Bridging the Gap From In Vitro to In Vivo

BioMAP® Database Overview

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BioMAP Reference Database

>3000 agents* Drugs - Approved, Failed

Experimental Chemicals - Research tool compounds, environmental chemicals

• Biologics - Cytokines, factors, peptides, antibodies, soluble receptors

Database is expanding based on client feedback Well-characterized, target-selective compounds or clinically important

agents are prioritized

Caveats for reference database agents Not all agents in the database are equally useful (many have multiple

targets and are poorly selective)

Not all agents have been run in all BioMAP systems

* Contact us at BusDev@bioseekinc.com for a list of references

Applications for BioMAP® Reference Database

Specific Comparisons

• Overlay of Database reference profile with Client compound profile

• Competitive analysis - To compare with competitor compounds

– E.g. same target

• Portfolio analysis - To compare with other compounds in therapeutic area

– E.g. different targets, same indication

Mechanism of Action Studies

• Computational query of BioMAP® database for reference

compounds that are functionally similar to a Client compound

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Distribution of Mechanism Classes

Distribution of Mechanism Classes in the BioMAP Reference Database

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Representative List of Target Mechanisms

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List of Compounds in Selected Classes

Bridging the Gap From In Vitro to In Vivo

Contacts

BioSeek, LLC

310 Utah, Suite 100

South San Francisco, CA 94030

650-416-7600

BusDev@bioseekinc.com

www.bioseekinc.com

BioSeek, LLC310 Utah, #100South San Francisco, CA 94080