Bionanoimaging

An unexpected journey to a wonderful world

Presented By: Mehdi SoleymaniGoloujeh

Supervisor: Dr. A. Barzegar

Medical Nanotechnology DepartmentTabriz University of Medical Sciences

Presentation Layout:

Introduction

Classifications

New approaches

Future trends

Conclusions

Mehdi Soleymani Goloujeh

Medical Nanotechnology Department

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Introduction to Bionanoimaging

Introduction

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Bionanoimaging

An unexpected journey to a wonderful world

Nowadays we use in cancer detection,molecular imaging, MRI & US

Some facilities and materials are prerequisite to reach our goals

So we should classify these materials to study them easily



Introduction to Bionanoimaging



Classifications

Bionanoimaging

QDs

UICAMNPs

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Quantum Dots

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QUANTUM DOTS• Emission of photons under excitation, which are visible• Emission depends on size not on the material

“Size Matters”

• Smaller the dot –

• Larger the dot – red end of spectrum

• They can also be tuned beyond visible light to IR or UV

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Quantum dots (QDs) are incredibly small particles. They range between 2

to 10 nanometers in diameter, which is equivalent to 50 atoms

The colour light that a quantum dot emits is directly related to its size;

smaller dots appear blue, larger ones more red.

Quantum dots are a "semiconductor nano-crystal

A quantum dot as this: tiny pieces of matter with unique properties,

including the ability to emit light at very specific wavelengths. Sort of like

microscopic pieces of glitter that glow green, red, or blue depending on their

size.

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The smaller the nanoparticle, the higher the energy difference between the valence band

and conduction band, which results in a deeper blue color. For a larger nanoparticle, the

energy difference between the valence band and the conduction band is lower, which shifts

the glow toward red.

Quantum dots are very, very tiny particules on the order of a nanometer in size. They are

composed of a hundred to a thousand atoms. These semiconductor materials can be made

from an element, such as silicon or germanium, or a compound, such as CdS or CdSe.

These tiny particles can differ in color depending on their size. Below is a collection of CdSe

quantum dot nanoparticles that different in size as a result of how long they were allowed to

form in the synthersis reaction

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MEDICAL IMAGING

The quantum dots (QD) can be injected to asubject, and then be detected by exciting themto emit light

Source: Department of immunology, University of Toronto

Solutions of CdSe QD’s of different diameter

CdSe nanoparticle (QD) structureSource: Laurence Livermore Laboratories

Imaging of QD’s targeted on cellular structures

Nano Letters 2008., Vol. 8, pp3887-3892

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QD LOCALIZATION OF A TUMORA. It is possible to overlap X-ray images with infrared images to localize a tumor. The X-rayimages give the images an anatomical context, while the infrared images detect the QD’semission, which correlates to the tumor location (see B.)

Annu. Rev. Biomed. Eng. 2007. Vol. 9, pp. 257–288

B. C. 560-QD-Streptadivin targets and images In-vitrobreast cancer cells having the IgG factor characteristicof chemotherapy responsive cells

Nature Biotechnology 2003. Vol. 9, pp. 41-46

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ULTRASOUND CONTRAST AGENTS

Ultrasound is currently a well-established technology enabling real-time imaging of the human body

Traditional ultrasound, however, has its own limitation including increase in

attenuation with increasing insonating frequency, yielding low resolution of thickerstructures, and thus prohibiting deeper scans

A possible solution to overcoming the issues of deep scans and achieving improved

resolution is the use of contrast agents (CA) for ultrasound imaging [25, 26]. The

ultrasound imaging contrast agents (UICA) can be classified into liposomes, polymeric

nanosomes, and these are further classified according to the type of ultrasound agentencapsulated in them.

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MAGNETIC NANOPARTICLES



Paramagnetic

Super-paramagnetic Iron Oxide(SPIO)

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Passive Targeting Active Targeting Cell Tracking Magnetic Relaxation Switching(MRS)

Applications:



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New approaches

New Developments

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New approaches



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Future trends

Science-fictionJules Verne Stories

Imaginations

Insights Documents

Experiences

Thoughts

C O O H

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50 µm

Fe3O4 NPs

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Conclusions



Conclusions

Bionanoimaging

Science

Transcript of Bionanoimaging