Bones Chapter 7. Pre bone Cartilage All bone starts out as cartilage. Contains no blood vessels or...
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![Page 1: Bones Chapter 7. Pre bone Cartilage All bone starts out as cartilage. Contains no blood vessels or nerves Surrounded by the perichondrium (dense irregular.](https://reader035.fdocuments.us/reader035/viewer/2022062806/5697bfa71a28abf838c98cc3/html5/thumbnails/1.jpg)
Bones
Chapter 7
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Pre bone Cartilage
• All bone starts out as cartilage.• Contains no blood vessels or nerves• Surrounded by the perichondrium (dense
irregular connective tissue) that resists outward expansion
• Three types – hyaline, elastic, and fibrocartilage
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Hyaline Cartilage
• Provides support, flexibility, and resilience (due to water)
• Is the most abundant skeletal cartilage• Is present in these cartilages:– Articular – covers the ends of long bones– Costal – connects the ribs to the sternum– Respiratory – makes up the larynx and reinforces
air passages– Nasal – supports the nose
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• Similar to hyaline cartilage but contains elastic fibers
• Found in the external ear and the epiglottis• Highly compressed with great tensile strength• Contains collagen fibers• Found in menisci of the knee and in
intervertebral discs
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Growth of CartilageAppositional – cells in the perichondrium secrete matrix against the external face of existing cartilageInterstitial – lacunae-bound chondrocytes inside the cartilage divide and secrete new matrix, expanding the cartilage from withinCalcification of cartilage occurs
During normal bone growthDuring old age
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Skeletons
• Axial skeleton – bones of the skull, vertebral column, and rib cage
• Appendicular skeleton – bones of the upper and lower limbs, shoulder, and hip
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Classification of bones
• Long Bones• Short Bones• Flat Bones• Irregular Bones• Sesamoid Bones
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Classification by shape
• Long bones –• longer than• they are wide
(e.g., humerus
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By shape:
• Short bones– Cube-shaped – bones of the – wrist and ankle– Bones that form within tendons (e.g., patella)
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By Shape:
• Flat bones –• thin, flattened• , and a bit curved (e.g., sternum, and most skull bones)
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By Shape:
• Irregular bones• – bones with complicated shapes (e.g., vertebrae and hip bones)
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Functions of Bones
• Support – form the framework that supports the body and cradles soft organs
• Protection – provide a protective case for the brain, spinal cord, and vital organs
• Movement – provide levers for muscles• Mineral storage – reservoir for minerals,
especially calcium and phosphorus• Blood cell formation – hematopoiesis occurs
within the marrow cavities of bones
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Bone Markings
• Bulges, depressions, and holes that serve as: – Sites of attachment for muscles, ligaments, and
tendons– Joint surfaces– Conduits for blood vessels and nerves
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Projections: Sites of Muscle and Ligament Attachments
Tuberosity – rounded projection• Crest – narrow, prominent ridge of bone• Trochanter – large, blunt, irregular surface• Line – narrow ridge of bone• Tubercle – small rounded projection• Epicondyle – raised area above a condyle• Spine – sharp, slender projection• Process – any bony prominence
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Projections That Help Form Joints
• Head – bony expansion carried on a narrow neck
• Facet – smooth, nearly flat articular surface• Condyle – rounded articular projection• Ramus – armlike bar of bone
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Depressions and Openings
• Meatus – canal-like passageway• Sinus – cavity within a bone• Fossa – shallow, basinlike depression• Groove – furrow• Fissure – narrow, slitlike opening• Foramen – round or oval opening through a
bone
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Bone Textures
Compact bone – dense outer layer
Spongy bone – honeycomb of trabeculae filled with yellow bone marrow
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Structure of a Long Bone
• Long bones consist of a diaphysis and an epiphysis
• Diaphysis– Tubular shaft that forms the axis of long bones– Composed of compact bone that surrounds the
medullary cavity– Yellow bone marrow (fat) is contained in the
medullary cavity
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• Epiphyses– Expanded ends of long bones– Exterior is compact bone, and the interior is
spongy bone– Joint surface is covered with articular (hyaline)
cartilage– Epiphyseal line separates the diaphysis from the
epiphyses
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Bone Membranes• Periosteum – double-layered protective
membrane– Outer fibrous layer is dense regular connective
tissue– Inner osteogenic layer is composed of osteoblasts
and osteoclasts– Richly supplied with nerve fibers, blood, and
lymphatic vessels, which enter the bone via nutrient foramina
– Secured to underlying bone by Sharpey’s fibers• Endosteum – delicate membrane covering
internal surfaces of bone
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Structures of Short, Flat and Irregular Bones
Thin plates of periosteum-covered compact bone on the outside with endosteum-covered spongy bone (diploë) on the inside
Have no diaphysis or epiphyses
Contain bone marrow between the trabeculae
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Structure of a Flat bone
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Hematopoetic tissueRed Marrow Formation
• In infants– Found in the medullary cavity and all areas of
spongy bone
• In adults– Found in the diploë of flat bones, and the head of
the femur and humerus
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Compact Bone Structure
• Haversian system, or osteon – the structural unit of compact bone– Lamella – weight-bearing, column-like matrix
tubes composed mainly of collagen– Haversian, or central canal – central channel
containing blood vessels and nerves– Volkmann’s canals – channels lying at right angles
to the central canal, connecting blood and nerve supply of the periosteum to that of the Haversian canal
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Microscopic structures of bone• Osteocytes – mature bone cells• Lacunae – small cavities in bone that contain
osteocytes• Canaliculi – hairlike canals that connect lacunae
to each other and the central canal• Osteoblasts – bone-forming cells and secretes
matrix• Osteocytes – mature bone cells• Osteoclasts – large cells that resorb or break
down bone matrix• Osteoid – unmineralized bone matrix composed
of proteoglycans, glycoproteins, and collagen
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Compact Bone
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Inorganic Composition
• Hydroxyapatites, or mineral salts– Sixty-five percent of bone by mass– Mainly calcium phosphates– Responsible for bone hardness and its resistance
to compression
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Bone Development
• Osteogenesis and ossification – the process of bone tissue formation, which leads to:
– The formation of the bony skeleton in embryos
– Bone growth until early adulthood
– Bone thickness, remodeling, and repair
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Formation of the Skeleton
• Begins at week 8 of embryo development Intramembranous ossification – bone
develops from a fibrous membraneEndochondral ossification – bone forms by replacing hyaline cartilage
• Formation of most of the flat bones of the skull and the clavicles
• Fibrous connective tissue membranes are formed by mesenchymal cells
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Ossification
• An ossification center appears in the fibrous connective tissue membrane
• Bone matrix is secreted within the fibrous membrane
• Woven bone and periosteum form • Bone collar of compact bone forms, and red
marrow appears
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Endochondral Ossification• Begins in the second month of development• Uses hyaline cartilage “bones” as models for
bone construction• Requires breakdown of hyaline cartilage prior to
ossification• Formation of bone collar• Cavitation of the hyaline cartilage• Invasion of internal cavities by the periosteal bud,
and spongy bone formation• Formation of the medullary cavity; appearance of
secondary ossification centers in the epiphyses• Ossification of the epiphyses, with hyaline
cartilage remaining only in the epiphyseal plates
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Formation of bone collar around hyaline cartilage model.
1
2
3
4
Cavitation of the hyaline cartilage within the cartilage model.
Invasion of internal cavities by the periosteal bud and spongy bone formation.
5 Ossification of the epiphyses; when completed, hyaline cartilage remains only in the epiphyseal plates and articular cartilages
Formation of the medullary cavity as ossification continues; appearance of secondary ossification centers in the epiphyses in preparation for stage 5.
Hyaline cartilage
Primary ossification center
Bone collar
Deteriorating cartilage matrix
Spongy bone formation
Blood vessel of periosteal bud
Secondary ossification center
Epiphyseal blood vessel
Medullary cavity
Epiphyseal plate cartilage
Spongy bone
Articular cartilage
Stages of Endochondral Ossification
Figure 6.838
Formation of bone collar around hyaline cartilage model.
1
2
3
4
Cavitation of the hyaline cartilage within the cartilage model.
Invasion of internal cavities by the periosteal bud and spongy bone formation.
5 Ossification of the epiphyses; when completed, hyaline cartilage remains only in the epiphyseal plates and articular cartilages
Formation of the medullary cavity as ossification continues; appearance of secondary ossification centers in the epiphyses in preparation for stage 5.
Hyaline cartilage
Primary ossification center
Bone collar
Deteriorating cartilage matrix
Spongy bone formation
Blood vessel of periosteal bud
Secondary ossification center
Epiphyseal blood vessel
Medullary cavity
Epiphyseal plate cartilage
Spongy bone
Articular cartilage
Stages of Endochondral Ossification
Figure 6.8
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Postnatal bone growth
• Growth in length of long bones– Cartilage on the side of the epiphyseal plate
closest to the epiphysis is relatively inactive– Cartilage abutting the shaft of the bone organizes
into a pattern that allows fast, efficient growth – Cells of the epiphyseal plate proximal to the
resting cartilage form three functionally different zones: growth, transformation, and osteogenic
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Growth in Long Bones• Growth zone – cartilage cells undergo mitosis,
pushing the epiphysis away from the diaphysis• Transformation zone – older cells enlarge, the
matrix becomes calcified, cartilage cells die, and the matrix begins to deteriorate
• Osteogenic zone – new bone formation occurs• Growth in length – cartilage continually grows
and is replaced by bone as shown • Growth in width (Remodeling) – bone is resorbed
and added by appositional growth as shown
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i
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latio
42
Osteoblasts beneath the periosteum secrete bone matrix, forming ridges that follow the course of periosteal blood vessels.
1 2 3 4As the bony ridges enlarge and meet, the groove containing the blood vessel becomes a tunnel.
The periosteum lining the tunnel is transformed into an endosteum and the osteoblasts just deep to the tunnel endosteum secrete bone matrix, narrowing the canal.
As the osteoblasts beneath the endosteum form new lamellae, a new osteon is created. Meanwhile new circumferential lamellae are elaborated beneath the periosteum and the process is repeated, continuing to enlarge bone diameter.
Artery Periosteum Penetrating canal
Central canal of osteonPeriosteal ridge
Appositional Growth of Bone
Figure 6.1142
Osteoblasts beneath the periosteum secrete bone matrix, forming ridges that follow the course of periosteal blood vessels.
1 2 3 4As the bony ridges enlarge and meet, the groove containing the blood vessel becomes a tunnel.
The periosteum lining the tunnel is transformed into an endosteum and the osteoblasts just deep to the tunnel endosteum secrete bone matrix, narrowing the canal.
As the osteoblasts beneath the endosteum form new lamellae, a new osteon is created. Meanwhile new circumferential lamellae are elaborated beneath the periosteum and the process is repeated, continuing to enlarge bone diameter.
Artery Periosteum Penetrating canal
Central canal of osteonPeriosteal ridge
Appositional Growth of Bone
Figure 6.11
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Hormone Regulation of Bone Growth• During infancy and childhood, epiphyseal plate activity
is stimulated by growth hormone
• During puberty, testosterone and estrogens: – Initially promote adolescent growth spurts– Cause masculinization and feminization of specific
parts of the skeleton– Later induce epiphyseal plate closure, ending – longitudinal bone growth
Therefore, a deficiency of growth hormone will cause a decrease proliferation of the epiphyseal plate cartilage
Remodeling units – adjacent osteoblasts and osteoclasts deposit and resorb bone at periosteal and endosteal surfaces
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How Bone is Deposited• Occurs where bone is injured or added strength
is needed• Requires a diet rich in protein, vitamins C, D, and
A, calcium, phosphorus, magnesium, and manganese
• Alkaline phosphatase is essential for mineralization of bone
• Sites of new matrix deposition are revealed by the:– Osteoid seam – unmineralized band of bone matrix– Calcification front – abrupt transition zone between
the osteoid seam and the older mineralized bone
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How Bone is Reabsorbed
• Accomplished by osteoclasts• Resorption bays – grooves formed by
osteoclasts as they break down bone matrix• Resorption involves osteoclast secretion of:– Lysosomal enzymes that digest organic matrix– Acids that convert calcium salts into soluble forms
• Dissolved matrix is transcytosed across the osteoclast’s cell where it is secreted into the interstitial fluid and then into the blood
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Calcium for Bones?
• Calcium is necessary for:– Transmission of nerve impulses– Muscle contraction– Blood coagulation– Secretion by glands and nerve cells– Cell division– Remodeling of bone
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Remodeling
• Two control loops regulate bone remodeling– Hormonal mechanism maintains calcium homeostasis in
the blood– Mechanical and gravitational forces acting on the skeleton
• Rising blood Ca2+ levels trigger the thyroid to release calcitonin
• Calcitonin stimulates calcium salt deposit in bone• Falling blood Ca2+ levels signal the parathyroid glands
to release PTH• PTH signals osteoclasts to degrade bone matrix and
release Ca2+ into the blood
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Response to Mechanical Stress• Wolff’s law – a bone grows or remodels in
response to the forces or demands placed upon it
• Observations supporting Wolff’s law include– Long bones are thickest midway along the shaft
(where bending stress is greatest)– Curved bones are thickest where they are most
likely to buckle• Trabeculae form along lines of stress• Large, bony projections occur where heavy,
active muscles attach
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Fractures• Bone fractures are classified by:– The position of the bone ends after fracture– The completeness of the break– The orientation of the bone to the long axis– Whether or not the bones ends penetrate the skin
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Fractures Nondisplaced – bone ends retain their normal position Displaced – bone ends are out of normal alignment Complete – bone is broken all the way through Incomplete – bone is not broken all the way through Linear – the fracture is parallel to the long axis of the
bone Transverse – the fracture is perpendicular to the long
axis of the bone Compound (open) – bone ends penetrate the skin Simple (closed) – bone ends do not penetrate the skin
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FracturesComminuted – bone fragments into three or more pieces; common in the elderlySpiral – ragged break when bone is excessively twisted; common sports injuryDepressed – broken bone portion pressed inward; typical skull fractureCompression – bone is crushed; common in porous bonesEpiphyseal – epiphysis separates from diaphysis along epiphyseal line; occurs where cartilage cells are dyingGreenstick – incomplete fracture where one side of the bone breaks and the other side bends; common in children
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Healing a bone fracture
• Hematoma formation– Torn blood vessels hemorrhage– A mass of clotted blood (hematoma) forms atthe fracture site– Site becomes swollen painful, and inflamed
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Stages in the Healing of a Bone Fracture• Fibrocartilaginou
s callus forms• Granulation
tissue (soft callus) forms a few days after the fracture
• Capillaries grow into the tissue and phagocytic cells begin cleaning debris
Figure 6.14.2
2 Fibrocartilaginous callus formation
External callus
New blood vessels
Spongy bone trabeculae
Internal callus (fibrous tissue and cartilage)
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Healing of Fracture
The fibrocartilaginous callus forms when:Osteoblasts and fibroblasts migrate to the fracture and begin reconstructing the boneFibroblasts secrete collagen fibers that connect broken bone endsOsteoblasts begin forming spongy boneOsteoblasts furthest from capillaries secrete an externally bulging cartilaginous matrix that later calcifies
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Stages in the Healing of a Bone Fracture• Bony callus formation– New bone trabeculae
appear in the fibrocartilaginous callus
– Fibrocartilaginous callus converts into a bony (hard) callus
– Bone callus begins 3-4 weeks after injury, and continues until firm union is formed 2-3 months later
Figure 6.14.3
3 Bony callus formation
Bony callus of spongy bone
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Stages in the Healing of a Bone Fracture• Bone remodeling– Excess material on
the bone shaft exterior and in the medullary canal is removed
– Compact bone is laid down to reconstruct shaft walls
Figure 6.14.4
4 Bone remodeling
Healing fracture
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Factors Affecting Bone Growth and Development
• Deficiency of Vitamin A – retards bone development• Deficiency of Vitamin C – results in fragile bones • Deficiency of Vitamin D – rickets, osteomalacia• Insufficient Growth Hormone – dwarfism• Excessive Growth Hormone – gigantism, acromegaly • Insufficient Thyroid Hormone – delays bone growth• Sex Hormones – promote bone formation; stimulate
ossification of epiphyseal plates• Physical Stress – stimulates bone growth
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Homeostasis?
• Osteomalacia– Bones are inadequately mineralized causing
softened, weakened bones– Bone formed is poorly mineralized and soft. • Deforms on weight-bearing
– Main symptom is pain when weight is put on the affected bone
– Caused by insufficient calcium in the diet, or by vitamin D deficiency
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Rickets
RicketsBones of children are inadequately mineralized causing softened, weakened bonesBowed legs and deformities of the pelvis, skull, and rib cage are commonCaused by insufficient calcium in the diet, or by vitamin D deficiency
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• Osteoporosis– Group of diseases in which bone reabsorption
outpaces bone deposit– Spongy bone of the spine is most vulnerable– Bones are porous and thin but bone composition
is normal– Occurs most often in postmenopausal women– Bones become so fragile that sneezing or stepping
off a curb can cause fractures
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• Calcium and vitamin D supplements• Increased weight-bearing exercise• Hormone (estrogen) replacement therapy
(HRT) slows bone loss• Natural progesterone cream prompts new
bone growth• Statins increase bone mineral density
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Paget’s Disease• Characterized by excessive bone formation and breakdown
– Abnormal bone formation and reabsorption• Pagetic bone with an excessively high ratio of woven to
compact bone is formed• Pagetic bone, along with reduced mineralization, causes
spotty weakening of bone• Osteoclast activity wanes, but osteoblast activity continues to
work• May be prevented by increasing dietary vitamin C• Usually localized in the spine, pelvis, femur, and skull• Unknown cause (possibly viral)• Treatment includes the drugs Didronate and Fosamax
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Developmental Aspects
Mesoderm gives rise to embryonic mesenchymal cells, which produce membranes and cartilages that form the embryonic skeletonThe embryonic skeleton ossifies in a predictable timetable that allows fetal age to be easily determined from sonogramsAt birth, most long bones are well ossified (except for their epiphyses)
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By age 25, nearly all bones are completely ossified
In old age, bone resorption predominatesA single gene that codes for vitamin D docking determines both the tendency to accumulate bone mass early in life, and the risk for osteoporosis later in life
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What bones do we need to know?
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Skull
Frontal (1)• forehead• roof of nasal cavity• roofs of orbits• frontal sinuses• supraorbital foramen• coronal suture
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Skull
Parietal (2)• side walls of cranium• roof of cranium• sagittal suture
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Skull
Occipital (1)• back of skull• base of cranium• foramen magnum• occipital condyles• lambdoidal suture
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Skull
Ethmoid (1)• roof and walls of nasal cavity• floor of cranium• wall of orbits• cribiform plates• perpendicular plate• superior and middle nasal conchae• ethmoidal sinuses• crista gallis
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FacialMaxillary (2)
• upper jaw• anterior roof of mouth• floors of orbits• sides of nasal cavity• floors of nasal cavity• alveolar processes• maxillary sinuses
palatine process
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Frontal
Palatine (2)• posterior roof of mouth• floor of nasal cavity• lateral walls of nasal cavity
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Facial
Zygomatic (2) • prominences of cheeks• lateral walls of orbits• floors of orbits• temporal process
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FacialLacrimal (2)
• medial walls of orbits• groove from orbit to •nasal cavity
Nasal (2)• bridge of nose
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Facial
Vomer (1)• inferior portion of nasal septum
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Facial
Inferior Nasal Conchae (2)• extend from lateral• walls of nasal cavity
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Facial
Mandible (1)• lower jaw• body• ramus• mandibular condyle• coronoid process• alveolar process• mandibular foramen• mental foramen
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Infantile skull
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Vertebral Column
•cervical vertebrae (7)• thoracic vertebrae (12)• lumbar vertebrae (5)• sacrum • coccyx
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Vertebral Column• cervical curvature• thoracic curvature• lumbar curvature• pelvic curvature• rib facets• vertebra prominens• intervertebral discs• intervertebral foramina
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Sacrum•five fused vertebrae• median sacral crest• dorsal sacral foramina• posterior wall of pelvic cavity• sacral promontory
Coccyx:Tailbone4 Fused Vertebrae
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Thoracic cageRibs
• Sternum• Thoracic vertebrae• Costal cartilages• Supports shoulder girdle• Protects viscera• Role in breathing
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Ribs
•True ribs (7)• False ribs (5)
• floating (2)
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Sternum
• Manubrium• Body• Xiphoid process
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Pectoral girdle
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Clavicles
•articulate with manubrium• articulate with scapulae (acromion process articulate with manubrium)• articulate with scapulae (acromion process)
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Upper Limb
7-45
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Pelvis
• Coxae (2)• supports trunk of body• protects viscera
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Male and Female Pelvis
Female• iliac bones more flared• broader hips• pubic arch angle greater• more distance between ischial spine and ischial tuberosity• sacral curvature shorter and flatter• lighter bones
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Lower bodyFemur
• longest bone of body• head• fovea capitis• neck• greater trochanter• lesser trochanter• linea aspera• condyles• epicondyles
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Patella
•kneecap• anterior surface of knee• flat sesmoid bone located in a tendon
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Tibia
•shin bone• medial to fibula• condyles• tibial tuberosity• anterior crest• medial malleolus
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Fibula
• lateral to tibia• long, slender• head• lateral malleolus• does not bear any body weight
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Ankle and Foot•Tarsals (14)
• calcaneus• talus• navicular• cuboid• lateral cuneiform• intermediate cuneiform• medial cuneiform
•Metatarsals (10)
•Phalanges (28)• proximal• middle• distal
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Life Span Changes•decrease in height at about age 30• calcium levels fall• bones become brittle• osteoclasts outnumber osteoblasts• spongy bone weakens before compact bone• bone loss rapid in menopausal women• hip fractures common• vertebral compression fractures common