BioPathwise 2.0 A System for Pathway-Centric Collaborative Research.

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BioPathwise 2.0 BioPathwise 2.0 A System for Pathway-Centric Collaborative Research
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Transcript of BioPathwise 2.0 A System for Pathway-Centric Collaborative Research.

Page 1: BioPathwise 2.0 A System for Pathway-Centric Collaborative Research.

BioPathwise 2.0BioPathwise 2.0A System for Pathway-Centric

Collaborative Research

Page 2: BioPathwise 2.0 A System for Pathway-Centric Collaborative Research.

2001-2006 The BioAnalytics Group LLC. All Rights Reserved

OutlineOutline

The BioAnalytics Group

The Problem and Potential of Collaboration

BioPathwise 2.0

Page 3: BioPathwise 2.0 A System for Pathway-Centric Collaborative Research.

2001-2006 The BioAnalytics Group LLC. All Rights Reserved

The BioAnalytics GroupThe BioAnalytics Group

Offers software-based products and services to biomedical researchers.

Services include custom software development, modeling research, data analysis, and training.

Products include image analysis, optimization and pathway analysis software.

A participant in the Program for Immune Modeling & Experimentation (PRIME), funded by the NIAID.

Page 4: BioPathwise 2.0 A System for Pathway-Centric Collaborative Research.

2001-2006 The BioAnalytics Group LLC. All Rights Reserved

Multidisciplinary CollaborationMultidisciplinary Collaboration

Biological Researchers

Computational Biologists

Bioinformaticians

How do I communicate my results to other researchers and make use of their hard work in my research?

Page 5: BioPathwise 2.0 A System for Pathway-Centric Collaborative Research.

2001-2006 The BioAnalytics Group LLC. All Rights Reserved

BioPathwise 2.0BioPathwise 2.0

A computer-based solution designed to organize, view, analyze and share data and knowledge in the form of pathways.

Building & Viewing

Pathways

Simulation, Data Analysis &

Visualization

Data & Pathway Repository

Page 6: BioPathwise 2.0 A System for Pathway-Centric Collaborative Research.

2001-2006 The BioAnalytics Group LLC. All Rights Reserved

Building Pathways with Building Pathways with BioPathwiseBioPathwise

Import pathways

Pathways constructed by querying Reaction Database

Constructing networks from data

Enhancing existing pathways with your knowledge

Page 7: BioPathwise 2.0 A System for Pathway-Centric Collaborative Research.

2001-2006 The BioAnalytics Group LLC. All Rights Reserved

The BioPathwise RepositoryThe BioPathwise Repository

Searchable Collection of Pathways

Molecule PagesDynamically formatted Reports

The Rest of Biology

Access to Current Literature

Reaction Database

Page 8: BioPathwise 2.0 A System for Pathway-Centric Collaborative Research.

2001-2006 The BioAnalytics Group LLC. All Rights Reserved

Annotating PathwaysAnnotating Pathways

Text

Structured Annotations

Attached Documents, Images, and Data

Hyperlinks to any web resource

Page 9: BioPathwise 2.0 A System for Pathway-Centric Collaborative Research.

2001-2006 The BioAnalytics Group LLC. All Rights Reserved

Pathway-CentricPathway-CentricData VisualizationData Visualization

Importing Data

Visualization of Categorical and Time Series Data

Page 10: BioPathwise 2.0 A System for Pathway-Centric Collaborative Research.

2001-2006 The BioAnalytics Group LLC. All Rights Reserved

Pre-kinetic Pathway AnalysisPre-kinetic Pathway Analysis

Network analysis to highlightCritical points

Complementary Paths

Shortest Paths

Page 11: BioPathwise 2.0 A System for Pathway-Centric Collaborative Research.

2001-2006 The BioAnalytics Group LLC. All Rights Reserved

SimulationSimulation

Hypothesis testing

Experimental Design and Automation

Parameter Estimation and Sensitivity

Pathway-Centric Visualization

Page 12: BioPathwise 2.0 A System for Pathway-Centric Collaborative Research.

2001-2006 The BioAnalytics Group LLC. All Rights Reserved

CollaborationCollaboration

Share Models using the Repository

Export Models to Third-Party Formats

Publish Models to the Web

Export Publication Quality Graphics

Page 13: BioPathwise 2.0 A System for Pathway-Centric Collaborative Research.

2001-2006 The BioAnalytics Group LLC. All Rights Reserved

BioPathwise BioPathwise Programming InterfaceProgramming Interface

Interfacing with 3rd party products

Algorithm Developers

Application Developers

Page 14: BioPathwise 2.0 A System for Pathway-Centric Collaborative Research.

2001-2006 The BioAnalytics Group LLC. All Rights Reserved

Availability and PricingAvailability and Pricing

BioPathwise 2.0 Available Mid-July ’06

Pricing:Desktop Application

$3000 commercial

$600 academic

$300 per class for classroom use

Server (includes 5 desktop licenses)Prices start at $25k commercial

Includes hardware, configuration, training

Page 15: BioPathwise 2.0 A System for Pathway-Centric Collaborative Research.

2001-2006 The BioAnalytics Group LLC. All Rights Reserved

AcknowledgmentsAcknowledgments

Physiome Sciences Team (PathwayPrism v. 3.0)Kam-Chuen Jim, Guanming Wu, Jinpeng Xing, Yi Ge, Jonathan M. Shuali, Haoyu Yu, Robert Tjon, Zhuang Zuo, Jose Fernandez, Ninu Mehta, Stephen Lin, Andrew LeBeau, Fred Livingston, Jian Wang, Ned Haubein, Scott Lett, Haoyu Yu, Guanming Wu, Abram Goykhman, Brett Bu Sha, Katarzyna Stanczewska

BioAnalytics Team (BioPathwise v. 1.0, 2.0)Ned Haubein, Rashmi Gupta, Steven Alfisi

PRIME Team (Hours of use, plenty of feedback)Mount Sinai School of Medicine

Ohio State

Princeton University

NIAID