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Transcript of Biotechnology and Medicine
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Biotechnology and Medicine
Esmaeil Sadroddiny, PhDMedical Biotechnology
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Biotechnology:An ancient job, a novel concept
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Biotechnology
Blue biotechnology Marine
Green biotechnology Agricultural
Red Biotechnology Medical
White biotechnology Industrial
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Medical Biotechnology
Public Health
Diagnosis
BioPharmaciutics
Treatment
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Biotechnological tools• Genetic engineering and recombination
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Biotechnological tools
• Cloning• Molecular pharming
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Purification
• Cell culture• Fermentation• Purification
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Biotechnology and public health• Vaccines• Genetically modified plants/animals- Improved nutrition - Improved shelf life and resistance to stress, herbicide,
pathogens- Molecular Pharming• Environmental pollution- Biofuels: 10% of transport energy, UK, by 2020 =4.3 m
tones of fossil oil each year - Biological pest control
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Vaccines
• Recombinant vaccines • DNA vaccines
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Vaccines: Global Market
• $32b, 2013• $56b, 2016
GLOBAL REVENUE OF HUMAN AND ANIMAL VACCINES, 2008-2015Ref: bcc research
$ MILLIONS
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Recombinant vaccines
• Hepatitis B, 1986• HPV vaccine, 2006
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Vaccine in our food
• Potatoes and tobacco: toxin from E.coli• Alfalfa plants: cholera toxin• Tomatoes and lettuce: hepatitis B surface
protein
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DNA vaccines
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Biotechnology and Diagnosis
• In vitro diagnosis, IVD and home testing- Immunodetections- Molecular diagnosis• Biosensors: global market (2012); $8.5b• Forensic medicine
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IVDs: Global market
• $46b 2012• $65b 2017• Share of recombinant market: 30%
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• Ref: Darkdaily.com
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• Ref: BioMarketTrends
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IVD market according to disease
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Biopharmacioticals
• Purified therapeutics• Recombinant drugs• Pharmed products
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Protein purification from plasma
• 289 proteins documented• About 100 are used in diagnostic assays• Fewer than 20 as plasma therapeutics• Three proteins accounting for 70% of the
revenue, Alb, IVIG, VIII
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Global market: Purified therapeutics
Ref: http://www.prometic.com/en/protein-technologies/plasma-derived.php
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Iran
The number of annual donation 1,735,000
Amount of plasma 300,000 L
Plasma used for fractionation 150,000 L
Total Alb Derived (30g/L) 4.5 tones
Recombinant Human Albumin in rice 2.75 g/kg
Total rice required 1636 tones
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Recombinant Drugs• 1982: Insulin• > 170 FDA approved recombinant therapeutic protein: 2012• Iran market: 28• Global market: $90 b, 13.8% share of the global
pharmaceotical market, 2010
Chart Title
Therapeutic proteins 13.8%Other Pharma-ceuticals
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Recombination for multi-functionality
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Biopharmaceoticals
• Biopharmaceuticals produced with animal cell technology (status 2012): 80 trade marks
• Monoclonal Antibodies Approved by the FDA for Therapeutic Use (status 2013): 29 trade marks
• Biopharmaceuticals produced from tissues & organs (status 2010): 26 trade marks
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Ref: Bartłomiej Żerek, Piotr Rózga, Adamed Sp. z o.o.
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Ref: http://biopharma.com/approvals_2011.html
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Animal pharming
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Pharmacogenomics
• Personalized medicine
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Biotechnology and Treatment
• Gene therapy• Stem cell therapy
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Gene therapy
• SCID: 1990• LPLD: Glybera 2012
Disease targets
severe combined immunodeficiencies,
lipoprotein lipase deficiency
cancer
AIDS
cystic fibrosis
muscular dystrophy
cardiovascular diseases
obesity
high blood pressure
alpha1-antitrypsin deficiency
peripheral artery disease)
various ocular diseases
Gaucher disease
rheumatoid arthritis
hemophilia A and B
familial hypercholesterolemia
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• BM transplantation: a successful cell therapy• First clinical trial: GRNOPC1, 2009• FDA approved products ( 2013): 9• Engineered stem cell therapy
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Medical biotechnology: Current state and future
• Vaccine market: 7 out of 78 marketed vaccine• IVD market: 30%• Biopharmacioticals: 13.8% recombinants• Gene therapy: only one case• Cell therapy (FDA product and devices): 9• Major challenges: - Economics of development- Ethics and public concern
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Thank you