Brain Imaging IC calcifications - SSR EgyptBrain Imaging IC calcifications Mamdouh mahfouz MD...
Transcript of Brain Imaging IC calcifications - SSR EgyptBrain Imaging IC calcifications Mamdouh mahfouz MD...
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Brain Imaging IC calcifications
Mamdouh mahfouz MD @gmail.com5mamdouh.m
www.ssregypt.com
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CT Hyper dense [ more than100 HU ]
MRI Low signal in T1 and T2 WIs [non mobile protons]
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Minute calcifications are seen on CT but not on MRI
High signal in T1 and low signal in T2 WIs
DD Fat
Early subacute blood (intracellular met Hb)
Exceptions
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Physiological intracranial calcifications
Choriod plexus
Pineal body
Falx
Tentorium
Diaphragma sellae
Petroclinoid ligament
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Pathological Intracranial Calcifications
Diagnostic Non diagnostic
Bilateral symmetrical basal ganglia calcification
Periventricular calcification
Gyral calcifications
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Diagnostic Calcifications
Bilateral symmetrical basal ganglia calcification
Periventricular calcification
Gyral calcifications
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Basal ganglia calcifications Idiopathic ▪ Familial
Hypoparathyroidism ▪ Hyperparathyroidism
Pseudohypoparathyroidism
Pseudo pseudohypoparathyroidism
Fahr disease [Ferro calcinosis]
Parkinsonism
Radiation therapy
Encephalitis
Carbon monoxide intoxication
Bilateral patchy
almost symmetrical
calcifications
Mainly affecting the
basal ganglia
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Basal ganglia calcifications
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Basal ganglia calcifications
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Periventricular calcifications
Spotty non symmetrical periventricular calcific foci
[ Congenital Intracranial infections] CT CT
Cytomegalovirus inclusion bodies
Toxoplasmosis
Cysticercosis
Tuberous sclerosis
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Congenital brain infection
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Cysticercosis
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Congenital and neonatal Infections
The classic TORCH infections include:
Toxoplasmosis
Rublla
Cytomegalovirus (CMV)
Herpes simplex virus (HSV) type2
Toxoplasmosis
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Transmission through three major routes Hematogenous / transplacental ( toxoplasmosis,
most viruses except HSV type2) Ascending cervical infection ( most bacteria)
During delivery through birth canal (HSV type2) The pattern of dystrophic calcification is not entirely specific, CMV calcifications are usually central with predilection for periventricular location, whereas toxoplasmosis calcifications are more widespread with slight predilection for basal ganglia
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Neuro ectodermal disorder 1:150,000 live births
Adenoma sebaceum 30% Seizures 80% Mental retardation 70%
Tuberous sclerosis
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Tuberous sclerosis with Subependymal GCA
F
35Y
Subependymal hamartomas Calcification with age progression 88% Subependymal Giant cell astrocytoma 5-15%
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Tuberous sclerosis
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Subependymal Giant Cell Astrocytoma
Very rare 0.3%
Develops from the nodules
Usually in the frontal horn near
the foramen of Monro Hydrocephalus
Low grade lesion [ No recurrence ]
CT Isodense or slightly hyper dense
Calcification
Homogenous enhancement
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Tuberous sclerosis with giant cell astrocytoma
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Tuberous sclerosis with giant cell astrocytoma operated upon with intraventricular hemorrhage
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Sturge- Webber syndrome
Vascular malformation with capillary venous angioma
in the face, ocular choroid , leptomeninges
Gyral calcification after 2 years of age
Parietooccipital more than frontal
Bilateral lesions in 20% of cases
• Cortical hemi atrophy
• Choroid plexus enlargement
• Thickened skull and orbits
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Sturge- Webber syndrome
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Sturge webber syndrome
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Non diagnostic calcification
Vascular Metabolic Inflammatory Neoplastic
Traumatic
AVM , aneyrysm hemangioma
arteriosclerosis
Carbon monoxide poisoning
Folic acid deficiency
Hypervitaminosis D
Homocystinuria
Lead poisoning
Wilson’s disease
healed brain abscess
Fungal cerebritis
Parasitic disease
Cysticercosis , hydatid
TB , Toxoplasma Meningioma , glioma, deposits , neurofibromatosis, treated lymphoma and leukaemia
Hematoma
scarring and
needle tracts
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Multiple tuberculomata Multiple tuberculomata
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Multiple tuberculomas
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Oligodendroglioma
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M
50Y
Oligodendroglioma
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Subfrontal meningioma
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Thank you
نستغفرك و نتوب اليك ×نشهد ان ال اله اال انت ×سبحانك اللهم و بحمدك
Mamdouh Mahfouz MD
ssr-eg.net