BioSignalling Oke
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Transcript of BioSignalling Oke
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MUSYARRAFAH
BAGIAN BIOKIMIAFAKULTAS KEDOKTERAN
UNIVERSITAS ISLAM AL-AZHAR
BIOSIGNALING(Pengsinyalan Biologi)
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SIGNAL IN OUR LIFE
SIGNAL Connecting
Commnic!tion
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Bio"ign!#ing in Ce##Commnic!tion
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Bio"ign!#ing in Ce##Commnic!tion
The cells communicatethrough secretion ofc$emic!# me""enge%" thatcarry ! "ign!# to anothercell.
In human, &i'e%ent ce##t()e" carry out &i'e%ent*nction"+
Signals c$!nge !ction" of
intracellular proteins(metabolic enzymes, generegulatory proteins, ionchannels, or cytoskeletalproteins) in t!%get ce##".
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E,!m)#e o* Sign!# Mo#ec#e
Loc!# Me&i!to%: Epidermalgrowth factor (!"),Platellet-derived growthfactor (PDGF), Nervegrowth factor (NGF),
Histamine, Nitric oxide (N)
Ho%mone": #$renaline,%ortisol, !lucagon,Insulin, Testosteronean$ Thyroi$
Ne%ot%!n"mitte%:#cetylcholine& !#B#
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Ho to "en& t$e "ign!#mo#ec#e to t$e t!%get ce##".
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T$e /%o)e%tie" o* "ign!#mo#ec#e"0 'y$rophobic an$ hy$rophilic
signal molecules
eseptornyabera$a $i
$alam sel
eseptornyabera$a $ipermukaanmembran
sel
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Gene%!# *e!t%e
o* "ign!#mo#ec#e"0Transmit messages
beteen cells
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Sign!# T%!n"&ction
eceptors contain
a bin$ing site speci*c for a singlechemical messengeranother bin$ing site in+ol+e$ in
transmitting message.
Bin$ing site may interact ithanother protein or ith -#:either plasma membrane receptors
or intracellular bin$ing proteins("ig.).
/hen a chemical messengerbin$s to a receptor:Signal is con+erte$ into an
intracellular response.This con+ersion is calle$ "ign!#
t%!n"&ction+
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Secon&me""enge%" are
non proteingenerate$ insi$e cellin response tohormone bin$ing thatcontinuetransmission ofmessage
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Sign!# Te%min!tion
Sign!#
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Sign!#Te%min!tion
Sites of signal termination.Processes that terminate
signals are shon in 1#e.
/ithin each pathay of signal
trans$uction, signal may beturne$ o0 at speci*c steps:.receptor might be $esensitize$ tomessenger by phosphorylation.1.! proteins automatically terminate
messages as they hy$rolyze !TP.2.$egra$ation of secon$ messenger(e.g., phospho$iesterase clea+age ofc#3P).4.remo+ing phosphate groups fromproteins by phosphatases.
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Re*e%ence"
. #lbert, 3olecular %ell an$ Biology 5the$ition
1. ssensial %ell an$ Biology2. 'arper Biochemistry, 16the$ition
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