Biotechnology R&D in India Dr. Renu Swarup, AdviserDepartment of BiotechnologyMinistry of Science & Technology Government of India28 February, 2013

What is Biotechnology?Biotechnology is .

Any technique that uses living organisms, or substances from those organisms, to make or modify a product to improve plants or animals, or to develop microorganisms for specific uses.

Indias Research Scenario Population 1.2 billionNo. of researchers - 0.15 million ( 140 per million)No. of universities - 457No. of publications 65,000 per year ( 3.1% share)About 1% of GDP is spent on R&DWorld share of output over 2006-2010 3.3%Citation impact 2006-2010 0.68Narrowing gap between India and established economics

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India Major S&T AgenciesMinistry of Science and TechnologyDepartment of Biotechnology (DBT)Department of Science and Technology (DST)Council of Scientific and Industrial Research (CSIR)Ministry of Earth Sciences Department of Atomic Energy (DAE)Department of Space (DoS)Ministry of New & Renewable EnergyMinistry of Health & Family WelfareDepartment of Health & Family WelfareIndian Council of Medical Research (ICMR)Ministry of AgricultureIndian Council of Agricultural Research (ICAR)Ministry of Environment and Forests

Department of Biotechnology1982 : National Biotechnology Board (NBTB)

1986 : Department of Biotechnology (DBT)

2012 : Biotechnology Industry Research Assistance Council (BIRAC)

Attaining new heights in biotechnology research, shaping biotechnology into a premier precision tool of the future for creation of wealth and ensuring social justice specially for the welfare of the poor. VISION

Budget allocation for S&T agencies*Directions of Growth

Chart1

621

1653

5062

17887

(Rs. in crore)

Department of BiotechnologyBudget Allocation

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9th Plan621

10th Plan1653

11th Plan5062

12th Plan (Projected)17887

Sheet1

(Rs. in crore)

Department of BiotechnologyFinancial Summary

Sheet2

Sheet3

BIOTECHNOLOGY FOR THE NEW MILLENIUM A FEW GLIMPSES

Micropropagation

Plant Genome Research

Crop Biotechnologyand Transgenics

Neurosciences

Immunology

Cell Science

Diagnostics Molecular probesGene therapy and functional genomics Special Societal Programmes

Human Resource Development

Bioinformatics

Aquaculture and Marine ResourceBiodiversity Inventorisation, Characterisation, ConservationPatenting in Biotechnology and BiosafetyProspecting of Genes and MoleculesEnvironmental Pollution abatemantAnimal Biotechnology

New Generation Vaccines Bioproduct Development Down Stream Processing

*Biotechnology pervades multiple facets of lifeAgricultureTransgenics crops, designer breeding, plants as biofactories, biopesticides, biofertilizers, diagnosticsHuman healthBiodrugs, vaccines, diagnostics, biomarkers, cell & tissue engineering products, artificial organs, nano based drug delivery systems, biobased implants and devices AnimalTransgenics, vaccines, diagnostics, feed, biofactoriesBioresources Bioactives and drugs, biological processes, microbial prospecting Environment Bioremediation, pollution abatement, biofuelsIndustrial /ManufacturingEnzymes, biomass based bioproducts, disposable GMP biofactories, plant based bioactives bionutraceuticals, biosensors, bioequipment and enabling technology platforms

*Biotechnology is a multidisciplinary field Integrated development is essentialBiological and material sciencePhysical ScienceChemical ScienceEngineering bioengineering, electronicsMedicineAgronomicsAquacultureAnimal ScienceEnergy BioscienceEnvironment ScienceBioresourceNano ScienceForestryInvestment and Finance

Management

Law

DBT Technology Focus Vaccines and Diagnostics -Human , AnimalStem CellsImplants and devicesTransgenics and marker assisted breedingAnimal vaccines, feed and breedingBioresources utilization (drugs, antivirals others) Food and nutrition technology Bio-pesticides and bio-fertilizers Novel and green manufacturing /technologies

Genomics based strategy is now required for drought, salinity, heat .Strategic basic researchDiscover genes, genomic regions and their functionDesigner breedingTransgenicsMolecular assisted breedingNew Models of R&DMajor capacity building in genomics and designer breeding

RiceTomatoGenome Initiative: India Moves Ahead !SugarcaneChickpeaWheatCoffeeChromosome 11Chromosome 5Complete Bacterial GenomeSilk worm

National Programme on Energy BiosciencesMore than 53 research institutes, universities and industries involved

Screening for Bio-Molecules from Microbial Diversity from Different Ecological Niches

Countrys largest Microbial Culture Collection Centre Set Up at NCCS, Pune

Recognized as International Depositary Authority (IDA) w.e.f. 9th April 2011Has a capacity to hold more than 2,00,000 bacteria and fungiPresently holding 100,000 culture

Oil Zapper

Bacterial consortium (5 strains) - Oilzapper for remediation of oily sludge and crude oil spills developed by TERI, New Delhi and demonstrated at a number of refineries

Technology transferred to Bharat Petroleum Corporation Ltd, Mumbai and Sriram Biotech Ltd.; used in Kuwait and Oman on contract basisEnvironmental Biotechnology

Stem Cell Research - Strategy

Vaccine Grand ChallengeVaccines in Trials or Transferred to IndustryRotaviral DiarrhoeaJapanese EncephalitisRabiesDengueTyphoidMalariaLeprosyAnthraxCholeraInfectious Bovine Rhinotracheitis

India A Vaccine Manufacturing Hub

National Biodesign Alliance: partnering institutions

An effective and consistent way to deliver chest compressions to sudden cardiac arrest victimsA better way to gain intra-osseous access in emergency patients.Non-invasive, rapid and definitive way of airway management.Esophagus EntryTrachea EntryStanford-India Biodesign ProgrammeCreating Entrepreneurs

New InstitutionsNational Institute of Biomedical Genomics, KalyaniRegional Centre for Biotechnology, Faridabad, Haryana National Institute of Animal Biotechnology, Hyderabd Translational Health Sciences and Technology Institute, Faridabad National Agri-Food Biotechnology Institute and Bioprocessing Unit, Mohali, PunjabInstitute of Stem Cell Biology and Regenerated Medicine, BangaloreInstitute of Bioinformatics & Computational BiologyInstitute of Marine & Microbial Biotechnology Biotechnology Regulatory Authority of India (BRAI) Institute of Biodesign, Bioscience & Bioengineering (includes Medical Centre) Institute of Chronic Disease Science & Biotechnology Infectious Science & Biotechnology Institute in North East (linking to THSTI as partner for training & Education)

Automated high-throughput DNA sequencing facilitiesPhytotron FacilityNational Containment - cum - Quarantine Facility for transgenic planting materialNational Plant Gene RepositoryTechnology Platform for Translational Research on Transgenic CropsInternational Depository authority for patent deposits of microorganismsAccess to European Synchtron Research Facility, GrenoblePrimate Research PlatformMicrobial RespositoryNational Certification system for Tissue culture raised PlantsCore Immunological Laboratory for vaccine immune responsesBiomolecular characterisation centreResearch Facilities ,Resources,and Services

Bioinformatics NetworkTotal number of Centres -168Centre of Excellences (CoEs)- 5Distributed Information Centres (DICs)- 11Distributed Information Sub Centres- 50Bioinformatics Infra. Facility - 101Apex BTIC- 1Graphics Facility - 6MSc/M.Tech/Diploma - 5R&D Projects - 97

Developing the Human ResourceThe Department of Biotechnology is implementing an integrated programme of human resource development in biotechnology comprising of postgraduate teaching programmes in biotechnology to create a pool of talented students and upgrading skills of mid career scientists and faculty by specialized training in leading national laboratories and overseas laboratories . Postgraduate M.Sc./ M. Tech teaching programmeDetails of ongoing teaching programmesPG diplomas (Post M.Sc. /M.D./MS/ M.Tech)Biotech industrial training programmeTraining programmesStar college scheme for strengthening of life science and biotechnology education and training at undergraduate level

Career Development Opportunities

Rapid Grant for Young Investigators (RGYI)FAST TRACK Scheme for Young ScientistsNational Bioscience Awards for Career DevelopmentInnovative Young Biotechnologist Award (IYBA)Biotechnology Career Advancement and Re-orientation (Bio-care) Programme / Awards for Women ScientistsWomen Scientists Scheme (WOS-A)Tata Innovation FellowshipInnovation in Science Pursuit for Inspired Research (INSPIRE)

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Re-entry Fellowship / Grant Schemes

Ramanujan FellowshipRamalingaswamy FellowshipEnergy Bioscience Fellowship Wellcome Trust Fellowship

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Indo-SwissStanford BiodesignIndo-UKIndo-USCollaboration with IAVI, GATESFoundation, MVI, PATH,WellcomeTrustInternational partnerships HST,

*Indo-AustraliaIndo-CanadaIndo-DenmarkIndo-EUIndo-FinlandIndo-GermanIndo-Japan Indo-Norway

New Global Partnerships

InnovationDepartment of Biotechnology How it has evolved

30% budget to be spent on PPPBIRAC to Nurture Industry R&D

Drivers of InnovationReal Public R&D expenditureR&D personnel per million personsEducation share of GDPIP protectionCluster specific environment R&D funded by industryR&D performed by universities Global / National Model *

India is in 12th rank in the world in biotechnology and 3rd largest in Asia-Pacific after Japan and Korea. The Sector employees approximately 20,000 scientists and over 352 companies drive it towards further growth.

Science ClustersStrength of SynergyTeaching, discovery, creativity, innovation as a federation Faridabad

Mohali

Bangalore

Institutional RedesignMechanisms to make industry academia interaction happen

Concept and design centersTechnologies licensing and managementIncubation Ignition, pre competitive grants

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About BIRAC

BIRAC Strategies

How does BIRAC accomplish its Mission

To promote innovation, high risk research product development and commercialization

The Vision and Opportunity for Indian Biotechnology : An $100 billion dollar industry by 2025.

Science, Technology and Innovation Policy 2013The guiding vision of aspiring Indian STI enterprise is to accelerate the pace of discovery and delivery of science-led solutions for faster, sustainable and inclusive growth.

A Biotechnology Enterprise of future

*******6th September, 2011