeV) 10 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 20-30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




12 9 2 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F - DOPA, ESTRODINOL, PRESYNAPTIC RADIOAGENT

11C - METHIONINE, CHOLINE [9] Do you supply radionuclides to other institutions?



Yes No




180




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 20/hour >94 0.33 200 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F












Acetate 2.22 2/year Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 0.89 5/week 16O(p,α)13N Yes No Yes No Yes No




Water 4.44 90/year 15N(p, n)15O








181

COUNTRY: ITALY ITA-9 [1] INSTITUTE: Ospedale Maggiore di Milano

Servizio di Medicina Nucleare Via Francesco Sforza 35 Pad. Granelli, I-20133 Milano


+39 02 5503 3340 +39 02 5503 5510


Dr. Paolo Gerundini Gherardi Primario


Fabio Riccardo Colombo Rosangela Casati

[3] TYPE OF CYCLOTRON: PET Trace YEAR OF: (I) INSTALLATION 2000 MANUFACTURER: (II) UPGRADE: MODEL: PT GEMS [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.4 Yes No Maximum beam available (µA) 75 60 Typical beam employed (µA) 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




10 8 2 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) PET [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 15O - Water, 13N - Ammonia, 11C - Radiopharmaceuticals to be decided. [9] Do you supply radionuclides to other institutions?



Yes No




182




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 44.4 95 1.2 400 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 22.2 Daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No























183

COUNTRY: ITALY ITA-10 [1] INSTITUTE: Ospedale San Raffaele, Universita Degli Studi

Cattedra di Medicina Nucleare Via Olgettina 60 I-20132 Milano


+39 2 2153056/2643/ 2716 [email protected] +39 2 2640390


Professor Ferruccio Fazio


Mario Matarrese, in charge of the Cyclotron Francesco Perugini, in charge of Operations Sergio Todde, in charge of Radiochemistry

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 2000 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: Protons and deuterons beam. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 50 40 Typical beam employed (µA) 25 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




32 5 25 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE:

Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other


Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 5 Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 3 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



184




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 74 >94 2 700 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 37 1 run/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No























185

COUNTRY: JAPAN JAP-1 [1] INSTITUTE: Biomedical Imaging Research Centre

Fukui Medical University 23-3 Shimoaizuki, Matsuoka, Yoshida, Fukui, 910-1193


+81 776 61 8430 [email protected] +81 776 61 8170


Yoshiharu Yonekura Director, Professor of Medical Imaging


Yasuhisa Fujibayashi, Professor of Molecular Imaging Sadahiko Nishizawa, Associate Professor Atsuo Waki, Assistant Professor

[3] TYPE OF CYCLOTRON: OSCAR 5, superconducting, negative-ion


MANUFACTURER: NKK (II) UPGRADE: MODEL: Oxford [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 12 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




26 16 2 8 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 18F — 0.5/week Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




186




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 37 96 4.2 200 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F












Acetate 20 1/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 4 1/month 16O(p,α)13N Yes No Yes No Yes No




Water 0.37 20/week 15N(p,n) 15O CO CO2 O2

0.37 0.37 0.37

1/week 1/week 1/week

15N(p,n) 15O 15N(p,n) 15O 15N(p,n) 15O


Name (list)





64Cu 0.37 1- 2/week Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): 64Cu - ATSM (Hypoxia), 62Cu - ATSM (Hypoxia) and 67Cu - PTSM (Perfusion)

187

COUNTRY: JAPAN JAP-2 [1] INSTITUTE: Daiichi Radioisotope Laboratories, Ltd.

453-1 Shimo-okura Matsuo-machi Sanbu-gun Chiba 289-1592


+81 479 86 4721 [email protected] +81 479 86 5112


Mr. Takashi Syogenji Manager, RI Production Group


Yasuharu Sato

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 30 Yes No Maximum beam available (µA) 350 Typical beam employed (µA) 300 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




188




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F



























64Cu Yes No Yes No 67Ga 2/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 5/week Yes No Yes No 124I Yes No Yes No 201Tl 1/week Yes No Yes No 211At Yes No Yes No


189

COUNTRY: JAPAN JPN-3 [1] INSTITUTE: Daiichi Radioisotope Laboratories, Ltd.

453-1 Shimo-okura Matsuo-machi Sanbu-gun Chiba 289-1592


+81 479 86 4721 [email protected] +81 479 86 5112


Mr. Takashi Syogenji Manager, RI Production Group


Yasuharu Sato

[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1984 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-40 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 30 Yes No Maximum beam available (µA) 200 Typical beam employed (µA) 180 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




190




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F



























64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 4/week Yes No Yes No 211At Yes No Yes No


191

COUNTRY: JAPAN JPN-4 [1] INSTITUTE: Department of Radiology

University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113


+81 3 381 55411 ext. 5129 +81 3 5800 8935


Toshimitsu Momose, MD Assistant Professor


Shinya Oku

[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1988 MANUFACTURER: Sumitmo Heavy

Industries, Ltd. (II) UPGRADE:

MODEL: Cypris 370 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) PET clinical

applications [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




192




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG Yes No Yes No DOPA Yes No Yes No Yes No Yes No Yes No Yes No






NHSP Yes No Yes No NHPB Yes No Yes No Methionine Yes No Yes No Yes No Yes No






Ammpnia Yes No Yes No Yes No




O2 CO2 Water CO








193

COUNTRY: JAPAN JPN-5 [1] INSTITUTE: Gunma University School of Medicine

39-15 Showa-machi 3-chome Maebashi-shi, Gunma-ken 371




Professor Keigo Endo Chairman


Tomio Inoue, M.D. Kunio Matsubara, PhD. Katsumi Tomiyoshi, PhD.

[3] TYPE OF CYCLOTRON: Baby cyclotron YEAR OF: (I) INSTALLATION 1983 MANUFACTURER: Japan Steel Works,

Ltd. (II) UPGRADE:

MODEL: BC 1700 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 30 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




16 10 5 0.5 0.5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 0.5 Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F - α- Methyl - Tryptophan, 11C - Annexine [9] Do you supply radionuclides to other

institutions?


Yes No


Yes No




194




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 4 -5 60 2.0 50 Yes

No 20Ne (d, α) 18F 4 16O (α, d) 18F






18FDG 4 -5 5/week Yes No Yes No FAMT 4 1/week Yes No Yes No Yes No Yes No Yes No Yes No






Choline 10 - 15 1/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 10 1/month 16O(p, α)13N Yes No Yes No Yes No




O2 21 1/week 15N(p, n) 15O Water 10 1/month 15N(p, n) 15O








195

COUNTRY: JAPAN JPN-6 [1] INSTITUTE: HIMEDIC Imaging Center at Lake Yamanaka

562-12 Yanagihara, Hirano Yamanakako-mura, Minamitsuru-gun


+81 555 65 9135 [email protected] +81 555 20 3007


Dr. Michiru Ide President


[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1993 MANUFACTURER: Sumitomo Heavy


MODEL: HM 18 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 70 50 Typical beam employed (µA) 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




196




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 29 94 1.3 450 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F


















Ammonia 3 20/week 16O(p,α)13N Yes No Yes No Yes No











197

COUNTRY: JAPAN JPN-7 [1] INSTITUTE: Hokkaido University, Graduate School of Medicine

Department of Tracer Kinetics Kita 15 Nishi 7 Kita-ku, Sapporo 060-8638


+81 11 706 5150 [email protected] +81 11 706 7155


Nagara Tamaki Professor and Chairman


Yuji Kuge, Associate Professor

[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 1998 MANUFACTURER: Sumitomo Heavy


MODEL: CYPRIS-HM 18 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 20 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




20 15 2 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C - NHSP, 18F DOPA, 11C Palmitic Acid , 11C CGFI 2177 [9] Do you supply radionuclides to other

institutions?


Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 2 Gamma camera Single photon tomography (SPET) 5 Positron emission tomography (PET) – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



198




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 50 95 1.8 240 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F












Acetate 8 2/week Yes No Yes No Methyonine 7 1/week Yes No Yes No Flumazenil 5 1/week Yes No Yes No Yes No Yes No






Ammonia 2 Occasionally 16O(p,α)13N Yes No Yes No Yes No




Water 1.5 2/week 14N(d,n) 15O O2 0.5 2/week 14N(d,n) 15O CO CO2

2.0 1.0

3/week 2/week

14N(d,n) 15O 14N(d,n) 15O








199

COUNTRY: JAPAN JPN-8 [1] INSTITUTE: Hyogo Institute for Aging Brain and Cognitive Disorders

520 Saisho-ko, Himeji Hyogo 670


+81 792 95 5511 [email protected] +81 792 95 8199


Dr. Masahiro Sasaki Chief, Nuclear Pharmacology Laboratory


[3] TYPE OF CYCLOTRON: Superconducting negative ion cyclotron


MANUFACTURER: Oxford (II) UPGRADE: MODEL: OSCAR-2 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 12 Yes No Maximum beam available (µA) 100 Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




6 5 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C MPHA [9] Do you supply radionuclides to other institutions?



Yes No




200




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 15 50 5 25/ 95% Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 4 2 - 3/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Methionine 2 - 3/year Yes No Yes No NMSP 2 - 3/year Yes No Yes No Yes No Yes No Yes No Yes No










Water 5 6 - 10/week 13N(p, n ) 15O O2 5 2 - 5/month 13N(p, n ) 15O CO 5 2 - 5/month 13N(p, n ) 15O








201

COUNTRY: JAPAN JPN-9 [1] INSTITUTE: Institute for Biofunctional Research

5-7-1 Fujishiro-dai, Suita-shi Osaka 565


+81 6 834 7000 [email protected] +81 6 872 8761


Dr. Naoto Hashimoto Director


Norimasa Ejima



MODEL: HM 18 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 25 20 Typical beam employed (µA) 15-20 10-15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




~24 810 10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?


[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site? Specific to animal PET studies.

Yes No




202




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F












11C - N2 40-50 1 per month Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






13N – H2

16O+5mM EtOH

1.7 1 per 3 months Yes No

Yes No Yes No




15O – N2+O2 (0.4%)

7.5 (2-3) × (5-7)








203

COUNTRY: JAPAN JPN-10 [1] INSTITUTE: International Medical Centre of Japan

Radiology Department 1-21-1 Toyama, Shinjaku-ku


+81 3 3202 7181 [email protected] +81 3 3202 7181


Toshihiko Hara, MD Chief - Nuclear Medicine


Noboru Kosaka, MD }three technologists

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1994 MANUFACTURER: Japan Steel Works,

Ltd. (II) UPGRADE:

MODEL: BC 2010N [4] CYCLOTRON CHARACTERISTICS: p.d. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 20 1 Yes No Maximum beam available (µA) 50 30 Typical beam employed (µA) 30 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




20 10 5 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 1 Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




204




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 18.5 70 2 260 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 7.4 Yes No Yes No Choline 3.7 Yes No Yes No Yes No Yes No Yes No Yes No






Choline 14.8 Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No










Water 3.7








205

COUNTRY: JAPAN JPN-11 [1] INSTITUTE: Japan Atomic Energy Research Institute (JAERI)

1233 Watanuki, Takasaki Gunma 370-1292


+81 27 346 9420 [email protected] +81 27 346 9688


Dr. Toshiaki Sekine Deputy Director Department of Radiation Research for Environment and Resources


Ms. Noriko Shigeta Ishikoka Mr. Sutoshi Watanabe

[3] TYPE OF CYCLOTRON: AVF Cyclotron, K-110


MANUFACTURER: Sumitomo Heavy Industries

(II) UPGRADE:

MODEL: 930 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 90 50 100 Yes No Maximum beam available (µA) 5 7 7 Typical beam employed (µA) 5 5 3 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




101 15 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 32 Radiography: Materials science: 28 Proton therapy: Physics: 12 Neutron therapy: Activation analysis: Other (specify) 29,cyclotron technology

development [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 76Br, 77Br [9] Do you supply radionuclides to other

institutions?


Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry 2 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



206




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F 0.1






18FDG 0.03 1/month Yes No Yes No 18F - WATER 0.1 2/week Yes No Yes No Yes No Yes No Yes No Yes No






Mehionine 0.4 3/week Yes No Yes No CO2 3 8/week Yes No Yes No Yes No Yes No Yes No Yes No






NO-3 0.3 15/week 16O(p,α) 13N Yes No

Yes No Yes No










COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): – Products with our cyclotron are used in plant physiology only. Once, we have produced 186Re for medical research. – Production of this radionuclide, for medical purposes may be done again. – Metallic positron emitters 48V, 52 Mn, 52 Fe and 62 Zn are also produced.

207

COUNTRY: JAPAN JPN-12 [1] INSTITUTE: Kanazawa Cardiovascular Hospital

Ha 16 Tanaka, Kanazawa Ishikawa


+81 76 253 8000 [email protected] +81 76 253 0008


Mr. Toshihiko Morikawa


[3] TYPE OF CYCLOTRON: Baby cyclotron for medical use


MANUFACTURER: The Japana Steel Works Ltd.

(II) UPGRADE:

MODEL: BC 1710 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 10 Yes No Maximum beam available (µA) 60 60 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




~ 20 ~ 4 ~ 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




208




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F




























COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): …………

209

COUNTRY: JAPAN JPN-13 [1] INSTITUTE: Kyoto University Hospital

Kawahara-cho-54, Shogoin, Sakyo-ku Kyoto 606-8507


+81 75 753 4567 [email protected] +81 75 751 3306


Takahiro Mukai, PhD.


Mr. Haruhiro Kitano


Industries (II) UPGRADE: 1997 (change of electronic

circuit) MODEL: Cypris 325 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 8 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 25 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




14 13 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other: Radiopharmaceuticals

for clinical and animal studies 13

[7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C Raclopride, 11C SCH 23390, 18F DOPA, 18F FLT [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 3 Single photon tomography (SPET) 3 Positron emission tomography (PET) – Clinical 2 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



210




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 40 95 4 350 Yes

No 20Ne (d, α) 18F 17 16O (α, d) 18F






18FDG 14 75/year Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Acetate 4.6 14/year Yes No Yes No Flumazenil 2.5 18/year Yes No Yes No Methionine 6.9 2/year Yes No Yes No Yes No Yes No






Ammonia 2.3 2/year 16O(p,α) )13N Yes No Yes No Yes No




Water 1 100/year 14N(d, n ) 15O CO 1.5/min 100/year 14N(d, n ) 15O O2 CO2

1.5/min 1.5/min

100/year 100/year

14N(d, n ) 15O 14N(d, n ) 15O








211

COUNTRY: JAPAN JPN-14 [1] INSTITUTE: Kyushu University

Department of Radiology, Faculty of Medicine Maidashi 3-1-1, Higashi-ku Fukuoka 812-8582


+81 92 6425 788 +81 92 642 5833


Dr. Yasuo Kuwabara Chief, Nuclear Medicine Section


Masayuki Sasaki Isuyoshi Yoshida Toshimitsu Fukumura

[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1983 MANUFACTURER: Japan Steel Works,

Ltd. (II) UPGRADE: 1998








Yes No




212




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 10 95 2 40 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 2/week Yes No Yes No DOPA Yes No Yes No Estiradiol Yes No Yes No Yes No Yes No






Raclopride 1/week Yes No Yes No Methionine 1/week Yes No Yes No NMPB 1/week Yes No Yes No Yes No Yes No










H2O 1/week 14N(d, n ) 15O CO 1/week 14N(d, n ) 15O O2 CO2

1/week 1/week

14N(d, n ) 15O 14N(d, n ) 15O








213

COUNTRY: JAPAN JPN-15 [1] INSTITUTE: Medical School of Nagoya University

Department of Radiology 65 Tsurumaicho, Showa-ku Nagoya City 466


+81 52 741 2111 or 733 9415


Mr. Masanori Tadokoro


Takeo Ishigaki Masanari Nishino


Ltd. (II) UPGRADE:








Yes No




214




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 16 3 per week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






11C–Methionine 100 1 per month Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No











15O-Water 100 1 per week








215

COUNTRY: JAPAN JPN-16 [1] INSTITUTE: Nagoya City Rehabilitation and Sports Center

1-2 Mikanyama, Yatomi-cho Mizuho-ku, Nagoya 467-8622


+81 52 83 4573 [email protected] +81 52 835 3745


Yoshihiro Ito


Noriyuki Kato Katsumi Araki


Industries (II) UPGRADE:

MODEL: Cypris 370 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 40 40 Typical beam employed (µA) 20 5 - 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




8 2 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C Raclopride , Na 18H [9] Do you supply radionuclides to other institutions?



Yes No




216




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 18 16O (α, d) 18F






18FDG 1.8 1day/week Yes No Yes No DOPA 1 Yes No Yes No Yes No Yes No Yes No Yes No






NMSP 2.5 5 days/year Yes No Yes No Methionine 2.5 3days/year Yes No Yes No Palmitic Acid 2.5 6 days/year Yes No Yes No Acetic Acid Flumazenil

2.5 2.5

6 days/year 1 day/month

Yes No Yes No











Water 4 days/week 14N(d,n )15O CO, CO2 & O2 1.5 days/week








217

COUNTRY: JAPAN JPN-17 [1] INSTITUTE: National Cardiovascular Centre

5-7-1 Fujishirodai, Suita Osaka 565


+81 6 833 5012 [email protected] +81 6 872 7486


Dr. Yoshio Ishida Director of Nuclear Medicine


Dr. Yoshinori Miyake



MODEL: Cypris 370 [4] CYCLOTRON CHARACTERISTICS:

1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 70 70 Typical beam employed (µA) 20 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




20 1 2 5 12 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: 12 Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other

institutions?


Yes No


Yes No




218




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F

In future 22 94 0.7 60 Yes

No 20Ne (d, α) 18F 18.5 16O (α, d) 18F






18FDG 1.5 1/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Acetate 3.3 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 1.4 5/week Yes No Yes No Yes No





Water 3.3 3- 9/week 14N(d, n ) 15O CO,CO2,O2 0.01 9/week








219

COUNTRY: JAPAN JPN-18 [1] INSTITUTE: National Centre of Neurology and Psychiatry

4-1-1 Ogawahigashi-cho 4-chome, Kodaira, Tokyo 187


+81 423 412 711 [email protected] +81 423 446 745


Dr. Hiroshi Matsuda Director, Radiological Division


Yutaka Takayama; Satoru Horikoshi Kenichi Ogawa; Masato Kobayashi

[3] TYPE OF CYCLOTRON: Superconducting compact


MANUFACTURER: Oxford (II) UPGRADE: MODEL: OSCAR, SCC12P [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 12 Yes No Maximum beam available (µA) 11.4 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




220




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 20 1-2 per week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No

















15O-Water 18








221

COUNTRY: JAPAN JPN-19 [1] INSTITUTE: National Institute for Longevity Sciences

Gengo, Morioka Obu 474-8522


+81 562 46 2311 [email protected] +81 562 44 6 596


Dr. Kengo Ito


Dr. Kentaro Hatano Dr. Takashi Kato

[3] TYPE OF CYCLOTRON: Negative ion acceleration AVF


MANUFACTURER: Sumitomo Heavy Industries

(II) UPGRADE:

MODEL: HM-18 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 50 40 Typical beam employed (µA) 20 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




8 4 3 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 18F, 370MBq Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



222




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 17 >93 2 80 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 2.4 1/week Yes No Yes No DOPA 0.875 1/week Yes No Yes No Yes No Yes No Yes No Yes No






Raclopride 0.37 24/year Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No











Water 17.4 30/year 14N(d, n )15O CO 3.7 5/year







COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 11C - SCH 23390 and B-CFT are used for animal experiments (including PET). Some novel radiopharmaceuticals are produced for drug development research.

223

COUNTRY: JAPAN JPN-20 [1] INSTITUTE: National Institute of Radiological Sciences

Advanced Technology Division for Medical Imaging Anagawa 4-9-1, Inage-ku


+81 43 206 3262 [email protected] +81 43 206 3261


Dr. Kazutoshi Suzuki Head


Mr. Toshiaki Irie, Head Mr. Kiyoshi Fukushi, Senior Researcher Mr. Terushi Haradahira, Senior Researcher

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 2000 MANUFACTURER: Japan Steel Works,

Ltd. (II) UPGRADE:

MODEL: BC - 2010 BC-2010 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 20 10 Yes No Maximum beam available (µA) 70 50 Typical beam employed (µA) 20 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




40 36 10 4 26 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No for PET Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 2 Positron emission tomography (PET) 3 – Clinical – Small animal 2 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



224




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 1 - 10 50 1.5 30 Yes

No 20Ne (d, α) 18F 3 16O (α, d) 18F












Methionine 4 8/week Yes No Yes No McN5652X 1-2 3/week Yes No Yes No Raclopride 1-2 1/week Yes No Yes No MP4A 2 1/week Yes No Yes No






Ammonia 2-3 1/week 16O(p,α) 13N Yes No Yes No Yes No





Water 2 6/week 14N(d, n )15O







COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 11C - Ro 15-1788, Ro 15- 4513, NMSP and SCH 23390

225




+81 43 206 3262 [email protected] +81 43 206 3261





[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1994 MANUFACTURER: Sumitomo Heavy






40 34 18 6 16 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No PET Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




226




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 1- 10 20 - 50 1.5 30 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 1 - 10 1 - 2/week Yes No Yes No Labeled Compd. 1 1/week Yes No Yes No Yes No Yes No Yes No Yes No






Ro15 - 4513 3 1 - 2/week Yes No Yes No Methionine 4 6/week Yes No Yes No WAY 100635 1 -2 2 - 3/week Yes No Yes No MP4A 1 - 2 1/week Yes No Yes No






Ammonia 2-3 1/week 16O(p,α) 13N Yes No NPC 1 1/month Yes No Yes No





Water 2 12/week 14N(d, n) 15O







COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 11C - NMSP, McN 5652X(+),McN 5652, Ro15 - 1788, SCH 23390, Raclopride, FLB 457, NMPB and Cyanoimipramine

227




+81 43 206 3262 [email protected] +81 43 206 3261





[3] TYPE OF CYCLOTRON: AVF multi-particle YEAR OF: (I) INSTALLATION 1973 MANUFACTURER: Thomson CSF (II) UPGRADE: MODEL: AVF-930 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 90 55 145 110 Yes No Maximum beam available (µA) 20 20 10 10 Typical beam employed (µA) 20 15 10 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




40 9 6 6 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 4 Radiography: Materials science: Proton therapy: 3 Physics: 16 Neutron therapy: Activation analysis: Other (specify) 2 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




228




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 1-10 20-50 1.5 30 Yes

No 20Ne (d, α) 18F 3 16O (α, d) 18F






18FDG 1-10 1-2/week Yes No Yes No Labeled Compd 1 1/week Yes No Yes No Yes No Yes No Yes No Yes No






WAY 100635 1-2 1-2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 2-3 1/week Yes No NPC 1 1/month Yes No Yes No





Water 2 6/week 14N(d, n) 15O






64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 3 1/month Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 11C - NMSP, MCN 5652X(+), MCN 5652, RO15-1788, SCH 23390, RACLOPRIDE, FLB457, NMPB, CYANOIMIPRAMINE, 38K

229

COUNTRY: JAPAN JPN-23 [1] INSTITUTE: National Research Institute for Metals

1-2-1 Sengen, Tsukuba Ibaraki 305


+81 298 592 014 [email protected] +81 298 592 014


Mr. Johsei Nagakawa Group Leader


Mr. Norikazu Yamamoto, Subgroup Leader Mr. Yoshiharu Murase, Researcher Mr. Toshimitsu Fukuzawa, Researcher

[3] TYPE OF CYCLOTRON: AVF (fixed energy) YEAR OF: (I) INSTALLATION 1986 MANUFACTURER: Japan Steel Works,

Ltd. (II) UPGRADE:

MODEL: BC 1710 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 10 26 20 Yes No Maximum beam available (µA) 50 50 20 20 Typical beam employed (µA) 30 30 10 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




50 40 10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: 40 Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




230




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F





























COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) We use our cyclotron only for studying radiation damage in nuclear reactor materials and not for RADIONUCLIDE PRODUCTION

231

COUNTRY: JAPAN JPN-24 [1] INSTITUTE: Nihon Medi-Physics Co. Ltd. Chiba Facility

3-1 Kitasode, Sodegaura City Chiba Pref., 299-0266


+81 438 634 771 +81 438 633 306


Dr. Masaji Takahashi Manager of Technical Section 1




MODEL: 750 PV [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 30 Yes No Maximum beam available (µA) 130/55 Typical beam employed (µA) 120/50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




130 90 40 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? — everyday to hospitals. Yes No


Yes No




232




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F




























64Cu Yes No Yes No 67Ga 500(@EOB) 3/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 81Rb

233

COUNTRY: JAPAN JPN-25 [1] INSTITUTE: Nihon Medi-Physics Co. Ltd. Chiba Facility

3-1 Kitasode, Sodegaura City Chiba Pref., 299-0266


+81 438 634 771 +81 438 633 306


Dr. Masaji Takahashi Manager of Technical Section 1



Industries, Ltd. (II) UPGRADE: 1999 (H- acceleration)

MODEL: 480P [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 28 Yes No Maximum beam available (µA) 55 Typical beam employed (µA) 55 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide





If yes and available, name of institution/s & how often? — everyday, to hospitals. Yes No


Yes No




234




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F




























64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 300(@EOS) 5/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 81Rb

235

COUNTRY: JAPAN JPN-26 [1] INSTITUTE: Nihon Medi-Physics Co. Ltd., Hyogo Facility

9-1 Techno Park, Sanda City Hyogo Pref., 669-1339


+81 795 684 771 +81 795 683 071


Mr. Shigeaki Kataoka Manager of Technical Section 1


[3] TYPE OF CYCLOTRON: Fixed field, fixed frequency, accelerating H-ions


MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS:

1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 Yes No Maximum beam available (µA) 400 Typical beam employed (µA) 360 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




132 120 12 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F [9] Do you supply radionuclides to other

institutions? If yes and available, name of institution/s & how often? Everyday, to Hospitals

Yes No


Yes No




236




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F




























64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 120(EOB) 1/2week Yes No Yes No 123I 500(EOS) 2-3/week Yes No Yes No 124I Yes No Yes No 201Tl 400(EOS) 2-3/week Yes No Yes No 211At Yes No Yes No


237

COUNTRY: JAPAN JPN-27 [1] INSTITUTE: Nihon Medi-Physics Co. Ltd., Hyogo Facility

9-1 Techno Park, Sanda City Hyogo Pref., 669-1339


+81 795 684 771 +81 795 683 071


Mr. Shigeaki Kataoka Manager of Technical Section 1


[3] TYPE OF CYCLOTRON: Fixed field, fixed frequency, accelerating H-ions


MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16-30 Yes No Maximum beam available (µA) 400 Typical beam employed (µA) 360 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide





If yes and available, name of institution/s & how often? Everyday, to Hospitals Yes No


Yes No




238




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F




























64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 120(EOB) 1/2week Yes No Yes No 123I 500(EOS) 2-3/week Yes No Yes No 124I Yes No Yes No 201Tl 400(EOS) 2-3/week Yes No Yes No 211At Yes No Yes No


239

COUNTRY: JAPAN JPN-28 [1] INSTITUTE: Nikko Memorial Hospital

Shintomi-cho 1-5-13 Muroran-shi, Hokkaido 51


+81 143 24 1331 +81 143 22 5296


Masahiro Shinohara Chief of Radiology


Takafumi Mochizuki, Radiology

[3] TYPE OF CYCLOTRON: Deep valley fixed energy proton


MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




240




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 11 40% 1.1 100 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 3.7 1 Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
























241

COUNTRY: JAPAN JPN-29 [1] INSTITUTE: Nishidai Clinic Diagnostic Imaging Center, Inc.

1-83-8 Takashimadaira, Itabashi-ku Tokyo 175-0082


+81 3 5922 0700 [email protected] +81 3 5922 0701


Kimiichi Uno, M.D. Chairman


Keiichi Nakagawa, M.D. Katsumi Tomiyoshi, PhD., M.D.

[3] TYPE OF CYCLOTRON: Baby cyclotron YEAR OF: (I) INSTALLATION 2000 MANUFACTURER: Sumitomo Heavy






11 10 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F - α - Methyl Tyrosine (18F AMT) [9] Do you supply radionuclides to other institutions?



Yes No




242




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 20 95 2.0 100 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 10-15 1-2/day Yes No Yes No 18F 10 1/week Yes No Yes No Yes No Yes No Yes No Yes No






MET 5 1/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 10 3/day 16O(p,α) ) 13N Yes No Yes No Yes No





Water 5 1/week 13N(p, n) 15O CO, O2 & C O2 10 1/week







COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced We carry out clinic diagnostic studies only, in collaboration with Gunma University School of Medicine.

243

COUNTRY: JAPAN JPN-30 [1] INSTITUTE: Nishijin Hospital

1035 Mizomae-cho, Kamigyo-ku Kyoto 602




Dr. Takahiro Kanatsuna President


Akira Fijii Hitoshi Horii Kazuo Wakita

[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1985 MANUFACTURER: Japan Steel Works,

Ltd. (II) UPGRADE:

MODEL: BC 1710 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 10 Yes No Maximum beam available (µA) 10 ~ 50 Typical beam employed (µA) 70 ~ 80 extracting

efficiency: (60 ~ 65%)

[5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




6 ~10 6 ~10 4 ~ 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




244




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






























245

COUNTRY: JAPAN JPN-31 [1] INSTITUTE: Nishina Memorial Cyclotron Centre

348-58 Tomegamori, Takizawa Iwate 020-0173


+81 19 688 6071 [email protected] +81-19 688 6072


Tsuneo Takahashi Director


Shoji Futatsugawa, General Manager Kouichiro Sera, Professor Satoru Hatakeyama, Manager

[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1989 MANUFACTURER: Shimazu (II) UPGRADE: MODEL: MCY 1750 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.9 8.3 Yes No Maximum beam available (µA) 30 30 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




246




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 14.5 1 per week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No

















Oxygen Carbon dioxide Water








247

COUNTRY: JAPAN JPN-32 [1] INSTITUTE: Osaka City University Medical School

Division of Nuclear Medicine 1-4-3 Asahi-machi, Abenoku Osaka 545-8585




Dr. Hironobu Ochi Professor, Division of Nuclear Medicine


Dr. Masaji Okamoto Susumu Shiomi, Associate Professor

[3] TYPE OF CYCLOTRON: Compact superconducting, negative ion


MANUFACTURER: Oxford-NKK (II) UPGRADE: 1993 MODEL: OSCAR SCC12P [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 12 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




248




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 5 50 5 50 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 5 15/month Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Methionine 5 2/month Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 2 10/month Yes No Yes No Yes No





CO2 2 2/month O2 4 CO 4








249

COUNTRY: JAPAN JPN-33 [1] INSTITUTE: Research Institute for Brain & Blood Vessels Akita

6-10 Senshu-Kubota-machi Akita City


+81 188 330 115 [email protected] +81 188 332 104


Dr. Kazuhiro Takahashi Head


Masanobu Ibaraki


Ltd. (II) UPGRADE:

MODEL: BC-168 [4] CYCLOTRON CHARACTERISTICS:

1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 8 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 30 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




14 2 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other

institutions?


Yes No


Yes No




250




18O used


18OH2 (ml) 18O2 (ml) 18OH2

(g)

18O2 (l)

18O (p, n) 18F 20 60 1.5 40 Yes No

20Ne (d, α) 18F 16O (α, d) 18F












Methionine 6 2/week Yes No Yes No 3NHPB 2 15/year Yes No Yes No NMSP 2 15/year Yes No Yes No Yes No Yes No











H2O 4 20/week 14N(d, n )15O O2 20 6/week CO 10 6/week








251

COUNTRY: JAPAN JPN-34 [1] INSTITUTE: Tohohu University

Cyclotron and Radioisotope Center (CYRIC) Aramaki, Aoba-ku Sendai 980-7


+81 217 7798 [email protected] +81 263 5358


Professor Tsutomu Shinozuka


[3] TYPE OF CYCLOTRON: AVF multi particle YEAR OF: (I) INSTALLATION 1977 MANUFACTURER: Sumitomo Heavy


MODEL: 680 AVF [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 40 25 65 50 Yes No Maximum beam available (µA) 15 12 5 5 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




87 ~ 96 16 12 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




252




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 11 3-4 per week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Methionine Yes No Yes No Doxepin Yes No Yes No Nemonapride Yes No Yes No Yes No Yes No











Water ~ 30 2 per week








253

COUNTRY: JAPAN JPN-35 [1] INSTITUTE: Tokyo Metropolitan Institute of Gerontology

35-2 Sakaecho Itabashi Tokyo 173-0015


+81 3 3964 3241 ext. 3505 [email protected] +81 3 3964 2188


Dr. Kiichi Ishiwata Head, Positron Medical Center


Dr. Yuichi Kimura, Senior Research Scientist Dr. Toru Sasaki, Research Scientist Kenji Ishii, M.D., Research Scientist Keiichi Oda, Research Scientist

[3] TYPE OF CYCLOTRON: AVF, positive ion YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: Sumitomo Heavy


MODEL: Cypris 370 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 24 (not

routinely used)

18 (not routinely

used)

Yes No

Maximum beam available (µA) Typical beam employed (µA) 30 10 ~ 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




254




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG Yes No Yes No 18F-DOPA Yes No Yes No Yes No Yes No Yes No Yes No






Methionine Yes No Yes No Flumazenil Yes No Yes No N-methyl spiperone

Yes No Yes No


Name (list)





Yes No Yes No





Oxygen Carbon dioxide Carbon monoxide








255

COUNTRY: JAPAN JPN-36 [1] INSTITUTE: University of Tokyo

Department of Radiology 7-3-1 Hongo Bunkyo-ku Tokyo 113


+81 3 3815 5411 ext. 5129 +81 3 5800 8678


Professor Johru Ontoke


Toshimitsu Momose Shinya Oku

[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1988 MANUFACTURER: Sumitomo Heavy


MODEL: Cypris 370 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) Typical beam employed (µA) 50 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




256




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG Yes No Yes No 18F-DOPA Yes No Yes No Yes No Yes No Yes No Yes No






Methionine Yes No Yes No N-Methyl- spiperone

Yes No Yes No












Water Oxygen C. monoxide Carbon dioxide








257

COUNTRY: KAZAKHSTAN KAZ-1 [1] INSTITUTE: Institute of Nuclear Physics

480082 Almaty-82, Ibragimov str., 1


+7 327 2 546 433 [email protected] +7 327 2 546 517


Professor A.A. Arzumanov Head, Accelerator Laboratory


Sychikov Gennadi Popov Yuri Batischev Viktor

[3] TYPE OF CYCLOTRON: Variable energy isochronous K=50 MeV


MANUFACTURER: Efremov Institute, Leningrad

(II) UPGRADE: 1972, converted to variable energy isochronous

MODEL: U 150 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 6-30 12-25 18.5-62 25-50 Yes No Maximum beam available (µA) 500 200 50 100 Typical beam employed (µA) 300 100 20 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




40 16.5 15.7 4.3 3.5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: 1.8 Proton therapy: Physics: 15.7 Neutron therapy: Activation analysis: Other (specify) Neutron Source, 1.7 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 57Co, (5) Mössbauer sources? (specify which & quantity) Yes No 57Co, (1) X ray sources? (specify which & quantity) Yes No 57Co, (4)

109Cd, (6) Intense neutron beam? (specify average En = ?) Yes No 2 MeV [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 201Tl Chloride, 67Ga Citzate, 57Co, 109Cd, 111In, 237Pu, 88Y, 85 Sr [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Hospitals, central clinics, on request.

Yes No


Yes No




258




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α, d) 18F




























64Cu Yes No Yes No 67Ga 13 Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 3.0 Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 3.3 On request. Yes No Yes No 211At Yes No Yes No


259

` COUNTRY: KOREA, REPUBLIC OF ROK-1 [1] INSTITUTE: Asan Medical Center

Seoul


+82 2 2224 4590 [email protected] +82 2 2224 4588


Dr. Seung Jun Oh


[3] TYPE OF CYCLOTRON: H-/D- YEAR OF: (I) INSTALLATION 2001 MANUFACTURER: IBA, s.a., Belgium (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 50 25 Typical beam employed (µA) 38 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




12 9 3 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 12 Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C-neuroreceptor imaging radiopharmaceuticals [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Two-three times in a week. Yes No


Yes No




260




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 185 95 2.0 480 Yes

No 20Ne (d, α) 18F 16O (α,d )18F












Methonine 18.5 3-4/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 18.5 1-2/week 160 (p,a)13N Yes No Yes No Yes No





Water 18.5 1-2/week 14n(D,N)15O








261

COUNTRY: KOREA, REPUBLIC OF ROK-2 [1] INSTITUTE: Korea Cancer Centre Hospital

Korea Atomic Energy Research Institute 215-4 Gongneung-Dong Nowon-Ku, Seoul


+82 2 970 1331 [email protected] +82 2 970 1332


CHAI, Jong-Seo Senior Researcher/Project Manager


KIM, Yu-Seok, Senior Engineer HONG, Seong-Seok, Engineer LEE, Min-Yong, Engineer

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 2001 MANUFACTURER: KCCH (II) UPGRADE: MODEL: KCCH-13 [4] CYCLOTRON CHARACTERISTICS: H+ 13 MeV, 4 sector magnet, 4th harmonics, PIG internal ion source, GUI computer

control. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 13 Yes No Maximum beam available (µA) 60 Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




24 18 6 4 6 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): F-18, FDG [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? National Cancer Center; Ajou University Hospital, Yonsei University Hospital.

Yes No


Yes No




262




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α,d )18F






























263

COUNTRY: KOREA, REPUBLIC OF ROK-3 [1] INSTITUTE: Korea Cancer Centre Hospital

Korea Atomic Energy Research Institute 215-4 Gongneung-Dong Nowon-Ku, Seoul


+82 2 970 1331 [email protected] +82 2 970 1332


CHAI, Jong-Seo Senior Researcher/Project Manager


KIM, Yu-Seok, Senior Engineer HONG, Seong-Seok, Engineer LEE, Min-Yong, Engineer

[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1987 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 50 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 50 25 50.5 Yes No Maximum beam available (µA) 200 Typical beam employed (µA) 60 low current low current [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




40 20 6 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F production by 20Ne target; High purity 123I production by 124Xe target; on plan: 11C, 45Ti, 211At, 186Re, 124I [9] Do you supply radionuclides to other

institutions? If yes and available, name of institution/s & how often? 67Ga-citrate, 201TICI, Na123I, 123I-mIBG – 1 per week

Yes No


Yes No




264




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α,d )18F






























265

COUNTRY: KOREA, REPUBLIC OF ROK-4 [1] INSTITUTE: Samsung Medical Centre

Department of Nuclear Medicine Sungkyunkwan University School of Medicine 50 Ilwon-Dong, Kangnam-Ku Seoul 135-710


+82 2 3410 2623 [email protected] +82 2 3410 2639


Yearn Seong Choe Assistant Professor/Senior Research Scientist


[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1994 MANUFACTURER: GEMS (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.4 Yes No Maximum beam available (µA) 75 60 Typical beam employed (µA) 20 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 5 Single photon tomography (SPET) 5/5 Positron emission tomography (PET) 1 – Clinical 1/1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



266




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 37 97 1.5 ~ 310 Yes

No 20Ne (d, α) 18F 16O (α,d )18F






18FDG 7 -11 6/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






CFT Yes No Yes No Methionine 1/week Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia > 1.9 1/week 16O (p, α) 13N Yes No Yes No Yes No





Water > 3.7 1/week 14N(d, n) 15O








267

COUNTRY: KOREA, REPUBLIC OF ROK-5 [1] INSTITUTE: Seoul National University Hospital

Department of Nuclear Medicine 28 Yungun-Dong, Chongro-Ku Seoul 110-744


+82 2 760 3805 [email protected] +82 2 745 7690


Dr. Jae Min Jeong Director, Cyclotron and Radiochemistry; Associate Professor


In Won Lee, Chief Technologist

[3] TYPE OF CYCLOTRON: Proton only YEAR OF: (I) INSTALLATION 1994 MANUFACTURER: EBCO Technology (II) UPGRADE: MODEL: TR-13 [4] CYCLOTRON CHARACTERISTICS:

1H 2H 3He 4He Dual Beams Beam energies (MeV) 13 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide





If yes and available, name of institution/s & how often? Yunsei University Hospital — 5/week; National Cancer Center — 2/week

Yes No


Yes No




268




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 18 97 0.5 200 Yes

No 20Ne (d, α) 18F 16O (α,d )18F












Methionine 1 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No











Water 1.5 2/week 15N(p, n) 15O








269

COUNTRY: MEXICO MEX-1 [1] INSTITUTE: Unidad PET, Facultad de Medicina

Univesidad Nacional Autónoma de México Circuito Escolar S/N, Ciedad Universitaria Del. Coyoacán 04510 México, D.F.


+52 5623 22 88 or 5623 22 99 [email protected] +52 5623 21 15 or 5623 22 41


Dra. Nora E. Kerik Rotenberg Chief of Department


Dr. René Drucker Colín, Scientific Committee Member M. en C. Adolfo Zárate Morales, Cyclotron Operator M. en C. Martha Pedraza López, Radiopharmacist Q.F.I. Irma Martínez Hernández, Radiopharmacist Fís. Miguel Angel Avila Rodríguez, Cyclotron Operators

[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 2000 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




13 8 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F - DOPA and Raclopride [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? To hospitals in the future Yes No


Yes No




270




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 37 95-97 0.8 7 250 Yes

No 20Ne (d, α) 18F 16O (α,d )18F












HCN 33.3 1/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 3.7 2/week 16O(p, α)13N Yes No Yes No Yes No





Water 28 15N(p,n ) 15O








271

COUNTRY: NETHERLANDS NET-1 [1] INSTITUTE: Accrec B.V.

Eindhoven University of Technology (TUE) Cyclotron Building Postbus 513, NL-5600 MB Eindhoven


+31 40 247 4048 [email protected] +31 40 243 8060


Professor Dr. M.J.A. de Voight/Professor Dr. M.J. u.d. Wiel Directors, Accrec B.V.


[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION Planned during 2002 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18-30 Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




272




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α,d )18F






























273




+31 40 247 4048 [email protected] +31 40 243 8060




[3] TYPE OF CYCLOTRON: 2nd harmonic dees with 6th harmonic flat top dees


MANUFACTURER: Home-made (II) UPGRADE: MODEL: ILEC [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 3 Yes No Maximum beam available (µA) Typical beam employed (µA) 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




274




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α,d )18F






























275




+31 40 247 4048 [email protected] +31 40 243 8060




[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1963 MANUFACTURER: Philips (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 3- 30 2-20 Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




~ 80 ~ 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Yes Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) Catalysis/

radiochemistry [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 (PEP) Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



276




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α,d )18F












11C alkanes weekly Yes No Yes No Yes No Yes No






NO 16O(p, α)13N Yes No Ammonia 16O(p, α)13N Yes No Yes No





N2 150 14N (d, n) 15O


Name (list)






COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) – Commercial isotope production for Nycomed, Amersham and Cygne – Production of short - lived positron emitters for University Research in catalysis using PEP – Beam analysis techniques for material research (University related) – This AVF Cyclotron will be shut - down in 2002 - 03 and a new Negative ion , IBA, Cyclone 30, 18-30 MeV is planned.

277

COUNTRY: NETHERLANDS NET-4 [1] INSTITUTE: Groningen University Hospital

PET Centre P.O. Box 30.001 NL-9700 RB Groningen


+31 50 361 3311 +31 50 361 1687


Professor William Vaalburg


A.M.J. Paans P.H. Elsinga

[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 17F [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 8.5 Yes No Maximum beam available (µA) 780 750 Typical beam employed (µA) 20 - 30 20 - 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




20 3.5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




278




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 20 > 94 1 300 Yes

No 20Ne (d, α) 18F 7 16O (α,d )18F






18FDG > 8 200/year Yes No Yes No DOPA 0.5 60/year Yes No Yes No MPPF 0.5 10/year Yes No Yes No Yes No Yes No






Choline > 3 60/year Yes No Yes No Tyrosine 2-3 40/year Yes No Yes No Raclopride 0.5 30/year Yes No Yes No Verapamil Bicarbonate Acetate CSP - 12388

2 > 3 > 3 1

20/year 20/year 10/year 20/year








Ammonia 0.8 - 1.0 500/year 16O (p, n) 13N Yes No Yes No Yes No





Water 2-4 600/year








279

COUNTRY: NETHERLANDS NET-5 [1] INSTITUTE: Mallinckrodt Medical

P.O. Box 3 NL-1755 ZG Petten


+31 224 567 890 [email protected] +31 224 563 566


Eng. (Ir.) H. Buurlage General Manager


Eng. (Ir.) F. de Lange, Head of Cyclotron Operations

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1992 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 Yes No Maximum beam available (µA) 400 Typical beam employed (µA) 2×180 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




130 130 0 10 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 0 Radiography: 0 Materials science: 0 Proton therapy: 0 Physics: 0 Neutron therapy: 0 Activation analysis: 0 Other (specify) 0 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): None [9] Do you supply radionuclides to other institutions?



Yes No




280




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α,d )18F




























64Cu Yes No Yes No 67Ga 2/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 1/week Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 5/week Yes No Yes No 211At Yes No Yes No


281

COUNTRY: NETHERLANDS NET-6 [1] INSTITUTE: Mallinckrodt Medical

P.O. Box 3 NL-1755 ZG Petten


+31 224 567 890 [email protected] +31 224 563 566


Eng. (Ir.) H. Buurlage General Manager


Eng. (Ir.) F. de Lange, Head of Cyclotron Operations

[3] TYPE OF CYCLOTRON: AVF – Positive ion YEAR OF: (I) INSTALLATION 1966 MANUFACTURER: Philips (II) UPGRADE: 1996 MODEL: AVF [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10-30 Yes No Maximum beam available (µA) 150 Typical beam employed (µA) 120 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




100 100 0 10 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 0 Radiography: 0 Materials science: 0 Proton therapy: 0 Physics: 0 Neutron therapy: 0 Activation analysis: 0 Other (specify) 0 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




282




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α,d )18F




























64Cu Yes No Yes No 67Ga 2/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 1/week Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 5/week Yes No Yes No 211At Yes No Yes No


283

COUNTRY: NETHERLANDS NET-7 [1] INSTITUTE: Vrije Universiteit

BV Cyclotron VU De Boelelaan 1085c NL-1081 HV Amsterdam


+31 20 4449 123 [email protected] +31 20 4449 128


Dr. P.J. Van der Jagt CEO


P.J. van Leuffen, Manager – Daily Operations R. Mooy, Chief Cyclotron Operator Dr. Ing. F. van Langevelde, (Health) Physicist Dr. P. Kruyer, Chemist

[3] TYPE OF CYCLOTRON: H- YEAR OF: (I) INSTALLATION 1997 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 80 Typical beam employed (µA) 35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




25 22 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F, 11C, 13N, 15O [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 18F-FDG planned Yes No


Yes No




284




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α,d )18F












Flumazenil Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No


















285

COUNTRY: NETHERLANDS NET-8 [1] INSTITUTE: Vrije Universiteit

BV Cyclotron VU De Boelelaan 1085c NL-1081 HV Amsterdam


+31 20 4449 123 [email protected] +31 20 4449 128


Dr. P.J. Van der Jagt CEO


P.J. van Leuffen, Manager – Daily Operations R. Mooy, Chief Cyclotron Operator Dr. Ing. F. van Langevelde, (Health) Physicist Dr. P. Kruyer, Chemist

[3] TYPE OF CYCLOTRON: H+ YEAR OF: (I) INSTALLATION 1965 MANUFACTURER: Philips (II) UPGRADE: MODEL: AVF [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 6-28 3-16 10-45 6-32 Yes No Maximum beam available (µA) 200 Typical beam employed (µA) 35 15 10 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 3 Single photon tomography (SPET) 2 Positron emission tomography (PET) 2 – Clinical 1 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



286




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α,d )18F





























COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 81Rb is produced nine times per week for the production of rubidum/krypton generators.

287

COUNTRY: NORWAY NOR-1 [1] INSTITUTE: University of Oslo

Department of Physics P.O. Box 1048, Blindern N-0316 Oslo


+47 22 856 460 +47 22 856 422


Professor Magne Guttormsen


John Rekstad Svein Messelt

[3] TYPE OF CYCLOTRON: Sector focusing YEAR OF: (I) INSTALLATION 1979 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 35 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 35 17 47 35 Yes No Maximum beam available (µA) 100 80 10 20 Typical beam employed (µA) 70 50 5 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




288




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α) 18F 16O (α,d )18F






























289

COUNTRY: PHILIPPINES PHI-1 [1] INSTITUTE: Positron Emission Tomography and Cyclotron Facility

St. Luke’s Medical Center E. Rodriguez Avenue Quezon City 1102


+63 2 725 6717 [email protected] +63 2 725 6717


Jonas Y. Santiago, MD, FACNP Chief, Section of PET


Nathaniel B. de Vera, Manager, PET & Cyclotron Facility and Medical Physicist Katheryn S. Mandap, Radiochemist

[3] TYPE OF CYCLOTRON: Negative Ion YEAR OF: (I) INSTALLATION 2001 (September) MANUFACTURER: GE (II) UPGRADE: MODEL: Minitrace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 9.6 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




290




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F





























COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) This is the first cyclotron in the country; will be dedicated to produce 18F FDG and 13N Ammonia for use in PET procedures of the Medical Center and supply to other users on request. Detailed information will be supplied when the unit becomes operational. .

291

COUNTRY: POLAND POL-1 [1] INSTITUTE: Henryk Niewodnicanczanski Institute of Physics

(HNIP), Radzikowskiego 152 PL-31-341 Krakow


+48 12 637 0222 [email protected] +48 12 637 5441


Mr. Edmund Makewicz, MSc., EE Head of Cyclotron Unit


Mr. Henryk Doruch, MSc., EE/Mr. Marek Talach, MSc., EE Dr. Ryszard Taraszkiewicz, Cyclotron Research Dr. Barbara Petelenz, head – Laboratory of Physical Chemistry Dr. Ewa Ochab, Deputy Head, Laboratory of Physical Chemistry

[3] TYPE OF CYCLOTRON: AVF isochronous YEAR OF: (I) INSTALLATION 1997 MANUFACTURER: HNIP (II) UPGRADE: 2001 MODEL: AIC-144 [4] CYCLOTRON CHARACTERISTICS: K-factor = 60; extraction radius R = 0.62 M. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 20-60 15-30 30-60 Yes No Maximum beam available (µA) 100/45

MeV 100 30

Typical beam employed (µA) 2-5 n/a 3-5 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




Variable [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: planned Radiography: Materials science: Proton therapy: planned Physics: variable Neutron therapy: planned Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No variable X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No planned [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 111In, 211At [9] Do you supply radionuclides to other institutions?



Yes No




292




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F




























64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In variable Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 57Co — occasionally, used on site in test of Si strip detectors, 99Rh — occasionally, used on site for Mössbauer research, 173Hf — occasionally, used on site in model studies of chemistry of transuranium elements, 178W, 181W — occasionally, used on site in model studies of chemistry of transuranium elements.

293

COUNTRY: POLAND POL-2 [1] INSTITUTE: Henryk Niewodnicanczanski Institute of Physics

(HNIP), Radzikowskiego 152 PL-31-341 Krakow


+48 12 637 0222 [email protected] +48 12 637 5441


Mr. Edmund Makewicz, MSc., EE Head of Cyclotron Unit


Mr. Henryk Doruch, MSc., EE/Mr. Marek Talach, MSc., EE Dr. Ryszard Taraszkiewicz, Cyclotron Research Dr. Barbara Petelenz, head – Laboratory of Physical Chemistry Dr. Ewa Ochab, Deputy Head, Laboratory of Physical Chemistry

[3] TYPE OF CYCLOTRON: Isochronous, K-factor = 60


MANUFACTURER: HNIP (II) UPGRADE: 1997 MODEL: AIC-144 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10-60 15-30 30-60 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 5 3 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




Variable [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: variable Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




294




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG daily Yes No Yes No F-Dopa Yes No Yes No ML01 Yes No Yes No ML03 Yes No Yes No






Chlorine Yes No Yes No Deprenyl Yes No Yes No Methionine Yes No Yes No Yes No Yes No






Ammonia O16(p, α)N13 Yes No Yes No Yes No





Water weekly N14(p, α)O15






64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In variable Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At variable Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 173Hf, 175Hf — occasionally, used on site in model studies of chemistry of transuranium elements, 178W, 181W — occasionally, used on site in model studies of chemistry of transuranium elements.

295

COUNTRY: POLAND POL-3 [1] INSTITUTE: Warsaw University

Heavy Ion Laboratory uL Pasteura 5A PL-02-097 Warszawa


+48 22 658 2021 +48 22 659 2714


Professor Dr. hab. Jan Kowracki


Mr. Tomasz Czosnyka Mr. Jerzy Jastrzebski

[3] TYPE OF CYCLOTRON: AVF, 4-sector, 2-dee, 2 m diameter


MANUFACTURER: Magnet - Dubna, rest all Polish parts

(II) UPGRADE: ECR installation, 1997

MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) * Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




100 24 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 123I, 111In [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Planned after the ECR installation Yes No


Yes No




296




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F





























COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) – Basic research, e.g. Coulomb excitation, Giant Dipole Resonances – In-beam high-spin spectroscopy – Radioactive decays in He-jet system and isotope separation in-line.

297

COUNTRY: ROMANIA ROM-1 [1] INSTITUTE: National Institute for Physics and Nuclear Engineering

IFIN-HH Bucharest, Str. Atomistilor 407 Com Magurele, jud. Iiflov., POB MG-6, 76900 Bucharest-Magurele


+40 1 404 23 00/4406 [email protected] +401 4023 1701


Dipl. Eng. Dorin Dudu Head of the Cyclotron Accelerator


Dip. Eng. Nicolae Tetcu, Deputy Head Dr. Eugen Ivanov Dr. Petru Mihai Racolta Dipl. Eng. Dana Voiculescu

[3] TYPE OF CYCLOTRON: Classical, var. energy, 60 cm magnetic pole radius


MANUFACTURER: URSS - Petrograd/Leningrad

(II) UPGRADE: 1970 - development of 7 beam transport lines 1999 – upgrading of RF controls

MODEL: U-120/1956 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10-15 10-13 - 20-27 Yes No Maximum beam available (µA) 25 25 - 10 Typical beam employed (µA) 55 10 - 3 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




45 10 10 10 15 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: - Radiography: - Materials science: 15 Proton therapy: - Physics: 5 Neutron therapy: - Activation analysis: 5 Other (specify) - [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) 22Na/1 mCi Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) 5 MeV Ø –

1012n/cm2s typically for d (13 MeV) on Be target. Yes No

[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18f, 103Pd, 22Na, 67Ga, 111In, 123I, 68Ge [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical; – Small animal; – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



298




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F





























COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) …

299

COUNTRY: RUSSIA RUS-1 [1] INSTITUTE: Bakoulev Scientific Centre for Cardiovascular Surgery

Roubevsekoe sh 135 121552 Moscow


+7 095 414 7917 [email protected] +7 095 414 7782


Dr. Evgeny Derevyanko, PhD. Head of PET Radiochemistry


Professor Leo Bokeria, Director of Bakoulev Cardiosurgery Dr. Iracly Aslanidis, Head of Nuclear Diagnostics Dr. Vladimir Leonov, Cyclotron Engineer Dr. Tatiana Katunina, Cyclotron and Radiochemistry Engineer

[3] TYPE OF CYCLOTRON: Self-shielded, proton cyclotron

YEAR OF: (I) INSTALLATION 1998 - mounter

MANUFACTURER: CTI, Inc. (II) UPGRADE: 2001 - accepted MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 nil nil nil Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




6 2 - 4 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C, 15O, 11C - acetate, 11C - methinione, 15O - water [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence - Gamma camera - Single photon tomography (SPET) 2 Positron emission tomography (PET) – Clinical 1 – Small animal - – Plant biochemistry - [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



300




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 10 70-95 1.1 - 100 Yes

No Ne (d, α) 18F 16O (α, x) 18F


















13N - ammonia 1 1/month 16O(p,a) Yes No Yes No Yes No





Water







COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): ………………

301

COUNTRY: RUSSIA RUS-2 [1] INSTITUTE: Central Research Institute of Roentgenology and Radiology

189646 St. Petersburg Pesochny-2 Leningrad ul., 70


+7 812 596 6609 [email protected] or [email protected] +7 812 596 6609


Oleg A. Shtukovski, PhD. Head of the Department of Cyclotron Radiopharmaceuticals


Mikhail Korsakov, Scientific Expert

[3] TYPE OF CYCLOTRON: Isochronous cyclotron with variable energy


MANUFACTURER: Efremov Institute, St. Petersburg, Russia

(II) UPGRADE:

MODEL: MGC-20P [4] CYCLOTRON CHARACTERISTICS: H- and D- energy beam 16.4 MeV. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 4-18 7-10 10-28 4-20 Yes No Maximum beam available (µA) 100 50 30 25 Typical beam employed (µA) 30 - - - [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




60 40 12 8 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 67Ga, 111In [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 11 different clinical institutions in St. Petersburg, 2times/week

Yes No


Yes No




302




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 15-18 95+ 1,4 nil 150 Yes

No 20Ne (d, α) 18F 16O (α,d )18F






18FDG 5-10 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






11C – butyrate 4-6 2/week Yes No Yes No 11C – acetate 2-3 validation for

patient studies Yes No Yes No







13N – ammonia 3-5 1 runday/week Yes No Yes No Yes No










64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 2/week Yes No Yes No 124I 1/week Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): 123I - iodide, 123I – iodo hippurate, 123I – iodo bengal rose, 123I – iodo iodopentadecanoic acid.

303

COUNTRY: RUSSIA RUS-3 [1] INSTITUTE: Cyclotron Co. Ltd.

Bondarenko Sq. 1, Obninsk, Kaluga Region 249033


+7 95 255 2385 [email protected] +7 95 255 2326


Professor N.N. Krasnov Director General


A.A. Ponomarev, Chief Engineer Dr. Yuri Sevastianov, Deputy Director General

[3] TYPE OF CYCLOTRON: lsochronic YEAR OF: (I) INSTALLATION 1999 MANUFACTURER: Scientific Institute,

Electrophysics (II) UPGRADE:

MODEL: RIC - 14 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 14 Yes No Maximum beam available (µA) 1000 Typical beam employed (µA) 850 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




52 weeks 130 8 20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) 57Co, 109Cd

, 68Ge

[7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 68Ge Mössbauer sources? (specify which & quantity) Yes No 57Co X ray sources? (specify which & quantity) Yes No 57Co,109Cd Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




304




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α)18F 16O (α,d)18F




























64Cu Yes No Yes No 67Ga Upto 30 1/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Upto 200 1/week Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No


305

COUNTRY: RUSSIA RUS-4 [1] INSTITUTE: Cyclotron Co. Ltd.

Bondarenko Sq. 1, Obninsk, Kaluga Region 249033


+7 95 255 2385 [email protected] +7 95 255 2326


Professor N.N. Krasnov Director General


A.A. Ponomarev, Chief Engineer Dr. Yuri Sevastianov, Deputy Director General

[3] TYPE OF CYCLOTRON: Classical cyclotron YEAR OF: (I) INSTALLATION - 1963 MANUFACTURER: Scientific Institute

Electrophysics (II) UPGRADE: 1993

MODEL: U - 150 - 1 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 22 22 Yes No Maximum beam available (µA) 1000 1000 Typical beam employed (µA) 700 700 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




52 weeks in year 2000 144 hours 4 20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) 57Co,

109Cd, 68Ge

[7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 68Ge Mössbauer sources? (specify which & quantity) Yes No 57Co X ray sources? (specify which & quantity) Yes No 57Co,109Cd Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other

institutions?


Yes No


Yes No




306




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α)18F 16O (α,d)18F




























64Cu Yes No Yes No 67Ga Up to 30 1/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Up to 200 1/week Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No


307

COUNTRY: RUSSIA RUS-5 [1] INSTITUTE: Institute of Human Brain RAS

9 Pavlov Street St. Petersburg 197376


+7 812 234 9347 [email protected] +7 812 234 3247


Demianov Alexandr Cyclotron Engineer


Krasikova Raisa, Head of Radiopharmacy

[3] TYPE OF CYCLOTRON: Medical YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 85 Yes No Maximum beam available (µA) 100 Typical beam employed (µA) 15-40 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




16 7 4 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): PET 16 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




308




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 14.8 95 1.0 Yes

No Ne (d, α) 18F 16O (α, x) 18F












L-11C – methyl methionine

4.4 4/week Yes No Yes No

Yes No Yes No Yes No Yes No Yes No Yes No






13N[NH3] 2.6 1/month 15O(p,a)13N Yes No Yes No Yes No





15O[H2O] 4.4 25/week 14N(d,n)15O








309

COUNTRY: RUSSIA RUS-6 [1] INSTITUTE: Kurchatov Institute of Atomic Energy (KIAE)

Moscow 123 182


+7 095 196 9782 or +7 095 196 9977* +7 095 737 0600


Unezhev Vitaly


Oglobin Alexei* V.E. Jarosh

[3] TYPE OF CYCLOTRON: KIAEC YEAR OF: (I) INSTALLATION 1976 MANUFACTURER: (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 32 30 70 60 Yes No Maximum beam available (µA) 30 15 15 20 Typical beam employed (µA) 25 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




60 35 4 15 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: 2 Proton therapy: Physics: 4 Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No En=30MeV [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




310




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 98.6 1.5 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG Yes No Yes No Yes No Yes No On request Yes No Yes No Yes No Yes No






















64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 37 3 days/week Yes No Yes No On request 124I Yes No Yes No 201Tl 10 2 days/month Yes No Yes No 211At Yes No Yes No


311

COUNTRY: RUSSIA RUS-7 [1] INSTITUTE: Nuclear Physics Institute at Tomsk Polytechnic University

Lenina 2-1 St., P.O. Box 25 634050 Tomsk


+7 3822 417 953 or +7 3822 424 003* [email protected] +7 3822 423 934


V.M. Golovkov Deputy Director


A.I. Komov*, Chief of the Cyclotron Department

[3] TYPE OF CYCLOTRON: Tomsk(U-120) YEAR OF: (I) INSTALLATION 1959 MANUFACTURER: “Electrosila” St.

Petersburg (II) UPGRADE: 1971

MODEL: R - 7M [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15 14 30 28 Yes No Maximum beam available (µA) 35 50 20 55 Typical beam employed (µA) 30 45 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




35 19 5 11 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: 6 Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No En=7.5 MeV [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 123 I, Sodium Iodide, Iod - O - gippurate, MIBG, Iodophen [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Institute of Cardiology of Tomsk Research Centre (TRC) of Siberian Branch of Russian Academy Medical Sciences (SB RAMS)- 2 per week; Institute of Oncology of TRC SB RAMS- 2 per week; Siberian State Medical University- 2 per week.

Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 3 Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



312




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F





























COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Since 1990, TI-199 isotope is produced as analog of TI-201. The “Thallium Chloride, TI-99” radiopharmaceutical is provided to some medical institutes. Deliverables are realized twice per week. Quantity of the supplying radiopharmaceutical with the TI-11 is equal to 5-6 Ku/year.

313

COUNTRY: RUSSIA RUS-8 [1] INSTITUTE: Research Institute of Nuclear Physics

St. Petersburg Technical University 194223 St. Petersburg, ul. Kurchatova 10


+812 552 98 96 [email protected] +812 552 98 31


V.N. Lomasov Director, Research Institute of Nuclear Physics (RINP)


B.V. Zabrodin, Director of the Cyclotron Laboratory, RINP

[3] TYPE OF CYCLOTRON: MGC-20 YEAR OF: (I) INSTALLATION 1985 MANUFACTURER: SRIEPhA, Russia (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 27 20 Yes No Maximum beam available (µA) 50 50 20 25 Typical beam employed (µA) 20 20 5 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




0 – 50 0 - 50 0 - 20 2 - 5 50 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: 0 - 20 Proton therapy: Physics: 0 - 20 Neutron therapy: Activation analysis: sometimes Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 67Ga, 124I, 85Sr. [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? As required. Yes No


Yes No




314




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F




























64Cu Yes No Yes No 67Ga 1 - 10 As required Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 1 - 10 as required Yes No Yes No 124I 0,5 - 4 as required Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 85Sr

315

COUNTRY: RUSSIA RUS-9 [1] INSTITUTE: V.G. Khlopin Radium Institute

2nd Murinski Prospect 28 149 021 St. Petersburg


+7 812 247 [email protected] +7 812 237 6181


L.M. Solin, PhD. Head of Laboratory


[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 1988 MANUFACTURER: Efremov NIIEFA (II) UPGRADE: MODEL: MGC-20 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 5-18 3-10 8-24 8-20 Yes No Maximum beam available (µA) 50 50 20 20 Typical beam employed (µA) 5-15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




60 48 12 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Sodium iodide, 123I; Sodium-Iodohippurate, 123I; 123I -MIBG; 123I -BMIPP; 67Ga Citrate: [9] Do you supply radionuclides to other institutions?



Yes No




316




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F




























64Cu Yes No Yes No 67Ga 3.5 1/ month Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 10 2-3 / week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No


317

COUNTRY: SAUDI ARABIA SAU-1 [1] INSTITUTE: King Faisal Specialist Hospital and Research Centre

P.O. Box 3354 Riyadh 11211


+966 1 442 7856 [email protected] +966 1 442 4743


Eng. Salman Melibari Head of, Cyclotron Operations


Eng. Salam Rahma, Senior Engineer Ahmad Algaith, Engineer Faisal Alromayanman, Engineer

[3] TYPE OF CYCLOTRON: Positive ion, AVF, electrostatic extraction



(II) UPGRADE:

MODEL: CS 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 28.5 15 38 30 Yes No Maximum beam available (µA) 200 300 135 90 Typical beam employed (µA) 100 100 100 80 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




45 < 10 < 10 < 10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: 25 (on hold) Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No En =14 MeV [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C, 103Pd, and 123I [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Yes No 124I, 203Pb


Yes No




318




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 28 > 95 0.33 Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG 15 Every day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No












Ammonia 3.7 1-2/week Yes No Yes No Yes No










64Cu Yes No Yes No 67Ga 44.0 Every week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 16.7 Occasionally Yes No Yes No 123I 28.0 Every day Yes No Yes No 124I 16.0 Occasionally Yes No Yes No 201Tl 34.0 Every Week Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Kr81m generator production everyday.

319

COUNTRY: SLOVAKIA SLR-1 [1] INSTITUTE: Slovak Office for Standards, Metrology and Testing

Cyclotron Centre of the Slovak Republic Stefanovicova 4, P.O. Box 76, SK-81005 Bratislava


+421 7 524 91085 [email protected] +421 7 524 91050


Dr. Dusan Podhorsky Chairman


Dr. Peter Kovac, Senior Operators Dr. Josef Kristiak, Senior Scientist Professor Fedor Macasek, Senior Scientist Professor Jan Ruzicka, Scientific Secretary Professor Stefan Saro, Senior Scientist

[3] TYPE OF CYCLOTRON: Fixed energy H- and D- ions

YEAR OF: (I) INSTALLATION 2001 - 2002

MANUFACTURER: IBA, s.a., Belgium (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 80 35 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: 5 (Planned) Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F – FDG, 11C - Raclopride [9] Do you supply radionuclides to other institutions?



Yes No




320




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 2 x 50 Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG 2 x 20 Yes No Yes No 18F-DOPA Yes No Yes No Yes No Yes No Yes No Yes No






Raclopride 40 Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 4 16O(p,α) 13N Yes No Yes No Yes No





CO2 (10) 14N(p,n) 15O








321

COUNTRY: SOUTH AFRICA SAF-1 [1] INSTITUTE: National Accelerator Centre (NAC)

Radionuclide Production Group P.O. Box 72, Faure, 7131


+27 21 843 3820 [email protected] or [email protected]* +27 21 843 3525


Professor J.F. Sharpey-Schafer Director


Mr. M.E. Murphy, Deputy Director Dr. T.N. Van der Walt*, Head-Radionuclide Production Dr. L. Conradie, Head-Accelerator Group

[3] TYPE OF CYCLOTRON: Separated sector w/ solid pole injector cyclotron


MANUFACTURER: NAC (II) UPGRADE: 1994 (2nd injector) MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 66 - 200 Yes No Maximum beam available (µA) 180 Typical beam employed (µA) 90 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




144 38 24 24 ~20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: 12 Physics: 24 Neutron therapy: 10 Activation analysis: Other (specify)

Radionuclide production 38

[7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F and 18F FDG; 103Pd; 68Ge; 82Sr [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Nuclear medicine centres in South Africa and Namibia — on a weekly basis.

Yes No


Yes No




322




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F




























64Cu Yes No Yes No 67Ga weekly Yes No Yes No $ 372 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I weekly Yes No Yes No $ 405 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No


323

COUNTRY: SPAIN SPA-1 [1] INSTITUTE: BARNATRON

Anselm Clave, 100 08950 Espluges de Llobregar Barcelona


+34 93 473 5144 [email protected] +34 93 473 4839


Isabel R. de Arellano Radiochemist, responsible for Installation


Carlos Piera, responsible for Quality Control Pedro Larroza, Technician – Production Martin Vargas, Technician – Quality Control

[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 2001 MANUFACTURER: GE (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: H- and D- energy beam 16.4 MeV. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.4 MeV Yes No Maximum beam available (µA) Typical beam employed (µA) 36 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




11 7 - 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 Advanced GE – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



324




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F >95.5 1.6 mL Yes

No 20Ne (d, α) 18F 16O (α,d )18F






18FDG 65/2 MR bomb 4/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
























325

COUNTRY: SPAIN SPA-2 [1] INSTITUTE: Centro Andaluz de Díagnóstíco PET (CADPET)

Ronda de Capuchinos, 11 41009 Sevilla


+34 954 432 537 administrací[email protected]/[email protected]/[email protected] +34 954 435 5850


Mr. Miguel Perez Consejero Delegado (Managing Director)


Mr. Miguel Cantero, Radiochemist Mrs. Rocío Iglesias, Radiopharmacist

[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 2001 MANUFACTURER: GE (II) UPGRADE: MODEL: PET Trace 2132402 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 Yes No Maximum beam available (µA) 75 Typical beam employed (µA) 36 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




2 2 n/a [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify)

Radiopharmaceuticals

2/week [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? CADPET Málaga: 4/week; Hospital Universitaria Virgen del Rocío (Sevilla): 4/week

Yes No


Yes No




326




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 95 1,5 mL Yes

No 20Ne (d, α) 18F 16O (α,d )18F






























327

COUNTRY: SPAIN SPA-3 [1] INSTITUTE: Centro PET Complutense (CPC)

Manuel Bartolome Cossio, 10 E-28040 Madrid


+34 91 534 4896 [email protected] +34 91 553 0845


José Miguel Alfonso President


Antonio Maldonado, Medical Director Magdalena Melgarejo Icaza, Laboratory Director José Manuel Nieto, Administrative Director

[3] TYPE OF CYCLOTRON: Superconducting, negative ion


MANUFACTURER: Oxford Intr. (II) UPGRADE: MODEL: OSCAR IV [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 12 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




15 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify):

FDG fabrication


If yes and available, name of institution/s & how often? IVO (Valencia): 3-4/week; Hospital del Rocío (Sevilla: 5-9/week; Hospital Dr. Peset (Valencia): 2-3/week

Yes No


Yes No




328




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 25 >95 5 ± 400 Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG 25 2-4/day Yes No Yes No P45,000/ injection to patient
























COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Centro PET Complutense S.A. is dedicated only in the production and utilization of 1`8FDG for clinical use. During this utilization it participates in diverse projects of clinical investigation.

329

COUNTRY: SPAIN SPA-4 [1] INSTITUTE: Clinica Universitaria de Navarra

Facultad de Medicina Apartado, 4029 31080 Pamplona


+34 948 255 400 ext. 4941 [email protected] +34 948 296 500


José A. Richter MD, PhD. Chief of Nuclear Medicine


Josep M. Marti-Climent, PhD. Iván Peñuelas, PhD. Javier Arbizu, MD María J. García-Velloso, MD, PhD.

[3] TYPE OF CYCLOTRON: Double particle YEAR OF: (I) INSTALLATION 1996 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 80 35 Typical beam employed (µA) 30 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




330




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d,a) 18F 16O (α, x) 18F






























331

COUNTRY: SPAIN SPA-5 [1] INSTITUTE: MOLYPHARMA

Avenida Dr. Severo Ochoa, 37-41-1 28100 Alcobendas Madrid


+34 91 490 5730 [www.molypharma.es] +34 91 490 5740


Mr. Rafael Jimenez Shaw Director de Operaciones


Mr. Tomas Arroyo, Radiopharmacist

[3] TYPE OF CYCLOTRON: GE Minit-11 YEAR OF: (I) INSTALLATION 2001 MANUFACTURER: (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 9.6 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 35 [5] CYCLOTRON OPERATION: (ESTIMATION) Total hours (h)/ week h/week for radionuclide





If yes and available, name of institution/s & how often? 5 during 2001 (expected) Yes No


Yes No




332




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 52 96 0.5 Yes

No 20Ne (d,α)18F 16O (α, d)18F


















Ammonia 5 Daily 16O(p, α)13N Yes No Yes No Yes No












333

COUNTRY: SWEDEN SWE-1 [1] INSTITUTE: Uppsala Universitet

PET-Centrum UAS, S-75185 Uppsala


+46 18 471 5388 [email protected] +46 18 471 53890


Joachim Schultz Engineer


Mr. Gunnar Antonio, Senior Chemist

[3] TYPE OF CYCLOTRON: Isochron, deflector YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 17 [4] CYCLOTRON CHARACTERISTICS: 17 MeV protons, 8,5 deuterons, mx 50 µA on target 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 17 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 45 45 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




60 57 0 2 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 3 – Small animal 2 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



334




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 37 95 0.9 1.2 Yes

No Ne (d, α) 18F 16O (α, x) 18F












CO2 ~20 5/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No











15O water 1 5/week








335

COUNTRY: SWITZERLAND SWI-1 [1] INSTITUTE: Paul Scherrer Institute

CH-5232 Villigen-PSI


+41 56 310 2813 [email protected] +41 56 310 2849


Professor P.A. Schubiger Head of Centre for Radiopharmacy


Simon Ametamey Peter Bläuenstein Roger Schibli

[3] TYPE OF CYCLOTRON: PSI construction YEAR OF: (I) INSTALLATION 1974 MANUFACTURER: Philips (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: Total beam is 200 Micro Amp; a splitter divides into main beam and a small part for the

radiopharmacy; this sheet is filled out with respect to RPH applications 1H 2H 3He 4He Dual Beams Beam energies (MeV) 72 - - - Yes No Maximum beam available (µA) 70 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



336




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 50 >80 2 50 Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG Yes No Yes No Dopa Yes No Yes No Yes No Yes No Yes No Yes No






Flumazenil Yes No Yes No Raclopride Yes No Yes No Methionine Yes No Yes No Ketamine Yes No Yes No











Water






64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 20 2/month Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) We are concentrating on research of new radiopharmaceuticals for brain imaging and tumour therapy. The products are investigated in vitro and in vivo (animals). If good results are obtained, first clinical tests are started, but there is no regular distribution to hospitals anywhere. In addition to 18F, we are producing 11C, 67Cu and 76Br.

337

COUNTRY: SWITZERLAND SWI-2 [1] INSTITUTE: University Hospital of Geneva

Department of Radiology, Cyclotron Unit 24, rue Micheli-du-Crest CH-1211 Geneva


+41 22 37 27 580 [email protected] +41 22 37 27 585


Professor Gerd-Jürgen Beyer Dr. habil, Head of Cyclotron Unit


Dmitri Soloviev, PhD., Radiochemist Claire Tamburella, PhD., Cyclotron Physicist

[3] TYPE OF CYCLOTRON: PET YEAR OF: (I) INSTALLATION 2001 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 80 40 Typical beam employed (µA) 35 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




20 10 5 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): – 124-I via 124-Te(p,n)124-I with optimized targetry and dedicated module,

– 86-Y via 86-Sr(p,n) reaction, – 64-Cu and probably 67-Cu.

[9] Do you supply radionuclides to other institutions? If yes and available, name of institution/s & how often? Distribution is planned — to be organized via a private company; integration into a network system is foreseen.

Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) 4 Positron emission tomography (PET) 1 – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



338




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 150 95 2.5 600 Yes

No Ne (d, α) 18F 10 16O (α, x) 18F






18FDG 80 daily Yes No Yes No See comments FDOPA planned Yes No Yes No Other tracers planned Yes No Yes No Yes No Yes No






Yes No Yes No Planned Yes No Yes No Yes No Yes No Yes No Yes No











H2O N(d,n)






64Cu planned Yes No Yes No 67Ga Yes No Yes No 86Y planned Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 0.8 weekly Yes No Yes No planned 211At Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Comment concerning pricing:The philosophy is to charge for individual injection doses, and not for delivered activities. Fixed tracer price is important for harmonization of the costs per PET study to be reimbursed. We just became operational, legislation procedure I under way. Most of the mentioned activities are according to plan. Given activities are results of related tests. First priority has reliable large scale FDG production.

339

COUNTRY: SWITZERLAND SWI-3 [1] INSTITUTE: University Hospital of Geneva

Department of Radiology, Cyclotron Unit 24, rue Micheli-du-Crest CH-1211 Geneva


+41 22 37 27 580 [email protected] +41 22 37 27 585


Professor Gerd-Jürgen Beyer Dr. habil, Head of Cyclotron Unit


Dmitri Soloviev, PhD., Radiochemist Claire Tamburella, PhD., Cyclotron Physicist

[3] TYPE OF CYCLOTRON: Negative ion, fixed energy


MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




40 30 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C, 13N, 15O, 18F, 64Cu, 67Cu, 86Y, 120I, 123I, 124I [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 18FDG to 8 Centres daily beginning in September, 1997.

Yes No


Yes No




340




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























341

COUNTRY: SWITZERLAND SWI-4 [1] INSTITUTE: University Hospital Zürich, PET Center

Raemistrasse 100 CH-8081 Zürich


+41 1 255 1111 [email protected] +41 1 255 4428


Professor A. Schubiger


Dr. G. Westera

[3] TYPE OF CYCLOTRON: Fixed energy, negative ion


MANUFACTURER: GE (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.5 Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




40 Stand-by 20 Beam on target 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F – DOPA, FLT, 11C - Various [9] Do you supply radionuclides to other institutions?



Yes No




342




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 110 95 1.6 600 Yes

No Ne (d, α) 18F 600 MBq 16O (α, x) 18F






18FDG 45 1/day Yes No Yes No SFR 200 18FET 2.5 1/week Yes No Yes No 18F- 1.5 1/week Yes No Yes No Yes No Yes No






Raclopride 2.5 1/2 weeks Yes No Yes No Flumarenil 2.5 1/2 weeks Yes No Yes No Acetate 2.5 1/month Yes No Yes No Yes No Yes No






13NH3 10 10 / week 16O (p, a) 13N Yes No Yes No Yes No





H2O Continuous 10 / week 15N(p.n)15O








343

COUNTRY: SYRIAN ARAB REPUBLIC SYR-1 [1] INSTITUTE: Atomic Energy Commission of Syria (AECS)

P.O. Box 6091 Damascus


+963 11 391 2896 or 391 3923 +963 11 611 2289


Dr. Abdul Hamid Al-Reyyes


[3] TYPE OF CYCLOTRON: Negative ion, variable energy


MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 Yes No Maximum beam available (µA) 350 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 123I, 111In, 103Pd, 11C, 15O [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Not yet. Yes No


Yes No




344




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F ~ 90 97 1.3 250 Yes

No Ne (d, α) 18F 16O (α, x) 18F






























345

COUNTRY: TURKEY TUR-1 [1] INSTITUTE: Monrol Isotopes Services

Perpa Ticaret Merkezi, A Blok Kat 2 No. 9/0006 Okmeydani


+909 212 222 3828 [email protected] +909 212 222 3817


Mr. Ugur Bozluolcay General Manager


Ayse Sungur, PhD., Manager Harun Kügükmidil, Technical Service Manager Güleren Albak, MSc., Radiation Safety Officer Baris Çakir, Cyclotron Operator





8 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify)

Radiopharmaceutical production [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Istanbul, International Hospital Yes No


Yes No




346




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 33.3 95 1.2 500 Yes

No Ne (d, α) 18F 16O (α, x) 18F






























347

COUNTRY: UNITED KINGDOM UK-1 [1] INSTITUTE: Douglas Cyclotron Unit

Clatterbridge for Oncology Bebington, Wirral L63 4JY


+44 151 334 6366 [email protected] +44 151 334 2845


Dr. Andrzej Kacperek Head, Cyclotron Unit


B. Marsland

[3] TYPE OF CYCLOTRON: AVF, single particle, fixed energy


MANUFACTURER: Scandinotrix (II) UPGRADE: 1988 (beamline of proton therapy)

MODEL: MC-62 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 62 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 20 - 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




10 5 2 10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: 15 Physics: 2 Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 22Na Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 64Cu, 55Co [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Paterson Institute, Christie Hospital, (4-8/month) Manchester, M20 4BX, U.K.

Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



348




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 40 95 1 Mostly

recycled Yes

No Ne (d, α) 18F 16O (α, x) 18F




























64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 1 1/month Yes No Yes No (Research

contract) 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) We only produce isotopes, not pharmaceuticals.

349

COUNTRY: UNITED KINGDOM UK-2 [1] INSTITUTE: Imaging Research Solutions Limited

Cyclotron Building Hammersmith Hospital Ducane Road, London W12 ONN


+44 (0) 208 383 3162 [email protected] +44 (0) 208 383 2029


Dr. John Thornback Managing Director


Bruce Mackay, Cyclotron Operations Manager Mike Renton, Chief Cyclotron Engineer Dave Turton, Radiochemistry Production Manager David Ellison, Commercial Director

[3] TYPE OF CYCLOTRON: O-15 generator YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 3D [4] CYCLOTRON CHARACTERISTICS: Positive ion, fixed energy, fixed frequency, internal beam only. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 3.8 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 5 – Clinical 4 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



350




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F























15H2O continuous daily 14N(d,n)15O 15CO continuous daily 14N(d,n)15O 15O continuous weekly 14N(d,n)15O








351

COUNTRY: UNITED KINGDOM UK-3 [1] INSTITUTE: Imaging Research Solutions Limited

Cyclotron Building Hammersmith Hospital Ducane Road, London W12 ONN


+44 (0) 208 383 3162 [email protected] +44 (0) 208 383 2029


Dr. John Thornback Managing Director


Bruce Mackay, Cyclotron Operations Manager Mike Renton, Chief Cyclotron Engineer Dave Turton, Radiochemistry Production Manager David Ellison, Commercial Director

[3] TYPE OF CYCLOTRON: Positive ion, variable energy


MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 40 Mark II [4] CYCLOTRON CHARACTERISTICS: Isochronous cyclotron for acceleration of light ions, delivers high quality external beams

via a beam transport system with seven (7) lines to more than 20 installed targets. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10-40 5-20 12-53 10-40 Yes No Maximum beam available (µA) 65 65 50 60 Typical beam employed (µA) 30 30 30 55 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide





If yes and available, name of institution/s & how often? Daily Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 5 – Clinical 4 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



352




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 10/F2; 55/F- 95 1.2 150 400 10 Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG 20 daily Yes No Yes No Wide range of compounds

Yes No Yes No







Extensive range of compounds

daily Yes No Yes No











15CO continuous daily 14N(d,n)15O 15CO2 continuous daily 14N(d,n)15O 15H2O continuous daily 14N(d,n)15O






64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 0.3 Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 81Rb/Kr generators

353

COUNTRY: UNITED KINGDOM UK-4 [1] INSTITUTE: John Mallard Scottish PET Centre

University of Aberdeen Department of Biomedical Physics and Bioengineering Foresterhill, Aberdeen, AB9 2ZD


+44 1 22484 0907 [email protected] +44 1 22484 9179


Dr. Andrew Welch Director


M.G. Dodd, Cyclotron Engineer Dr. Lutz Schweiger, Senior Chemist





17 12 4 0.2 0.5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 16 Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): Target dev. 1 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



354




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 12 30 1.1 180 Yes

No Ne (d, α) 18F 16O (α, x) 18F












Choline 2 weekly Yes No Yes No Methylene blue weekly Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 3 as required 16O(p, α)13Ν Yes No Yes No Yes No





Water 3 weekly 15N(p,n)15O








355

COUNTRY: UNITED KINGDOM UK-5 [1] INSTITUTE: St. Thomas Hospital

The Clinical PET Centre Guy’s, King’s, St. Thomas School of Medicine Lambeth Palace Road London SE1 7EH


+44 207 922 8068 +44 207 922 0790


Professor M.N. Maisey Chairman, Division of Radiological Sciences


Ms. Margaret Dakin Ms. Julie Sutcliffe-Goulden Mr. Paul Halstead Mr. Paul Marsden

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11.5 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




19 15 4 As required [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 64Cu – In development; 18F – FLT – In development; 18F –Peptides – In development [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Fluoride for scanner applications Yes No


Yes No




356




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F > 95 Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG 2 /day Yes No Yes No £ 325/ patient

dose FLT Yes No Yes No Yes No Yes No Yes No Yes No






11C Metnionine Yes No Yes No 11C Fumazenl Yes No Yes No 11C Methyl acetate

Yes No Yes No


Name (list)





13NH3 16O(p, α)13N Yes No Yes No Yes No





Water 15N(p,n)15O








357

COUNTRY: UNITED KINGDOM UK-6 [1] INSTITUTE: University of Cambridge

Wolfson Brain Imaging Centre Box 65, Addenbrook's Hospital Cambridge CB2 2QQ


+44 1223 33 1820 [email protected] +44 1223 33 1826


John C. Clark, DSc. PET Science Director


Professor John D. Pickard, Clinical Director and Chairman Dr. Franklin I. Aigbirhio, Radiopharmaceutical Chemist Dr. Peter J. Johnstrom, Radiopharmaceutical Chemist Mr. Paul Burke, Cyclotron Engineer

[3] TYPE OF CYCLOTRON: Negative ion, fixed energy


MANUFACTURER: GE (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 8.5 Yes No Maximum beam available (µA) 100 40 Typical beam employed (µA) 45 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




28 6 10 4 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): PET [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F peptides; 11C ligands and substrates; 64Cu antibody fragments/chelates [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 3/week to two centres. Yes No


Yes No




358




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F























Water CO O2







COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) …

359

COUNTRY: UNITED STATES OF AMERICA USA-1 [1] INSTITUTE: Bowman Gray School of Medicine

Medical Centre Boulevard Winston-Salem, NC 27157


+1 910 716 7461


Dr. Richard L. Witcofski Director


Richard Ehrenkaufer Henry Chilton

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS-112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




15 15 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 18F-FDG, daily Yes No


Yes No




360




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






18F – FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






11C - methionine Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No











15O - water








361

COUNTRY: UNITED STATES OF AMERICA USA-2 [1] INSTITUTE: Brookhaven National Laboratory

Chemistry Department, Bldg. 901 Upton, NY 11973


+631 344 4587 [email protected] +631 344 4587


David J. Schlyer Manager, BNL Cyclotron Facility


Joanna Fowler, Programme Director Richard Ferrieri, Chemist Michael Schueller, Assistanct Chemist

[3] TYPE OF CYCLOTRON: Isochronous YEAR OF: (I) INSTALLATION 1981 MANUFACTURER: Japan Steel Works,

Ltd. (II) UPGRADE:





30 30 0 4 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




362




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 13.5 95 3.1 45 Yes

No 20Ne (d, α)18F 16O (α, d) 18F






18FDG 3.5 daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Cocaine 0.5 3/week Yes No Yes No Raclopride 0.5 3/week Yes No Yes No Deprenyl 0.5 2/week Yes No Yes No Clorgyline 0.5 2/week Yes No Yes No






Ammonia 1.0 On demand 160(p, α)13N Yes No Yes No Yes No











COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 195m Pt

363

COUNTRY: UNITED STATES OF AMERICA USA-3 [1] INSTITUTE: Brookhaven National Laboratory

Chemistry Department, Bldg. 901 Upton, NY 11973


+631 344 4587 [email protected] +631 344 4587


David J. Schlyer Manager, BNL Cyclotron Facility


Joanna Fowler, Programme Director Richard Ferrieri, Chemist Michael Schueller, Assistanct Chemist

[3] TYPE OF CYCLOTRON: Collins Radio YEAR OF: (I) INSTALLATION 1958 MANUFACTURER: (II) UPGRADE: 1968 MODEL: [4] CYCLOTRON CHARACTERISTICS: Four particle, variable energy. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 35 23 57 46 Yes No Maximum beam available (µA) 20 15 10 10 Typical beam employed (µA) 15 10 10 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




364




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 7.4 95 2 5 Yes

No 20Ne (d, α)18F 16O (α, d) 18F






18FDG 1 monthly Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






















64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I On demand Yes No Yes No 124I On demand Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No


365

COUNTRY: UNITED STATES OF AMERICA USA-4 [1] INSTITUTE: Carolinas Medical Center

Department of NM & PET 1000 Blyth Blvd., P.O. Box 32861 Charlotten NC 28232




Dr. Ron Borchert


[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 1993 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11.5 Yes No Maximum beam available (µA) 80 Typical beam employed (µA) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




80 80 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Confidential Yes No


Yes No




366




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F ~ 37 95 0.5 500 Yes

No 20Ne (d, α)18F 16O (α, d) 18F






18FDG 400-450 2-4/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No












Ammonia 15 - 22 1-2/week 16O(p, α)13N Yes No Yes No Yes No












367

COUNTRY: UNITED STATES OF AMERICA USA-5 [1] INSTITUTE: Case Western Reserve University

and University Hospitals of Cleveland Division of Radiology 11100 Euclid Avenue, Cleveland, OH 44139




Dr. Marc Berridge Associate Professor


Lei Zheng Ken Voelker

[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 1985 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 8 Yes No Maximum beam available (µA) Typical beam employed (µA) 30 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




25 25 average: 6 (some weeks, none)


If yes and available, name of institution/s & how often? 18F-Fluoride; 13N-Ammonia; 18F-FDG

Yes No


Yes No




368




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























369

COUNTRY: UNITED STATES OF AMERICA USA-6 [1] INSTITUTE: Childrens Hospital of Michigan

PET Center 3901 Beaubien Boulevard Detroi, MI 48201


+1 313 993 2618 [email protected] +1 313 993 3845


Dr. Thomas J. Mangner Director, PET Chemistry


Dr. Harry T. Chugani, Medical Director

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1993 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 100 Typical beam employed (µA) 20 - 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




40 20-24 10 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 20 - 24 Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C – leucine; 11C - DWAY [9] Do you supply radionuclides to other institutions?



Yes No




370




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 22 >95 0.35 150 Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG 12 5-6/week Yes No Yes No 18F FLT 2 1/week Yes No Yes No 18F FMAU 1.5 1/monoth Yes No Yes No Yes No Yes No






11C FMZ 15 2-3/week Yes No Yes No 11C AMT 6 2-3/week Yes No Yes No Yes No Yes No Yes No Yes No






13N NH3 2 5-10/week 16O(p, α)13N Yes No Yes No Yes No





15O Water 4 5-6/month 15N(p,n)15O







COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Other radiopharmaceuticals produced on an irregular basis: C-11 acetate, C-11 m-hydroxyephedrine (HED), 2-C-11 thymidine, C-11 methionine, F-18 FAU, F-18 FIAU, F-18 FBAU.

371

COUNTRY: UNITED STATES OF AMERICA USA-7 [1] INSTITUTE: Columbia Presbyterian Medical Centre

Milstein Hospital Building 622 W. 168th Street New York, NY 10032


+1 212 305 8815


Jerry Strugala Manager


Tom Boland Michael Sanfilippo

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1992 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) Typical beam employed (µA) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




25 25 ~ 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 18F-FDG to 15 external institutions, 5 × per week.

Yes No

[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site? Off-site, too.

Yes No




372




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F












11C-methionine Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






13N-ammonia Yes No Yes No Yes No





11O-water








373

COUNTRY: UNITED STATES OF AMERICA USA-8 [1] INSTITUTE: Creighton University

Center for Metabolic Imaging 901 Dorcas Street Omaha, NE 88106


+1 402 346 4181


Dr. Marc Wrichelt Manager


Dr. Mike Harrington Mr. Steve Torres





~ 7 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other

institutions?

If yes and available, name of institution/s & how often? 18F-FDG

Yes No


Yes No




374




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























375

COUNTRY: UNITED STATES OF AMERICA USA-9 [1] INSTITUTE: Crocker Nuclear Laboratory

University of California, Davis 1 Bainer Drive Davis, CA 95616


+1 916 752 1460 [email protected] +1 916 752 0952


Dr. Manuel C. Lagunas-Solar Senior Radiochemist


Mr. Nolan X. Zeng Mr. Carlos M. Castaneda Ms. Krystyna Trzepla-Nabaglo Mr. Omar F. Carvacho

[3] TYPE OF CYCLOTRON: 76 inch isochronous YEAR OF: (I) INSTALLATION 1964-1966 MANUFACTURER: W.M. Brobeck &

Associates (II) UPGRADE:

MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 4-68 15-45 20-90 16-90 Yes No Maximum beam available (µA) Typical beam employed (µA) 30 40 1 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




112 4-8 ~ 16 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) Food irradiation &

conservation [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F; 205Bi; 206Bi; 67Cu [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Benedict Nuclear Pharmaceuticals, CO. USA – 4/w; University of California, Irvine, CA, USA – 1-2/w; University of California, Berkley, CA, USA –1-2/w; VA Hospital, Palo Alto CA. USA – 1-2/w; National Institute of Health, MD, USA – 2-4/y; NeoRx Corporation, WA, USA – 2-4/y

Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical; – Small animal; – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



376




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F




























64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 3.7 – 7.4 4/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): 205Bi, 206Bi

377

COUNTRY: UNITED STATES OF AMERICA USA-10 [1] INSTITUTE: Downstate Clinical PET Center

Methodist Medical Center 221 North East Glen Oak Ave. Illinois 61606


+1 309 6724 191 +1 309 6712 166


Dr. Danny Bingham Manager


Brenda Shields

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) Typical beam employed (µA) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




20 20 0.5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often?18F-FDG, 5/week Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



378




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























379

COUNTRY: UNITED STATES OF AMERICA USA-11 [1] INSTITUTE: Duke University Medical Centre

Department of Radiology Box 3808 Durham, NC 27710


+1 919 684 7708 [email protected] +1 919 684 7121


Dr. Bruce Wieland Director, Cyclotron


Dr. Michael Zalutsky, Professor

[3] TYPE OF CYCLOTRON: Isochronous fixed field, positive ion



(II) UPGRADE:

MODEL: CS-30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 27.6 14 28.3 Yes No Maximum beam available (µA) 120 120 100 Typical beam employed (µA) 70 70 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




380




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F




























64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 0.1 4/week Yes No Yes No 201Tl Yes No Yes No 211At 1 1/week Yes No Yes No


381

COUNTRY: UNITED STATES OF AMERICA USA-12 [1] INSTITUTE: Emory University, Division of Nuclear Medicine

1364 Clifton Road NE Atlanta, GA 30322


+1 404 712 7930


Mark Goodman


Ronald Crowe





30 ~ 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




382




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























383

COUNTRY: UNITED STATES OF AMERICA USA-13 [1] INSTITUTE: Gershenson Radiation Oncology Center

Harper University Hospital and Wayne State University 3990 John R Detroit, MI 48201


+1 313 745 2487 [email protected] +1 313 745 2314


Dr. Richard L. Maughan


Mark Yudelev, PhD., Senior Clinical Medical Physicist

[3] TYPE OF CYCLOTRON: 50 MeV deuteron superconducting cyclotron


MANUFACTURER: Michigan State University

(II) UPGRADE:

MODEL: K100-Harper [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 48.5 Yes No Maximum beam available (µA) ~ 20 Typical beam employed (µA) ~ 12 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




71 6 15 50 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 1 Radiography: Materials science: Proton therapy: Physics: (medical) 5 Neutron therapy: 50 Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No En = 19MeV,

55 [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): None [9] Do you supply radionuclides to other institutions?



Yes No




384




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α)18F 16O (α, d) 18F






























385

COUNTRY: UNITED STATES OF AMERICA USA-14 [1] INSTITUTE: Good Samaritan Medical Center

PET Net Pharmaceutical Services 1111 E. McDowell Road, West Tower, Lower Level 1


+1 602 239 4100/4747 +1 602 239 2810


Dr. Tricia Giurlani PDC Manager


Dr. Michael Lawson Mr. David Stith Mr. Jay Stivers

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40-100 Typical beam employed (µA) 20-100 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




15-30 5-10 5-10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 18F-FDG, daily; 13N-ammonia, 1/month.

Yes No


Yes No




386




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























387

COUNTRY: UNITED STATES OF AMERICA USA-15 [1] INSTITUTE: Indiana University Cyclotron Facility

2401 Milo B. Sampson Lane Bloomington, IN 47408


+1 812 8559 365 @iucf.indiana.edu +1 812 8556 645


Dr. John M. Cameron Director


D. Friesel J. Collins G. East

[3] TYPE OF CYCLOTRON: Separated sector YEAR OF: (I) INSTALLATION 1975 MANUFACTURER: In-house (II) UPGRADE: MODEL: K200 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 205 Yes No Maximum beam available (µA) 5 Typical beam employed (µA) 5 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




125 10 20 95 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 5 Radiography: Materials science: 50 Proton therapy: 90 Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): None [9] Do you supply radionuclides to other institutions?



Yes No




388




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α)18F 16O (α, d) 18F






























389

COUNTRY: UNITED STATES OF AMERICA USA-16 [1] INSTITUTE: Indiana University Cyclotron Facility

2401 Milo B. Sampson Lane Bloomington, IN 47408


+1 812 8559 365 @iucf.indiana.edu +1 812 8556 645


Dr. John M. Cameron Director


D. Friesel J. Collins G. East

[3] TYPE OF CYCLOTRON: Separated sector YEAR OF: (I) INSTALLATION 1972 MANUFACTURER: In-house (II) UPGRADE: MODEL: K16 [4] CYCLOTRON CHARACTERISTICS: (Used as injector to K2000). 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 Yes No Maximum beam available (µA) 20 Typical beam employed (µA) 5 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




125 10 20 95 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 5 Radiography: Materials science: 50 Proton therapy: 90 Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




390




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No 20Ne (d, α)18F 16O (α, d) 18F






























391

COUNTRY: UNITED STATES OF AMERICA USA-17 [1] INSTITUTE: John Hopkins University School of Medicine

Division of Nuclear Medicine PET Center 600 North Wolfe Street Nelson B1-150 Baltimore, MD 21287


+1 410 955 2916 rfd @jhu.edu +1 410 955 0691


Robert F. Dannais, PhD. Professor, Radiology/Director, PET Center


Hayden T. Ravert, PhD. John L. Musachio, PhD. William B. Mathews, PhD.

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 2000 MANUFACTURER: GE (II) UPGRADE: The installation of the PETtrace MODEL: PET Trace represents an upgrace from our previous Scandinotrix MC-16F which

is still on-site, but no longer used. [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 75 40 Typical beam employed (µA) 60 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




40 39 20 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): Radiotracer chemistry [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




392




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F ~ 90 > 90 1.5 800 Yes

No 20Ne (d, α)18F 16O (α, d) 18F






18FDG > 55 2/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Many 11C ligands

~ 3.7 4/daily Yes No Yes No












Water On-line, ~ 3 GBq daily 14N(d,n) 15O








393

COUNTRY: UNITED STATES OF AMERICA USA-18 [1] INSTITUTE: Karmanos Cancer Institute

Gershenson Radiation Oncology Center Wayne State University 3990 John R Detroit, MI 48201


+1 313 745 2076 [email protected] +1 313 745 2314


Mark Yudelev, PhD. Medical Physicist


J.D. Forman, MD, Chairman, Rad. Oncology E. Blosser, Service Engineer, Medcyc Corporation C.G. Orton, PhD., Head - Medical Physics

[3] TYPE OF CYCLOTRON: Superconducting YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: NSCL (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 100K 1H 2H 3He 4He Dual Beams Beam energies (MeV) 48.5 Yes No Maximum beam available (µA) 15 Typical beam employed (µA) 10-12 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




80 n/a 10 20 50 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 5 Radiography: Materials science: Proton therapy: Physics: 5 Neutron therapy: 50 Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) 25 MeV Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




394




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























395

COUNTRY: UNITED STATES OF AMERICA USA-19 [1] INSTITUTE: Kettering Memorial Hospital

Department of Nuclear Medicine and PET 3535 Southern Boulevard Kettering, OH 45429


+1 937 296 7211 +1 937 296 4265


Dr. Joseph Mantil


Dr. Martin Satter

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1989 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 25-43 Typical beam employed (µA) 20-35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




396




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























397

COUNTRY: UNITED STATES OF AMERICA USA-20 [1] INSTITUTE: LA Tech Center

UCLA School of Medicine Department of Molecular and Medical Pharmacology and PETNet Pharmaceuticals, Inc.


+1 310 670 1010 [email protected] +1 310 670 2521


Henry C. Padgett, PhD. Managing Director


[3] TYPE OF CYCLOTRON: Deep Valley YEAR OF: (I) INSTALLATION 2000 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS-111 (2) [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 60 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




20-30 20-30 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 124I [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



398




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 95+ ~ 1 Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG 5 days/week Yes No Yes No F-dopa (in progress) Yes No Yes No Yes No Yes No Yes No Yes No






[11C] CO2 Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No


















399

COUNTRY: UNITED STATES OF AMERICA USA-21 [1] INSTITUTE: Lawrence Berkeley Laboratory

Department of Functional Imaging 1 Cyclotron Road, 55-121 Berkeley, CA 94720


+1 510 486 5276 [email protected] +1 510 486 6208


James P. O’Neil Supervisor, Biomedical Isotope Facility


Dr. Thomas F. Budinger Dr. Henry VanBrocklin

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1994 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: Prototype(1st built), H+ only, dual beam, 1 fixed 112–style target, 1 8 position turret

assembly 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: <10 Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 55Co, 124I, 94mTc, 76Br [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) KLEON Positron emission tomography (PET) ECAT 531

(1)

– Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



400




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 9

37 33

> 95 0.3 1

10 Yes No

20Ne (d, α)18F 16O (α, d) 18F






18FDG Various 1/week Yes No Yes No 18FMT 1.9 - 3.7 24/week Yes No Yes No Yes No Yes No Yes No Yes No






Choline Various 1 week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 1.1 3/month 16O(p, α)13N Yes No Yes No Yes No












401

COUNTRY: UNITED STATES OF AMERICA USA-22 [1] INSTITUTE: Mallinckrodt Institute of Radiology

Washington University 510 Kingshighway St. Louis, MO


+1 314 362 8435


Professor M.J. Welch Division Head of Radiological Sciences


[3] TYPE OF CYCLOTRON: Cyclone 30; 4 beam lines

YEAR OF: (I) INSTALLATION 1977 and 1991

MANUFACTURER: IBA, s.a., The Cyclotron Corp., and Japan Steel Works

(II) UPGRADE:

MODEL: CS-15 (3); JSW 168 (1)

[4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 8 Yes No Maximum beam available (µA) 80 80 Typical beam employed (µA) 40-50 30-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




35 35 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): PET 35 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




402




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 37-111 95 1.7

1.2 Yes

No 20Ne (d, α)18F 16O (α, d) 18F






18FDG 29-60 daily Yes No Yes No Captopi1 Yes No Yes No Yes No Yes No Yes No Yes No






Acetate 10 3/week Yes No Yes No Palmitate 8 3/week Yes No Yes No Glucose 1.5 3/week Yes No Yes No Yes No Yes No






Ammonia 4 16O(p, α)13N Yes No Yes No Yes No





Water 4-8 Varies 14N(d,n)15O Oxygen 4-8 Varies 14N(d,n)15O CO 4-8 Varies 14N(d,n)15O






64Cu 15 2/week Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 76Br, 66Ga

403

COUNTRY: UNITED STATES OF AMERICA USA-23 [1] INSTITUTE: Massachusetts General Hospital

Department of Radiology Boston, MA 02114


+1 617 726 8336 [email protected] +1 617 726 5123


John A. Correia, PhD. Director, Cyclotron Laboratory


Eli Livni, PhD., Radiochemist David Elmaleh, PhD., Radiochemist Alan Fischman, MD, PhD., Physician William Bucekwicz, Cyclotron Engineer

[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1989 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17 [4] CYCLOTRON CHARACTERISTICS: Fixed energy, 18 MeV protons, 8.5 MeV deuterons 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 8.5 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 35 35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide





If yes and available, name of institution/s & how often? 18FDG daily, ten local institutions/hospitals.

Yes No


Yes No




404




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 80 97+ 1 500 Yes

No 20Ne (d, α)18F 1.2 250 16O (α, d) 18F






18FDG 40 daily Yes No Yes No DOPA 0.05 weekly Yes No Yes No Setopirine 0.1-0.5 weekly Yes No Yes No Yes No Yes No






11C-CFT, Raclopride

Yes No Yes No

Altopene, SCH 50 mCi 10/week Yes No Yes No 11CO 100 mCi 2/week Yes No Yes No Yes No Yes No






13N2 100 mCi 10/week 12C(d,n) Yes No 13N2H3 300 mCi 5/week 16O(p, α) Yes No Yes No





C15O2 300 mCi 10/week 14N(d,n) 15O 15O2 300 mCi 2/week 14N(d,n) 15O H21

5O 300 mCi 5/week 14N(d,n) 15O OTHER ISOTOPES PRODUCED

Name (list)





64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 0.037 Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No


405

COUNTRY: UNITED STATES OF AMERICA USA-24 [1] INSTITUTE: Medi-Physics, Inc.

Amersham Healthcare 900 Durham Avenue South Plainfield, NJ 07080


+1 908 757 0500


Gordon Glass Site Administration Manager


William McClain

[3] TYPE OF CYCLOTRON: Negative ion, fixed field, fixed freq., var. energy


MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Proprietary Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




Proprietary info [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Proprietary info Yes No


Yes No




406




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























407


Amersham Healthcare 3350 Ridge Avenue Arlington Heights, IL 60004


+1 847 3988 400


Thomas Springer Director of Operations


Brian Carus



MANUFACTURER: Sumitomo & CGR (II) UPGRADE: MODEL: PV-750 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Proprietary Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




408




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























409


Amersham Healthcare 3350 Ridge Avenue Arlington Heights, IL 60004


+1 847 3988 400


Thomas Springer Director of Operations


Brian Carus



MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-40 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Proprietary Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




410




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























411


Amersham Healthcare 900 Durham Avenue South Plainfield, NJ 07080


+1 847 3988 400


Gordon Glass Site Administration Manager


William McClain

[3] TYPE OF CYCLOTRON: Positive ion, Azimuthally varying field, isochronous



(II) UPGRADE:

MODEL: MC-40 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Proprietary Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




412




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























413

COUNTRY: UNITED STATES OF AMERICA USA-28 [1] INSTITUTE: Mount Sinai Medical Center

4300 Alton Road Miami Beach, FL 33140


+1 305 674 2465 +1 305 674 2428


Dr. Thomas E. Boothe Director, Cyclotron/Radiochemistry


Mike Plitnikes Patricia Smith Manny Tavana

[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1972 MANUFACTURER: The Cyclotron


MODEL: CS-30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Proprietary Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




Proprietary Proprietary Proprietary [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 67Ga-chloride; 111In-chloride; 201Tl-chloride – world wide

Yes No


Yes No




414




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























415

COUNTRY: UNITED STATES OF AMERICA USA-29 [1] INSTITUTE: National Institute of Drug Abuse

NIDA/IRP, NIH 5500 Nathan Shock Drive, Room 405 Baltimore, MD 21224


+1 410 550 1440 (general)/ +1 410 550 2916 (cyclotron) [email protected] +1 410 550 2724


Alane Kimes, PhD. Acting Branch Chief


Andrew Horti, PhD., Chief Radiochemist Carlo Contoreggi, MD, Authorized Radiation User/ Nuclear Medicine Physician

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1997 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 25-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




20 0 8 20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 0 Radiography: 0 Materials science: 0 Proton therapy: 0 Physics: 0 Neutron therapy: 0 Activation analysis: 0 Other (specify): 20: PET [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




416




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 12-15 95 1.1 200 Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG 4-8 1-2/week Yes No Yes No 18F – 2-Fa 1 0-2/week Yes No Yes No Yes No Yes No Yes No Yes No






Raclopride 4-8 0-6/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






n/a Yes No Yes No Yes No





Water 0.7-1 0-30/week 15N(p,n)15O







COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Many research tracers labeled with 11C and 18F.

417

COUNTRY: UNITED STATES OF AMERICA USA-30 [1] INSTITUTE: National Institute of Health

Building 10, Room 1C401, MSC 1180 Bethesda, MD 20892


+1 301 496 0345 [email protected] +1 301 402 3521


Dr. William Eckelman Chief, PET Department


Paul S. Plascjak

[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 1999 MANUFACTURER: (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.4 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 35 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




40 5 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 40 Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? ORNL - monthly; NIST - yearly.

Yes No


Yes No




418




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 40 95 1.5 600 Yes

No 20Ne (d, α) 18F 10 16O (α, d) 18F






18FDG 20 1/day Yes No Yes No Dopamine 0.3 1/week Yes No Yes No DOPA 0.3 1/week Yes No Yes No FPTZTP 0.2 1/week Yes No Yes No






Raclopride 1 1/week Yes No Yes No Palmitic acid 1 2/week Yes No Yes No Aracidonic 0.5 4/week Yes No Yes No CO 2 2/week Yes No Yes No






Ammonia 1.5 10/week 16O(p, α)13N Yes No Yes No Yes No





Water Continuous daily 14N(d, n)15O






64Cu Yes No Yes No 67Ga Yes No Yes No 86Y 0.75 1/week Yes No Yes No 94mTc 1.0 1/week Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 1.5 1/month Yes No Yes No 201Tl Yes No Yes No 211At 1.5 1/month Yes No Yes No


419




+1 301 496 0345 +1 301 402 3521




Paul S. Plascjak

[3] TYPE OF CYCLOTRON: Fixed energy compact


MANUFACTURER: Japan Steel Works, Ltd.

(II) UPGRADE:

MODEL: JSW-1710 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17.5 9.8 Yes No

Maximum beam available (µA) 150 150 Typical beam employed (µA) 50 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




72 (6 days/ week) ~ 35 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 18F FDG provided to one centre 1/week

Yes No


Yes No




420




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG Yes No Yes No Dopa Yes No Yes No Dopamine Yes No Yes No F Pr TZPZ Yes No Yes No























COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 6 -18F – Cylofoxy.

421




+1 301 496 0345 [email protected] +1 301 402 3521




Paul S. Plascjak

[3] TYPE OF CYCLOTRON: Fixed energy compact



(II) UPGRADE:

MODEL: CS 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 26.5 14.8 38.1 29.6 Yes No Maximum beam available (µA) 200 300 135 90 Typical beam employed (µA) 60 100 60 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




72 (6 days/week) ~ 35 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 18FDG provided to one centre, 1/week

Yes No

[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site? Research/diagnosis on site.

Yes No




422




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG Yes No Yes No Dopa Yes No Yes No Dopamine Yes No Yes No F Pr TZPZ Yes No Yes No























COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 6 -18F – Cylofoxy.

423

COUNTRY: UNITED STATES OF AMERICA USA-33 [1] INSTITUTE: National Superconducting Cyclotron Laboratory

South Shaw Lane East Lansing, MI 48824-1321


+1 517 355 9671 +1 517 353 5967


Dr. C.-K. Gelbke Director


Peter S. Miller

[3] TYPE OF CYCLOTRON: Superconducting magnet cyclotron


MANUFACTURER: In-house (II) UPGRADE: 1996-1998 MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide





If yes and available, name of institution/s & how often? We supply beams of radionuclides to users, many from other institutions.

Yes No


Yes No




424




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























425

COUNTRY: UNITED STATES OF AMERICA USA-34 [1] INSTITUTE: National Superconducting Cyclotron Laboratory

Michigan State University South Shaw Lane East Lansing, MI 48824-1321


+1 517 355 9671 +1 517 353 5967


Dr. C.-K. Gelbke Director4


Peter S. Miller

[3] TYPE OF CYCLOTRON: Superconducting magnet cyclotron


MANUFACTURER: In-house (II) UPGRADE: 1996-1998 MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




426




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























427

COUNTRY: UNITED STATES OF AMERICA USA-35 [1] INSTITUTE: North Shore University Hospital

Research Department - Cyclotron/ PET Facility 350 Community Drive Manhasett, NY 11021


+1 516 562 1055 [email protected] +1 516 562 1120


Dr. J. Robert Dahl


Thomas Chaly

[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1987 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17F [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17.5 8.75 17.5 Yes No Maximum beam available (µA) 180 180 Typical beam employed (µA) 30-40 30-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




20 20 4, plus 2 weeks/year for periodic maintenance


If yes and available, name of institution/s & how often? Only to research collaborators with continuing joint projects.

Yes No


Yes No




428




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























429

COUNTRY: UNITED STATES OF AMERICA USA-36 [1] INSTITUTE: Northern California PET Imaging Center

3195 Folsom Boulevard Sacramento, CA 95816


+1 916 737 3200


Dr. Peter Valk


Mason Jones






If yes and available, name of institution/s & how often? 18F-FDG, 1/month Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



430




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F


















13N-ammonia Yes No Yes No Yes No





15O-water








431

COUNTRY: UNITED STATES OF AMERICA USA-37 [1] INSTITUTE: Oak Ridge National Laboratory

Bldg. 6000, MS 6368 Oak Ridge, TN 37831-6368


+1 423 574 4111 +1 423 574 1268


B.A. Tatum Engineering Manager


S.W. Mosko

[3] TYPE OF CYCLOTRON: K=100 Isochronous YEAR OF: (I) INSTALLATION 1960 MANUFACTURER: ORNL (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) < 60 < 40 Yes No Maximum beam available (µA) < 100 < 200 Typical beam employed (µA) < 50 < 100 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




432




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























433

COUNTRY: UNITED STATES OF AMERICA USA-38 [1] INSTITUTE: PET Net - Chicago

200 E. Howard Street No. 240 Des Plaines, IL 60018


+1 847 297 1322


Mr. Russ Greenberg Manager


Clyde Cole






If yes and available, name of institution/s & how often? 18F-FDG, 5 × per week Yes No


Yes No




434




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























435

COUNTRY: UNITED STATES OF AMERICA USA-39 [1] INSTITUTE: PETNet Pharmaceutical Services

1350 Manufacturing Drive, Suite 105 Dallas, TX 75207


+1 214 741 2075 [email protected] +1 214 741 9323


Mr. Steve Torres









Yes No




436




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 133 96 1.3 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 59 3 /day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
























437

COUNTRY: UNITED STATES OF AMERICA USA-40 [1] INSTITUTE: PETNet Pharmaceutical Services

1350 Manufacturing Drive, Suite 105 Dallas, TX 75207


+1 214 741 2075 [email protected] +1 214 741 9323


Mr. Steve Torres









Yes No




438




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 133 96 1.3 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F






18FDG 59 3 /day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
























439

COUNTRY: UNITED STATES OF AMERICA USA-41 [1] INSTITUTE: PET Net/VAMC Palo Alto

Nuclear Medicine Service (115) 3801 Miranda Avenue




Dr. Henry C. Padgett Manager


Dave Wilson





5-15 5-15 ~ 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 15O [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 2-3/ week Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) 3 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



440




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























441

COUNTRY: UNITED STATES OF AMERICA USA-42 [1] INSTITUTE: Positron Emission Tomography Facility

Room 0402 Yellow Zone, Box 3808 Department of Radiology Duke University Medical Center Durham, NC 27710


+1 919 684 7836 [email protected] +1 919 684 7130


Bruce W. Wieland, PhD. Cyclotron Director, Associate Research Professor


Caludio Illan, MSEE Michael Dailey, Operator Shawn Murphy, BSNE, Operator

[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1985 MANUFACTURER: The Cyclotron

Corporation (II) UPGRADE: 2001 — vacuum lock ion source

system by Cyclotron, Inc. MODEL: CS-30 [4] CYCLOTRON CHARACTERISTICS: Switching magnet into seven external target beam lines, internal 211At target system MIT-1

by Cyclotron, Inc. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 27 15 39 30 Yes No Maximum beam available (µA) 40 external 20 external 20 external 100 internal Typical beam employed (µA) 20 15 20 60 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



442




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 40 97 0.4 300 Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG 12 3/day Yes No Yes No Yes No Yes No












Ammonia 1 3/week 13C(p, n) 13N Yes No Yes No Yes No





H2 O 1 2/week 14N(d, n) 15O O2 8 2/week 14N(d, n) 15O CO 8 2/week 14N(d, n) 15O






64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At 4 1/week Yes No Yes No


443

COUNTRY: UNITED STATES OF AMERICA USA-43 [1] INSTITUTE: Regional Nuclear Pharmaceutical, LLC

1224 3rd Avenue South University Park Birmingham, Alabama 35233


+1 205 322 4252 [email protected] +1 205 322 4859


Mr. John Haynes Director of Operations






30 25 0 2 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify):

18F production

25/week [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? New Orleans, Regional PET; Memphis Regional PET; Jeff Anderson Regional Medical Centre.

Yes No


Yes No




444




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 37 >95 1 Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG 55 2/day Yes No Yes No $750/dose Yes No Yes No Yes No Yes No Yes No Yes No
























445

COUNTRY: UNITED STATES OF AMERICA USA-44 [1] INSTITUTE: Saint Louis University

Health Sciences Center, School of Medicine Division of Nuclear Medicine 3635 Vista Avenue at Grand Blvd. P.O. Box 15250 St. Louis, MO 63110-0250


+1 314 577 8801 +1 314 268 5486


Dr. Ranajit K. Bera Assistant Professor


Dr. James W. Fletcher, Director





20 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify):

Radiopharmaceuticals

20 h/week [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) Advanced – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



446




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 40 95 0.38 140 Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG 15-20 everyday Yes No Yes No Yes No Yes No












13NH3 0.8 13C(p,n)13N Yes No Yes No Yes No





H215O 15 15N(p,n)15O







COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 18F - Cyclofoxy

447

COUNTRY: UNITED STATES OF AMERICA USA-45 [1] INSTITUTE: Saint Joseph's Positron Center

3003 W. Dr. Martin Luther King, Jr. Boulevard Tampa, FL 33607-4227


+1 813 876 5620


John Mather


Kathie Krista Mike Mosley John O'Connen






If yes and available, name of institution/s & how often? 18F-FDG, 5 days/week Yes No


Yes No




448




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























449

COUNTRY: UNITED STATES OF AMERICA USA-46 [1] INSTITUTE: State University of New York at Buffalo

Department of Nuclear Medicine 105 Parker Hall, 3435 Main Street Buffalo, NY 14214-3007


+1 716 838 5889 [email protected] +1 716 838 4918


Prof. R. E. Ackerhalt Director of the Cyclotron Facility


Michael S. Haka

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1992 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 Yes No Maximum beam available (µA) 0-450 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




164 8 ~ 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 103 Pd [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 18F-FDG VA, daily; 13N-ammonia, weekly; -18F-FDG, MFH 3-4 x/week/Roswell 1/week/Biomedical Research, 1-2/week

Yes No


Yes No




450




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG 1/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No












Ammonia 1/week Yes No Yes No Yes No





Water CO







COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 62Cu, 62Zn

451

COUNTRY: UNITED STATES OF AMERICA USA-47 [1] INSTITUTE: Texas A & M Cyclotron Institute

Texas A & M University College Station, TX 77843-3366


+1 409 845 1411 [email protected] +1 409 845 1899


J.B. Natowitz Director


D. May F. Abegglen

[3] TYPE OF CYCLOTRON: Superconducting with ECR source


MANUFACTURER: TAMU (II) UPGRADE: MODEL: K500 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 60 120 130 240 Yes No Maximum beam available (µA) Typical beam employed (µA) 0.2 0.1 0.2 0.1 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




452




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 7.5 - 15 96 Yes

No Ne (d, α) 18F 16O (α, x) 18F






























453

COUNTRY: UNITED STATES OF AMERICA USA-48 [1] INSTITUTE: The Christ Hospital

2139 Auburn Avenue Cincinnati, OH 45219


+1 513 585 0836 [email protected] +1 513 585 0835


Mr. Thomas G. Kemme Manager


Ms. Carla C. Pemberton, RPh. Mr. George H. Day, RPh.





12 12 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F- FDG, 13NH3 [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? University of Cincinnati – 2/week; Fort Hamilton Hughes Hostpital – 1/month; Proctor & Gamble – 1/month

Yes No


Yes No




454




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 32 > 95 0.33 100 Yes

No Ne (d, α) 18F 16O (α, x) 18F












Acetate 30 1-2/yr Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 1.2 1/week Yes No Yes No Yes No












455

COUNTRY: UNITED STATES OF AMERICA USA-49 [1] INSTITUTE: The Queen's Medical Center

1301 Punchbowl Street Honolulu, HI 96813


+1 808 537 7077 [email protected] +1 808 585 5095


Pat McGuigan Manager


Marc Coel, MD

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1998 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) (yes) Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




5 1 5 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [F-18] Choline [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Tripler Hospital and Kuakini Hospital

Yes No


Yes No




456




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F > 95 1.1 200 Yes

No Ne (d, α) 18F 16O (α, x) 18F





























COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) [F-18] Choline

457

COUNTRY: UNITED STATES OF AMERICA USA-50 [1] INSTITUTE: Theragenics Corporation

5325 Oakbrook Parkway Norcross, GA 30093


+1 770 381 8447


Tony Longo Cyclotron Facility Manager


Tom West; Ty Tobin Mr. Joe Rodgers; J. Hwung

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1996 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18+ [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 Yes No Maximum beam available (µA) various Typical beam employed (µA) N/A [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




144-168 Typical 0-36 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Medical; Typical 1 to 10 / month/ client

Yes No


Yes No




458




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F




























64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd 10 - 60 1/week Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Brachytherapy

459




+1 770 3818 447




Tom West; Ty Tobin Mr. Joe Rodgers; J. Hwung







Yes No


Yes No




460




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























461




+1 770 381 8447




Tom West; Ty Robin Joe Rodgers; J. Hwung







Yes No


Yes No




462




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























463

COUNTRY: UNITED STATES OF AMERICA USA-53 [1] INSTITUTE: University of California at Los Angeles

Biomedical Cyclotron 10833 Le Conte Avenue Los Angeles, CA 90095


+1 310 825 6231 +1 310 825 4517


N. Satyamurthy






40 20 10 2-3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Several 18F and 11C labeled radiopharmaceuticals [9] Do you supply radionuclides to other institutions?



Yes No




464




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 40 95 0.8 15 750 5 Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG 20 10/week Yes No Yes No Variety of 18F-labeled prods.

10/week Yes No Yes No







11C-Acetate 10 2/week Yes No Yes No Variety of 11C-labeled prods.

4/week Yes No Yes No







Ammonia 3 20/week 16O(p, α) 13N Yes No Yes No Yes No





H2O 4 10/week 15N(p, n) 15O O2 4 3/week CO 4 3/week








465

COUNTRY: UNITED STATES OF AMERICA USA-54 [1] INSTITUTE: University of California-Irvine

Brain Imaging Centre Irvine, CA 92697


+1 714 824 2018 [email protected] +1 714 824 2230


Dr. Ahmod A. Najafi


[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1988 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 17 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 8-10 Yes No Maximum beam available (µA) 20 Typical beam employed (µA) 2-3 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




12 12 2 -3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) (yes) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



466




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG Yes No Yes No Dopa Yes No Yes No Yes No Yes No Yes No Yes No
























467

COUNTRY: UNITED STATES OF AMERICA USA-55 [1] INSTITUTE: University of Iowa

PET Imaging Centre Iowa City, IA 52242


+1 319 356 4100 [email protected] +1 319 353 6512


Professor Richard D. Hichwa Director


G. Leonard Watkins Laura Boles Ponto Mark T. Madsen

[3] TYPE OF CYCLOTRON: Positive ion, sector-focused, resistive magnet


MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17 F [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 7.3 (fixed energy) Yes No Maximum beam available (µA) 1-70 1-70 Typical beam employed (µA) 25-50

100 max 10-15

100 max

[5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




> 40 20-30 < 1 target maintenance 1/year



[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site? Medical research/diagnosis

Yes No




468




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG Yes No Yes No Yes No Yes No Yes No Yes No






Mehionine Yes No Yes No Acetate Yes No Yes No CO, CO2 Yes No Yes No Receptor ligands

Yes No Yes No






Yes No Yes No





Water CO, CO2 O2







COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 48V

469

COUNTRY: UNITED STATES OF AMERICA USA-56 [1] INSTITUTE: University of Michigan

3480 Kresge III Ann Arbor, MI 48109-0552


+1 313 763 9244 +1 313 764 0288


Professor Michael R. Kilbourn Director, PET Chemistry


Dr. Robert Koeppe Mr. James Moskwa

[3] TYPE OF CYCLOTRON: Medical YEAR OF: (I) INSTALLATION 1982 MANUFACTURER: The Cyclotron


MODEL: CS-30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 26.0 15.0 38.0 30.0 Yes No Maximum beam available (µA) 200 300 100 90 Typical beam employed (µA) 30 30 50 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




470




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F












Epinephrine Yes No Yes No Pseuolophedrine Yes No Yes No Diahydiotetabenazine

Yes No Yes No

Acetate Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED

Name (list)










Water







COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 62Zn

471

COUNTRY: UNITED STATES OF AMERICA USA-57 [1] INSTITUTE: University of Pennsylvania

Department of Radiology 1 Silverstein Philadelphia, PA 19104


+1 215 662 7552 [email protected] +1 215 662 7551


Dr. Carlos Gonzalez Lepera Facility Manager


Harry White

[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1986 MANUFACTURER: Japan Steel Works,

Ltd. (II) UPGRADE:

MODEL: BC 3015 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 13/22/30 11/15 17/23/40 13/22/30 Yes No Maximum beam available (µA) Typical beam employed (µA) 25 25 20 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




15 12 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 55Co; 89Zr [9] Do you supply radionuclides to other institutions?



Yes No




472




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG Yes No Yes No Yes No Yes No Yes No Yes No






Flumazenil Yes No Yes No Yes No Yes No Yes No Yes No











Water








473

COUNTRY: UNITED STATES OF AMERICA USA-58 [1] INSTITUTE: University of Southern California

1510 San Pablo, #350 Los Angeles, CA 90033


+1 213 342 5884 [email protected] +1 213 342 5778


Dr. Peter S. Conti Director, PET Imaging & Radiological Resources


James R. Bading; Miar Alauddin Mr. John Fissikis; Mr. Keith Higa






If yes and available, name of institution/s & how often? 18F-FDG daily Yes No

[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site? Both on and off site

Yes No




474




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F























Water O CO, CO2








475

COUNTRY: UNITED STATES OF AMERICA USA-59 [1] INSTITUTE: University of Tennesse Medical Centre

Biomedical Imaging Center 1924 Alcoa Highway, Knoxville, TN 37920


+1 865 544 9818 or 865 544 9697 [email protected] OR [email protected] +1 865 544 8395


C.P.D. Longford Manager


K.F. Hubner

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1987 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 2000 - two (2) high pressure target; APS power supply upgraded

2001 - new main magnet power supply - solid state; new automated chemistry equipment

[4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11.2 Yes No Maximum beam available (µA) Typical beam employed (µA) 32/target [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




30-40 30-40 1-2 4-8 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Daily deliveries of 18FDG to hospitals within 4-5 km radius. Currently have 20 customers, shipping up to 20 doses/day with planned expansion to ship 60 doses/day.

Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



476




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 65 > 94 0.90 5 1200 None Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG 30-60 2-3/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






ACBC 3.0 5-10/year Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No

















COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Planned: 18F -BPA and DOPA – not yet available.

477

COUNTRY: UNITED STATES OF AMERICA USA-60 [1] INSTITUTE: University of Texas Houston

6431 Fannin Street, Houston, TX 77030


+1 713 500 7755 [email protected] +1 713 500 7771


Carlos Gonzalez Lepera Associate Professor and Executive Director

OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION NAME/POSITION NAME/POSITION

Nancy Haberman, Chemist Kevin Grilley, Radiopharmacist Russell Hildebrandt, Radiopharmacist Isidoro Vaquila, Cyclotron Engineer David Andews, Cyclotron Operator

[3] TYPE OF CYCLOTRON: Variable energy isochronous


MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-40 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 40 20 40 Yes No Maximum beam available (µA) 150 40 30 Typical beam employed (µA) 40 15 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




50 25 10 4 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 1 Radiography: Materials science: 1 Proton therapy: Physics: 1 Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 22Na, 0.037 GBq Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 124I , 211At [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Hospitals and PET Centres throughout Southeast Texas

Yes No


Yes No




478




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 100 95 1.4 300 Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG 50 2/day Yes No Yes No NaF 50 1/day Yes No Yes No Yes No Yes No












Ammonia 4 6/day 160(p, α)13N Yes No Yes No Yes No





Water 4 1/day 14N(d, n)15O






64Cu Yes No Yes No 67Ga 555 Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 370 Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No


479

COUNTRY: UNITED STATES OF AMERICA USA-61 [1] INSTITUTE: University of Texas Research Imaging Center

Health Science Center, San Antonia 7703 Floyd Curl Drive San Antonio, TX 78284


+1 210 567 8190 [email protected] +1 210 567 8152


Dr. Peter Fox Director


Paul Jerabbk

[3] TYPE OF CYCLOTRON: Fixed energy, isochronous, positive ion


MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17F [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17.2 8.6 Yes No Maximum beam available (µA) < 10 < 10 Typical beam employed (µA) 10-50 10-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




3-5 3-5 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No




480




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F












Acetate Yes No Yes No Methionine Yes No Yes No Yes No Yes No Yes No Yes No











Water








481

COUNTRY: UNITED STATES OF AMERICA USA-62 [1] INSTITUTE: University of Washington Medical Centre

Department of Radiation Oncology Box 356043, Room NN-136, 1959 NE Pacific Street Seattle, WA 98195-6043


+1 206 548 4136 [email protected] +1 206 548 6218


Dr. Ruedi Risler Senior Cyclotron Engineer


Professor Kenneth A. Krohn Professor Jeanne A. Link

[3] TYPE OF CYCLOTRON: Compact room temperature cyclotron


MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 50.5 Yes No Maximum beam available (µA) 60 Typical beam employed (µA) 60 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




10 3 6 30 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 1 Radiography: Materials science: Proton therapy: Physics: Neutron therapy: 30 Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No 35 [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F, 11C, 15O, 13N, 86Y, 99Tc, 124I, 19Ne [9] Do you supply radionuclides to other institutions?



Yes No




482




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 15-20 95 3 No 60 None Yes

No Ne (d, α) 18F No 16O (α, x) 18F No






18FDG 5 2/day Yes No Yes No FES 1 3/month Yes No Yes No FM180 1 3/month Yes No Yes No FLT 1 3/month Yes No Yes No






Glucose 1 1/month Yes No Yes No Thyamidine 1 3/momth Yes No Yes No MHED 1 4/month Yes No Yes No CGP12177 2 8/month Yes No Yes No Flumazenile 1 1/month Yes No Yes No











H2O O2






64Cu Yes No Yes No 67Ga Yes No Yes No 86Y 2/yr Yes No Yes No 94mTc 2/yr Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I planned Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No


483

COUNTRY: UNITED STATES OF AMERICA USA-63 [1] INSTITUTE: University of Wisconsin

Medical Physics Department, 1530 Med. Serv. Center 1300 University Avenue Madison, WI 53706


+1 608 262 2170 +1 608 263 3910


Professor R.J. Nickels


Andrew Roberts Onofre de Jesus

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1986 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 3 Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



484




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























485

COUNTRY: UNITED STATES OF AMERICA USA-64 [1] INSTITUTE: VA Medical Centre (11P)

1 Veterans Drive Minneapolis, MN 55417


+1 612 725 2230 [email protected] +1 612 725 2068


Dr. David Rotenberg


Mr. Rashid Syed Ms. Carroll Arnett E. Akguen Munawwar Sajjad

[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1985 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-40 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 40 20 Yes No Maximum beam available (µA) 40 50 Typical beam employed (µA) 25 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




30 15 2 6 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other


Yes No


Yes No




486




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 15 > 95 1.2 100

Yes No

Ne (d, α) 18F 11 99.999 16O (α, x) 18F












Acetate 1.8 on demand Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No






Ammonia 2.2 5/week 16O(p,a)13N Yes No Yes No Yes No





15O Water 6.0 36/week 14N(d,n)15O 14O Water 3.5 on demand 14N(p,n)14O








487

COUNTRY: UNITED STATES OF AMERICA USA-65 [1] INSTITUTE: VAMC & University of Pittsburgh Medical Facility

PET Center -9B 200 Lothrop Street Pittsburg, PA 15213


+1 412 647 0736 [email protected] +1 412 647 0700


Professor Chet Mathis Co-Director, PET Facility


Professor David Townsend, Co-Dir., PET Facility

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 80 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION:


h/week for research



35 20 15 <5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Many, various – 11C-CFT, 11C-acetate and choline [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 3 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 + 2 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



488




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 22 > 95 0.3 200 Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG 7 5/week Yes No Yes No 18F-Altanarin 2 2/week Yes No Yes No Yes No Yes No






Flumezenil 4 1/week Yes No Yes No McN 5652 4 2/week Yes No Yes No Way 100635 1 4/week Yes No Yes No PMD 4 4/week Yes No Yes No Raclopride 3 10/week Yes No Yes No






NH3 3 4/week 16O(p,a)13N Yes No Yes No





H2O 4-20 20/week O2 4-10 5/week 15N(p,n)15O








489

COUNTRY: UNITED STATES OF AMERICA USA-66 [1] INSTITUTE: Vanderbilt University Medical Center

Radiology Department 100 Medical Center South Nashville, TN 3723206315




Dr. Ronald G. Manning


Jeff Clanton Jeff Clauton,; Dominique Delbeke Robert Kessler

[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1989 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 80 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide





If yes and available, name of institution/s & how often? PETNet Site; Several Customers >15

Yes No

[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site? Both on & off sites.

Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) 4 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



490




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























491

COUNTRY: UNITES STATES OF AMERICA USA-67 [1] INSTITUTE: Weill Medical College at Cornell University and

Memorial Sloan Kettering Cancer Center Consortium 1300 York Avenue New York, NY 10021


+1 212 639 2458 [email protected] +1 212 717 3821


Dr. Ron Finn Head, Cyclotron Division


Yiauchung Sheh, MS, Senior Cyclotron Engineer

[3] TYPE OF CYCLOTRON: Negative Ion YEAR OF: (I) INSTALLATION Ongoing and in progress (2001) MANUFACTURER: EBCO Industries (II) UPGRADE: Incorporation of external beam MODEL: TR 19/9 line with target changer [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide




[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: 10% anticipated Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): Radionuclide

preparation 90% anticipated


If yes and available, name of institution/s & how often? On scientific collaborative basis

Yes No


Yes No




492




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F >95 Yes

No Ne (d, α) 18F 16O (α, x) 18F





























COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Imaging Center building completion scheduled for October 2001. Cyclotron already in vault, awaiting building service availability for start of the assembly.

493

COUNTRY: UNITED STATES OF AMERICA USA-68 [1] INSTITUTE: West Virginia University Hospital PET Centre

P.O. Box 9236 Morgantown, WV 26506-9236


+1 304 293 7798 [email protected] +1 304 293 7142


Dr. Naresh C. Gupta Director


Mr. Samuel M. Mazza Mr. Raymond R. Raylman

[3] TYPE OF CYCLOTRON: Negative ion, dual beam


MANUFACTURER: General Electric (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.5 Yes No Maximum beam available (µA) Typical beam employed (µA) 20 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide





If yes and available, name of institution/s & how often? 18F-Fluoride – irregularly; 18F-FDG - planned

Yes No


Yes No




494




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F























Water








495

COUNTRY: UNITED STATES OF AMERICA USA-69 [1] INSTITUTE: William Beaumont Hospital

Department of Nuclear Medicine 3601 West Thirteen Mile Road Royal Oak, MI 48083-6769


+1 313 551 831


Dr. Ram B. Sharma Radiochemist






13 13 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Nucl. Med. 40 Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C and 15O [9] Do you supply radionuclides to other institutions?



Yes No




496




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F 30 95-98 0.3 Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG 16/batch 5/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No












13NH3 1.9 2/month Yes No Yes No Yes No












497

COUNTRY: UNITED STATES OF AMERICA USA-70 [1] INSTITUTE: Yale University/VAMC West Haven

PET Imaging Center (115A) 950 Campbell Avenue West Haven, CT 06516




Dr. Pradeep Garg Director, Radiopharmaceutical Chemistry






30-40 ~ 10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F- labeled androgens, 18F- labeled prostate probes [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Yale University and VA Nuclear Medicine: 0-2 times/month

Yes No


Yes No




498




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F ~16 >98 0.32 Yes

No Ne (d, α) 18F 16O (α, x) 18F






18FDG 5 - 6 4 - 10/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No












Ammonia ~1 1-10/month 16O(p,a)13N Yes No Yes No Yes No





Water 3-4 0-40/week







COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 11C - NNC 112, Dolipram, Tropanes; 18F Deutero-Altanserine, para fluoro benzylguanidine, Fallypride.

499

SAMPLE QUESTIONNAIRE COUNTRY: [1] INSTITUTE:




[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION MANUFACTURER: (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS:

1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide







Yes No




500




18O used


18OH2 (ml) 18O2 (ml) 18OH2 (g)

18O2 (l) 18O (p, n) 18F Yes

No Ne (d, α) 18F 16O (α, x) 18F






























C ARGENTINA ARG-1 - IAEA9 COUNTRY: ARGENTINA ARG-2 [1] INSTITUTE: Fundación Escuela de Medicina...

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Transcript of C ARGENTINA ARG-1 - IAEA9 COUNTRY: ARGENTINA ARG-2 [1] INSTITUTE: Fundación Escuela de Medicina...