Biochemical markers of bone cell activity

BIOCHEMICAL MARKERS OF BONE RESORPTION

Abbr Name Mechanism Company

NTX Aminoterminal cross-linking telopeptide of bone collagen Collagen-based Ostex (Osteomark)

CTX Carboxyterminal cross-linking telopeptide of bone collagen Collagen-based Cross-laps

(Osteometer)

PYD Pyridinoline Collagen-based

DPD Free Lysyl-pyridinoline (deoxypyridinoline) Collagen-based Metra (PyrilinksD)

TRACP Tartrate-resistant acid phosphatase Secreted by osteoclasts

Hyp Hydroxy-proline (not very specific) Collagen-based

BIOCHEMICAL MARKERS OF BONE FORMATION

Abbr Name Mechanism Company

Bone ALP, BAP Bone-specific alkaline phosphatase

Secreted by osteoblasts

Hybritech (Ostase), Metra (Alkphase-B)

PICP Procollagen type I C propeptide Collagen-based Orion, Metra (Prolagen)

PINP Procollagen type I N propeptide Collagen-based Incstar

OC Osteocalcin (bone gla-protein)

Secreted by osteoblasts

Nichols, Cis Biointernational

ALP Alkaline phosphatase (not very specific)

Secreted by osteoblasts