Black Patients Die Earlier after Surgery for Esophageal Cancer Andrea S. Wolf, MD, MPH, Emanuela...

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Black Patients Die Earlier after Surgery for Esophageal Cancer Andrea S. Wolf, MD, MPH , Emanuela Taioli MD, PhD, Marlene Camacho-Rivera, ScD, MPH, Andrew Kaufman, MD, Dong-Seok Lee, MD, Faiz Bhora, MD, Raja M. Flores, MD Department of Thoracic Surgery The Icahn School of Medicine at Mount Sinai The Mount Sinai Health System New York, NY

Transcript of Black Patients Die Earlier after Surgery for Esophageal Cancer Andrea S. Wolf, MD, MPH, Emanuela...

Page 1: Black Patients Die Earlier after Surgery for Esophageal Cancer Andrea S. Wolf, MD, MPH, Emanuela Taioli MD, PhD, Marlene Camacho-Rivera, ScD, MPH, Andrew.

Black Patients Die Earlier after Surgery for Esophageal Cancer

Andrea S. Wolf, MD, MPH, Emanuela Taioli MD, PhD,

Marlene Camacho-Rivera, ScD, MPH, Andrew Kaufman, MD,

Dong-Seok Lee, MD, Faiz Bhora, MD, Raja M. Flores, MD

Department of Thoracic SurgeryThe Icahn School of Medicine at Mount Sinai

The Mount Sinai Health System New York, NY

Page 3: Black Patients Die Earlier after Surgery for Esophageal Cancer Andrea S. Wolf, MD, MPH, Emanuela Taioli MD, PhD, Marlene Camacho-Rivera, ScD, MPH, Andrew.

Introduction

• Esophageal cancer in black patients

Higher incidence and mortalityHigher rate of squamous cell CALower use of surgeryWhen adjusted for surgery, no

difference in survival

Page 4: Black Patients Die Earlier after Surgery for Esophageal Cancer Andrea S. Wolf, MD, MPH, Emanuela Taioli MD, PhD, Marlene Camacho-Rivera, ScD, MPH, Andrew.

Objective

• To determine whether race affects short and long-term mortality in patients having surgery for esophageal cancer using SEER

Page 5: Black Patients Die Earlier after Surgery for Esophageal Cancer Andrea S. Wolf, MD, MPH, Emanuela Taioli MD, PhD, Marlene Camacho-Rivera, ScD, MPH, Andrew.

Methods

• SEER 1973-2011

• Inclusion:• Blacks, Whites• Adenocarcinoma, SCC

• Exclusion:• Distant metastases• Cervical esophageal CA

Page 6: Black Patients Die Earlier after Surgery for Esophageal Cancer Andrea S. Wolf, MD, MPH, Emanuela Taioli MD, PhD, Marlene Camacho-Rivera, ScD, MPH, Andrew.

Methods

• Cox proportional hazards model

• Outcome: Overall survival

• Predictors: • Race• Age• Sex• Year of dx• Stage• Cancer-directed surgery• Radiation

Page 7: Black Patients Die Earlier after Surgery for Esophageal Cancer Andrea S. Wolf, MD, MPH, Emanuela Taioli MD, PhD, Marlene Camacho-Rivera, ScD, MPH, Andrew.

Baseline characteristicsVariable Categories Whites

(n = 13,678)Blacks

(n = 2,894)

p-value

Sex Male 10,168 (74%) 2,079 (72%) 0.005

  Female 3,510 (26%) 815 (28%)  

Mean age in yr (95% CI)   67.8 (67.6-68.0) 61.6 (61.2-61.9) <0.0001

Overall Stage 

Localized 6,609 (48%) 1,508 (52%) <0.0001

Regional 7,069 (52%) 1,386 (48%)  

Histology 

SCC 6,775 (50%) 2,777 (96%) <0.0001Adenocarcinoma 6,903 (50%) 117 (4%)  

Cancer-directed surgery 

No 6,428 (47%) 1,726 (60%) <0.0001

Yes 7,250 (53%) 1,168 (40%)  

Radiation  

No 4,960 (36%) 935 (32%) <0.0001

Yes 8,476 (62%) 1,870 (65%)  

Unknown 242 (2%) 89 (3%)  

Therapy    

None 1,619 (12%) 411 (14%) <0.0001

Surgery only 3,341 (25%) 524 (19%)  

Radiation only 4,678 (35%) 1,258 (45%)  

Both surgery and radiation

3,798 (28%) 612 (22%)  

Page 9: Black Patients Die Earlier after Surgery for Esophageal Cancer Andrea S. Wolf, MD, MPH, Emanuela Taioli MD, PhD, Marlene Camacho-Rivera, ScD, MPH, Andrew.

Cox model 1-year mortality    Overall SCC AC

Variable   Adjusted HR (95% CI)

Race Black versus White 1.24 (1.16-1.32) 1.21 (1.13-1.30) 1.06 (0.77-1.45)

Sex Female versus Male 0.95 (0.90-1.01) 0.94 (0.88-1.00) 0.97 (0.86-1.09)

Age Per increased year 1.02 (1.01-1.02) 1.01(1.01-1.02) 1.02 (1.02-1.02)

Stage Regional versus Localized

1.60 (1.53-1.69) 1.48 (1.39-1.58) 1.78 (1.63-1.94)

Histology SCC versus AC 1.22 (1.15-1.30) -- --

Therapy None 1.0 (REF) 1.0 (REF) 1.0 (REF)

  Surgery only 0.30 (0.27-0.33) 0.31 (0.28-0.35) 0.27 (0.24-0.31)

  Radiation only 0.56 (0.52-0.60) 0.53 (0.48-0.58) 0.63 (0.56-0.72)

  Both surgery and radiation

0.34 (0.31-0.37) 0.36 (0.32-0.40) 0.30 (0.26-0.35)

Year of Diagnosis

Per increased year 0.97 (0.97-0.97) 0.97 (0.97-0.98) 0.96 (0.96-0.97)

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Cox model 1-year mortality

    Overall SCC AC

Variable   Adjusted HR (95% CI)

Race Black versus White

1.24 (1.16-1.32) 1.21 (1.13-1.30) 1.06 (0.77-1.45)

Page 11: Black Patients Die Earlier after Surgery for Esophageal Cancer Andrea S. Wolf, MD, MPH, Emanuela Taioli MD, PhD, Marlene Camacho-Rivera, ScD, MPH, Andrew.

Cox model 1-year mortality

    Overall SCC AC

Variable   Adjusted HR (95% CI)

Stage Regional versus Localized

1.60 (1.53-1.69) 1.48 (1.39-1.58) 1.78 (1.63-1.94)

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Cox model 1-year mortality

    Overall SCC AC

Variable   Adjusted HR (95% CI)

Histology SCC versus AC

1.22 (1.15-1.30) -- --

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Cox model 1-year mortality

    Overall SCC AC

Variable   Adjusted HR (95% CI)

Therapy None 1.0 (REF) 1.0 (REF) 1.0 (REF)

  Surgery only 0.30 (0.27-0.33) 0.31 (0.28-0.35) 0.27 (0.24-0.31)

  Radiation only 0.56 (0.52-0.60) 0.53 (0.48-0.58) 0.63 (0.56-0.72)

  Both surgery and radiation

0.34 (0.31-0.37) 0.36 (0.32-0.40) 0.30 (0.26-0.35)

Page 19: Black Patients Die Earlier after Surgery for Esophageal Cancer Andrea S. Wolf, MD, MPH, Emanuela Taioli MD, PhD, Marlene Camacho-Rivera, ScD, MPH, Andrew.

Conclusions

• Black race is independently associated with higher mortality in esophageal cancer

• Black patients treated with surgery have poorer survival than Whites

• Racial difference in mortality most pronounced at first year

Page 20: Black Patients Die Earlier after Surgery for Esophageal Cancer Andrea S. Wolf, MD, MPH, Emanuela Taioli MD, PhD, Marlene Camacho-Rivera, ScD, MPH, Andrew.

Future directions

• Differences in how black and white patients are being selected for surgery?

• Racial disparities in access to dedicated thoracic surgeons doing safe esophagectomies at high volume centers?

• Disparities in treatment at cancer centers with coordinated multi-disciplinary care?

Page 25: Black Patients Die Earlier after Surgery for Esophageal Cancer Andrea S. Wolf, MD, MPH, Emanuela Taioli MD, PhD, Marlene Camacho-Rivera, ScD, MPH, Andrew.

Baseline CharacteristicsVariable Categories Whites

(n = 13,678)Blacks

(n = 2,894)

p-value

Sex Male 10,168 (74%) 2,079 (72%) 0.005

  Female 3,510 (26%) 815 (28%)  

Mean age in yr (95% CI)   67.8 (67.6-68.0) 61.6 (61.2-61.9) <0.0001

Overall Stage 

Localized 6,609 (48%) 1,508 (52%) <0.0001

Regional 7,069 (52%) 1,386 (48%)  

Histology 

SCC 6,775 (50%) 2,777 (96%) <0.0001Adenocarcinoma 6,903 (50%) 117 (4%)  

Cancer-directed surgery 

No 6,428 (47%) 1,726 (60%) <0.0001

Yes 7,250 (53%) 1,168 (40%)  

Radiation  

No 4,960 (36%) 935 (32%) <0.0001

Yes 8,476 (62%) 1,870 (65%)  

Unknown 242 (2%) 89 (3%)  

Therapy    

None 1,619 (12%) 411 (14%) <0.0001

Surgery only 3,341 (25%) 524 (19%)  

Radiation only 4,678 (35%) 1,258 (45%)  

Both surgery and radiation

3,798 (28%) 612 (22%)  

Page 26: Black Patients Die Earlier after Surgery for Esophageal Cancer Andrea S. Wolf, MD, MPH, Emanuela Taioli MD, PhD, Marlene Camacho-Rivera, ScD, MPH, Andrew.

Cox model 1-year mortality    Overall SCC AC

Variable   Adjusted HR (95% CI)*

Race Black versus White 1.24 (1.16-1.32) 1.21 (1.13-1.30) 1.06 (0.77-1.45)

Sex Female versus Male 0.95 (0.90-1.01) 0.94 (0.88-1.00) 0.97 (0.86-1.09)

Age Per increased year 1.02 (1.01-1.02) 1.01(1.01-1.02) 1.02 (1.02-1.02)

Stage Regional versus Localized 1.60 (1.53-1.69) 1.48 (1.39-1.58) 1.78 (1.63-1.94)

Histology SCC versus AC 1.22 (1.15-1.30) -- --

Therapy None 1.0 (REF) 1.0 (REF) 1.0 (REF)

  Surgery only 0.30 (0.27-0.33) 0.31 (0.28-0.35) 0.27 (0.24-0.31)

  Radiation only 0.56 (0.52-0.60) 0.53 (0.48-0.58) 0.63 (0.56-0.72)

  Both surgery and radiation 0.34 (0.31-0.37) 0.36 (0.32-0.40) 0.30 (0.26-0.35)

Year of Diagnosis

Per increased year 0.97 (0.97-0.97) 0.97 (0.97-0.98) 0.96 (0.96-0.97)

Page 27: Black Patients Die Earlier after Surgery for Esophageal Cancer Andrea S. Wolf, MD, MPH, Emanuela Taioli MD, PhD, Marlene Camacho-Rivera, ScD, MPH, Andrew.

Cox model 3-year mortality    Overall SCC AC

Variable   Adjusted HR (95% CI)*

Race Black versus White 1.24 (1.17-1.30) 1.22 (1.15-1.29) 1.09 (0.86-1.39)

Sex Female versus Male 0.94 (0.89-0.98) 0.91 (0.87-0.96) 0.98 (0.90-1.07)

Age Per increased year 1.01 (1.01-1.02) 1.01(1.01-1.02) 1.02 (1.01-1.02)

Stage Regional versus Localized  1.67 (1.60-1.73) 1.47 (1.40-1.55) 1.90 (1.78-2.03)

Histology SCC versus AC 1.15 (1.10-1.21) -- --

Therapy None 1.0 (REF) 1.0 (REF) 1.0 (REF)

  Surgery only 0.33 (0.31-0.36) 0.37 (0.33-0.41) 0.29 (0.26-0.33)

  Radiation only 0.64 (0.60-0.68) 0.59 (0.54-0.64) 0.74 (0.66-0.82)

  Both surgery and radiation 0.42 (0.39-0.45) 0.42(0.38-0.46) 0.41 (0.37-0.46)

Year of Diagnosis

Per increased year 0.97 (0.97-0.97) 0.97 (0.97-0.98) 0.96 (0.96-0.96)

Page 28: Black Patients Die Earlier after Surgery for Esophageal Cancer Andrea S. Wolf, MD, MPH, Emanuela Taioli MD, PhD, Marlene Camacho-Rivera, ScD, MPH, Andrew.

Cox model overall mortality    Overall SCC AC

Variable   Adjusted HR (95% CI)*

Race Black versus White 1.25 (1.19-1.31) 1.23 (1.17-1.29) 1.04 (0.83-1.30)

Sex Female versus Male 0.91 (0.88-0.95) 0.89 (0.85-0.94) 0.98 (0.90-1.06)

Age Per increased year 1.02 (1.01-1.02) 1.01(1.01-1.02) 1.02 (1.02-1.03)

Stage Regional versus Localized 1.60 (1.55-1.66) 1.44 (1.38-1.51) 1.78 (1.68-1.89)

Histology SCC versus AC 1.13 (1.09-1.18) -- --

Therapy None 1.0 (REF) 1.0 (REF) 1.0 (REF)

  Surgery only 0.37 (0.34-0.39) 0.40 (0.36-0.44) 0.33 (0.30-0.37)

  Radiation only 0.69 (0.65-0.74) 0.64 (0.59-0.70) 0.79 (0.71-0.87)

  Both surgery and radiation

0.47 (0.44-0.50) 0.47(0.43-0.51) 0.47 (0.42-0.52)

Year of Diagnosis

Per increased year 0.97 (0.97-0.97) 0.98 (0.97-0.98) 0.96 (0.96-0.96)