BLUE PEOPLE OF KENTUCKY
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Transcript of BLUE PEOPLE OF KENTUCKY
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BLUE PEOPLE OF KENTUCKY
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We’re not talking about...• The smurfs• Clinically depressed people• Fans of B.B. King• The Blue Man Group• Avatarians
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Ingesting elemental silver can also turn the skin blue. This man, Paul Karason, rubbed colloidal
silver on his face and skin many years ago to treat a skin condition, which made him slowly turn a
bluish/grey color.
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WHO ARE THEY?"Blue People" are descendants of Martin Fugate, who suffered from a recessive gene which limits or stops the production of the enzyme diaphorase (enzymes that catalyze the reduction of various dyes to act as hydrogen acceptors NADH + NADPH).
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What makes them blue?• Methemoglobinemia• Red blood cells (RBC) from blue people are
deficient in NADH diaphorase activity and cannot reduce the oxidized iron in methemoglobin (metHb).
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• The lack of this enzyme gives people a blueish cast to their skin rather than pink. Lack of oxygen to RBC gives this color.
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Interview
• '"He was almost purple,"' his father, Alva Stacy, recalls." Benjy was born in a maternity ward near Hazard, Kentucky and was rushed by ambulance to a medical clinic in Lexington to find help for his blue problem. Days of testing provided no answers; but then Benjy's grandmother told the doctor a story about the "blue" Fugates. Incredibly, Benjy had inherited a gene dating back over 162 years! Thankfully, Benjy lost his blue shade after a few weeks and the only lingering effects were blue fingernails and lips when he was cold or angry.
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Fugate FamilyFather + 4 children are blue
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Luna Fugate and John Stacey
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• Lorenzo Dow Fugate and Eleanor Fugate. Lorenzo Dow was also know as "Blue Anze"
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Real Folks
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Of Lonesome Creek, Kentucky
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In Hazard, the County Seat
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Symptoms
• Blue colored skin• Headaches• Fatigue• Coma• Death
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Treatment
• The homozygous patient (bb) daily ingestion of ascorbic acid to increase non- enzymatic reduction of methemoglobin
• or the use of methylene blue (oddly enough)- acts as an e- donor
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Degree of Blueness
• BB for the normal allele – not blue• Bb - heterozygotes for the blue trait -
do contain some NADH diaphorase activity –(blue lips, blue fingernails)
• bb – homozygous recessive - blue skin
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Blue Pedigree of Fugates
Get Handout • = male with it
• = female with it
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Pedigree Symbols
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More Pedigree Symbols
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Found on WikiPedia: There is a mistake here. Can you find it?
bb Bb BB
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Pedigree of Fugates
•Can you work out the genotypes?
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Pedigree with Genotypes
• trait visible
• carrier
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PRINT AND COLOR
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Pedigree Videos• Media Showcase: Pedigree
• Understanding Pedigrees (6:41)• Solving a Pedigree - the Fast Way (example
1) (6:42)
• Solving a Pedigree The Fast Way -example 2(6:46)
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You Will Make a Pedigree of Your Own Family
GET INSTRUCTION SHEET
Choose a trait from the lab of Variations of a Human Face (the one you drew the face on)