Book Sections (revised 1/7/18)lw26/course... · 2018. 1. 8. · Book Sections (revised 1/7/18) Chem...
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Book Sections (revised 1/7/18) Chem 4511 & Chem 6501 Lehninger Principles of Biochemistry, 7 th Edition Professors Hud and Williams 1. The Foundations of Biochemistry (40 pages, 1-40) 1.1 Cellular Foundations 1.2 Chemical Foundations 1.3 Physical Foundations 1.4 Genetic Foundations 2. Water (23 pages, 47-69) 2.1 Weak Interactions in Aqueous Systems (47-58) 2.2 Ionization of Water, Weak Acids, and Weak Bases (58-63) 2.3 Buffering against pH Changes in Biological Systems (63-69) 2.4 Water as a Reactant (69) 2.5 The Fitness of Aqueous Environment for Living Organisms (69) 3. Amino Acids, Peptides, and Proteins (35 pages, 75-109) 3.1 Amino Acids (75-85) 3.2 Peptides and Proteins (85-89) 3.3 Working with Proteins (89-96) 3.4 The Structure of Proteins: Primary Structure (96-109) (Use of protein sequences to construct evolutionary trees). 4. The Three-Dimensional Structure of Proteins (37 pages, 115-151) 4.1 Overview of Protein Structure (115-119) 4.2 Protein Secondary Structure (119-125) 4.3 Protein Tertiary and Quaternary Structures (125-142) 4.4 Protein Denaturation and Folding (142-151) 5. Protein Function (27 pages, 157-183) 5.1 Reversible Binding of a Protein to a Ligand: Oxygen-Binding Proteins (157-174) 5.2 Complementary Interactions between Proteins and Ligands: The Immune System and Immunoglobulins (174-179) 5.3 Protein Interactions Modulated by Chemical Energy: Actin, Myosin, and Molecular Motors (179- 183) 6. Enzymes (50 pages, 187-236; 27 pages 187-213) 6.1 An Introduction to Enzymes (187-189) 6.2 How Enzymes Work (190-198) 6.3 Enzyme Kinetics as an Approach to Understanding Mechanism (198-213) 7. Carbohydrates and Glycobiology (35 pages, 241-275) 7.1 Monosaccharides and Disaccharides (241-252) 7.2 Polysaccharides (252-261) 7.3 Glycoconjugates: Proteoglycans, Glycoproteins, and Glycolipids (261-267)
Transcript of Book Sections (revised 1/7/18)lw26/course... · 2018. 1. 8. · Book Sections (revised 1/7/18) Chem...
BookSections(revised1/7/18)
Chem4511&Chem6501
LehningerPrinciplesofBiochemistry,7thEditionProfessorsHudandWilliams
1.TheFoundationsofBiochemistry (40pages,1-40)1.1CellularFoundations1.2ChemicalFoundations1.3PhysicalFoundations1.4GeneticFoundations2.Water(23pages,47-69)2.1WeakInteractionsinAqueousSystems(47-58)2.2IonizationofWater,WeakAcids,andWeakBases(58-63)2.3BufferingagainstpHChangesinBiologicalSystems(63-69)2.4WaterasaReactant(69)2.5TheFitnessofAqueousEnvironmentforLivingOrganisms(69)3.AminoAcids,Peptides,andProteins(35pages,75-109)3.1AminoAcids(75-85)3.2PeptidesandProteins(85-89)3.3WorkingwithProteins(89-96)3.4TheStructureofProteins:PrimaryStructure(96-109)(Useofproteinsequencestoconstructevolutionarytrees).4.TheThree-DimensionalStructureofProteins(37pages,115-151)4.1OverviewofProteinStructure(115-119)4.2ProteinSecondaryStructure(119-125)4.3ProteinTertiaryandQuaternaryStructures(125-142)4.4ProteinDenaturationandFolding(142-151)5.ProteinFunction(27pages,157-183)5.1ReversibleBindingofaProteintoaLigand:Oxygen-BindingProteins(157-174)5.2ComplementaryInteractionsbetweenProteinsandLigands:TheImmuneSystemandImmunoglobulins(174-179)5.3ProteinInteractionsModulatedbyChemicalEnergy:Actin,Myosin,andMolecularMotors(179-183)6.Enzymes(50pages,187-236;27pages187-213)6.1AnIntroductiontoEnzymes(187-189)6.2HowEnzymesWork(190-198)6.3EnzymeKineticsasanApproachtoUnderstandingMechanism(198-213)7.CarbohydratesandGlycobiology(35pages,241-275)7.1MonosaccharidesandDisaccharides(241-252)7.2Polysaccharides(252-261)7.3Glycoconjugates:Proteoglycans,Glycoproteins,andGlycolipids(261-267)
7.4CarbohydratesasInformationalMolecules:TheSugarCode(267-272)7.5WorkingwithCarbohydrates(272-275)8.NucleotidesandNucleicAcids(35pages,279-313)8.1SomeBasics(279-285)8.2NucleicAcidStructure(285-295)8.3NucleicAcidChemistry(295-310)8.4OtherFunctionsofNucleotides(310-313)9.DNA-BasedInformationTechnologies(37pages,319-355)9.1StudyingGenesandTheirProducts(319-335)9.2UsingDNA-BasedMethodstoUnderstandProteinFunction(335-344)9.3GenomicsandtheHumanStory(334-355)10.Lipids(24,pages,361-384)10.1StorageLipids(361-366)10.2StructuralLipidsinMembranes(366-374)10.3LipidsasSignals,Cofactors,andPigments(374-381)10.4WorkingwithLipids(381-384)24.GenesandChromosomes(25pages,957-981)24.1ChromosomalElements(957-963)24.2DNASupercoiling(963-972)24.3TheStructureofChromosomes(972-981)25.DNAMetabolism(43pages,989-1031)25.1DNAReplication(989-1005)25.2DNARepair(1005-1016)25.3DNARecombination(1016-1031)26.RNAMetabolism(40pages,1035-1074)26.1DNA-DependentSynthesisofRNA(1036-1047)26.2RNAProcessing(1047-1063)26.3RNA-DependentSynthesisofRNAandDNA(1063-1074)27.ProteinMetabolism(46pages,1077-1123)27.1TheGeneticCode(1078-1087)27.2ProteinSynthesis(1088-1114)27.3ProteinTargetingandDegradation(1114-1123)28.RegulationofGeneExpression(42pages,1127-1168)28.1PrinciplesofGeneRegulation(1128-1138)28.2RegulationofGeneExpressioninBacteria(1138-1147)28.3RegulationofGeneExpressioninEukaryotes(1147-1168)
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