BIOMATERIALS BIOMECHANICS AND STEM CELLS AT NIHinfluids/NIH Stem Cells and... · Biomaterials, and...
Transcript of BIOMATERIALS BIOMECHANICS AND STEM CELLS AT NIHinfluids/NIH Stem Cells and... · Biomaterials, and...
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BIOMATERIALS , BIOMECHANICS AND
STEM CELLS
AT NIHRosemarie HunzikerRosemarie HunzikerTissue Engineering/Regenerative Medicine, Biomaterials/Biomechanics, and Implantable Medical Devices Program DirectorNational Institute of Biomedical Imaging
and Bioengineering (NIBIB)National Institutes of Health (NIH)
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FIVE TAKE AWAYS� The NIH is not one organization, but 27 individual fiefdoms,
each with a culture and set of practices. Find your niche.
� In tight budget times, conservatism rules, but reviewers
and staff are eager to be “wowed”. Let us help you!
� NIH has many ways to support science (e.g. types of grants)
and many portals to access that support (e.g. FOAs).
� There is little interest in advancing BIOMATERIALS or
BIOMECHANICS per se, but rather in applying new materials-
based technologies and approaches to advance health.
� NIH is chiefly concerned with finding and funding the best
science and engineering. Foreign applications and/or
participation is part of that search.
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NIH is the steward of medical and behavioral research for the Nation. Its mission is science in pursuit of fundamental knowledge about the nature
and behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens
of illness and disability.
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Applications, Awards, Success Rates
NEDB 4
More info available at: http://report.nih.gov/success_rates/index.aspx
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NIH FY12 Budget NIH FY12 Budget NIH Divides most of its investment according to the interests of the
component parts (i.e. Institutes or Centers), with <4%) allocated to trans-
NIH initiatives.
NCI
OD/CF
NCCAM
NIDA
NIEHS
NIAMS
NHGRINIDCRNIAAA
NIDCDNIMHDNLM
NIBIB
FIC
Total = $31 B
NEI
NINR
= Institutes with significant percentages of budgets in Regenerative Medicine.
NIAID
NHLBI
NIGMSNIDDK
NINDS
NIMH
NICHD
NCRR
NIA
OD/CF
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There are two kinds of scientific revolutions, those driven by new
tools and those driven by new concepts… The effect of a concept-
driven revolution is to explain old things in new ways. The effect
of a tool-driven revolution is to discover new things that have to
be explained. -Freeman Dyson, 1997
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the NIBIB distinction…• Technology development• Enabling tools/approaches
…integrating the physical and engineering sciences w ith the life sciences to turn discovery into health.
It’s not enough to be UNIQUE… you must also be USEFUL.
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Need Help with Your Proposal…
Who Ya’ Gonna’ Call?� about the scientific and
technical aspects of your
application…
� for questions during the
review…
� Find them on the solicitation
� See also the IC’s programmatic descriptions
(http://www.nih.gov/icd/index.html).
Program
Director
review…
Scientific
Review
Officer
� for help with the business
aspects of a proposal…
Grants
Specialist
� Listed on the eRA Commons link to your
submitted proposal
� See also the review group rosters at the CSR
web site
� Listed on the eRA Commons link to your
submitted proposal
� See also the IC’s programmatic descriptions
(http://www.nih.gov/icd/index.html).
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NIH Institute/Center Web Sites
www.nih.gov/icd/
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Institute/Center
Each NIH has a HOME PAGE
http://www.nibib.nih.gov/
Model: http://www.xxxxx.nih.gov
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Does NIH Already Support My Interest Area?
http://report.nih.gov/quicklinks.aspx
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NIH Searchable Databases Contain Abstracts of All Funded Projects
Search by� MESH terms� Key words� Organizations� States/Countries� Investigators� Mechanisms� Solicitations� Institutes� Investigators � …
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RePORTer Delivers a Treasure Trove…
Click for
Abstract
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… of Useful Information.
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https://loop.nigms.nih.gov/index.php/2012/12/03/how-to-use-
reporter-when-preparing-new-grant-applications/
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Getting to the Top: Writing Great Grants
• Components of successful applications
– Strong Idea
– New Science/Engineering
– Right Team, Resources
– Compelling Presentation
• Match idea/science to the right place at NIH• Match idea/science to the right place at NIH
– Every Institute or Center (IC) has specific mission
– Each Study Section (Review Group) is a little different
• Hone high-quality grant writing skills
– Articulate the need to capture the opportunity
– Communicate scientific content accurately and concisely
– Follow all the instructions
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Plan Ahead… Seriously!
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“Family Tree” for Grants
R01(standard P01
P30, P50, P41, U54, etc.
(large collabortives)
(standard grant)
P01(collection of grants)
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Different Grants Serve Different Purposes� R01
– Workhorse of NIH research, highly valued by peers
– An outline for rigorous investigation, provides new fulcrum for the
field without gaps for others to fill
– Based on solid preliminary data
– 4-5 years, often renewable, generally $400-$500K per year
� R03
– A “mini-R01” popular with new investigators– A “mini-R01” popular with new investigators
– Self-contained: data analysis, pilots, methods development
– $50K per year for two years
– Not used by all institutes.
� R21 (Exploratory/Developmental)– Ideal = High Risk/High Reward (HR2)
– Innovation is a key, no preliminary data “required”
– $275K per year, typically 2 years, NOT renewable
– Success = quantum leap requiring follow up (sometimes with an
R33) and/or validation (i.e. an R01 submission)
– NOT a “new investigator starter grant”!
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Grants: A to Z
http://grants.nih.gov/grants/about_grants.htm
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How Does NIH Solicit Applications?
� Parent Announcements cover basic activity codes- investigator-initiated applications
� Federal Opportunity Announcements (FOA)
published through - the NIH Guide (http://grants.nih.gov/grants/guide/)
- grants.gov
- investigator-initiated applications
� Special Opportunities to fill gaps- Requests for Applications (RFA), a one-time call with set aside
funds
- Program Announcement (PA) highlights areas of focus
- Program Announcement with Special Review (PAR) for special consideration and “protected” review
- Program Announcement with Set Aside (PAS) essentially, an
RFA with multiple receipt dates
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NIH Funding Opportunities (FOAs)
http://grants.nih.gov/grants/guide/
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PAR 11-203: Predictive Multiscale Models for Biomedical,
Biological, Behavioral, Environmental, and Clinical Research
(Interagency U01)
MultiMulti--Agency NIH Funding Opportunities…Agency NIH Funding Opportunities…
� next generation of cutting edge multiscale modelsmultiscale models
� Participating Agencies: NIH, NSF, DOE, FDA
� Active until February, 2014
http://grants.nih.gov/grants/guide/pa-files/PAR-11-203.html
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NOT-EB-11-006:
NIH Participation in the
National Robotics Initiative.
NSF-led with NIH (NIBIB, NIA,
NICHD, NINR, NINDS) and
NIH and the NIH and the
National Robotics InitiativeNational Robotics Initiative
NICHD, NINR, NINDS) and
NASA, USDA.
� Next generation robotics, particularly co-robotics.
� NIH interests: home care, personalized care for special needs
populations, rehabilitation and behavorial therapy, surgical and
interventional robots, high-throughput technologies
� Apply through NSF
http://www.nsf.gov/pubs/2011/nsf11553/nsf11553.htm# toc
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NIH Bioengineering Program Announcements
� PAR-10-234: Bioengineering Research Partnerships (BRP) [R01] Supports a team approach to basic, applied, and translational multi-
disciplinary research that addresses important biological, clinical or
biomedical research problems.
� PA-12-284: Exploratory/Developmental Bioengineering Research
Grants (EBRG) [R21] Supports early and conceptual stages of new
Reissue with changes coming!
Grants (EBRG) [R21]exploratory and developmental research that may involve considerable
risk but may lead to a breakthrough.
� PA-13-137: Bioengineering Research Grants (BRG) [R01] Supports
an integrated, systems approach to basic and applied multi-disciplinary
research that addresses important biological, clinical or biomedical
research problems.
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� Small (~100 nm)
� Man-made/manipulated
� Functional properties emerge at nanoscale
NIH is a charter memberNanomaterials
� Functional properties emerge at nanoscale
Funding
� PA-11-149: Nanoscience and Nanotechnology in Biology and Medicine (R21)
Early and conceptual stages of new exploratory and developmental
nanoscience and technology research that may involve considerable risk but
have high potential reward.
� PA-11-148: Nanoscience and Nanotechnology in Biology and Medicine (R01)
New and ongoing research in nanoscience and technology research focused on
problems in biology.
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Cross-Cutting, trans-NIH Programs
PROMIS:PROMIS:Clinical Clinical
OutcomesOutcomesAssessmentAssessment
NIHNIHCenter forCenter for
RegenerativeRegenerativeMedicineMedicine
Gulf Oil Gulf Oil SpillSpill
MetabolmicsMetabolmics
Single CellSingle CellAnalysisAnalysis
Medical Medical ResearchResearchScholarsScholarsTrainingTraining
Health Health EconomicsEconomics
Library of Library of Integrated NetworkIntegrated Network--
Based Cellular Based Cellular
MolecularMolecularLibrariesLibraries
and Imagingand Imaging
Building Blocks,Building Blocks,BiologicalBiological
Pathways andPathways andNetworksNetworks
Big Data to Big Data to KnowledgeKnowledge
Human Human MicrobiomeMicrobiome
RegulatoryRegulatoryScienceScience
Bridging Bridging InterventionalInterventional
Development GapsDevelopment Gaps((BrIDGsBrIDGs))
Health CareHealth CareSystemsSystems
CollaboratoryCollaboratory
Science ofScience ofBehaviorBehaviorChangeChange
Protein Protein CaptureCapture
NanomedicineNanomedicineEarly IndependenceEarly IndependenceNew innovatorsNew innovatorsPioneersPioneersTransformative R01sTransformative R01s
GenotypeGenotype--TissueTissue
ExpressionExpression
HighHigh--riskriskResearchResearch
NIHCommon Fund
EpigenomicsEpigenomics
http://commonfund.nih.gov/
ExtracellularExtracellularRNA RNA
CommunicationCommunication
Based Cellular Based Cellular Signatures (LINCS)Signatures (LINCS)
Bioinformatics andBioinformatics andComputational BiologyComputational Biology
StructuralStructuralBiologyBiology UndiagnosedUndiagnosed
DiseasesDiseases
Knockout Knockout Mouse Mouse
PhenotypingPhenotyping
Increasing Research Increasing Research Workforce DiversityWorkforce Diversity
Strengthening BiomedicalStrengthening BiomedicalResearch WorkforceResearch Workforce
Global Global HealthHealth
May 2013
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NIH Funding Initiatives: Get the scoop!
� NIH Guide to Grants and Contracts http://grants.nih.gov/grants/guide/listserv.htm
� NIH Extramural Nexus: Rock Talk! http://nexus.od.nih.gov/all/category/blog/
� NIBIB Listserve https://list.nih.gov/cgi-bin/wa.exe?SUBED1=NIBIB_LISTSERV&A=1
Sally Rockey
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“Biomaterials” Projects in NIH Portfolios“Biomaterials” Projects in NIH Portfolios
NIBIB54 (6.4%)
NIDCR
OD/CF10 (5.1%)
NHLBI
NIGMS31 (0.9%)
NIDDK18 (0.7%)
NIDCD6 (0.6%)
NIA5 (0.5%)
NIH ICs with <0.5% investment
NCATS, NCCAM, NCI, NEI,
NHGRI, NIAAA, NIAID, NICHD,
NIDA, NIEHS, NINDS, NINR, NLM Source: NIH RePORTer, “Active Projects, 2012”
Total Funding: $146 M, 320 awards
NIDCR38 (5.1%)
FIC2 (1.5%)
NIAMS24 (1.4%)
NHLBI54 (0.9%)
NIMH9 (1.0%)
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NIH Research Solves Health Concerns
High resolution CARS image
of live cells showing fine
structural detail.
Coherent anti-Stokes Raman
Spectroscopy (CARS) generates
quantitative, microscopic images
based on vibrational constrast. Signal results from multiple incident
photons and the material response at
frequencies that reduce background,
increasing specificity and specificity.
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“Cellular Mechanics ” Projects in “Cellular Mechanics ” Projects in
NIH PortfoliosNIH Portfolios
NIBIB6 (0.6%) NIDCD
10 (1.9%)
NIMH3 (0.5%)
NIGMS540 (0.6%)
NIH ICs with <0.5% investment
FIC, NCATS, NCCAM, NCI, NEI, NHGRI, NIA,
NIAAA, NIAID, NICHD, NIAMS, NIDA, NIDCR,
NIDDK, NIEHS, NIMHD, NINDS, NINR, OD/CF
Source: NIH RePORTer, “Active Projects, 2012”
Total Funding: $45M, 125 awards
NHLBI34 (0.6%)
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$35 M
in TE/RM
(Army MRMC)
Federal Investment in
Tissue Engineering and
Regenerative Medicine
$600 M
in TE/RM
$33 M
In TE/RM $1,000 M
in stem cells
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US Government Support for Global Health
http://www.globalhealth.gov/index.html
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NIH Common Fund and Global Health
https://commonfund.nih.gov/globalhealth/
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Currently Active Funding Opportunities
http://h3africa.org/funding.cfm#al-1
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NIH’s Focus on Global Health
http://www.fic.nih.gov/Global/Global-Health-NIH/Pag es/default.aspx
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Foreign Applications: Special Considerations
Review procedures include�Study Section’s evaluation of the opportunity
Must offer opportunities not readily available in t he US� Unusual talent� Unique resources� Special populations� Restricted Environments
�Study Section’s evaluation of the opportunity�Individual consideration at Advisory Council
Awards (including subcontracts) require�US State Department approval�Additional processing time
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Step #1: Do your homework; learn a bit about the gr ant process and the options.
Path to Success at NIH
Office of Extramural Research:
Basics - http://grants.nih.gov/grants/grant_basics.htm
Overview - http://grants.nih.gov/grants/grants_process.htm
IC priorities: http://www.nih.gov/icd/index.html
NIH Guide Provides Weekly Updates on Funding Opportunities:
http://grants.nih.gov/grants/guide/
Step #2: Contact us because… We’re from the Government, we’re here to help you!
http://grants.nih.gov/grants/guide/
NIH RePORTer – lots of statistics and abstracts of funded grants
http://report.nih.gov/
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Rosemarie Hunziker, Ph.D.Program Director, Tissue
Engineering/Regenerative Medicine,
Biomaterials, and Medical Devices
National Institute of Biomedical Imaging and
Bioengineering (NIBIB)Bioengineering (NIBIB)
National Institutes of Health (NIH)
301-451-1609
www.nibib.nih.gov
National Institute ofBiomedical Imaging
and Bioengineering