BORDERLINE TUMORS OF THE OVARY: ADDITIONAL...
Transcript of BORDERLINE TUMORS OF THE OVARY: ADDITIONAL...
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BORDERLINE TUMORS OF THE OVARY:
ADDITIONAL THOUGHTS
Steven G. Silverberg, M.D., FRCPathUniversity of Maryland, American Registry
of Pathology
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BORDERLINE
Definition: Tumors with known behavior intermediate between fully benign and fully malignant
Example: Serous borderline tumor of ovary
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LOW MALIGNANT POTENTIAL (LMP)
Definition: Minimally aggressive cancersExamples: Granulosa cell tumor of ovary
Papillary carcinoma of thyroid
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ATYPICAL PROLIFERATING (APT)
Definition: In the ovary, used as a synonym for borderline tumors that are assumed to be really benign; in other organs, usually refers to non-neoplastic reactive processes.
Examples: Regeneration of mucosa after biopsy/curettage “Pseudosarcomatous” polyps of nasal mucosa, vagina, etc. Lymph nodes in infectious mononucleosis
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UNCERTAIN MALIGNANT POTENTIAL (UMP)
Definition: “I don’t know” if benign or malignant (BUT the tumor knows – so not a true entity – all UMPs are either benign or malignant
Example: Uterine smooth muscle tumor of uncertain malignant potential (STUMP)
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PERCENTAGES OF BENIGN, BORDERLINE, AND INVASIVE CARCINOMATOUS OVARIAN TUMORS BY
HISTOLOGIC SUBTYPE
5≠95951023Carcinoma
<1<1<11012Borderline
955*5*8065Benign
BrennerClear CellEndometrioidMuinous (G-I)Serous
*Excluding endoemetriosis, including atypical adenofibromas≠malignant Brenner tumor, transitional cell carcinoma
Notes: 1. Proportions unknown for mucinousendocervical/müllerian/seromucinous tumors, but probably mostly benign and borderline;
2. Undifferentiated epithelial tumors are by definition carcinomas, but
3. Unclassified and mixed epithelial tumors may be benign, borderline or carcinoma
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IMMUNOHISTOCHEMISTRY OF MUCINOUS BOT
(Vang et al, IJGP 25:83, 2006)
50%(5)0%Mesothelin
91%0%CA-125
33%(4)0%PR
64%(3)0%ER
0%32%(2)CK20
100%71%(1)CK7
EndocervicalIntestinal
(1) 21% focal; (2) 54% focal; (3) 36% focal; (4) 33% focal; (5) 33% focal
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ATYPICAL ADENOFIBROMAS / CYSTADENOFIBROMAS
• Defined as architecturally benign but cytologically atypical
• Most commonly endometrioid and clear cell• Should be sectioned extensively to rule out the
coexistence of an obvious carcinoma or borderline tumor
• If no CA or BT, the behavior should be benign, but relatively few cases have been reported
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ENDOMETRIOID BORDERLINE TUMOR: PROPOSED CRITERIA FOR CARCINOMA
Glandular confluence or stromaldisappearance, penetrating stromal invasion, non-intracysticvilloglandular or sertoliform (rare) pattern
Roth et. al. (AJSP 27: 1253, 2000)
Glandular confluence or (13%) destructive stromal invasion
Bell and Kurman(AJSP 24:1465, 200)
Disorderly penetration of usually reactive stroma or back-to-back glands
Scully et. al.
Epithelial component complex and irregular, with desmoplastic stroma
Russell(in Haines and Taylor, 1995)
> 5 mm atypical epithelial proliferation uninterrupted by stroma
Snyder et. al.(AJSP 12:661, 1988)
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OVARIAN ENDOMETRIOID NEOPLASIA: MY CRITERIA
AbsentEndometrial carcinoma* ≥ 5 mmInvasive Carcinoma
AbsentEndometrial carcinoma* but <5 mm in greatest linear measurement
Borderline with Microinvasion
AbsentEndometrial hyperplasia/atypical hyperplasia
Borderline Tumor
AbsentDispersed glands with/without squamous metaplasia, in fibrotic(not desmoplastic) stroma
Adenofibroma
PresentHyperplastic and/or cytologicallyatypical endometrium
Atypical Endometriosis
PresentNormal/metaplasticendometrium
Endometriosis
ENDOMETRIAL STROMAEPITHELIUM LOOKS LIKE DIAGNOSIS
*Confluent/cribriform mazelike, desmoplastic or necrotic stroma, villoglandular or sertoliform pattern
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BRENNER TUMOR CLASSIFICATION
• Benign – small cell nests, uniform small cells without nuclear atypia
• Proliferating – large cell nests, papillae, minimal atypia
• Borderline/LMP – large cell nests, papillae, moderate to marked atypia, no stromal invasion
• Carcinoma – any tumor with stromal invasion: Malignant Brenner tumor if benign/borderline elements present – Transitional cell carcinoma if benign/borderline elements absent
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SUMMARY OF BRENNER/TCC CATEGORY
• Benign Brenner tumor ≥ 95% - usually small, incidental –small nests with minimal atypia, often include mucinousepithelium (“metaplastic Brenner tumor”) – stromanormal/fibrotic/hormonally active
• Borderline Brenner tumor (rare, ?1%) – average 14 cm, often cystic – usually characterized by papillary growth, mild to moderate atypia, resembling low grade urothelialcarcinoma of bladder, but may show solid or cystic nested pattern (“atypical adenofibroma”) or severe atypia(? “intraepithelial carcinoma”) – usually have foci of benign BT – microinvasion not reported, but probably occurs
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• Malignant Brenner tumor – invasive transitional cell CA accompanied by benign or borderline BT
• Transitional cell carcinoma – same tumor without benign or borderline BT
• Mixed transitional cell carcinoma –invasive TCC plus one or more other cell types (serous, endometrioid, etc) – more common than pure TCC or MBT
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372 PRIMARY OVARIAN NEOPLASMS IN GILDA RADNER FAMILIAL OVARIAN CANCER
REGISTRY(Piver, et al., Gynecol Oncol 78:166, 2000)
0.8%3Others
1.1%4Carcinosarcoma
1.3%4BORDERLINE
96.8%359ALL CARCINOMAS
4.9%18Undifferentiated/other carcinoma
3.5%13Mucinous carcinoma
4.6%17Clear cell carcinoma
5.4%20Endometrioid carcinoma
13.5%50Carcinoma NOS65.2%242Serous carcinoma
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TUBAL INVOLVEMENT IN PELVIC SEROUS CARCINOMA (Kindelberger et al, AJSP 31:161-169, 2007)
• 55 Consecutive cases of pelvic serous CA• Classified as ovarian (43), peritoneal (7), or
tubal (5)• 41 of 55 (75%) had TIC (tubal intraepithelial
carcinoma) when tubes were entirely sectioned and examined (93% in fimbriae)
• Same p53 mutations in TIC and ovarian CA• Can TIC be precursor of some (? Most) ovarian
and 1º peritoneal CA?