Brain Tumours – what should I know? Dr Hannah Lord Consultant Clinical Oncologist.
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Transcript of Brain Tumours – what should I know? Dr Hannah Lord Consultant Clinical Oncologist.
Brain Tumours – what should I know?
Dr Hannah LordConsultant Clinical Oncologist
Causes of brain tumours
Causes:
DNA damage Radiation Genetics
NF- 1 (acoustic neuromas)
Li Fraumeni syndrome
Tuberous sclerosis ( astrocytomas)
multiple endocrine neoplasia type 1(pituitary
macroadenoma) Infection
HIV
Diagnosis
So – how do you suspect a brain tumour?
What makes you suspect a brain tumour in patient?
Morning headache, n+v, confusion New onset of seizures Motor deficit Sensory deficit Personality change Dyshasia Ataxia
Investigations
What would you do?
Ix?
CT brain
MRI brain/spine – to exclude multiple metastaic deposits; to better characterise tumour
How would you classify brain tumours?
Types of Brain Tumours
Primary: benign or malignant (rare)
Secondary: malignant (majority)
Primary brain tumour
Primary brain tumour
Radiology - brain mets
Questions:
Where do brain metastases come from?
Secondary Brain Tumours
Lung
Breast
GI
Any primary potentially
Questions:
How will you initially treat brain secondaries?
How to treat?
Oedema – steroids
Pain – analgaesia
Nausea - antiemetics
How to treat - secondaries
Depends on Primary cancer and its extent / control
Depends on patient fitness and wishes
Can occasionally debulk and give post op XRT, or XRT alone (20Gy in 5#)
Primary brain tumours
Types of primary brain tumours?
BENIGN
Primary brain tumours
I Benign
Pituitary – adenoma, cranio-pharyngioma Meningioma Acoustic neuroma Dermoid tumour
Benign brain tumours
Treatment?
Observation Surgery Radiotherapy BSC
Can behave in a malignant fashion due to location and recurrent nature
Primary brain tumours
Types of primary brain tumours?
MALIGNANT
Malignant brain tumours
II Malignant:
Glioma Primary Cerebral Lymphoma Germinoma Pineoblastoma Medulloblastoma
Primary Brain Tumours
GLIOMA
Malignant: Gliomata
Glioma Commonest Primary Brain Tumours
WHO Grades:
I: Fibrillary astrocytoma
II: Astroctytoma or Oligodendroglioma
III: Anaplastic Astrocytoma /oligodendrglioma
IV: Glioblastoma multiforme
GBM – radiology
Treatment of gliomata
Observation – low grade Surgery
Treatment of gliomata
Radiotherapy 60Gy in 30# over 6 weeks +/- Temozolamide chemotherapy
(25% alive at 2 years)
Or 30Gy in 6# over 2 weeks (months)
Gliadel wafers
Or BSC ( weeks)
Benefits of Temozolamide
Survival with TMZ
OS(Years)
TMZ + XRT XRT
2 27.2% 10.9%
3 16.0% 4.4%
4 12.1% 3.0%
5 9.8% 1.9%
Gliadel Wafers
Gliadel wafers at time of surgery (carmustine soaked) in completely resected high grade glioma (3 or 4)
Pathology - GBM
High Ki 67NecrosisPleomorphismAbnormal vasculatureGFAP +ve
Primary CNS Tumours
Ependymoma
Ependymoma
Ependymoma
Grade I- III
Location?
Treatment?
Surgery +/- radiotherapy 54Gy in 30# over 6 weeks
Primary CNS Lymphoma
Primary Cerebral Lymphoma
Primary cerebral lymphoma – HIV related Steroids Chemo (methotrexate based)+/- XRT Cognitive impairment Poor outcomes
Primary CNS Lymphoma
Pathology
Blue cellsB CellsPerivascular cuffing
Effects on patient and family
Loss of autonomy Can not drive Neurological deficit Confusion and personality change Family lose the person they knew Financial loss Social loss
Effects on patient and family
Effects of treatment – steroids, anti epileptics, surgery and XRT
Invasion of space by supportive teams Death Genetic consequences
Multidisciplinary teams
Need GP, neurosurgeon, oncologist, endocrinologist, neurologist, specialist CNS nurse, palliative care team, pathologist, radiologist
Community Macmillan, DNs Social work, OT, physiotherapy input
??
Research