Blood and Hematopoiesis Quiz. ResponseWare Login ResponseWare Web Web Address: Session ID: 752003...

Blood and Hematopoiesis Quiz

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1. Reticulocytes may be identified by light microscopy due to their containing basophilic remnants of

Amino acids

DNA

Lipids

RNA

Suga

rs

0%

40%

7%

33%

20%

A. Amino acidsB. DNAC. LipidsD. RNAE. Sugars

2. As the last step in neutrophilic granulocytopoiesis,

Antigen-stimul...

Band ce

ll nucl.

..

Orth

ochro

matop...

Monoblasts

div...

Eosin

ophilic g.

..

14%

55%

10%3%

17%

A. Antigen-stimulated monocytes differentiate into plasma cells

B. Band cell nuclei will begin to become segmented

C. Orthochromatophylic eryhtroblasts divide to form reticulocytes

D. Monoblasts divide to form lymphocytes

E. Eosinophilic granules are produced

3. Hereditary spherocytosis is a condition which involves a defect in a cytoskeletal protein of the

erythrocyte, causing an abnormal spherical cell shape. This protein is

Albumin

Band 3 pro

tein

Hemoglobin

Spectr

in

P-selecti

n

0%6%

0%

94%

0%

A. AlbuminB. Band 3 proteinC. HemoglobinD. SpectrinE. P-selectin

4. One function of the helper T lymphocytes is to stimulate B lymphocytes to undergo mitosis and

subsequent differentiation into

Antibodies

Antigens

Cytoto

xic ce

ll...

Natu

ral k

iller..

.

Plasma ce

lls

11%

0%

77%

8%4%

A. AntibodiesB. AntigensC. Cytotoxic cellsD. Natural killer cellsE. Plasma cells

5. The predominant component(s) of blood plasma, making up roughly 90% of its weight

is/are

Albumin

Neutro

phils

Prote

in

Solute

s

Wate

r

14%

2%

84%

0%0%

A. AlbuminB. NeutrophilsC. ProteinD. SolutesE. Water

6. The predominant protein(s) in blood plasma is/are

Albumins

Fibrin

ogens

Globulin

s

Hemoglobin

Red blood cell..

.

94%

0% 0%4%2%

A. AlbuminsB. FibrinogensC. GlobulinsD. HemoglobinE. Red blood cells

7. The predominant cell type(s) in blood is/are

Leukocy

tes

Lymphocy

tes

Neutro

phils

Platelets

Red blood cell..

.

2% 0%

85%

6%7%

A. LeukocytesB. LymphocytesC. NeutrophilsD. PlateletsE. Red blood cells

8. The predominant leukocytic cell type in blood is/are

Basophils

Lymphocy

tes

Monocy

tes

Neutro

phils

T cells

0% 4% 0%

94%

2%

A. BasophilsB. LymphocytesC. MonocytesD. NeutrophilsE. T cells

Eryth

rocy

tes

Macro

phages

Mega

karyocytes

Monocy

tes

Neutro

phils

12% 12%

0%

72%

5%

9. The agranulocyte lineage of leukocytes contains the lymphocytes and what other

cell type?A. ErythrocytesB. MacrophagesC. MegakaryocytesD. MonocytesE. Neutrophils

Chloride ch

ann...

Cytosk

eletal f..

.

Platelet

Stere

ocilia

Tight ju

nction

72%

16%

6%0%

6%

10. Senescence of red blood cells is a process in which aged cells are destroyed by macrophages. The Band 3 protein involved in

this process is actually a type of

A. Chloride channelB. Cytoskeletal

filamentC. PlateletD. StereociliaE. Tight junction

HbA

HbA2

HbF

HbH

HbS

88%

11%

0%0%2%

11. What is the most common human hemoglobin type?

A. HbAB. HbA2

C. HbFD. HbHE. HbS

Liver

Lymph nodes

Spleen

Thymus

Yellow bone m

a...

13%

2% 0%0%

85%

12. Erythrocyte senesence ultimately leads to destruction by macrophages predominantly in which organ ?

A. LiverB. Lymph nodesC. SpleenD. ThymusE. Yellow bone

marrow

1-2 hours

2 days

120 days

2 weeks

2 years

5%11%

0%5%

78%

13. The typical lifespan of a circulating erythrocyte is

A. 1-2 hoursB. 2 daysC. 120 daysD. 2 weeksE. 2 years

Both A

and B antibodies

No A or B

antibodies

Only A antibodies

Only B antibodies

Only C antibodies

83%

15%

2%0%0%

13. Of the 4 common, human blood types, Type O is unique in that an individual possesses red blood cells

with no A or B antigens and

A. Both A and B antibodies

B. No A or B antibodiesC. Only A antibodiesD. Only B antibodiesE. Only C antibodies

Actin and m

yos...

Larg

e cell s

iz...

Non-st

aining g...

Prolonge

d life...

Segmenta

tion o...

88%

4% 6%0%2%

15. Neutrophils are motile cells. Microtubules play an important role in this locomotion ability along with

A. Actin and myosinB. Large cell sizeC. Non-staining

granules D. Prolonged lifespanE. Segmentation of

their nuclei

Collagen

Collagenase

Hemoglobin

Keratin

Major b

asic pr..

.

19%

4%

62%

2%

13%

16. Eosinophil specific granules stain eosinophilic giving the cell its characteristic red color. The predominant protein in the

eosinophil specific granule is

A. CollagenB. CollagenaseC. HemoglobinD. Keratin E. Major basic protein

Antibodies

Collagenase

Heparin

and Hist

amine

Major b

asic pro

tein

P-selecti

n

2% 2% 2%0%

94%

17. Basophils are functionally similar to mast cells in that they secrete granules containing similar protein content, notably

A. AntibodiesB. CollagenaseC. Heparin and

HistamineD. Major basic proteinE. P-selectin

B cell

Macro

phage

Natu

ral K

iller..

.

Plasma ce

ll T ce

ll

7% 5% 5%

68%

15%

18. Humoral immunity is mediated by B cells which upon activation by antigen recognition differentiate into a cell capable

of producing antibodies, the

A. B cellB. MacrophageC. Natural Killer cellD. Plasma cellE. T cell

Cytoto

xic

Helper

Memory

Natu

ral

Suppre

ssor

83%

8%0%

8%2%

19. Cell-mediated immunity is a function of many cells including T cells. A T cell which directly acts to kill cells expressing foreign

antigens on their surface is termed

A. CytotoxicB. HelperC. MemoryD. NaturalE. Suppressor

It doesn

’t occ

...

It invo

lves t

h...

It is

larger i.

..

It is

slower

It is

smalle

r

3% 6%0%0%

91%

20. Memory B cells derive from a naïve B cells initial exposure to a foreign antigen. What is true of the immune response of a

memory B cell after a second exposure to that antigen?

A. It doesn’t occurB. It involves the CNSC. It is larger in scopeD. It is slowerE. It is smaller

Mega

karyocytes

Monocy

tes

Oste

ocyte

s

Plasma ce

lls

T lymphocy

tes

94%

4% 2%0%0%

21. Platelets are cell fragments that derive from which cell type?

A. MegakaryocytesB. MonocytesC. OsteocytesD. Plasma cellsE. T lymphocytes

Lecti

n

Major h

istoco

mpatibilit...

Platelet-d

erived gro

wth ...

P-selecti

n

Perforin

12%5%

20%

7%

56%

22. Platelets contain structures called granulomeres that contain numerous proteins. A key protein in the granulomere is a growth factor important in blood vessel growth and regeneration, and is

named

A. LeptinB. Major

histocompatibility complex

C. Platelet-derived growth factor

D. P-selectinE. Perforin

Actin and m

yos...

Demarca

tion me...

Gran

ulomeres

Mega

karyocyto

p...

Smooth

muscl

e

71%

5%

17%

7%0%

23. Platelets possess contractile activity, and play an important role in repairs to blood vessels. This contractile activity in

platelets is mediated in part by

A. Actin and myosinB. Demarcation

membranesC. GranulomeresD. MegakaryocytopoiesisE. Smooth muscle

Multi

locular

Red

Unilo

cular

White

Yellow

0% 0%

89%

6%6%

24. Inactive marrow that functions primarily to store fat is termed

A. MultilocularB. RedC. UnilocularD. WhiteE. Yellow

B lymphocy

tes

Basophils

, eos..

.

Eryth

rocy

tes

Mega

karyocytes

T lymphocy

tes

8%

64%

6%11%11%

25. Colony stimulating factors (CSFs) are compounds which influence hematopoiesis and promote the production of specific cell types. One key

example, GM-CSF, when released, could lead to the increased production of which of the following cell types?

A. B lymphocytesB. Basophils, eosinophils,

neutrophils, monocytesC. ErythrocytesD. MegakaryocytesE. T lymphocytes

B lymphocy

tes

Basophils

Eryth

rocy

tes

Mega

karyocytes

T lymphocy

tes

3% 2% 0%0%

95%

26. Hematopoietic growth factors direct the production of cell types in the bone marrow. Erythropoietin, a factor produced by the kidney increases the

production of which cell type?

A. B lymphocytesB. BasophilsC. ErythrocytesD. MegakaryocytesE. T lymphocytes

CFU-E

CFU-G

EMM

CFU-G

M

CFU-Ly

CFU-M

eg

0%

17%

3%0%

80%

27. Colony forming units (CFUs) are groups of cells which have committed to a common lineage in hematopoiesis. CFU-Ly defines cells which have

committed to the lymphocyte lineage. Which common colony forming unit is responsible for the formation of granulocytes, monocytes, erythrocytes, and

megakaryocytes?

A. CFU-EB. CFU-GEMMC. CFU-GMD. CFU-LyE. CFU-Meg

Colony stimula...

Hemonecti

n

Heparin

Lymphokin

e

P-selecti

n

11%

50%

29%

0%

11%

28. The bone marrow stroma is composed of adventitial cells which form a reticular network to support the marrow tissue and hematopoietic cell

network. Hematopoietic cells bind to this network through a marrow-specific adhesion protein called

A. Colony stimulating factor

B. HemonectinC. HeparinD. LymphokineE. P-selectin

Basophil

Eosin

ophil

Lymphocy

te

Monocy

te

Neutro

phil

26%

2%6%

65%

2%

29. Examination of a normal peripheral blood smear reveals a cell more than twice the diameter of an erythrocyte with a kidney-shaped nucleus. These

cells were <10% of total leukocytes. Which of the following cell types is being described?

A. BasophilB. EosinophilC. LymphocyteD. MonocyteE. Neutrophil

Eryth

roblast

Lymphoblast

Platelet

Promyelocy

te

Unilo

cular a

di...

4%

15%

0%

81%

0%

30. Basophils, neutrophils, and eosinophils differentiate through a final common granulocytic precursor cell termed the

A. ErythroblastB. LymphoblastC. PlateletD. PromyelocyteE. Unilocular adipocyte

Eryth

roblast

Mye

loblast

Platelet

Reticulocy

te T ce

ll

0% 0% 0%0%0%

31. In the pathway of erythrocytopoiesis, the final defined precursor cell before the formation of a mature erythrocyte is

called a

:30

A. ErythroblastB. MyeloblastC. PlateletD. ReticulocyteE. T cell

IgE antibody

Collagenase

Hemonecti

n

Major b

inding ...

P-selecti

n

0% 0% 0%0%0%

32. The neutrophil is considered to ‘reside’ in several theoretical compartments during its development and lifespan. From its circulation in the

bloodstream the neutrophil is able to migrate into connective tissue spaces upon binding a key endothelial cell adhesion molecule called

:30

A. IgE antibodyB. CollagenaseC. HemonectinD. Major binding proteinE. P-selectin

IgE antibody

Collagenase

Hemonecti

n

Major b

inding pro

tein

Stick

y glycopro

tein coat

0% 0% 0%0%0%

33. When a blood vessel is damaged a coordinated sequence of events involving many cell types and proteins takes place. One of the initial steps is the aggregation of platelets to form a platelet plug at the site of the damage

where collagen from connective tissue is exposed to the blood. The aggregation at this site is possible due to the platelets having

:30

A. IgE antibodyB. CollagenaseC. HemonectinD. Major binding proteinE. Sticky glycoprotein coat

Basophil

Eosin

ophil

Lymphocy

te

Monocy

te

Neutro

phil

0% 0% 0%0%0%

34. Identify this cell (arrow, black).

:30


Basophil

Eosin

ophil

Lymphocy

te

Monocy

te

Neutro

phil

0% 0% 0%0%0%


:30


Cellular

debri...

Eryth

rocy

tes

Platelets

Proce

ssing art.

..

Reticulocy

tes

0% 0% 0%0%0%

37. Identify these structures (arrows, black).

:30

A. Cellular debrisB. ErythrocytesC. PlateletsD. Processing artifactE. Reticulocytes

Basophil

Eosin

ophil

Lymphocy

te

Monocy

te

Neutro

phil

0% 0% 0%0%0%


:30


B lymphocy

te

Eosin

ophil

Mega

karyocyte

Monocy

te

Neutro

phil

0% 0% 0%0%0%


:30

A. B lymphocyteB. EosinophilC. MegakaryocyteD. MonocyteE. Neutrophil

Eosin

ophil

Lymphatic v

essel

Mega

karyocyte

Sinuso

id

T lymphocy

te

0% 0% 0%0%0%

46. Identify this structure (arrow, black).

:30

A. EosinophilB. Lymphatic vesselC. MegakaryocyteD. SinusoidE. T lymphocyte

Adipocyte

s

Eryth

rocy

tes

Lymphocy

tes

Mega

karyocytes

Monocy

tes

0% 0% 0%0%0%

47. Identify these cells (arrows, black).

:30

A. AdipocytesB. ErythrocytesC. LymphocytesD. MegakaryocytesE. Monocytes

B lymphocy

tes

Eosin

ophils

Mega

karyocytes

Monocy

tes

Neutro

phils

0% 0% 0%0%0%

48. Identify these cells (arrows, black).

:30

A. B lymphocytesB. EosinophilsC. MegakaryocytesD. MonocytesE. Neutrophils

Eosin

ophils

Lymphatic v

ess...

Mega

karyocytes

Sinuso

ids

Wove

n bone

0% 0% 0%0%0%

49. Identify these structures (arrows, black).

:30

A. EosinophilsB. Lymphatic vesselsC. MegakaryocytesD. SinusoidsE. Woven bone

B lymphocy

te

Eryth

roid

Lymphoid

Monocy

tic

Mye

loid

0% 0% 0%0%0%

50. In this image of a bone marrow smear, the indicated cells belong to which hematopoietic lineage (arrows, black)?

:30

A. B lymphocyteB. ErythroidC. LymphoidD. MonocyticE. Myeloid

Basophils

Eosin

ophils

Lymphocy

tes

Monocy

tes

Neutro

phils

0% 0% 0%0%0%

51. Your patient is suffering from an infestation of parasites. To determine the proper therapy, you perform an analysis of a peripheral blood sample. Which of the following cells would you expect to be increased in a peripheral blood

smear?

:30

A. BasophilsB. EosinophilsC. LymphocytesD. MonocytesE. Neutrophils

Basophils

Eryth

rocy

tes

Monocy

tes

Neutro

phils

Mega

karyocytes

0% 0% 0%0%0%

52. A decrease in the number of tissue macrophages would result from reduced activity of precursor cells to

which of the following cell types?

:30

A. BasophilsB. ErythrocytesC. MonocytesD. NeutrophilsE. Megakaryocytes

Basophil

Eosin

ophil

Lymphocy

te

Monocy

te

Neutro

phil

0% 0% 0%0%0%

53. Which of the following cells is the primary phagocytic cell within peripheral blood?

:30


Amino acid ch

a...

Decre

ased le

ve...

Decre

ased iro

n

Decre

ased plat..

.

Decre

ased sy

nt...

0% 0% 0%0%0%

54. Pernicious anemia develops as a consequence of which of the following?

:30

A. Amino acid change of the globin moecule

B. Decreased levels of intrinsic factor

C. Decreased ironD. Decreased plateletsE. Decreased synthesis of

hemoglobins

Bacte

rial in

fe...

Hemorrh

age

Org

an transp

la...

Parasiti

c infe...

Pollen in

festa

...

0% 0% 0%0%0%

55. While examining a peripheral blood smear, you notice an increased number of cells slightly larger than an erythrocyte. These cells have a large,

round nucleus and scant cytoplasm. Which of the following would cause this condition?

:30

A. Bacterial infectionB. HemorrhageC. Organ transplant

rejectionD. Parasitic infectionE. Pollen infestation

Hemophilia

Pernici

ous ane...

Polycyto

themia

Thalassemia

Thrombocy

topen...

0% 0% 0%0%0%

56. A young man complains that he bruises easily. A laboratory report showed a normal white cell count. Erythrocytes were 5 million/mm3, whereas

platelets were 50,000/mm3. Which of the following was the diagnosis?

:30

A. HemophiliaB. Pernicious anemiaC. PolycytothemiaD. ThalassemiaE. Thrombocytopenia

Basophils

Eosin

ophils

Mega

karyocytes

Neutro

phils

T lymphocy

tes

0% 0% 0%0%0%

57. Which of the following blood cells differentiate outside of the bone marrow?

:30

A. BasophilsB. EosinophilsC. MegakaryocytesD. NeutrophilsE. T lymphocytes

Cell-mediate

d ...

Hemorrh

age

Humoral

-mediat..

.

Infe

ction

Mye

locytic l

eu...

0% 0% 0%0%0%

58. An analysis of a peripheral blood smear showed that reticulocytes were 10% of total cells. Which of the following

represents the proper diagnosis?

:30

A. Cell-mediated immune response

B. HemorrhageC. Humoral-mediated

immune responseD. InfectionE. Myelocytic leukemia

Monocy

te

Oste

oblast

Polychro

matoph...

Platelet

Proeryth

roblas..

.

0% 0% 0%0%0%

59. Which of the following is not derived by a mitotic division of a precursor cell?

:30

A. MonocyteB. OsteoblastC. Polychromatophilic

erythroblastD. PlateletE. Proerythroblast

Basophils

Eryth

rocy

tes

Lymphocy

tes

Monocy

tes

Platelets

0% 0% 0%0%0%

60. Examining a peripheral blood smear, you note a cell type that consists of both large and small cells intermixed with normal size cells, a condition

described as anisocytosis. This abnormal condition refers to which of the following?

:30

A. BasophilsB. ErythrocytesC. LymphocytesD. MonocytesE. Platelets

Basophilic

ery...

Hemato

poietic ...

Orth

ochro

matop...

Polychro

matoph...

Proeryth

roblas..

.

0% 0% 0%0%0%

61. Your patient suffers from a blood disorder that requires chemotherapy. A bone marrow transplant is subsequently performed. Transplants containing

which of the following cells in the erythrocytic series would not provide proliferative cells?

:30

A. Basophilic erythroblastB. Hematopoietic stem cellC. Orthochromatophilic

erythroblastD. Polychromatophilic

erythroblastE. Proerythroblast

Hemato

poietic ...

Metamyelocy

te

Mye

loblast

Mye

locyte

Promyelocy

te

0% 0% 0%0%0%

62. At which of the following stages are specific cells of the granulocytic series first recognizable?

:30

A. Hematopoietic stem cellB. MetamyelocyteC. MyeloblastD. MyelocyteE. Promyelocyte

Basophilic

erythro

blast

Orth

ochro

matophilic

er...

Polychro

matophilic

eryt...

Proeryth

roblast

Reticulocy

te

0% 0% 0%0%0%

63. Hemoglobin is first seen in which of the following cells of the erythrocytic series?

:30

A. Basophilic erythroblastB. Orthochromatophilic

erythroblastC. Polychromatophilic

erythroblastD. ProerythroblastE. Reticulocyte

Basophilic

erythro

blast

Orth

ochro

matophilic

er...

Polychro

matophilic

eryt...

Proeryth

roblast

Reticulocy

te

0% 0% 0%0%0%

64. In which of the following cells of the erythrocytic series is the nucleus extruded?

:30

A. Basophilic erythroblastB. Orthochromatophilic

erythroblastC. Polychromatophilic

erythroblastD. ProerythroblastE. Reticulocyte

Basophilic

ery...

Mye

locyte

Neutro

philic m

...

Polychro

matoph...

Promyelocy

te

0% 0% 0%0%0%

65. While examining cells of a bone marrow smear with the light microscope, you notice a cell whose cytoplasm has no noticeable granules. The nucleus of this cell in indented and contains no nucleoli. Which of the following cells are

you examining?

:30

A. Basophilic erythroblastB. MyelocyteC. Neutrophilic

metamyelocyteD. Polychromatophilic

erythroblastE. Promyelocyte

All blood ce

ll...

Destr

uction of...

Lymphocy

tes m

a...

Monocy

tes matu

...

Yellow bone m

a...

0% 0% 0%0%0%

66. Which of the following best characterizes bone marrow?

:30

A. All blood cells undergo maturation within the bone marrow

B. Destruction of erythrocytes is carried out in red bone marrow

C. Lymphocytes mature in bone marrow

D. Monocytes mature in bone marrow

E. Yellow bone marrow does not function to produce blood cells

Basophilic

leu...

Eosin

ophilic l..

.

Lymphoblasti

c ...

Promyelocy

tic ...

Stem ce

ll leuk...

0% 0% 0%0%0%

67. A sample of peripheral blood from a patient reveals a larger than normal population of cells that have large, round nuclei with 1 or 2 nucleoli. The

cytoplasm of these cells shows azurophilic granules. Which of the following forms of leukemia would you suspect?

:30

A. Basophilic leukemiaB. Eosinophilic leukemiaC. Lymphoblastic leukemiaD. Promyelocytic leukemiaE. Stem cell leukemia

Mye

loblast

Neutro

philic m

...

Neutro

philic m

...

Orth

ochro

matop...

Polychro

matoph...

0% 0% 0%0%0%

68. A peripheral blood smear of a person suffering from a mild form of leukemia showed a large number of cells with more than

1 nucleolus. Which of the following cells is being described?

:30

A. MyeloblastB. Neutrophilic

metamyelocyteC. Neutrophilic myelocyteD. Orthochromatophilic

erythroblastE. Polychromatophilic

erythroblast

Basophilic

ery...

Mega

karyoblast...

Metamyelocy

tes

Orth

ochro

matop...

Reticulocy

tes

0% 0% 0%0%0%

69. Your patient suffers from lymphocytic leukemia. Chemotherapy is administered to destroy cancerous cells of the bone marrow. Precursor cells

to erythrocytes are destroyed. To specifically re-establish the erythrocytic cell line, which of the following cells should be transplanted?

:30

A. Basophilic erythroblastsB. MegakaryoblastsC. MetamyelocytesD. Orthochromatophilic

erythroblastsE. Reticulocytes

Chromatin beco

...

Nucle

i beco

me ...

Nucle

i decre

as...

Nucle

oli incre

...

Rough endoplas..

.

0% 0% 0%0%0%

70. As cells undergo the process of erythropoiesis, which of the following occurs?

:30

A. Chromatin becomes more diffuse

B. Nuclei become lobulatedC. Nuclei decrease in sizeD. Nucleoli increase in numberE. Rough endoplasmic

reticulum increases within the cytoplasm

Blood and Hematopoiesis Quiz. ResponseWare Login ResponseWare Web Web Address: Session ID: 752003...

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