Common carotid artery CCA External Carotid artery ECA Internal ...
By Dr. Mohamed Dorgham, MD Lecturer of Anesthesia, Critical Care medicine and Pain Therapy Carotid...
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Transcript of By Dr. Mohamed Dorgham, MD Lecturer of Anesthesia, Critical Care medicine and Pain Therapy Carotid...
By Dr. Mohamed Dorgham, MD Lecturer of Anesthesia, Critical Care medicine and Pain Therapy
Carotid End ArterectomyCarotid End Arterectomy
Anatomy Anatomy
PathophysiologyPathophysiology
Atheroscelero-sis
Carotid Artery Occlusive Dis-
ease
Stroke TIA Amaurosis Fugax
Asympto-matic Bruit
Embolization
Hypoperfusion
StrokeStroke is the 3rd leading
cause of Death
andlong term disability
in USA
Perioperative Stroke
Carotid Stenosis
> 50%
Asymptomatic Carotid
Bruit1.0%
3.6%
IndicationsIndications
North American SymptomaticCEA Trial
North American SymptomaticCEA Trial European Carotid Surgery TrialEuropean Carotid Surgery Trial
1992
Definitive results for symptomatic patients with high grade stenosis
> 70%
SurgicalMedical0%5%
10%15%20%25%30%
2 years Stroke Rate
2 years Stroke Rate
Surgi
cal
Med
ical
0.00%5.00%
10.00%15.00%20.00%
Long Term Stroke Rate
Long Term Stroke Rate
9% # 26%9% # 26% 2.8% # 16.8%2.8% # 16.8%
70-99%70-99%
CA Surgery Asymptomatic Narrowing Operation Versus ASA
CA Surgery Asymptomatic Narrowing Operation Versus ASA
Mayo Asymptomatic CEA StudyMayo Asymptomatic CEA Study
5 Randomized trials evaluated CEA in Asymptomatic Pts
European Asymptomatic CA Surgery TrialCAS ~70%
European Asymptomatic CA Surgery TrialCAS ~70%
Asymptomatic CA (60%) Atherosclerosis Study
Asymptomatic CA (60%) Atherosclerosis Study
Depatment of veteransCEA + Aspirin Versus Asprin alone
>or= 50%
Depatment of veteransCEA + Aspirin Versus Asprin alone
>or= 50%
Largest Trial
CEA is not indicated 50-90% stenosis
Increased no. of MI & TIA
In Surgical Group
No difference in the incidenceOf Stroke & Death
5 yrs risk of Ipsilateral StrokeCEA+ASA: 5.1%
ASA alone: 11.0%
CEA+ASA: 6.4%ASA alone: 11.8%
Perioperative Morbidity and Mortality rates
Perioperative Morbidity and Mortality rates
Sympt
omati
c CAS
Asym
ptom
atic C
AS0
1
2
3
4
5
6
StrokeMortality
Systematic review of 51 studies ( from 1980- 1995) reported the results below
Systematic review of 51 studies ( from 1980- 1995) reported the results below
5.6%5.6%
1.6%1.6%1.3%1.3%
3.8%3.8%
Preoperative EvaluataionPreoperative Evaluataion
Cor-rectable
CAD28%
Severe ValvularDisease
Severe ValvularDisease Decompensated
CHF
DecompensatedCHF
Recent MIRecent MIUnstable AnginaUnstable Angina
Systemic Atherosclerosis
CAD Leading cause of
Early & Late Mortalities
Evaluation of Myocardial Function
Evaluation of Myocardial Function
Trials established that CEA prevents Stroke in selected patients
Perioperative medical TTT is standard for all CEAsFurther tests would have little potential to alter TTT
Percutaneous angioplasty + Stenting may be an alternative in high risk ptsCEA Remains the Gold Standard
1
2
3
No reduction in short term mortality with prophylactic revascularizationLow overall rates of cardiac M & M
It would be unlikely that further specialized tests would cancel the procedure
It would be unlikely that further specialized tests would cancel the procedure
4
Severe CAD (Unstable)+
Severe Carotid Artery Occlusive disease(Symptomatic)
Combined CEA +
Coronary revascularization
Role of Carotid Angioplasty + StentingBefore Staged CABG
Still unproven
Ablation of Stress re-sponses
Heart Protection
Brain Protection
Goals
Anesthetic management
Awake patient during or at the end of surgeryFor neurological examination
HR & BP control
Ablation of Surgical pain
Regional Versus General Anesthesia
No large scale prospective randomized trials evaluated the difference in Neurologic & Cardiac outcomes with Regional versus General Anesthesia
Most reports indicate no difference in perioperative mortality rates on basis of anesthetic technique
Rate of conversion from RA to GA 2-6%Decision to use one technique is based on:• Surgeon’s & Anesthetist’s experience
• Patient pereference
General Versus Regional Anesthesia
No clinical neurological assessment
Less BP stability
1. Inability to use pharmacological cerebral protection2. Inadequate access to airway 3. Near toxic level of LA4. Phrenic nerve paresis5. Claustrophobia6. Increased catechoamine level
1. Continuous neurological assessment2. Greater stability of BP.3. Reduced need for shunting4. Avoidance of expensive monitoring & Reduced hospital costs5. High patients preference (92%)
Advantages
Disadvantages
Disadvantages
1. Difficult vascular anatomy• Short neck• High carotid bifurcation
2. Control of respiration3. Brain protective measures4. Avoids excessive neck palpitations
Advantages
Commonly used Induction agentsCommonly used maintenance anestheticsShort to Intermediate acting NDMRStable hemodynamicsAwake patient at the end of procedure
General Anaesthesia
Sufentanil: 0.5-1.0 mcg/kg for sedation slow speech or delayed response to questionsThiopental / Etomidate / PropofolO2 50% + Low dose (< 0.5 MAC) inhaled AnestheticVecuroniumCombined Remifentanil + Propofol infusion
IsofluraneLow Critical rCBF
Less EEG changes during CA clamping
SevofluraneSame Critical rCBFRapid Emergence
Stress of Laryngoscopy &Intubation
EsmololUsed liberally
during induction
High normal BPInduced HTN
Hemodynamic Fluctuation
IV volume depletion
EsmololNitroglycerine
Nitroprusside
Light anesthesiaPhenylephrine
EphedrineVasopressors
IV fluids 5ml/KgTitration of Anesthetics
Immediate TTT
Anesthetic Problems
Phenylephrine 50-100 mcg
Surgical manipulations of carotid sinus
Infiltration of Carotid Biforcation
Barorecep-tors activa-
tion
Hypotention & Bradycar-
dia
Intra&
Postop-ertive
Hyperten-sion
Anesthetic Problems
CO2 management
Poor Collaterals
Poor Collaterals
ChronicHypo
perfusion
ChronicHypo
perfusionVasomotorParalysis
VasomotorParalysis
Hypercarbia
Hypocarbia
SteelPhenomenon
Inverse steelPhenomenon
Relation between hypercarbia & cerebral ischemia is unproven
NormocapniaOr
Mild Hypocapnia
Little clinical evidence of Inverse steelPaCO2 23 mmHg increases risk of ischemia
Vasoplegia significantly improve after CEA
Anesthetic Problems
Blood Sugarmanagement
Hyperglycemia increases ischemic injury
Blood glucose > 200mg% Increase incidence of
Stroke / TIA / MI / Death
Maintain blood sugar < 200 mg%
Avoid dangerousHypoglycemia
Anesthetic Problems
Emergence
NeurologicalDeficits
Hypertension&
Tachycardia
Myocardial Ischemia
Discuss with SurgeonAngioplastyReoperation
Aggressive pharmacological
TTT
Propofol # IsofluraneControl BP
Propofol # IsofluraneDecreased pharmacological intervention during emer-
gence
Propofol > IsofluraneDecreased incidence of My-
ocardial ischemia during emergence
All patients with myocardial ischemia on emergence had
SBP>200mmHg
Regional Anesthesia
Blocking C2 to C4 dermatomesSuperficial & Deep Cervical Plexus block
1. Requires Patient cooperation Constant communication Gentle handling of tissues2. Supplemental infiltration of LA by surgeon especially at the lower border and ramus of mandible3. Sedation must be kept to minimum
1.Assess conscious / speech / contralateral hand grip2.Clamp test 2-3 mins in awake pt indicates the need of shunt placement3. BP augmentation with phenylephrine if neurologic deficit
During Clamp Test After shunt placement
Monitoring
Prevent IO Strokes
Identify need of shunting
Identify benefit from BP augmentation
GoalsStump Pressure
It’s the back pressure from the contralateral CA & verte-
brobasilar system
EasyInexpensive
Continously available
Critical Stump pressure is Un-known
<50mmHg is associated with hypoperfusion
Monitoring
Prevent IO Strokes
Identify need of shunting
Identify benefit from BP augmentation
Goals Regional cerebral Blood Flow
Iv or CA injection of Radioac-tive Xenon
Detectors placed over the ipsi-lateral cortex supplied by
MCA
Before – During – AfterCA clamping
Provided the relationship be-tween
Critical rCBF (ml/100gm/min) & EEG
Isoflurane: 10 Enflurane:15
Sevofluran: 10 Halothane: 20
Limitations:Expenses & Expertise
Monitoring
Prevent IO Strokes
Identify need of shunting
Identify benefit from BP augmentation
Goals Electroencephalogram
Incidence of ischemic changes: 7.5-20%Contralateral CA stenosis: 50%
Ischemic changes:CA clamping HypotensionShunt malfunction Cerebral emboli
Limitations: Subcortical & small cortical infarctsFalse negative results Affected by: BP Temperature Anesthetic depth False +ve results perioperative strokes occur PO
Monitoring
Prevent IO Strokes
Identify need of shunting
Identify benefit from BP augmentation
Goals SSEP
Based on the response of sensory cortex “supplied by
MCA” to peripheral sensory nerve
stimulation
Decreased CBF: Decrease amplitudeIncrease latency or both
CBF<12ml/100gm/min:Abolished response
Limitations:Affected by: BP Hypothermia AnestheticsFalse –ve resultsValidity not definitively established
Monitoring
Prevent IO Strokes
Identify need of shunting
Identify benefit from BP augmentation
Goals Transcranial Doppler
Continuous measurement of mean blood flow velocity:
Detects microemblic events in MCA
Shunt function
Need of early CA clamping
Detects early asymptomatic CA occlusion
Hyperperfusion syndrome
Limitations:High rate of technical failureImproved outcome not yet reported
Monitoring
Prevent IO Strokes
Identify need of shunting
Identify benefit from BP augmentation
Goals Cerebral Oxygenation
Jugular BulbVenous monitoring
Cerebral Oximeter
Global cerebral O2 Metabolism: Arterial – Jugular venous O2 content
SjvO2
Global cerebral O2 Metabolism: Arterial – Jugular venous O2 content
SjvO2
Continuous regional cerebral SO2 Through Scalp
Limitations:Wide Pt to Pt variability
Lack of clinical threshold
Continuous regional cerebral SO2 Through Scalp
Limitations:Wide Pt to Pt variability
Lack of clinical threshold
Postoperative Considerations
1. Neurological Complications
ThromboembolicMajor mechanism
Hemodynamic21%
Hypoperfusion Hyperperfusion
Syndrome of abrupt increased blood flow + Loss of autoregulation in surigically reperfused brain
Headache SeizuresFocal neurological signs Brain edemaIntracerebral hage 1-5 days PO (0.4-2.0%)
Risk Factors•Post operative HTN•Preop. severe CA stenosis•Recent contralateral CEA
Postoperative Considerations
2. Post operative Hypotension
Occurs as frequent as HTNOccurs as frequent as HTN
Carotid sinus hypersensitivity and reactivationMore common after regional anesthesiaCarotid sinus hypersensitivity and reactivationMore common after regional anesthesia
Myocardial ischemia & Cerebral ischemiaMyocardial ischemia & Cerebral ischemia
COP: Normal or elevated SVR: reducedCOP: Normal or elevated SVR: reduced
Judicious fluids + VasopressorsJudicious fluids + Vasopressors
Resolves within 12-24 hrsResolves within 12-24 hrs
Postoperative Considerations
3. Cranial & Cervical nerve dysfunction
Recurrent Laryngeal
Nerve
Superior Laryngeal
Nerve
Hypoglossal Nerve
MarginalMandibular
Nerve
Postoperative Considerations
4. Carotid Body Denervation
Unilateral Bilateral
Due to Surgical manipulationDue to Surgical manipulation
Impaired ventilatory response to mild hypoxemia
Impaired ventilatory response to mild hypoxemia
Loss of normal ventilatory responsesLoss of normal ventilatory responses
Loss of normal arterial pressure Responses to acute hypoxia
Loss of normal arterial pressure Responses to acute hypoxia
Increased resting PaCO2Increased resting PaCO2
Central chemoreceptors are the primary sensors for maintaining ventilationSerious respiratory depression in response to opioid administration
Postoperative Considerations
5. Wound Hematoma
North American Symptomatic CEA Trial: 5.5%Most of cases due to venous oozing
North American Symptomatic CEA Trial: 5.5%Most of cases due to venous oozing
External CompressionAggressive BP control
Immediate evacuation
Endovascular InterventionEndovascular InterventionManagement of carotid artery stenosis
By percutaneous interventionFemoral or CCA
Management of carotid artery stenosis By percutaneous intervention
Femoral or CCA
Angioplasty Stenting
GA with short acting drugs
GA with short acting drugs
Sedation With MACSedation
With MAC
Heparin ........> ACT= 250-300 secHeparin ........> ACT= 250-300 sec
Protective devices against embolizationProtective devices against embolization
AnticholinergicsAnticholinergics Intolerance to antiplateletsIntolerance to antiplatelets
Aortic arch diseaseAortic arch disease
CA torsiousityCA torsiousity
Calcification / Heavy thrombus burden / Unstable plaque Calcification / Heavy thrombus burden / Unstable plaque
Considerations Considerations Contraindications Contraindications
1.Manifestations: of CAD (Asymptomatic bruit ...> Stroke)2.Indications: Symptomatic Pt. +/- High grade stenosis3.Further evaluation of myocardial function4.Combined versus Staged operation5.Goals of anesthetic management 6.Regional versus GA7.Anesthetic problems8.Postoperative considerations9.Endovascular intervention
Summary