By Gucci Aguh Shannon Murphy
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Transcript of By Gucci Aguh Shannon Murphy
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ByGucci AguhShannon Murphy
STRONGLYLOIDES STERCORALIS
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Introduction Strongyloides
stercoralis is a common enteric helminthic parasite
“Thread worm” Parasite of man
• 38 Species found in dogs, cats and many other mammals• 2 different life cycle forms
• Free-living• Parasytic
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Who gets it? Where?
The Definitive host of Stronglyloides Stercoralis is Humans S. Fulleboni infects Chimpanzees and
Baboons Geographic Distribution
Tropical and Subtropical Areas Cases also occur in temperate zones Most frequently found in rural areas,
Insitutional settings and lower socioeconomic groups
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Morphology Adult females measure 2-3 mm in length by 20 to 50 μm.
Long cylindrical Esophagus which occupies 1/3 the length of the worm.
Rhabditiod is (L-1 stage) 180 – 380 by 14-20 μm.
Rhabditoid larvae have a short buccal cavity, an attenuated tail and a prominent genital in its early stage. These features are used to differentiate S. stercoralis from Hookworm rhabditiod larvae.
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Morphology Filariform larvae (L3, the infective stage) have a long non bulbous esophagus of about 2/5 of the lenght of the body.
Filariform larvae are slender and have a notched tip of the tail.
Filariform larvae measure 300-600 µm in lenght by 10-20 µm.
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Life
Cyc
le
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Rhabditiod Eosophagus
Filariform larvae have a long non bulbous esophagus
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The intestinal mucosa during S.stercoralis hyperinfection: a) histological section of the mucosa showing an adult worm, larvae and eggs; b) at higher magnification larvae and eggs within the mucosa; c) cross section of an adult female in the crypt: 2 reproductive tubes and the intestine are visible; d) egg (50-60 by 30-35 µm) of S.stercoralis within the mucosa; e) longitudinal section of an adult female showing a reproductive tube the intestine.
The intestinal mucosa during S.stercoralis hyperinfection:
ab c d
e
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The free living females measure about 1 mm in lenght by 50-75 µm: a) a free living female containing embryonated eggs; b) the free living females have a rhabdithoid esophagus; c) particular of the buccal cavity; d) the rhabdithoid esophagus; e) eggs within the free-living female.
a bc
e
d
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Pathogenesis Frequently is Asymptomatic GI Symptoms
Abdominal Pain and Diarrhea Pulmonary symptoms can occur Dermatological symptoms
Uticarial Rashes in Buttocks and waist area
Immunocompromised patients Abdominal Pain, Distension, shock,
pulmonary and neurological complications with septicemia and is potentially fatal.
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Diagnosis Larvae in stool using concentration methods. Filter paper technique and wet mount
preparation. larvae in duodenal fluid. Serial Samples. Antibody detection. Morphological comparison to other
parasites.
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Treatment & Prevention Anthelmintics
Ivermectine (200 micrograms/Kg in a single dose)
Albendazole (25 mg/Kg twice a day for 2 days)
Prevention Teaching sanitation Proper disposal of human waste
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References
http://www.dpd.cdc.gov/dpdx/html/Strongyloidiasis.htm Center for Disease Control and Prevention
http://www.diagnose-me.com/cond/C654193.html
Strongyloides Stercoralis. http://www.cdfound.to.it/html/str1.htm#ss0