66 Radiation Oncology ??Biology ??Physics November 1986, Volume 12, Sup. 1

ASTRO REFRESHER COURSE DESCRIPTIONS

MONDAY, NOVEMBER 3, 1986

7:30 a.m. - 9:00 a.m.

101

BRACHYTHERAPY PHYSICS

John Day, Ph.D. Department of Radiation Oncology and Nuclear Medicine, Hahnemann University, Philadelphia, PA

This course begins with a review of some of the basic concepts encountered in brachytherapy. Consideration is given to the comparison of various "systems" for the distribution of the sources and the use of various isotopes.

Since intracavitary implants are an important part of brachytherapy, the steps necessary for dosage calculations are reviewed. These steps include the necessity of good radiographs, the choice of applicator and the input of physicians, physicists and technologists.

Finally, the various radiation safety concepts and regulations associated with brachytherapy are discussed.

102

CLINICAL TRIALS IN HYPERTHERMIC CANCER RESEARCH

Ned B. Hornback Department of Radiation Oncology, Indiana University, Indianapolis, Indiana 46223

For many years there has been a plethora of scientific articles appearing in the medical Journals which attempt to define the biological parameters and effects of heat on normal and malignant cells under in vitro and in vivo conditions. Many of these studies have significantly enhanced our basic understanding and knowledge as to how heat may be used to potentiate the effects of ionizing radiation against malignant cells. Unfortunately, the information gained under the exacting conditions ot the laboratory are not always applicable to the realism of clinical practice. Despite our newly yained knowledge in hyperthermia the design, implantation and evaluation of human clinical hyperthermia trials presents enormous technical and pragmatic problems. Major problems still exist in the design and development of heat therapy and temperature monitoring systems despite the significant improvements which have been made over the past few years. Before hyperthermia is accepted by the medical community as a viable treatment method, a heat delivery system must be made available to the physician which produces a consistently uniform heating pattern throughout the tumor volume area. This refresher course will briefly review the basic biology of heat therapy and describe the equipment which is currently available tor clinical hyperthermic studies. The results of recently published clinical trials will be presented alony with the potential problems and complications which may be encountered during the use of hyperthermia tor the treatment of cancer patients.

103

HODGKIN'S DISEASE REFRESHER COURSE

Leonard R. Prosnitz, M.D.

Division of Radiation Oncology, Duke University Medical Center, Box 3085, Durham, NC 27710

This course will review in detail the staging and subsequent treatment of patients with Hodgkin's disease. Staging issues to be considered include the indications for lymphangiography, and staging laparotomy, and the complications to be anticipated from these procedures, the role of CT scanning, and gallium scanning. Treatment results and recommendations for the different stages of Hodgkin's disease will be presented in some detail as well as results and recommendations for certain substages, e.g. stage I or II patients with large mediastinal masses, subsets of stage IIIA patients. Results from chemotherapy and combined modality therapy trials in advanced disease wilt1 also be presented. The long term toxicity of therapy will also be considered in some detail, as will the treatment of Hodgkin's disease in children.

104

RADIATION THERAPY OF INTRAOCULAR TUMORS

Arnold M. Markoe, M.D., Sc.D., *James J. Augsburger, M.D. Department of Radiation Oncology and Nuclear Medicine, Hahnemann University Hospital, Philadelphia, PA *Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA