Bubpha techapattaraporn equal partnership case studies from biotec
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Transcript of Bubpha techapattaraporn equal partnership case studies from biotec
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Equal Partnership: case studies from BIOTEC
Bubpha Techapattaraporn BioLaw Research Unit, Bioresources Technology Unit, BIOTEC, Thailand
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OUTLINES
1. Thai Biodiversity; 2. Thailand and ABS regulation; 3. BIOTEC: the introduction; 4. ABS case studies at BIOTEC 5. Conclusion
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Biodiversity for Biodiversity for bioresourcesbioresourcesThailand accounts for ca. 7-10 % of the world’s species richness
Marine and Mangrove FungiSeed and Leaf-litter Fungi
Freshwater Fungi
Basidiomycota
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Overview of Thai ABS rules and regulations
Enactment of - Thai PVPA Act -The Protection and Enhancement of Thai Traditional Medicinal Wisdom Act
Enactment of
- The National Committee on Conservation Sustainable Use of Biodiversity’s Regulation on Criteria and Methods for ABS from the Use of BR (Thai ABS Regulation)
1999
2004 Ratifying the CBD
2011
2012
Signing the NP -Under consideration and preparation of ratifying; -More of ABS Rules and Regulation??
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Status: Established in 1983 A member of the National Science and Technology Development Agency .
NSTDA is a quasi-government agency, affiliated to Ministry of Science and Technology
Location: Headquarter at Thailand Science Park, 30 kilometers north of Bangkok Personnel: 570 (470 research and scientific staff and approx. 170 Ph.Ds) Budget: Approx 20 million USD (from government and revenue from service
provision and commercialization) 5 Research Units at Thailand Science Park & 10 Satellite Labs at various universities and government agencies
BIOTEC at a glance
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1
NSTDA Organization
NSTDA : National Science and Technology Development AgencyBIOTEC : National Center for Genetic Engineering and BiotechnologyMTEC : National Metal and Materials Technology CenterNECTEC : National Electronics and Computer Technology CenterNANOTEC : National Nanotechnology CenterTMC : Technology Management Center
established by Sci. & Tech. Dev. Act. in 1991
NSTDA Board chaired by Minister of Science and Technology
1983 1985 1985
20032006
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RDE (Conduct research on basic science, platform technology, applied science)TT(Technology transfer to industry and public sector)InfrastructureDevelop and maintain (support the establishment and maintenance of specialized units at universities, conduct policy research, support and subsidize service labs and maintain public databases)HRD (Provide scholarships, organize training, support the establishment of new graduate program in universities)
Support FunctionsSupport Functions- Create public relations and provide science awareness - Seek and maintain international relations
BIOTEC Roles & Core FunctionsBIOTEC Roles & Core Functions
Core FunctionsCore Functions
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Cordyceps sp.
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BIOTEC
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Hirsutella nivea on hopper BCC 2594, collected from Homoptera leaf-hopper, Khao Yai National Park,
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Compound Anti-TB Cytotoxicity MIC; µg/mL vero; IC50 µg/mL 1 0.78 >50 2 0.78 >50 3 0.78 12 4 3.13 not tested
Isaka, M., et al., Tetrahedron Lett. (2005), 61, 5577-5583
Hirsutella nivea BCC 2594 Hirsutellones A-E
R
O NH
O
OH
H
H
H H
H
H3C
O
1 : R = H (A) 4 : R = CH3 (D)
R
OH
H H
H
H3C
ONH
OH
OH
2 : R = H (B) 5 : R = CH3 (E)
OH
H H
H
H3C
O NH
OH
O
O
H
3 (C)
(MeOH extract of mycelia)
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Research at Bioresources Technology Unit, BIOTEC
Bioresources
Culture-dependent approachCulture-dependent approach
Culture-independent approachCulture-independent approach
Screening Value-added products
ConservationConservation
AcademicsAcademics
IndustryIndustryUtilization of
Microbes
BiocontrolBioactive compounds
EnzymesHigh-value products
Managementof microbesManagementof microbes
Conservationand microbialidentification
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BIOTEC-NOVARTIS
3 Phases of collaboration:
1st: 2005-2008
2nd: 2008-2011
3rd : 2011-2014
Objective: to find potential use of microorganisms and natural compounds as sources of potential new medicines.
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The contributions
• Diversity of microbes in Thailand;
• Expertise in knowledge of microorganisms, i.e. collection, identification, preservation, isolation and elucidation of pure natural compound;
• Technology transfer via training (internship, experts, and seminar);
• Consultant
BIOTEC NOVARTIS
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The achievement
• Capacity building via technology transfer (able to automate and improve its extraction and chemical screening system, actenomycetes expert);
• Enable BIOTEC to accumulate more strains;
• Able to set different research directions.
• Diversity of compounds (7,200 microbial isolates and 115 pure compounds have been evaluated against a battery of drug targets).
BIOTEC NOVARTIS
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ABS mechanisms
Equal partnership (based on
complementary expertise of both parties)
Agreement: negotiation (based on the
concept of Mutually Agreed Terms)
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Conclusion: Factors for the success of equal
partnership
• Organisation’s vision and policy; • Expertise of organisation; • Trust between involved parties; • Simple ABS rules and regulation (Mutually
agreed terms)
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Acknowledgement
1. Dr. Kanyawim Kirtikara 2. Dr. Lily Eurwilaichitr 3. Ms. Sronkanok Tangjaijit 4. Ms. Suwanee Chunhametha 5. Dr. Vanicha Vichai
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Thank you very much