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大阪大学大学院薬学研究科研究業績集 (2002)

青字論文は（薬学研究科内）分野間共同研究

高分子化学 (Biophysical Chemistry) Novel trimeric adenylate kinase from an extremely thermoacidophilic archaeon, Sulfolobus solfataricus: molecular cloning, nucleotide sequencing, expression in Escherichia coli, and characterization of the recombinant enzyme Toshihide OKAJIMA, Daisuke KITAGUCHI, Kumiko FUJII, Hidetada MATSUOKA, Sachio GOTO, Susumu UCHIYAMA, Yuji KOBAYASHI and Katsuyuki TANIZAWA Biosci. Biotech. Biochem. 66, 2112-2124 (2002) Solution structure of ascidian trypsin inhibitor determined by nuclear magnetic resonance spectroscopy Hikaru HEMMI, Takuya YOSHIDA, Takashi KUMAZAKI, Nobuaki NEMOTO, Jun HASEGAWA, Fujio NISHIOKA, Yoshimasa KYOGOKU, Hideyoshi YOKOSAWA and Yuji KOBAYASHI Biochemistry, 41, 10657-10664 (2002) Crystallization and preliminary X-ray crystallographic studies of a mutant of ribosome recycling factor from Escherichia coli, Arg132Gly Hiroaki NAKANO, Susumu UCHIYAMA, Takuya YOSHIDA, Tadayasu OHKUBO, Hiroaki KATO, Yuriko YAMAGATA and Yuji KOBAYASHI Acta Cryst. Section D, 58, 124-126 (2002) Backbone NMR assignments of ribosome recycling factors (RRFs) from Escherichia coli and Thermotoga maritima Takuya YOSHIDA, Hiroyuki KIJIMA, Shinichiro OKA, Susumu UCHIYAMA, Hiroaki NAKANO, Tadayasu OHKUBO and Yuji KOBAYASHI J. Biomolecular NMR, 22, 195-196 (2002) Interaction among silkworm ribosomal proteins P1, P2 and P0 required for functional protein binding to the GTPase-associated domain of 28S rRNA Tomomi SHIMIZU, Masao NAKAGAKI, Yoshinori NISHI, Yuji KOBAYASHI, Akira HACHIMORI and Toshio UCHIUMI Nucleic Acids Research , 30, 2620-2627 (2002) Thermodynamic characterization of variants of mesophilic cytochrome c and its thermophilic counterpart Susumu UCHIYAMA, Jun HASEGAWA, Yuko TANIMOTO, Hiroshi MORIGUCHI, Masayuki MIZUTANI, Yasuo IGARASHI, Yoshihiro SAMBONGI and Yuji KOBAYASHI Protein Engineering, 15, 455-461 (2002)

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Remodeling of gp41-C34 peptide leads to highly effective inhibitors of the fusion of HIV-1 with target cells Akira OTAKA, Miki NAKAMURA, Daisuke NAMEKI, Eiichi KODAMA, Susumu UCHIYAMA, Syota NAKAMURA, Hiroaki NAKANO, Hirokazu TAMAMURA, Yuji KOBAYASHI, Masao MATSUOKA and Nobutaka FUJII Angew. Chem. Int. Ed., 41, 2937-2940 (2002) Simple and efficient syntheses of Boc- and Fmoc-protected 4(R)-and 4(S)-fluoroproline solely from 4(R)-hydroxyproline Masamitsu DOI, Yoshinori NISHI, Naruto KIRITOSHI, Tomoya IWATA, Mika NAGO, Hiroaki NAKANO, Susumu UCHIYAMA, Takashi NAKAZAWA, Tateaki WAKAMIYA and Yuji KOBAYASHI Tetrahedron, 58, 8453-8459 (2002) Influence of amino acid side chain packing on Fe-methionine coordination in thermostable cytochrome c Yasuhiko YAMAMOTO, Norifumi TERUI, Naoki TACHIIRI, Kazuhisa MINAKAWA, Hitomi MATSUO, Tsunenori KAMEDA, Jun HASEGAWA, Yoshihiro SAMBONGI, Susumu UCHIYAMA, Yuji KOBAYASHI and Yasuo IGARASHI J. Am. Chem. Soc., 124, 11574-11575 (2002) 創薬の標的タンパク質の立体構造決定

内山進, 小林祐次

バイオサイエンスとインダストリー, 60, 239-242 (2002)

機能素子化学 (Medicinal and Organic Chemistry) Pd-catalyzed asymmetric sulfinylzincation of 1-alkynoates using 1-alkynyl sulfoxides bearing a chiral auxiliary Naoyoshi MAEZAKI, Suguru YAGI, Shizuka OHSAWA, Hirofumi OHISHI and Tetsuaki TANAKA Tetrahedron: Asymmetry, 13, 1961-1964 (2002) Highly stereoselective and stereodivergent synthesis of four types of THF cores in

acetogenins using a C4-chiral building block

Naoyoshi MAEZAKI, Naoto KOJIMA, Mikito ASAI, Hiroaki TOMINAGA and Tetsuaki TANAKA Org. Lett., 4, 2977-2980 (2002) 3-Phosphono-2-(N-cyanoimino)thiazolidine derivatives, new phosphorylating agents for alcohols

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Naoyoshi MAEZAKI, Akemi FURUSAWA, Yuki HIROSE, Shuji UCHIDA and Tetsuaki TANAKA Tetrahedron, 58, 3493-3498 (2002) スルフィニル基の特性を利用した新規合成反応の開発と天然物合成への応用

前崎直容，田中徹明 生産と技術，54, 54-57 (2002) The first samarium(II)-mediated stereoselective spirocyclization onto an aromatic ring Hiroaki OHNO, Shin-ichiro MAEDA, Mitsuaki OKUMURA, Ryutaro WAKAYAMA and Tetsuaki TANAKA Chem. Commun., 316-317 (2002) Synthesis of allenes from allylic alcohol derivatives bearing a bromine atom using a palladium(0)/diethylzinc system Hiroaki OHNO, Kumiko MIYAMURA, Tetsuaki TANAKA, Shinya OISHI, Ayako TODA, Yoshiji TAKEMOTO, Nobutaka FUJII and Toshiro IBUKA J. Org. Chem., 67, 1359-1367 (2002) Asymmetric synthesis of β 2,3-amino acids by InI–Pd(0)-promoted metalation and addition of chiral 2-vinylaziridines Miyuki ANZAI, Reiko YANADA, Nobutaka FUJII, Hiroaki OHNO, Toshiro IBUKA and Yoshiji TAKEMOTO Tetrahedron, 58, 5231-5239 (2002) A highly cis-selective synthesis of 2-ethynylaziridines by intramolecular amination of chiral bromoallenes: improvement of stereoselectivity based on the computational investigation Hiroaki OHNO, Kaori ANDO, Hisao HAMAGUCHI, Yusuke TAKEOKA and Tetsuaki TANAKA J. Am. Chem. Soc., 124, 15255-15266 (2002) 生体機能分子化学 (Bio-Functional Molecular Chemistry) Enhancing effect of Zinc on hepatoprotectivity of epigallocatechin gallate in isolated rat hepatocytes Noritaka KAGAYA, Masaya KAWASE, Hatsuo MAEDA, Yoh-ichi TAGAWA, Hitoshi NAGASHIMA, Hidenobu OHMORI and Kiyohito YAGI Biol. Pharm. Bull., 25, 1156-1160 (2002) Suppression of cytotoxin-induced cell death in isolated hepatocytes by tea

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cathechins Noritaka KAGAYA, Yoh-ichi TAGAWA, Hitoshi NAGASHIMA, Ryoyasu SAIJO, Masaya KAWASE and Kiyohito YAGI Eur. J. Pharmacol., 450, 231-236 (2002) Cloning and molecular analysis of the poly(3-hydroxyalkanoate) biosynthesis genes in Pseudomonas aureofaciens Tomohiro NISHIKAWA, Keiko OGAWA, Ryoko KOHDA, Wang ZHIXIONG, Hitoshi MIYASAKA, Fusako UMEDA, Isamu MAEDA, Masaya KAWASE and Kiyohito YAGI Curr. Microbiol., 44, 132-135 (2002) Polyethyleneimine/chitosan hexamer-mediated gene transfection into intestinal epithelial cell cultured in serum-containing medium Yukiteru OUJI, Ayako YOSHIDA-TERAKURA, Yuka HAYASHI, Isamu MAEDA, Masaya KAWASE, Eiji YAMATO, Jun-ichi MIYAZAKI and Kiyohito YAGI J. Biosci. Bioeng., 94, 81-83 (2002) 分子生物学 (Biochemistry and Molecular Biology) Activation of the Sarcophaga lectin gene promoter in transgenic Drosophila Takahiro TANJI, Ayako KOBAYASHI and Shunji NATORI Arch. Insect Biochem. Physiol., 50, 131-138 (2002) H+/K+-ATPase 前田正知 酵素 4.3 ヒドロラーゼ III, 廣川書店, 161-167 (2002) Na+/K+-ATPase 小林綾子, 前田正知 酵素 4.3 ヒドロラーゼ III, 廣川書店, 168-174 (2002) Ca2+-ATPase 前田正知 酵素 4.3 ヒドロラーゼ III, 廣川書店,175-183 (2002) 分子合成化学 (Synthetic Organic Chemistry) Efficient lipase-catalyzed enantioselective desymmetrization of prochiral 2,2-disubstituted 1,3-propanediols and meso 1,2-diols using 1-ethoxyvinyl 2-furoate Shuji AKAI, Tadaatsu NAKA, Tetsuya FUJITA, Yasushi TAKEBE, Toshiaki TSUJINO

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and Yasuyuki KITA J. Org. Chem, 67, 411-419 (2002) Synthetic studies on the sulfur-cross-linked core of antitumor marine alkaloid, discorhabdins: Total synthesis of discorhabdin A Hirofumi TOHMA, Yuu HARAYAMA, Miki HASHIZUME, Minako IWATA, Masahiro EGI and Yasuyuki KITA

Angew. Chem. Int. Ed., 41, 348-350 (2002) A simple and efficient iodination of alcohols on polymer-supported triphenylphosphine Gopinathan ANILKUMAR, Hisanori NAMBU and Yasuyuki KITA Org. Proc. Res. & Dev., 6, 190-191 (2002) Facile and clean oxidation of alcohols in water using hypervalent iodine(III) reagents Hirofumi TOHMA, Tomohiro MAEGAWA, Shinobu TAKIZAWA and Yasuyuki KIT Adv. Synth. Catal., 344, 328-337 (2002) A novel and efficient oxidative biaryl coupling reaction of phenol ether derivatives using a combination of hypervalent iodine(III) reagent and heteropoly acid Hiromi HAMAMOTO, Gopinathan ANILKUMAR, Hirofumi TOHMA and Yasuyuki KITA Chem. Commun., 450-451 (2002) The direct synthesis of thioesters using an intermolecular radical reaction of aldehydes with dipentafluorophenyl disulfide in water Hisanori NAMBU, Kayoko HATA, Masato MATSUGI and Yasuyuki KITA Chem. Commun., 1082-1083 (2002) Concise asymmetric synthesis of a model compound, (4S,5S,6S)-6-(2,2-dimethoxy) ethyl-4,5-epoxy-6-hydroxy-2-cyclohexenone, for the cyclohexenone core of scyphostatin Hiromichi FUJIOKA, Naoyuki KOTOKU, Yoshinari SAWAMA, Yasushi NAGATOMI and Yasuyuki KITA Tetrahedron Lett., 43, 4825-4828 (2002) Lipase-catalyzed domino kinetic resolution/intramolecular diels-alder reaction: One-Pot synthesis of optically active 7-oxabicyclo[2.2.1]heptenes from furfuryl alcohols and β -substituted acrytic acids Shuji AKAI, Tadaatsu NAKA, Sohei OMURA, Kouichi TANIMOTO, Masashi IMANISHI, Yasushi TAKEBE, Masato MATSUGI and Yasuyuki KITA

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Chem. Eur. J., 8, 4255-4264 (2002) The improved synthesis of OPC-29030, a platelet adhesion inhibitor via diastereoselective oxidation of chiral non-racemic sulfide Masato MATSUGI, Rieko SHIMADA, Shinji OHATA, Masatomo NOJIMA, Norio FUKUDA, Jun-ichi MINAMIKAWA and Yasuyuki KITA Chem. Pharm. Bull, 50, 1511-1513 (2002) Regioselective synthesis of 2,3,5-trisubstituted indoles from p-sulfinylaniline by dual use of the sulfinyl group Shuji AKAI, Norihito KAWASHITA, Nobuyoshi MORITA, Yuka NAKAMURA, Kiyosei IIO and Yasuyuki KITA Heterocycles, 58, 75-78 (2002) A novel and useful oxidative intramolecular coupling reaction of phenol ether derivatives on treatment with a cimbination of hypervalent iodine(III) reagent and heteropoly acid Hiromi HAMAMOTO, Gopinathan ANILKUMAR, Hirofumi TOHMA and Yasuyuki KITA Chem. Eur. J., 8, 5377-5383 (2002)

1H NMR determination of absolute configuration of 1- or 2-aryl-substituted

alcohols and amines by means of their diastereomers: Novel separation technique of diastereomeric derivatives of pyridyl alcohols by extraction Masato MATSUGI, Kinuyo ITOH, Masatomo NOJIMA, Yuri HAGIMOTO and Yasuyuki KITA

Chem. Eur. J., 8, 5551-5564 (2002)

Novel and efficient oxidative biaryl coupling reaction of alkylarenes using a hypervalent iodine(III) reagent Hirofumi TOHMA, Minako IWATA, Tomohiro MAEGAWA and Yasuyuki KITA Tetrahedron Lett., 43, 9241-9244 (2002) Hypervalent iodine-induced oxidation reactions: Total synthesis of biologically important natural products (Review) Yasuyuki KITA and Hirofumi TOHMA My Favorite Organic Synthesis 有機合成創造の軌跡-126 のマイルストーン, 有機

合成化学協会編, 76-77 (2002) 新規有機合成の開発を基盤とする抗腫瘍活性天然物ならびに創薬先導化合物の

合成研究 (Review) 北泰行

薬学雑誌 (学会賞受賞記念総説), 122, 1011-1035 (2002)

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分子反応解析学 (Analytical Chemistry) Assessment of acyl groups and reaction conditions in the competition between perhydrolysis and hydrolysis of acyl resorufins for developing an indicator reaction for fluorometric analysis of hydrogen peroxide Hatsuo MAEDA, Shinya MATSU-URA, Mari NISHIDA, Yuji YAMAUCHI and Hidenobu OHMORI Chem. Pharm. Bull., 50, 169-174 (2002) Blood glucose determination with reduction of resazurin as a fluorometric indicator reaction Shinya MATSU-URA, Yuji YAMAUCHI, Hidenobu OHMORI and Hatsuo MAEDA Bunseki Kagaku , 51, 111-115 (2002) 過酸化水素蛍光プローブにまつわる新展開なき進歩

前田初男 ぶんせき, 2002, 643-644 (2002)

薬用資源解析学（三栄源エフ・エフ・アイ）寄附講座

(Medicinal Plant Resource Exploration) New Rev-transport inhibitor with anti-HIV activity from Valerianae Radix Nobutoshi MURAKAMI, Ying YE, Motoyuki KAWANISHI, Shunji AOKI, Nobuaki KUDO, Minoru YOSHIDA, Emi E. NAKAYAMA, Tatsuo SHIODA and Motomasa KOBAYASHI Bioorg. Med. Chem. Lett., 12, 2807-2810 (2002) Facilely accessible multidrug resistance modulator derived from sucrose Nobutoshi MURAKAMI, Satoru TAMURA, Etsuko IWATA, Shunji AOKI, Shin-ichi AKIYAMA and Motomasa KOBAYASHI Bioorg. Med. Chem. Lett., 12, 3267-3270 (2002) 天然物をシードとする制がんリード化合物の合成化学的創製研究 (Review) 村上啓寿 Natural Medicines, 56, 73-77 (2002)

細胞生物学 (Cell Biology)

Crystal structure of bacterial multidrug efflux transporter AcrB Satoshi MURAKAMI, Ryosuke NAKASHIMA, Eiki YAMASHITA and Akihito YAMAGUCHI

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Nature, 419, 587-593 (2002) The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC Satoshi NAGAKUBO, Kunihiko NISHINO, Takahiro HIRATA and Akihito YAMAGUCHI J. Bacteriol., 184, 4161-4167 (2002) EvgA of the two-component signal transduction system modulates production of the yhiUV multidrug transporter in Escherichia coli Kunihiko NISHINO and Akihito YAMAGUCHI J. Bacteriol., 184, 2319-2323 (2002) Membrane topology of a multidrug efflux transporter, AcrB, in Escherichia coli Erika FUJIHIRA, Norihisa TAMURA and Akihito YAMAGUCHI J. Biochem. (Tokyo), 131, 145-151 (2002)

多剤排出トランスポーターAcrB の結晶構造解析

村上聡, 山口明人

細胞工学, 21, 1520-1521 (2002)

細菌ゲノムに潜む薬剤耐性因子 (Review)

西野邦彦, 山口明人

日本細菌学雑誌, 57, 453-464 (2002)

生物有機化学 (Bioorganic Chemistry) Synthesis and conformation of a novel bridged nucleoside with S-type sugar puckering, trans-3',4'-BNA monomer Satoshi OBIKA, Mitsuaki SEKIGUCHI, Tomohisa OSAKI, Nao SHIBATA, Miyuki MASAKI, Yoshiyuki HARI and Takeshi IMANISHI Tetrahedron Lett., 43, 4365-4368 (2002) Effective synthesis of C-nucleosides with 2',4'-BNA modification Yoshiyuki HARI, Satoshi OBIKA, Minako SAKAKI, Ken-ichiro MORIO, Yuriko YAMAGATA and Takeshi IMANISHI Tetrahedron, 58, 3051-3063 (2002) Synthesis and conformation of 3', 4' - BNA monomers, 3'-O, 4'-C- Methyleneribonucleosides Satoshi OBIKA, Ken-ichiro MORIO, Daishu NANBU, Yoshiyuki HARI, Hiromi ITOH

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and Takeshi IMANISHI Tetrahedron, 58, 3039-3049 (2002) Stable oligonucleotide-directed triplex formation at target sites with CG

interruptions: strong sequence-specific recognition by 2',4'-bridged nucleic- acid-containing 2-pyridones under physiological conditions Satoshi OBIKA, Yoshiyuki HARI, Mitsuaki SEKIGUCHI and Takeshi IMANISHI Chem. Eur. J., 8, 4796-4802 (2002) 2’O-,4’C-Ethylene-bridged nucleic acids (ENA): highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug Koji MORITA, Chikako HASEGAWA, Masakatsu KANEKO, Shinya TSUTSUMI, Junko SONE, Tomio ISHIKAWA, Takeshi IMANISHI and Makoto KOIZUMI Bioorg. Med. Chem. Lett., 12, 73-76 (2002) A 3,4-Epoxypiperidine structure as a novel and simple DNA-cleavage unit Kazuyuki MIYASHITA, Myunji PARK, Sayako ADACHI, Sayori SEKI, Satoshi OBIKA and Takeshi IMANISHI Bioorg. Med. Chem. Lett., 12, 1075-1077 (2002) Total synthesis of fostriecin (CI-920) via a convergent route Kazuyuki MIYASHITA, Masahiro IKEJIRI Hitomi KAWASAKI, Satoko MAEMURA and Takeshi IMANISHI Chem. Commun., 742-743 (2002)

β -Replacement reaction of serine-O-carbonate derivatives with thiols catalyzed by a pyridoxal model having an ionophore side-chain Kazuyuki MIYASHITA, Hidenobu MURAFUJI, Hiroshi IWAKI, Eito YOSHIOKA and Takeshi IMANISHI Chem. Commun., 1922-1923 (2002) A pivotal role for CC chemokine receptor 5 in T-cell migration to tumor sites induced by interleukin 12 treatment in tumor-bearing mice Yasuhiro UEKUSA, Wen-Gong YU, Takao MUKAI, Ping GAO, Nobuya YAMAGUCHI, Masako MURAI, Kouji MATSUSHIMA, Satoshi OBIKA, Takeshi IMANISHI, Yuji HIGASHIBATA , Shintaro NOMURA, Yukihiko KITAMURA, Hiromi FUJIWARA and Toshiyuki HAMAOKA Cancer Res., 62, 3751-3758 (2002) A non-peptide CCR5 antagonist inhibits collagen-induced arthritis by modulating T cell migration without affecting anti-collagen T cell responses Yi-Fu YANG, Takao MUKAI, Ping GAO, Nobuya YAMAGUCHI, Shiro ONO, Hiroshi IWAKI, Satoshi OBIKA, Takeshi IMANISHI, Takahiro TSUJIMURA, Toshiyuki

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HAMAOKA and Hiromi FUJIWARA Eur. J. Immunol., 32, 2124-2132 (2002) Effects of RNA interference in gene expression (RNAi) in cultured mammalian cells of mismatches and the introduction of chemical modifications at the 3’-ends of siRNAs Makiko HAMADA, Toshiaki OHTSUKA, Reimi KAWAIDA, Makoto KOIZUMI, Koji MORITA, Hidehiko FURUKAWA, Takeshi IMANISHI, Makoto MIYAGISHI and Kazunari TAIRA Antisense Nucleic Acid Drug Dev., 12, 301-309 (2002) Synthesis and properties of oligonucleotides containing novel 2',4'-BNA analogues (2',4'-BNACOC) Yoshiyuki HARI, Tomohisa OSAKI, Ken EGUCHI, Satoshi OBIKA and Takeshi IMANISHI Nucleic Acids Res. Suppl., 147-148 (2002) Synthesis and properties of 5'-amino-2',4'-BNA modified oligonucleotides with P3'→N5' phosphoramidate linkages Satoshi OBIKA, Osamu NAKAGAWA, Akiko HIROTO, Yoshiyuki HARI and Takeshi IMANISHI Nucleic Acids Res. Suppl., 25-26 (2002) Triplex formation involving 2',4'-BNA with isoquinolone base analogue: efficient and selective recognition of C:G interruption Hidetaka TORIGOE, Yoshiyuki HARI, Satoshi OBIKA and Takeshi IMANISHI Nucleic Acids Res. Suppl., 183-184 (2002) Binding of threading intercalator to nucleic acids: thermodynamic analyses Hidetaka TORIGOE, Shinobu SATO, Ken-ichi YAMASHITA, Satoshi OBIKA, Takeshi IMANISHI and Shigeori TAKENAKA Nucleic Acids Res. Suppl., 55-56 (2002) Down-regulation of VEGF mRNA expression by 2’-O,4’-C-ethylene-bridged nucleic acid (ENA) antisense oligonucleotides and investigation of non-target gene expression Koji MORITA, Koji YAMATE, Shin-ichi KURAKATA, Koji ABE, Takeshi IMANISHI and Makoto KOIZUMI Nucleic Acids Res. Suppl., 99-100 (2002) BNAs: novel nucleic acid analogs with a bridged sugar moiety (Review) Takeshi IMANISHI and Satoshi OBIKA Chem. Commun., 1653-1659 (2002).

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アンチセンス BNA オリゴヌクレオチドを用いた遺伝子発現抑制 (Review) 今西武, 小比賀聡 日本薬理学雑誌, 120, 85-90 (2002) 高機能性人工核酸の開発に向けて (Review) 今西武, 張功幸

脳 21, 5, 309-314 (2002)

細胞生理学 (Immunology) Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine Hiromasa HAMADA, Takachika HIROI, Yasuhiro NISHIYAMA, Hidemi TAKAHASHI, Yohei MASUNAGA, Satoshi HACHIMURA, Shuichi KAMINOGAWA, Hiromi TAKAHASHI-IWANAGA, Toshihiko IWANAGA, Hiroshi KIYONO, Hiroshi YAMAMOTO and Hiromichi ISHIKAWA J. Immunol., 168, 57-64 (2002) Muscle regeneration by reconstitution with bone marrow or fetal liver cells from green fluorescent protein-gene transgenic mice So-ichiro FUKADA, Yuko MIYAGOE-SUZUKI, Hiroshi TSUKIHARA, Katsutoshi YUASA, Saito HIGUCHI, Shiro ONO, Kazutake TSUJIKAWA, Shin’ichi TAKEDA and Hiroshi YAMAMOTO J. Cell Science, 115, 1285-1293 (2002) Homeostatic regulation of intestinal villous epithelia by B lymphocytes Yasuhiro NISHIYAMA, Hiromasa HAMADA, Satoshi NONAKA, Hiroshi YAMAMOTO, Masanobu NANNO, Yasuo KATAYAMA, Hidemi TAKAHASHI and Hiromichi ISHIKAWA J. Immunol., 168, 2626-2633 (2002) Interleukin 6 induces overexpression of the sarcolemmal utrophin in neonatal mdx skeletal muscle Keita FUJIMORI, Yuka ITOH, Kanji YAMAMOTO, Yuko MIYAGOE-SUZUKI, Katsutoshi YUASA, Kazuyuki YOSHIZAKI, Hiroshi YAMAMOTO and Shin’ichi TAKEDA Human Gene Therapy, 13, 509-518 (2002) Molecular cloning and characterization of mouse calcitonin gene-related peptide receptor Kosuke MIYAUCHI, Noriko TADOTSU, Tamon HAYASHI, Yuuichi ONO, Koji TOKOYODA, Kazutake TSUJIKAWA and Hiroshi YAMAMOTO

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Neuropeptides, 36, 22-33 (2002) Adeno-associated virus vector-mediated gene transfer into dystrophin-deficient skeletal muscles evokes enhanced immune response against the transgene product Katsutoshi YUASA, Miki SAKAMOTO, Yuko MIYAGOE-SUZUKI, Aki TANOUCHI, Hiroshi YAMAMOTO, Juan LI, Jeffrey S. CHAMBERLAIN, Xiao XIAO, Shin’ichi TAKEDA Gene Therapy, 9, 1576-1588 (2002) Regulation of Lck and Fyn tyrosine kinase activities by transmembrane protein tyrosine phosphatase leukocyte common antigen-related molecule Kazutake TSUJIKAWA, Tomoko ICHIJO, Kazuki MORIYAMA, Noriko TADOTSU, Kazuhiro SAKAMOTO, Naoki SAKANE, So-ichiro FUKADA, Tatsuhiko FURUKAWA, Haruo SAITO and Hiroshi YAMAMOTO Mol. Cancer Res., 1, 155-163 (2002) 毒性学 (Toxicology) Metallothionein modulates lipopolysaccharide-stimulated tumor necrosis factor expression in mouse peritoneal macrophages Masako KANEKIYO, Norio ITOH, Atsuko KAWASAKI, Akiko MATSUYAMA, Kimihiro MATSUDA, Tsuyoshi NAKANISHI and Keiichi TANAKA Biochem. J., 361, 363-369 (2002) Detection of increased icb-1 transcript levels in maturing HL-60 cells: a novel marker for granulocytic and monocytic in vitro differentiation Oliver TREECK, Tomoyuki ODANI, Norio ITOH, Harue IMAI, Sayaka FUJITA, Jyunya KOHROKI, Tsuyoshi NAKANISHI, Klaus DIEDRICH, Olaf ORTMANN, Keiichi TANAKA and Guenter VOLLMER Leukemia Res., 26, 765-769 (2002) Metallothionein is required for zinc-induced expression of the macrophage colony stimulating factor gene Masako KANEKIYO, Norio ITOH, Atsuko KAWASAKI, Kimihiro MATSUDA, Tsuyoshi NAKANISHI and Keiichi TANAKA J. Cell. Biochem., 86, 145-153 (2002) MRE-binding transcription factor-1 is activated during endotoxemia: a central role for metallothionein Tomoki KIMURA, Norio ITOH, Miyako TAKEHARA, Ikuyo OGURO, Jun-ichi ISHIZAKI, Tsuyoshi NAKANISHI and Keiichi TANAKA Toxicol. Lett., 129, 77-84 (2002)

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Trialkyltin compounds enhance human CG secretion and aromatase activity in human placental choriocarcinoma cells Tsuyoshi NAKANISHI, Junya KOHROKI, Shizuko SUZUKI, Jun-ichi ISHIZAKI, Youhei HIROMORI, Shinri TAKASUGA, Norio ITOH, Yoshiteru WATANABE, Naoki UTOGUCHI and Keiichi TANAKA J. Clin. Endocrinol. & Metab., 87, 2830-2837 (2002) 神経薬理学 (Molecular Neuropharmacology) Higher brain functions of PACAP and a homologous Drosophila memory gene amnesiac: insights from knockouts and mutants Hitoshi HASHIMOTO, Norihito SHINTANI and Akemichi BABA Biochem. Biophys. Res. Commun., 297, 427-432 (2002) PAC1 receptor-mediated relaxation of longitudinal muscle of the mouse proximal colon Kazunori MUKAI, Yuji SATOH, Akikazu FUJITA, Tadayoshi TAKEUCHI, Norihito SHINTANI, Hitoshi HASHIMOTO, Akemichi BABA and Fumiaki HATA Jpn. J. Pharmacol., 90, 97-100 (2002) Defects in reproductive functions in PACAP-deficient female mice Norihito SHINTANI, Wakaba MORI, Hitoshi HASHIMOTO, Masayuki IMAI, Kazuhiro TANAKA, Shuhei TOMIMOTO, Megumi HIROSE, Chihiro KAWAGUCHI and Akemichi BABA Regul. Pept., 109, 45-48 (2002) Involvement of intracellular Ca2+ elevation but not cyclic AMP in PACAP-induced p38 MAP kinase activation in PC12 cells Yoshiyuki SAKAI, Hitoshi HASHIMOTO, Norihito SHINTANI, Ayako ICHIBORI, Shuhei TOMIMOTO, Kazuhiro TANAKA, Megumi HIROSE and Akemichi BABA Regul. Pept., 109, 149-153 (2002) Knockout mice for pharmacological screening: testing the specificity of Na+-Ca2+ exchange inhibitors Hannes REUTER, Scott A. HENDERSON, Tieyan HAN, Toshio MATSUDA, Akemichi BABA, Robert S. ROSS, Joshua I. GOLDHABER and Kenneth D. PHILIPSON. Circ. Res., 91, 90-92 (2002)

神経系における下垂体アデニル酸シクラーゼ活性化ポリペプチド（PACAP）の生

理的意義（Review）

橋本均

薬学雑誌, 122, 1109-1121 (2002)

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遺伝子改変マウスを用いた神経ペプチド PACAP の中枢神経機能の研究（Review）

橋本均

生産と技術, 54, 50-53 (2002)

新しいペプチドシグナル系と創薬標的分子 -感覚ニューロン特異的オーファン

GPCR(G 蛋白共役型受容体)SNSR-（Review）

橋本均

脳 21, 5, 425-429 (2002) 薬剤学 (Biopharmaceutics) Lack of antigen-specific immune responses in anti-IL-7 receptor α chain antibody-treated Peyer's patch-null mice following intestinal immunization with microencapsulated antigen Jun KUNISAWA, Ichiro TAKAHASHI, Akiko OKUDAIRA, Takachika HIROI, Kazufumi KATAYAMA, Teruko ARIYAMA, Yasuo TSUTSUMI, Shinsaku NAKAGAWA, Hiroshi KIYONO and Tadanori MAYUMI Eur. J. Immunol., 32, 2347-2355 (2002) Nitration of PPARγ inhibits ligand-dependent translocation into the nucleus in a macrophage-like cell line, RAW 264 Atsuhito SHIBUYA, Koichiro WADA, Atsushi NAKAJIMA, Makio SAEKI, Kazufumi KATAYAMA, Tadanori MAYUMI, Takashi KADOWAKI, Hitoshi NIWA and Yoshinori KAMISAKI FEBS Letters, 525, 43-47 (2002) Therapy of rat tracheal carcinoma IC-12 in SCID mice: vascular targeting with [213Bi]-MAb TES-23 S. J. KENNEL, T. LANKFORD, S. DAVERN, L. FOOTE, Kenji TANIGUCHI, Iwao OHIZUMI, Yasuo TSUTSUMI, Shinsaku NAKAGAWA, Tadanori MAYUMI and S. MIRZADEH Eur. J. Cancer, 38, 1278-1287 (2002) PPARγ ligands inhibit nitrotyrosine formation and inflammatory mediator expressions in adjuvant-induced rheumatoid arthritis mice Tomoko SHIOJIRI, Koichiro WADA, Atsushi NAKAJIMA, Kazufumi KATAYAMA, Atsuhito SHIBUYA, Chiho KUDO, Takashi KADOWAKI, Tadanori MAYUMI, Yoshiaki YURA and Yoshinori KAMISAKI Eur. J. Pharmacol., 448, 231-238 (2002) Development of a novel cytomedical treatment that can protect entrapped cells from host hummoral immunity

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Ryo SUZUKI, Yauo YOSHIOKA, Etsuko KITANO, Tatsunobu YOSHIOKA, Hiroaki OKA, Takayuki OKAMOTO, Naoki OKADA, Yasuo TSUTSUMI, Shinsaku NAKAGAWA, Jun-ichi MIYAZAKI, Hajime KITAMURA and Tadanori MAYUMI Cell Transplantation, 11, 787-798 (2002) Tumor necrosis factor α-gene therapy for an established murine melanoma using RGD (Arg-Gly-Asp) fiber-mutant adenovirus vectors Yuka OKADA, Naoki OKADA, Shinsaku NAKAGAWA, Hiroyuki MIZUGUCHI, Koichi TAKAHASHI, Nobuyasu MIZUNO, Takuya FUJITA , Akira YAMAMOTO, Takao HAYAKAWA and Tadanori MAYUMI Jpn. J. Cancer Res., 93, 436-444 (2002) Strength evaluation of transcriptional regulatory elements for transgene expression by adenovirus vector Zhi-Li XU, Hiroyuki MIZUGUCHI, Akiko ISHII-WATABE, Eriko UCHIDA, Tadanori MAYUMI and Takao HAYAKAWA J. Control. Release, 81, 155-163 (2002) Cyotomedical therapy for insulinopenic diabetes using microencapsulated pancreatic â cell lines Ryo SUZUKI, Naoki OKADA, Hajime MIYAMOTO, Tatsunobu YOSHIOKA, Kayoko SAKAMOTO, Hiroaki OKA, Yasuo TSUTSUMI, Shinsaku NAKAGAWA, Jun-ichi MIYAZAKI and Tadanori MAYUMI Life Sci ., 71, 1717-1729 (2002) Fiber-mutant technique can augment gene transduction efficacy and anti-tumor effects against established murine melanoma by cytokine-gene therapy using adenovirus vectors Yuka OKADA, Naoki OKADA, Shinsaku NAKAGAWA, Hiroyuki MIZUGUCHI, Makiko KANEHIRA, Naoko NISHINO, Koichi TAKAHASHI, Nobuyasu MIZUNO, Takao HAYAKAWA and Tadanori MAYUMI Cancer Letters, 177, 57-63 (2002) Preparation and biological activities of a bivalent poly(ethylene glycol) hybrid containing an active site and its synergistic site of Fibronection Yuichi SUZUKI, Keiko HOJO, Ikuko OKAZAKI, Haruhiko KAMATA, Masahiko SASAKI, Mitsuko MAEDA, Motoyoshi NOMIZU, Yoko YAMAMOTO, Shinsaku NAKAGAWA, Tadanori MAYUMI and Koichi KAWASAKI Chem. Pharm. Bull., 50, 1229-1232 (2002) Molecular design of bioconjugated cell adhesion peptide with a water-soluble polymeric modifier for enhancement of antimetastatic effect (Review) Yoko YAMAMOTO, Yasuo TSUTSUMI and Tadanori MAYUMI

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Current Drug Targets, 3, 123-130 (2002) 粘膜ワクチンのドラッグ・デリバリーシステム (Review) 真弓忠範 MEDICAL CORNER, 110, 21-23 (2002) 抗原の性状と抗体産生におけるパイエル板の役割 (Review) 國澤純，高橋一郎，清野宏，真弓忠範

臨床免疫, 37, 387-391 (2002) ファージディスプレイシステムを利用した部位特異的 PEGylation., Drug Delivery System (Review) 山本陽子, 堤康央, 中川晋作, 真弓忠範

Drug Delivery System, 17, 427-434 (2002) ナノサイエンス・ナノテクノロジーによる次世代薬物療法を目指して (Review) 堤康央

生命とくすり, 18, 11 (2002) 天然物化学 (Natural Product Chemistry) New readily accessible peroxides with high anti-malarial potency Nobutoshi MURAKAMI, Motoyuki KAWANISHI, Sawako ITAGAKI, Toshihiro HORII and Motomasa KOBAYASHI Bioorg. Med. Chem. Lett., 12, 69-72 (2002) Lembehsterols A and B, novel sulfated sterols inhibiting thymidine phosphorylase, from the marine sponge Petrosia strongylata Shunji AOKI, Yoshiharu NAKA, Takuya ITOH, Tatsuhiko FURUKAWA, Rachmaniar RACHMAT, Shin-ichi AKIYAMA and Motomasa KOBAYASHI Chem. Pharm. Bull., 50, 827-830 (2002) New Rev-transport inhibitor with anti-HIV activity from Valerianae Radix Nobutoshi MURAKAMI, Ying YE, Motoyuki KAWANISHI, Shunji AOKI, Nobuaki KUDO, Minoru YOSHIDA, Emi E. NAKAYAMA, Tatsuo SHIODA and Motomasa KOBAYASHI Bioorg. Med. Chem. Lett., 12, 2807-2810 (2002) Facilely accessible multidrug resistance modulator derived from sucrose Nobutoshi MURAKAMI, Satoru TAMURA, Etsuko IWATA, Shunji AOKI, Shin-ichi AKIYAMA and Motomasa KOBAYASHI Bioorg. Med. Chem. Lett., 12, 3267-3270 (2002)

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A positively charged amino acid proximal to the C-terminus of TM17 of MRP1 is indispensable for GSH-dependent binding of substrates and for transport of LTC4 Xiao-Qin REN, Tatsuhiko FURUKAWA, Shunji AOKI, Tomoyuki SUMIZAWA, Misako HARAGUCHI, Yuichi NAKAJIMA, Ryuji IKEDA, Motomasa KOBAYASHI and Shin-ichi AKIYAMA Biochemistry, 41, 14132-14140 (2002) Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle Hiroshi OZAKI, Masatoshi HORI, Yoon-Sun KIM, Seong-Chun KWON, Duck-Sun AHN, Hiroshi NAKAZAWA, Motomasa KOBAYASHI and Hideaki KARAKI Br. J. Pharmacol., 137, 1207-1212 (2002) Structure-activity relationship of neuritogenic spongean acetylene alcohols, lembehynes Shunji AOKI, Kouhei MATSUI, Hong WEI, Nobutoshi MURAKAMI and Motomasa KOBAYASHI Tetrahedron, 58, 5417-5422 (2002) 複合薬物動態学 (Medicinal Pharmacology) The nitric oxide donor NOC12 protects cultured astrocytes against apoptosis via a cGMP-dependent mechanism Kazuhiro TAKUMA, Patamawan PHUAGPHONG, Eibai LEE, Riyo ENOMOTO, Koichi MORI, Akemichi BABA and Toshio MATSUDA Jpn. J. Pharmacol., 89, 64-71 (2002) Modulation by 5-HT2A receptors of aggressive behavior in isolated mice Masaki SAKAUE, Yukio AGO, Chikako SOWA, Yayoi SAKAMOTO, Beni NISHIHARA, Yutaka KOYAMA, Akemichi BABA and Toshio MATSUDA Jpn. J. Pharmacol., 89, 89-92 (2002) Heat shock inhibits hydrogen peroxide-induced apoptosis in cultured astrocytes Kazuhiro TAKUMA, Koichi MORI, Eibai LEE, Riyo ENOMOTO, Akemichi BABA and Toshio MATSUDA Brain Res., 946, 232-238 (2002) Selective reduction by isolation rearing of 5-HT1A receptor-mediated dopamine release in vivo in the frontal cortex of mice Yukio AGO, Masaki SAKAUE, Akemichi BABA and Toshio MATSUDA J. Neurochem., 83, 353-359 (2002)

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脳傷害時のアストログリアの機能変化とその細胞内機構

小山豊 日薬理誌, 119, 135-143 (2002) NSAID によるアミロイド β ペプチド 42 産生の抑制 小山豊 日薬理誌, 119, 262 (2002) 臨床薬効解析学 (Clinical Evaluation of Medicines and Therapeutics) Microsomal enzyme induction and clinical aggravation of porphyria:The evaluation of human urinary 6â-hydroxycortisol/cortisol ratio as the index of hepatic CYP3A4 Activity Etsuko UEJIMA, Kyoko TAKAHASHI, Tomoko MORISAKI, Koichi TAKAHASHI, Masako OHNO, Yuko NISHIDA, Masayuki MORIYA, Misako KAIDO, Kazuo ABE, Saburo SAKODA, Takehiko YANAGIHARA, Nobuo KUROKAWA and Junichi AZUMA J. Clin. Pharmacol., 42, 1374-1379 (2002) Taurine modulates induction of cytochrome P450 3A4 mRNA by rifampicin in the HepG2 cell line Hideyasu MATSUDA, Kayoko KINOSHITA, Akihiko SUMIDA, Koichi TAKAHASHI, Shuichi FUKUEN, Tsuyoshi FUKUDA, Kyoko TAKAHASHI, Isamu YAMAMOTO and Junichi AZUMA Biochem. Biophys. Acta., 1593, 93-98 (2002) Novel detection assay by PCR-RFLP and frequency of the CYP3A5 SNPs, CYP3A5*3 and *6, in a Japanese population Shuichi FUKUEN, Tsuyoshi FUKUDA, Hiromi MAUNE, Yuka IKENAGA, Isamu YAMAMOTO, Tadanobu INABA and Junichi AZUMA Pharmacogenetics., 12, 331-334 (2002) Identification of the novel splicing variants for the hPXR in human livers Shuichi FUKUEN, Tsuyoshi FUKUDA, Hideyasu MATSUDA, Akihiko SUMIDA, Isamu YAMAMOTO, Tadanobu INABA and Junichi AZUMA Biochem. Biophys. Res. Commun., 298, 433-438 (2002) Sodium tanshinone IIA sulfonate derived from Danshen (Salvia milriorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells Kyoko TAKAHASHI, Xinshou OUYANG, Katsuko KOMATSU, Norio NAKAMURA, Masao HATTORI, Akemichi BABA and Junichi AZUMA

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Biochem. Pharmacol., 64, 745-750 (2002) 薬効の個体差をどう評価していくか

大野雅子, 東純一

月刊薬事, 44, 33-38 (2002) ヒト尿中 6â-hydroxycortisol/cortisol 比測定とポルフィリン症治療のフォローア

ップ

上島悦子, 高橋京子, 廣谷芳彦, 高橋幸一, 大野雅子, 佐竹渉, 阿部和夫,

佐古田三郎, 荒川行生, 黒川信夫, 東純一

臨床薬理, 33, 97S-98S (2002)

中国伝統医薬の薬物相互作用について：丹参製剤に含有される CYP 代謝阻害物

質の探索

高橋京子, 花谷忠昭, 渡邊麻里子, 高谷朋夏, 小松かつ子, 高橋幸一, 東純一

臨床薬理, 33, 409S-410S (2002)

医薬情報解析学 (Pharmaceutical Information Science) The comparison of generalized additive model with artificial hierarchical neural network in the analysis of pharmaceutical data Tatsuya TAKAGI, Emiko KUROKAWA, Kouji MIYATA, Kousuke OKAMOTO, Yuko TANAKA, Ken KUROKAWA and Teruo YASUNAGA Journal of Computer Aided Chemistry, 3, 56-62 (2002) FISH analysis of 142 EGFP transgene integration sites into the mouse genome Tomoko NAKANISHI, Asato KUROIWA, Shuichi YAMADA, Ayako ISOTANI, Atsuko YAMASHITA, Ai TAIRAKA, Tamon HAYASHI, Tatsuya TAKAGI, Masahito IKAWA, Yoichi MATSUDA and Masaru OKABE Genomics, 80, 564-574 (2002) コンピュータ集約型統計解析法の化学、薬学への応用

高木達也

化学工業, 53, 54-58 (2002) 分子生理病態学 (Molecular Pathophysiology)

Evaluation of mexiletine clearance in a Japanese population Kazuyuki UENO, Akira TAMAMURA, Kana MATSUMOTO, Kazuo KOMAMURA, Shiro KAMAKURA, Kunio MIYATAKE and Masahiko SHIBAKAWA The Annals of Pharmacotherapy, 36, 241-245 (2002)

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HPLC法による血清中カルベジロール濃度簡易測定法とその臨床応用

加藤隆児, 上野和行, 土下喜正, 吉村尋典, 高田充隆, 駒村和雄, 鎌倉史郎,

宮武邦夫, 柴川雅彦

医療薬学, 28, 9-15 (2002)

ワルファリンとリファンピシン併用患者のカルテ調査による相互作用の検討

和田恭一, 小島悦子, 高田充隆, 柴川雅彦

医療薬学, 28, 85-90 (2002) ワルファリンとフルボキサミン併用患者のカルテ調査による相互作用の検討

和田恭一, 保田智恵子, 花房小百合, 高田充隆, 柴川雅彦

医療薬学, 28, 468-472 (2002) 日本人におけるアロプリノール適正投与量の検討

岡田博, 老田章, 上野和行, 高田充隆, 柴川雅彦

医療薬学, 28, 564-570 (2002) 薬剤師からみた一般名処方と後発医薬品 (Review) 高田充隆, 柴川雅彦

医療, 56, 465-468 (2002) Determination of probability distribution of diplotype configuration (diplotype distribution) for each subject from genotypic data using the EM algorithm Yutaka KITAMURA, M. MORIGUCHI, H. KANEKO, Hiroko MORISAKI, Takayuki MORISAKI, Keiko TOYAMA and Naoyuki KAMATANI Ann. Hum. Genet., 66, 183-193 (2002) Bone marrow stromal cells contract synchronously with cardiomyocytes in a coculture system Shinji TOMITA, Takeshi NAKATANI, Shinya FUKUHARA, Takayuki MORISAKI, Chikao YUTANI and Soichiro KITAMURA Jpn. J. Thorac. Cardiovasc. Surg., 50, 321-324 (2002) Comparison of cell labeling procedures for bone marrow cell transplantation to treat heart failure: long-term quantitative analysis Shinya FUKUHARA, Shinji TOMITA, Takeshi NAKATANI, Akio KISHIDA, Takayuki MORISAKI, Chikao YUTANI and Soichiro KITAMURA Transplant Proc., 34, 2718-2721 (2002)

Marfan 症候群の遺伝子異常

森崎隆幸 Annual Review 循環器, 中外医学社, 86-91 (2002)

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ゲノム研究における液体クロマトグラフィー分析法の応用：一塩基多型の検出

と 遺 伝 子 型 解 析 法 と し て の Denaturing High Performance Liquid Chromatography (DHPLC)法 森崎隆幸, 岩尾睦美, 遠山桂子, 高嶋 敦, 栗木智子, 森崎裕子 島津評論, 58, 131-136 (2002) SNPs 検出のための新しい方法 (5) Denaturing HPLC法 森崎裕子, 森崎隆幸 Clinical Neuroscience, 20, 254-255 (2002) AMP deaminase 欠損症

森崎隆幸 高尿酸血症と痛風, 10, 39-45 (2002) DHPLC 法を用いた遺伝子多型・変異解析 森崎裕子, 森崎隆幸 Bio ベンチャー, 2, 94-99 (2002) Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products (AGE) Tadashi JONO, Akira MIYAZAKI, Ryoji NAGAI, Tatsuya SAWAMURA, Toshinori KITAMURA and Seikoh HORIUCHI FEBS Lett., 511, 170-174 (2002) レクチン様酸化LDL受容体LOX-1の同定とその病態生理学的意義の解析

沢村達也 日本薬理学雑誌, 119, 145-154 (2002) 血管内皮細胞に発現する酸化LDL受容体LOX-1

沢村達也

生化学, 74, 365-376 (2002) Statins modulate oxidized low-density lipoprotein-mediated adhesion molecule expression in human coronary artery endothelial cells: role of LOX-1 Dayuan LI, Hongjiang CHEN, Francesco ROMEO, Tatsuya SAWAMURA, Tom SALDEEN and Jawahar L. MEHTA J. Pharmacol. Exp. Ther., 302, 601-605 (2002) A myosin light chain kinase inhibitor, ML-9, lowers the intraocular pressure in rabbit eyes Megumi HONJO, Masaru INATANI, Noriaki KIDO, Tatsuya SAWAMURA, Beatrice Y. J. T. YUE, Yoshihito HONDA and Hidenobu TANIHARA Exp. Eye Res., 75, 135-142 (2002)

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LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis Mingyi CHEN, Tomoh MASAKI and Tatsuya SAWAMURA Pharmacol. Ther., 95, 89-100 (2002) Augmented endothelial uptake of oxidized low-density lipoprotein in response to endothelin-1 Henning MORAWIETZ, Nicole DUERRSCHMIDT, Bernd NIEMANN, Jan GALLE, Tatsuya SAWAMURA and Juergen HOLTZ Clin. Sci., 103 (Suppl. 48), 9S-12S (2002) Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation Yves DELNESTE, Giovanni MAGISTRELLI, Jean-François GAUCHAT, Jean-François HAEUW, Jean-Pierre AUBRY, Kayo NAKAMURA, Naoko KAWAKAMI-HONDA, Liliane GOETSCH, Tatsuya SAWAMURA, Jean-Yves BONNEFOY and Pascale JEANNIN Immunity, 17, 353-362 (2002) Lectin-like oxidized low-density lipoprotein receptor 1 mediates leukocyte infiltration and articular cartilage destruction in rat zymosan-induced arthritis Takefumi NAKAGAWA, Masao AKAGI, Hajime HOSHIKAWA, Mingyi CHEN, Tadashi YASUDA, Shogo MUKAI, Kunitaka OHSAWA, Tomoh MASAKI, Takashi NAKAMURA and Tatsuya SAWAMURA Arthritis Rheum., 46, 2486-2494 (2002) LOX-1 inhibition in myocardial ischemia-reperfusion injury: modulation of MMP-1 and inflammation Dayuan LI, Victor WILLIAMS, Ling LIU, Hongjiang CHEN, Tatsuya SAWAMURA, Tamim ANTAKLI and Jawahar L. MEHTA Am. J. Physiol. Heart. Circ. Physiol., 283, H1795-H1801 (2002) Oxidized low density lipoprotein potentiation of fas-induced apoptosis through lectin-like oxidized-low density lipoprotein receptor-1 in human umbilical vascular endothelial cells Toshio IMANISHI, Takuzo HANO, Tatsuya SAWAMURA, Shigeho TAKARADA and Ichiro NISHIO Circ. J., 66, 1060-1064 (2002) LOX-1 expressed in cultured rat chondrocytes mediates oxidized LDL-induced cell death-possible role of dephosphorylation of Akt Takefumi NAKAGAWA, Tadashi YASUDA, Hajime HOSHIKAWA, Makoto SHIMIZU, Takumi KAKINUMA, Mingyi CHEN, Tomoh MASAKI, Takashi NAKAMURA and Tatsuya SAWAMURA

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Biochem. Biophys. Res. Commun., 299, 91-97 (2002) Statin inhibits leukocyte-endothelial interaction and prevents neuronal death induced by ischemia-reperfusion injury in the rat retina Megumi HONJO, Hidenobu TANIHARA, Kazuaki NISHIJIMA, Junichi KIRYU, Yoshihito HONDA, Beatrice Y. J. T. YUE and Tatsuya SAWAMURA Arch. Ophthalmol., 120, 1707-1713 (2002) 発生制御学 (Developmental Regulation) Cloning and characterization of a human orthologue of testis-specific succinyl CoA: 3-oxo acid CoA transferase (Scot-t) cDNA Hiromitsu TANAKA, Junya KOHROKI, Naoko IGUCHI, Masayoshi ONISHI and Yoshitake NISHIMUNE Mol. Hum. Reprod., 8, 16-23 (2002) Restoration of spermatogenesis and fertility in azoospermic mutant mice by suppression and reelevation of testosterone followed by intracytoplasmic sperm injection Akira TOHDA, Tsuyoshi OKUNO, Kiyomi MATSUMIYA, Masaru OKABE, Hidefumi KISHIKAWA, Kayoko DOHMAE, Akihiko OKUYAMA and Yoshitake NISHIMUNE Biol. Reprod., 66, 85-90 (2002) Induction of instability of p34(cdc2) expression by treatment with cisplatin(CDDP) in mouse teratocarcinoma F9 cells Toshihide DOI, Takashi MORITA, Nobunao WAKABAYASHI, Tetsuro SUMI, Souichi A. IWAI, Shigeki AMEKAWA, Masayoshi SAKUDA and Yoshitake NISHIMUNE Cancer Lett., 176, 75-80 (2002)

Molecular cloning and characterization of a complementary DNA encoding sperm tail protein SHIPPO 1 Egydio de Carvalho CARLOS, Hiromitsu TANAKA, Naoko IGUCHI, Sami VENTELA, Hiroshi NOJIMA and Yoshitake NISHIMUNE Biol. Reprod., 66, 785-795 (2002) Use of stepwise subtraction to comprehensively isolate mouse genes whose transcription is up-regulated during spermiogenesis Takayuki FUJII, Kazutoshi TAMURA, Kumiko MASAI, Hiromitsu TANAKA, Yoshitake NISHIMUNE and Hiroshi NOJIMA EMBO Rep., 3, 367-372 (2002) Homeostatic regulation of germinal stem cell proliferation by the GDNF/FSH

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pathway Yuko TADOKORO, Kentaro YOMOGIDA, Hiroshi OHTA, Akira TOHDA and Yoshitake NISHIMUNE Mech. Dev., 113, 29-39 (2002)

Development of the stages of the cycle in mouse seminiferous epithelium after transplantation of green fluorescent protein-labeled spermatogonial stem cells Sami VENTELA, Hiroshi OHTA, Martti PARVINEN and Yoshitake NISHIMUNE Biol. Reprod., 66, 1422-1429 (2002) Cloning and characterization of the human tektin-t gene Naoko IGUCHI, Hiromitsu TANAKA, Yoshihiro NAKAMURA, Masami NOZAKI, Tsutomu FUJIWARA and Yoshitake NISHIMUNE Mol. Hum. Reprod., 8, 525-530 (2002) Spermatogonia-dependent expression of testicular genes in mice Kiyoko TANAKA, Hiroshi TAMURA, Hiromitsu TANAKA, Masaki KATOH, Yoshiki FUTAMATA, Naohiko SEKI, Yoshitake NISHIMUNE and Takahiko HARA Dev. Biol., 246, 466-479 (2002) Molecular cloning and characterization of the human orthologue of male germ cell-specific actin capping protein α3 (cpα3) Yasushi MIYAGAWA, Hiromitsu TANAKA, Naoko IGUCHI, Kouichi KITAMURA, Yoshihiro NAKAMURA, Tohru TAKAHASHI, Kiyomi MATSUMIYA, Akihiko OKUYAMA and Yoshitake NISHIMUNE Mol. Hum. Reprod., 8, 531-539 (2002) Molecular cloning and characterization of oppo 1: a haploid germ cell-specific complementary DNA encoding sperm tail protein Yoshihiro NAKAMURA, Hiromitsu TANAKA, Minoru KOGA, Yasushi MIYAGAWA, Naoko IGUCHI, Egydio de Carvalho CARLOS, Kentaro YOMOGIDA, Masami NOZAKI, Hiroshi NOJIMA, Kiyomi MATSUMIYA, Akihiko OKUYAMA and Yoshitake NISHIMUNE Biol. Reprod., 67, 1-7 (2002)

Nectin couples cell-cell adhesion and the actin scaffold at heterotypic testicular junctions Kumi OZAKI-KURODA, Hiroyuki NAKANISHI, Hiroshi OHTA, Hiromitsu TANAKA, Hidetake KURIHARA, Steffen MUELLER, Kenji IRIE, Wataru IKEDA, Tatsuo SAKAI, Eckard WIMMER, Yoshitake NISHIMUNE and Yoshimi TAKAI Curr. Biol., 12, 1145-1150 (2002) Electroporated transgene-rescued spermatogenesis in infertile mutant mice with a

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sertoli cell defect Kentaro YOMOGIDA, Yo YAGURA and Yoshitake NISHIMUNE Biol. Reprod., 67, 712-717 (2002)

Structure and promoter activity of the gene encoding ornithine decarboxylase antizyme expressed exclusively in haploid germ cells in testis (OAZt/Oaz3) Akiko IKE, Shuichi YAMADA, Hiromitsu TANAKA, Yoshitake NISHIMUNE and Masami NOZAKI Gene, 298, 183-193 (2002) Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary Keiji SATO, Kentaro YOMOGIDA, Takayuki WADA, Tetuya YORIHUZI, Yoshitake NISHIMUNE, Nobuko HOSOKAWA and Kazuhiro NAGATA J. Biol. Chem., 277, 37678-37684 (2002) 臨床薬物学 (Clinical Pharmaceuticals) Microsomal enzyme induction and clinical aggravation of porphyria: The evaluation of human urinary 6â-hydroxycortisol/cortisol ratio as the index of hepatic CYP3A4 activity Etsuko UEJIMA, Kyoko TAKAHASHI, Tomoko MORISAKI, Koichi TAKAHASHI, Masako OHNO, Yuko NISHIDA, Masayuki MORIYA, Misako KAIDO, Kazuo ABE, Saburo SAKODA, Takehiko YANAGIHARA, Nobuo KUROKAWA and Junichi AZUMA J. Clin. Pharmacol., 42, 1374-1379 (2002) Prevention and regression of atopic dermatitis by ointment containing NF-kB decoy oligodeoxynucleotides in NC/Nga atopic mouse model Hiroshige NAKAMURA, Motokuni AOKI, Katsuto TAMAI, Masako OISHI, Toshio OGIHARA, Yasushi KANEDA and Ryuichi MORISHITA Gene Therapy, 9, 1221-1229 (2002) Immunochemical characterization and measurement of neuronal type nitric oxide synthase in human neuroblastoma NB-OK-1 cell using novel anti-synthetic peptide antibody and specific immunoassay system Yukio ARAKAWA, Etsuko TAKAO, Yoshihiko HIROTANI, Ikuo KATO, Jun LI, Noboru YANAIHARA, Chizuko YANAIHARA, Toshihiko IWANAGA and Nobuo KUROKAWA Regulatory Peptides, 106, 115-123 (2002) 「医薬品機構の医薬品情報提供システム」を利用した Web 環境による添付文書

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閲覧システムの構築

藤本勝博, 桑田成規, 松村泰志, 揚振君, 上田幹子, 郡孝子, 小西清信, 黒川信夫, 武田裕

医療情報学, 22, 333-340 (2002) ヒト尿中 6â-hydroxycortisol/cortisol 比測定とポルフィリン症治療のフォローア

ップ 上島悦子, 高橋京子, 廣谷芳彦, 高橋幸一, 大野雅子, 佐竹渉, 阿部和夫, 佐古田三郎, 荒川行生, 黒川信夫, 東純一

臨床薬理, 33, 97S-98S (2002) 注射薬自動払出装置装填医薬品の安定性と品質評価

廣谷芳彦, 山本薫, 池田賢二, 西川直樹, 但馬重俊, 荒川行生, 小西清信, 片岡和三郎, 黒川信夫

日本病院薬剤師会雑誌, 38, 421-423 (2002) 細胞構造学 (Cellular Physiology)

Characterization of the interaction between DNA gyrase inhibitor and DNA gyrase of Escherichia coli Akira NAKANISHI, Shinobu IMAJOH-OHMI and Fumio HANAOKA J. Biol. Chem., 277, 8949-8954 (2002)

Translesion synthesis by human DNA polymerase η across thymine glycol lesions Rika KUSUMOTO, Chikahide MASUTANI, Shigenori IWAI and Fumio HANAOKA Biochemistry, 41, 6090-6099 (2002)

The carboxy-terminal domain of the XPC protein plays a crucial role in nucleotide excision repair through interactions with transcription factor IIH Akio UCHIDA, Kaoru SUGASAWA, Chikahide MASUTANI, Naoshi DOHMAE, Marito ARAKI, Masayuki YOKOI, Yoshiaki OHKUMA and Fumio HANAOKA DNA Repair, 1, 449-461 (2002)

Two budding yeast RAD4 homologs in fission yeast play different roles in the repair of UV-induced DNA damage Yasunori FUKUMOTO, Hideki HIYAMA, Masayuki YOKOI, Yukinobu NAKASEKO, Mitsuhiro YANAGIDA and Fumio HANAOKA DNA Repair, 1, 833-845 (2002) Detection of reduced RNA synthesis in UV-irradiated Cockayne syndrome group B cells using an isolated nuclear system Ayumi YAMADA, Chikahide MASUTANI and Fumio HANAOKA

27

Biochim. Biophys. Acta, 1592, 129-134 (2002)

Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity Ken-ichiro YANAGI, Takeshi MIZUNO, Zhiying YOU and Fumio HANAOKA

J. Biol. Chem., 277, 40871-40880 (2002) 遺伝子機能解析学 (Experimental Genome Research) Sperm from the calmegin-deficient mouse have normal abilities for binding and fusion to the egg plasma membrane Kazuo YAMAGATA, Tomoko NAKANISHI, Masahito IKAWA, Ryou YAMAGUCHI, Stuart MOSS and Masaru OKABE Dev. Biol., 250, 348-57 (2002) Mouse sperm lacking cell surface hyaluronidase PH-20 can pass through the layer of cumulus cells and fertilize the egg Daichi BABA, Shin-ichi KASHIWABARA, Arata HONDA, Kazuo YAMAGATA, Qing WU, Masahito IKAWA, Masaru OKABE and Tadashi BABA J. Biol. Chem., 277, 30310-30314 (2002) Rapid compensation for glycosylphosphatidylinositol anchor deficient keratinocytes after birth: visualization of glycosylphosphatidylinositol-anchored proteins in situ Xing-Hua GAO, Gen KONDOH, Masahito TARUTANI, Mariko HARA, Shintaro INOUE, Tomoko NAKANISHI, Masaru OKABE, Yuji YAMAGUCHI, Kunihiko YOSHIKAWA, Satoshi ITAMI and Junji TAKEDA J. Invest. Dermatol., 118, 998-1002 (2002) Small interfering RNA and gene silencing in transgenic mice and rats Hidetoshi HASUWA, Kazuhiro KASEDA, Thorbijorg EINARSDOTTIR and Masaru OKABE FEBS Lett., 532, 227-230 (2002) Transgenic pigs expressing human decay-accelerating factor regulated by porcine MCP gene promoter Hiroshi MURAKAMI, Hiroshi NAKASHIMA, Yoichi TAKAHAGI, Shuji MIYAGAWA, Tatsuya FUJIMURA, Koji TOYOMURA, Rie NAKAI, Mako YAMADA, Takashi KURIHARA, Tamotsu SHIGEHISA, Masaru OKABE, Tsukasa SEYA, Ryota SHIRAKURA and Taroh KINOSHITA Mol. Reprod. Dev., 61, 302-311 (2002)

28

Inefficient response of T lymphocytes to glycosylphosphatidylinositol anchor-negative cells: implications for paroxysmal nocturnal hemoglobinuria Yoshiko MURAKAMI, Hiroshi KOSAKA, Yusuke MAEDA, Jun-ichi NISHIMURA, Norimitsu INOUE, Kazuhito OHISHI, Masaru OKABE, Junji TAKEDA and Taroh KINOSHITA Blood, 100, 4116-4122 (2002) FISH analysis of 142 EGFP transgene integration sites into the mouse genome Tomoko NAKANISHI, Asato KUROIWA, Shuichi YAMADA, Ayako ISOTANI, Atsuko YAMASHITA, Ai TAIRAKA, Tamon HAYASHI, Tatsuya TAKAGI, Masahito IKAWA, Yoichi MATSUDA and Masaru OKABE Genomics, 80, 564-574 (2002) Mechanism of host cell protection from complement in murine cytomegalovirus (CMV) infection: identification of a CMV-responsive element in the CD46 promoter region Midori NOMURA, Mitsue KURITA-TANIGUCHI, Kazuiro KONDO, Naokazu INOUE, Misako MATSUMOTO, Koichi YAMANISHI, Masaru OKABE and Tsukasa SEYA Eur. J. Immunol., 32, 2954-2964 (2002) Cardiac-specific activation of signal transducer and activator of transcription 3 promotes vascular formation in the heart Tomoaki OSUGI, Yuichi OSHIMA, Yasushi FUJIO, Masanobu FUNAMOTO, Atsuko YAMASHITA, Shinji NEGORO, Keita KUNISADA, Masahiro IZUMI, Yoshikazu NAKAOKA, Hisao HIROTA, Masaru OKABE, Keiko YAMAUCHI-TAKIHARA, Ichiro KAWASE and Tadamitsu KISHIMOTO J. Biol. Chem., 277, 6676-6681 (2002) Nonrandom X chromosome inactivation in mouse embryos carrying Searle's T(X;16)16H translocation visualized using X-linked lacZ and GFP transgenes N. TAKAGI, M. SUGIMOTO, S. YAMAGUCHI, M. ITO, S. S. TAN and Masaru OKABE Cytogenet. Genome. Res., 99, 52-58 (2002) 受精機構の分子生物学

山縣一夫, 岡部勝 Hormone Frontier in Gynecology, 9, 119-126 (2002) 光るマウスの応用

伊川正人，中西友子，岡部勝 分子細胞治療, 1, 523-531 (2002)

29

遺伝情報解析学 (Environmental Science and Microbiology) Monitoring of Ralstonia eutropha KT1 in groundwater in an experimental bioaugmentation field by in situ PCR Katsuji TANI, Masahiro MUNETA, Kanji NAKAMURA, Katsutoshi SIBUYA and Masao NASU Appl. Environ. Microbiol., 68, 412-416 (2002) 16S ribosomal DNA-based analysis of bacterial diversity in purified water used in pharmaceutical manufacturing processes by PCR and denaturing gradient gel Electrophoresis Mako KAWAI, Eiichi MATSUMURA, Hisashi KANDA, Nobuyasu YAMAGUCHI,

Katsuji TANI and Masao NASU Appl. Environ. Microbiol., 68, 699-704 (2002) 粘着集菌シートを用いた簡便な衛生微生物学的環境評価

数瀬能孝，有末一隆，山口進康，那須正夫 防菌防黴, 30, 285-289 (2002) 安全評価のために微生物モニタリング手法

谷佳津治，那須正夫 生物工学会誌，80, 536-538 (2002) 遺伝子情報を指標とする微生物モニタリング法の応用 (Review) 山口進康 生物工学会誌, 80, 487 (2002) 第３章ー分析法 第１節ー遺伝子分析法：環境中の微生物モニタリング

山口進康，那須正夫 微生物利用の大展開，今中忠行監修，エヌ・テイ・エス，1022-1027 (2002) 蛋白情報解析学 (Protein Molecular Engineering) HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors Toshinobu NAKAMURA, Jun-ichi HINAGATA, Toshiki TANAKA, Takeshi IMANISHI, Youichiro WADA, Tatsuhiko KODAMA and Takefumi DOI Biochem. Biophys. Res. Commun., 290, 858-864 (2002)

Hepatitis C virus core protein binds to a C-terminal region of NS5B RNA polymerase Masao UCHIDA, Nobumasa HINO, Takayuki YAMANAKA, Hitomi FUKUSHIMA, Takeshi IMANISHI, Yasutoshi UCHIYAMA, Tatsuhiko KODAMA and Takefumi DOI Hepatology Res., 22, 297-306 (2002)

30

Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein Takayuki YAMANAKA, Masao UCHIDA and Takefumi DOI Biochem. Biophys. Res. Commun., 294, 521-527 (2002) Subcellular localization of HCV core protein regulates its ability for p53 activation and p21 suppression Takayuki YAMANAKA, Tatsuhiko KODAMA and Takefumi DOI Biochem. Biophys. Res. Commun., 294, 528-534 (2002) Measurement of HCV RdRp activity with C-terminal 21 aa truncated NS5b protein: optimization of assay conditions Yasutoshi UCHIYAMA, Ying HUANG, Hiroshi KANAMORI, Masao UCHIDA, Takefumi DOI, Akihisa TAKAMIZAWA, Takao HAMAKUBO and Tatsuhiko KODAMA Hepatology Res., 23, 90-97 (2002) Identification of a chromosome-targeting domain in the human condensin subunit CNAP1/hCAP-D2/Eg7 Alexander R. BALL, Jr., John A. SCHMIESING, Changcheng ZHOU, Heather C. GREGSON, Yoshiaki OKADA, Takefumi DOI and Kyoko YOKOMORI Mol. Cell. Biol., 22, 5769-5781 (2002) The Generation of monoclonal antibodies against human peroxisome proliferator-activated receptors (PPARs) Toshiya TANAKA, Tetsu TAKENO, Yuichiro WATANABE, Yasutoshi UCHIYAMA, Takeshi MURAKAMI, Hisahiko YAMASHITA, Akifumi SUZUKI, Rie AOI, Hiroko IWANARI, Shu-Ying JIANG, Makoto NAITO, Keisuke TACHIBANA, Takefumi DOI, Andrew I. SHULMAN, David J. MANGELSDORF, Raphael REITER, Johan AUWERX, Takao HAMAKUBO and Tatsuhiko KODAMA J. Atheros. Throm., 9, 233-242 (2002) 微生物動態学 (Environmental Biochemistry) Isolation of up- or down-regulated genes in PPARγ -expressing NIH-3T3 cells during differentiation into adipocytes Masaaki OKUNO, Emi ARIMOTO, Makoto NISHIZUKA, Tsutomu NISHIHARA and Masayoshi IMAGAWA FEBS Letters, 519, 108-112 (2002) Induction of Bach1 and ARA70 gene expression at an early stage of adipocyte differentiation of mouse 3T3-L1 cells

31

Makoto NISHIZUKA, Tomoko TSUCHIYA, Tsutomu NISHIHARA and Masayoshi IMAGAWA Biochem. J., 361, 629-633 (2002) An arming yeast with the ability to entrap fluorescent 17b -estradiol on the cell surface M. YASUI, S. SHIBASAKI, K. KURODA, M. UEDA, N. KAWADA, J. NISHIKAWA, T. NISHIHARA and A. TANAKA Appl. Microbiol. Biotechnol., 59, 329-331 (2002) Functional analysis of Zinc finger proteins that bind to the silencer element in the glutathione transferase P gene Atsuhiro TANABE, Mitsumasa KURITA, Kazumi OSHIMA, Shigehiro OSADA, Tsutomu NISHIHARA and Masayoshi IMAGAWA Biol. Pharm. Bull., 25, 970-974 (2002) Biodegradation of dodecyltrimethylammonium bromide by Pseudomonas fluorescens F7 and F2 isolated from activated sludge Naohiro NISHIYAMA and Tsutomu NISHIHARA Microbes and Environments, 17, 164-169 (2002) 環境動態から見た化学物質のリスク評価 (Review) 西原力 ケミカルエンジニヤリング，47, 94-98 (2002) 化学物質の毒性を予測する (Review) 西原力, 松尾昌-

PETROTECH, 25, 851-854 (2002) 総論２．物質の安全（2.1.2 健康への影響，2.1.3 環境への影響），細菌，滅菌

西原力

安全の百科事典，田村昌三 (編集代表), 丸善， 東京, 28-41，41-50，473， 766-767 (2002) 微生物制御学 (Environmental Bioengineering) Effect of algal extract on H2 production by a photosynthetic bacterium Rhodobium marinum A-501: analysis of stimulating effect using a kinetic model Hideo KAWAGUCHI, Hiroyasu NAGASE, Kyoko HASHIMOTO, Shiho KIMATA, Mikio DOI, Kazumasa HIRATA and Kazuhisa MIYAMOTO J. Biosci. Bioeng., 94, 62-69 (2002)

32

Cellular toxicity of cadmium ions and their detoxification by heavy metal-specific plant peptides, phytochelatins, expressed in mammalian cells Masahiro TAKAGI, Hiroyuki SATOFUKA, Satoshi AMANO, Haruo MIZUNO, Yutaka EGUCHI, Kazumasa HIRATA, Kazuhisa MIYAMOTO, Kiichi FUKUI and Tadayuki IMANAKA J. Biochem., 131, 233-239 (2002) Cryopreservation of hairy root cultures of Vinca minor (L.) by encapsulation-dehydration Kazumasa HIRATA, Misuzu MUKAI, Saeko GODA, Masumi ISHIO-KINUGASA, Kenji YOSHIDA, Akira SAKAI and Kazuhisa MIYAMOTO Biotech. Lett., 24, 371-376 (2002) Enhancement of tolerance to heavy metals and oxidative stress in Dunaliella tertiolecta by Zn-induced phytochelatin synthesis Naoki TSUJI, Nayumi HIRAYANAGI, Megumi OKADA, Hitoshi MIYASAKA, Kazumasa HIRATA, Meinhart H. ZENK and Kazuhisa MIYAMOTO Biochem. Biophys. Res. Commun., 293, 653-659 (2002) 微細藻類を利用した物質循環型二酸化炭素固定および再資源化技術 (Review) 平田收正, 宮本和久 生物工学会誌, 80, 236-239 (2002) 排ガス中の窒素酸化物の除去 (Review) 宮本和久, 永瀬裕康, 平田收正 微生物利用の大展開, 今中忠行監修, エヌ・テイ・エス, 876-880 (2002) 生物的水素生産 (Review) 淺田泰男, 三宅淳, 宮本和久

微生物利用の大展開, 今中忠行監修, エヌ・テイ・エス, 1106-1113 (2002) 地球環境とバイオテクノロジー -微細藻類による環境浄化とエネルギー生産�

(Review) 宮本和久 先端バイオサイエンス �環境を中心に�, 196-216 (2002) 微生物で石油を作る (Review) 朴明玉, 宮本和久 グリーンバイオテクノロジー 持続的社会のための生物工学, 83-91 (2002)

33

環境病因病態学 (Clinical and Experimental Phathophysiology)

Coronary artery bypass grafting for a patient with Tangier disease H. TAKAMI, T. KOBAYASHI, T. NAKAGAWA, Makoto SAKURAI, Nobuhisa AWATA and S. YAMASHITA Jpn. J. Thorac. Cardiovasc. Surg., 50, 383-386 (2002)

Role of plaque proliferation in late lumen loss after directional coronary atherectomy Satoru SUMITSUJI, Osamu KATOH, Etsuo TSUCHIKANE, Satoru OTSUJI, Hitone TATEYAMA, Nobuhisa AWATA and T. KOBAYASHI Cir. J., 66, 362-366 (2002) Debulking and stenting versus debulking only of coronary artery disease in patients treated with cilostazol (final results of ESPRIT) Etsuo TSUCHIKANE, T. KOBAYASHI, T. KOBAYASHI, Y. TAKEDA, Satoru OTSUJI, Makoto SAKURAI and Nobuhisa AWATA Am. J. Cardiol., 90, 573-578 (2002) Frequent expression of smooth muscle markers in malignant fibrous histiocytoma of bone Takafumi UEDA, Nobuhito ARAKI, Masayuki MANO, Akira MYOUI, Shin JOYAMA, Shingo ISHIGURO, Hisako YAMAMURA, Katsuhito TAKAHASHI, Ikuo KUDAWARA and Hideki YOSHIKAWA J. Clin. Pathol., 55, 853-858 (2002) Expression of smooth muscle calponin in tumor vessels of human hepatocellular carcinoma and its possible association with prognosis Yo SASAKI, Hisako YAMAMURA, Yuriko KAWAKAMI, Terumasa YAMADA, Masahiro HIRATSUKA, Masao KAMEYAMA, Hiroaki OHIGASHI, Osamu ISHIKAWA, Shingi IMAOKA, Shingo ISHIGURO and Katsuhito TAKAHASHI Cancer, 94, 1777-1786 (2002) Smooth-muscle calponin in mesangial cells: regulation of expression and a role in suppressing glomerulonephritis Youichi SUGENOYA, Ashio YOSHIMURA, Hisako YAMAMURA, Kiyoko INUI, Hiroyuki MORITA, Hideaki YAMABE, Noboru UEKI, Terukuni IDEURA and Katsuhito TAKAHASHI J. Am. Soc. Nephrol., 13, 322-331 (2002) Altered mechanical properties in smooth muscle of mice with a mutated calponin locus Ayako FUJISHIGE, Katsuhito TAKAHASHI and Teizo TSUCHIYA

34

Zoolog. Sci., 19, 167-174 (2002)

Heterozygous mutation of the CYP gene in a 46, XY Japanese male patient with 17á-hydroxylase/17, 20-lyase deficiency Yoshio NISHIZAWA, Yasuko NISHIZAWA, Yoshiaki MATSUHISA, G. Hiroe GOTO, Fumi YOSHIOKA, Shuichi NOSAKA, Yasunori AMENOMORI, Yoshikuni AMAKATA and Shinji FUSHIKI Asian J. Clin. Gent., 1, 91-96 (2002)

Inhibition of murine osteosarcoma cell proliferation by glucocorticoid Takashi YAMAMOTO, Miyuki NISHIGUCHI, Naokazu INOUE, Hiroe G. GOTO, Ikuo KUDAWARA, Takafumi UEDA, Hideki YOSHIKAWA, Yumiko TANIGAKi and Yasuko NISHIZAWA Anticancer Res., 22, 4151-4156 (2002)

柴朴湯吸入療法によるアスピリン喘息患者発作治療・予防効果：Health related quality of life 改善効果

西澤芳男, 伏木信次, 吉岡二三, 野坂修一, 雨森保憲, 天方義邦, 後藤グレイ

シィ広恵, 竹村光一, 谷垣由美子, 西澤恭子

アレルギーの臨床, 22, 736-739 (2002)

非ステロイド系抗炎症薬と前記原因以外による致死的気管支喘息発作症例の臨

床比較的検討

西澤芳男, 西澤恭子, 天方義邦, 野坂修一, 吉岡二三, 伏木信次

蘇生, 21, 25-34 (2002)

ベクロメタゾン吸入量半減時の柴朴湯吸入療法とクロモグリセート吸入療法の

代替療法比較試験

西澤芳男, 西澤恭子, 永野富美代, 吉岡二三, 後藤グレイシィ広恵, 竹村光一,

谷垣由美子, 伏木信次

耳鼻咽喉科展望, 45, 8-15 (2002)

原発性シェーグレン症候群乾燥症状改善効果に関する長期、無作為比較試験、

漢方薬、麦門冬湯と Bromhexine hydrochloride の効果比較試験

西澤芳男, 西澤恭子, 吉岡二三, 野坂修一, 雨森保憲, 天方義邦, 後藤グレイ

シィ広恵, 伏木信次

J. Jap. Salivary Gland Society, 46, 62-66 (2002)

難治性・慢性内科疾患の慢性疼痛

西澤芳男, 西澤恭子, 後藤グレイシィ広恵, 谷垣由美子, 野坂修一, 吉岡二三,

永野冨美代, 天方義邦, 伏木信次

慢性疼痛, 21, 67-77 (2002)

35

柴朴湯の抗不安効果に基づく抗気管支喘息治療効果：抗不安薬との他施設無作

為前向き比較検討試験

西澤芳男, 西澤恭子, 吉岡二三, 野坂秀一, 雨森保憲, 天方義郎, 永野富美代,

山田まゆみ, 安田理絵, 後藤グレイシィ広恵, 伏木信次

日本東洋心身医学研究, 17, 20-27 (2002) 病原微生物学 (Bacterial Infections) Dominant-negative Rho, Rac, and Cdc42 facilitate the invasion process of Vibrio parahemolyticus into Caco-2 Cells Yukihiro AKEDA, Toshio KODAMA, Takashige KASHIMOTO, Vlademir CANTARELLI, Yasuhiko HORIGUCHI, Kenichi NAGAYAMA, Tetsuya IIDA and Takeshi HONDA Infect. Immun., 70, 970-973 (2002) Cortactin is necessary for F-actin accumulation in pedestal structures induced by enteropathogenic Escherichia coli infection Vlademir V. CANTARELLI, Akira TAKAHASHI, Itaru YANAGIHARA, Yukihiro AKEDA, Kinichi IMURA, Toshio KODAMA, Gengo KONO, Yoshihisa SATO, Tetsuya IIDA and Takeshi HONDA Infect. Immun., 70, 2206-2209 (2002) Comparison of genome structures of vibrios, bacteria possessing two chromosomes Kenichi TAGOMORI, Tetsuya IIDA and Takeshi HONDA J. Bacteriology, 184, 4351-4358 (2002) The EspB protein of enterohaemorrhagic Escherichia coli interacts directly with á-catenin Toshio KODAMA, Yukihiro AKEDA, Gengo KONO, Akira TAKAHASHI, Kinichi IMURA, Tetsuya IIDA and Takeshi HONDA Cellular Microbiology, 4, 213-222 (2002) Filamentous bacteriophages of vibrios are integrated into the dif-like site of the host chromosome Tetsuya IIDA, Kozo MAKINO, Hatsumi NASU, Katsushi YOKOYAMA, Kenichi TAGOMORI, Akiko HATTORI, Toshihiro OKUNO, Hideo SHINAGAWA and Takeshi HONDA J. Bacteriology , 184, 4933-4935 (2002) Surveillance of enterohaemorrhagic Escherichia coli O157 :H7 in southern Thailand Voravuthikunchai P. SUPAYANG., Keisaku OKADA, Tetsuya IIDA and Takeshi

36

HONDA J. Health Popul. Nutr., 20,189-191 (2002) Enterotxin of Vibrio cholerae Yoshio IIJIMA and Takeshi HONDA Recent Advances in Marine Biotechnology , 7, 41-52 (2002) Characterization of Escherichia coli O157 isolated in eastern China Zhenqiang BI, Myonsun YOH, Junko MATSUYAMA, Shuyu CUI, Weizhi GUO and Takeshi HONDA Microbiol. Cult. Col, 18, 69-75 (2002) Loss of the VT2 gene during preservation of enterohemorrhagic Escherichia coli at room temperature Myonsun YOH, Zhenqiang BI, Akihito KAMEI, Yoshiharu YAMAICHI, Junko MATSUYAMA, Tetsuya IIDA and Takeshi HONDA Microbiol. Cult. Coll., 18 , 77-82 (2002) 動物薬とヒトの健康

服部景子, 本田武司

からだの科学, 222, 82-86 (2002)

食中毒、特に新しいプロビデンシアアルカリファシエンス食中毒について

本田武司

食の科学, 293, 30-39 (2002)

腸管出血性大腸菌感染症 序:近年の食中毒

本田武司

日本臨床, 60, 1065-1069 (2002)

新型プロビデンシア・アルカフィファシエンス（PA）菌の病原性

本田武司

日本臨床, 60, 1228-1232 (2002)

新しい食中毒原因菌としてのプロビデンシア・アルカリファシエンス

本田武司

Infection Control, 11, 684-686 (2002)

変貌する腸管感染症 ―新興感染症を中心に―

中野政之, 本田武司

綜合臨床, 51, 2919-2922 (2002)

37

感染型の食中毒菌

服部景子, 本田武司

食と健康, 46, 8-16 (2002)

細菌毒素とは

余明順, 本田武司

小児感染免疫, 14, 257-262 (2002)

特集 最近のワクチン：序論

本田武司

最新医学, 57, 1887-1888 (2002)

特集 最近のワクチン：感染症の変貌とワクチン開発

谷口暢, 本田武司

最新医学, 57, 1889-1893 (2002)

消化器感染症 ―コレラ・腸チフス・赤痢

河野原吾, 本田武司

綜合臨床, 51, 2809-2813 (2002)

腸管感染症に果たす毒素の役割

中野政之, 本田武司

モダンフィジシャン, 22, 847-851 (2002)

新しい食中毒:プロビデンシア アルカリファシエンスによる食中毒

本田武司

感染症, 32, 148-151 (2002)

以上 259 件（論文：230 件, 総説：24 件, 単行書：5 件）