Biology sem1- chap9

111
1

Transcript of Biology sem1- chap9

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 1/111

1

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 2/111

2

OBJECTIVES Explain the significance of maintaining a

constant internal environment

Explain control of body temperature in

animal

Discuss some of the adaptations of plants

to environment

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 3/111

3

HOMEOSTASIS

(homeo=sameness;-stasis=standing still)

The condition in which the body¶s internalenvironment remains relatively constant,within physiological limits

Homeostasis is a dynamic condition²inresponse to changing condition, the body¶sequilibrium point can change over a narrowrange that is compatible with maintaining life

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 4/111

4

Important aspect of homeostasis is to maintaining the volume

and composition of body fluids

Intracellular fluids ± the fluid within cells

Extracellular fluids ± the fluid outside body cells

Interstitial fluid

  ± theextracellular fluids that fills the narrow spaces between cellsof tissues

Plasma ± extracellular fluids within blood vessels

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 5/111

5

Process to maintaining the dynamic equilibrium in the body include

the :

Excretion

Osmotic balance

Important factors to maintain dynamic equilibrium:

Substances dissolved in water: ±  Oxygen and carbon dioxide

 ±  Nutrients (proteins, fatty acids, glucose level)

 ±  Ions pH

Temperature

Osmotic pressure

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 6/111

6

The waste products:

Carbon dioxide Bile pigments (biliverdin and bilirubin)

Water from the cell respiration

Urea

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 7/111

7

Physiological control Body can regulate its internal environment through the feedback 

systems

Feedback system ± a cycle of events in which the status of body condition is continuallymonitored, evaluated, changed, remonitored, re-evaluated and so on.

Each monitored variable, such as body temperature, blood pressure, blood glucose level is termed a controlled condition

Any disruption that changes a controlled condition is called a stimulus

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 8/111

8

3 basic components make up a feedback system

1. R eceptor

body structure that monitors changes in a controlled condition and sendsinput in the form of nerve impulses or chemical signals to a control center.

2. Control centre set the range of values within which a controlled condition should be

maintained, evaluates the input it receives from receptors and generatesoutput commands when they are needed.

Output from the control center can occur in several forms: nerve impulses,

hormones , or 

other chemical signals

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 9/111

9

3. Effector

body structure that receives output from the control

centre and produces a response or effect that changesthe controlled condition.

As a control system operates, the effector 

response feed back and influences the magnitudeof the stimulus by either depressing it (negative

feedback) or enhancing it (positive feedback)

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 10/111

10

 N egative feedback 

Homeostatic mechanism that stops or reduces theintensity of the original stimulus and consequentlycauses a change in a variable that is opposite in directionto the initial change (The output is used to reduce input)

 Positive feedback  a feedback mechanism in which the response enhances

the original stimulus (The output is used to enhance theinput)

Example : The secretion of oxytocin duringchildbirth

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 11/111

11

Homeostatic regulation

i. Every changes in the physical or chemical factors

of the internal environment ± detected by receptor 

ii. Receptor send information about the changes to a

control systemiii. Action signals are transmitted through nerve

impulses or hormone to the target organ

 ± Trigger the correction mechanism to return the physical

or chemical factors to normal condition

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 12/111

12

iv. Any increase in the value of a physical or 

chemical factor in the internal environment will

trigger a correction mechanism to reduce thatvalue

Conversely, a reduction in the value of the

 physical or chemical factor will trigger a

mechanism to increase the amount of that factor.

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 13/111

13

If the control centre or correction

mechanism is disrupted, the change

occurring in the factor cannot be reversed

 ± The value of the factor continuing to rise or fall

 ± This is called positive feedback 

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 14/111

14

Schematic representation of homeostatic process

 Normal condition

Receptor Control centre Effector Correction

mechanism

 Normal

condition

restored

Receptor Control centre Effector  Correction

mechanism

Factor value increase accelerated

Factor value decrease accelerated

increase

decrease

Positive feedback 

Positive feedback 

Transmission

of nerve

impulse or 

secretion of 

hormone

 Negative feedback 

 Negative feedback 

decrease

increase

Transmission

of nerve or 

secretion of hormone

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 15/111

15

Negative feedback in

control of blood

glucose level

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 16/111

16

Control of blood sugar level

Regulated by the activities of several organs,

 particularly the pancreas and liver 

Any changes in blood sugar level

 ± Detected by pancreas

Endocrine gland

 ± Secrete insulin and glucagon

Beta cells of the islets

of Langerhans

Alpha cells of the islets of 

Langerhans

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 17/111

17

Schematic representation of blood sugar level regulation

 Normal sugar level

Beta cell of the

islets of 

Langerhans tosecrete insulin

Liver stimulated to convert

i. Glucose to CO2 + H2O

ii. Glucose to glycogen

iii. Glucose to fat

Blood sugar level falls

 Normal sugar level

Alpha cells of 

the islets of Langerhans

stimulated to

secrete

glucagon

Liver stimulated to convert

i. Glycogen to glucose

ii. Reduce glucose

oxidation

Blood sugar 

level rises

Blood sugar 

level rises

Blood sugar 

level falls

 Negative feedback 

 Negative feedback 

decrease

increase

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 18/111

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 19/111

19

An organism exchanges heat with its environment by

four physical processes

1. C onduction  ± The direct transfer of thermal motion (heat) between molecules of the

environment and a body surface

2. C onvection ± The transfer of heat by the movement of air or liquid past a body surface

3. Radiation ± The emission of electromagnetic waves produced by all objects warmer than the

absolute zero

4. E vaporation ± The loss of heat from a liquid¶s surface that is losing some molecule as gas

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 20/111

20

Body temperature regulation in humans and other mammals

Thermoreceptor 

in skin

Body temperature

Hypothalamus, the

thermoregulatory centre in brain

Blood

capilaries

Erector 

muscles

Sweat

gland

Skeletal

muscles

Adrenal

gland

Thyroid

gland

Vasodilation or 

vasocontraction

Erection or 

no erection

Sweating or 

no sweating

Shivering or 

no shivering

Adrenaline

level increases

or decreases

Thyroxine

level increases

or decreases

 E  fferent nerve

  Afferent nerve Afferent nerve

Temperature regulation through physical action Temperature regulation

through metabolic action

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 21/111

21

Schematic representation of body temperature regulation in mammals

 Normal bodytemperature

Thermoregulatory

centre(hypothalamus) in

 brain

Correction mechanism

Vasodilation

Sweating

Non-erection of hair 

Drop in metabolic rate

 Normal bodytemperature

Afferent

nerve

Thermoregulatory

centre

(hypothalamus) in

 brain

Correction mechanism

Vasocontriction

No sweating

Hair erection

Increase in metabolic

rate

Temperature

rises

Temperature

falls

Efferentnerve

Temperature

falls

Temperature

rises

Efferent

nerve

Afferent

nerve

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 22/111

22

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 23/111

23

LIVER 

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 24/111

24

Liver structure

Largest visceral organ inthe body

Metabolic centre in the body

Processed and stored food Received blood

 ± Hepatic artery

Oxygenated blood from the

dorsal aorta ± Hepatic portal vein

Nutrient rich blood fromsmall intestine

Sent blood to heart

 ± Hepatic vein

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 25/111

25

Liver cell ± hepatocyte

Liver is made up of 

many cylindrical lobes

Interlobular blood

vessel

 ± Branches of the hepatic

artery and hepatic

artery and hepatic

 portal vein

 ± Connect to periphery

of each lobes

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 26/111

26

Canalikuli

 ± Bile duct branches into

a network of finevessels

 ± Pass between cells of 

lobes

Sinusoid ± Capillaries which form

from hepatic arteriole

and hepatic portal

venule

 ± Flow to central vein

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 27/111

27

Kupffer cell

 ± Specialized ameboid

cell

 ± Attach to the inner wall

of sinusoid

 ± Phagocytosing old red

 blood cells and patogens

Bile duct

 ± Carry bile to gall

 bladder 

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 28/111

28

Functions of liver

1. Carbohydrate metabolism

Regulates blood sugar level

  ± Glycogenesis

Convert excess sugar to glycogen

  ± Glycogenolysis

Broken down the glycogen

  ± Cori cycle

Convert lactate into glucose

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 29/111

29

2. Lipid metabolism

 ± Breaks down fat

 ± Transport of lipid

Produces globulin to transport fat

Stored in the form of adipose tissues

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 30/111

30

3. Protein metabolism

Regulates protein and amino acid  ± Deamination

Produced non-nitrogenous and nitrogenous parts

Non-nitrogenous part - convert into glucose in liver and stored as glycogen or broken down to release heat

Nitrogenous part ± enter ornithine cycle

  ± Ornithine cycle To convert ammonia (toxic) into urea (less toxic)

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 31/111

31

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 32/111

32

4. Processing drugs and hormones

the liver can detoxify substances such as alcohol or excrete drugssuch as penicillin, erythromycin and sulfonamides into bile

5. Excretion of bilirubin

bilirubin derived from the heme of aged red blood cells, isabsorbed by the liver from the blood and secreted into bile

6. Synthesis of bile salts

bile salts are used in the small intestine for the emulsification andabsorption of lipids, cholesterol, phospholipids and lipoproteins

7. Storage

in addition to glycogen, the liver is a prime storage site for certainvitamins (A, cobalamin, D, E and K) and minerals (iron andcopper) which are released from the liver when needed elsewherein the body

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 33/111

33

8. Phagocytosis

Kupffer¶s cells phagocytize aged red blood cells

and white blood cells and some bacteria

9. Activation of vitamin D

the skin, liver and kidneys participate in

synthesizing the active form of vitamin D

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 34/111

34

R ole of the liver in (the

control) blood glucoselevel, fatty acids and

protein

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 35/111

35

Carbohydrate Metabolism

Regulation of blood sugar level

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 36/111

36

Carbohydrate Blood glucose Glucose-6-phosphate

(Tissue and liver)

Glucose-1-phosphate

Glycogen

(Liver)

Glycogen

(Muscle)

Pyruvate

aerobicanaerobic

Lactate + energy CO2 + H2O + energy

Amino acid Glycerol, fatty acid

digestion insulin

glycogenesis

glycogenolysisGluconeogenesis

Carbohydrate Metabolism

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 37/111

37

Cori Cycle shows glycogen and lactate

movement between the liver and muscle

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 38/111

38

Fats (lipid) metabolism

Fats in the liver can be modified for respiration and can be stored in the body

cells

Hepatocytes synthesize the cholesterolwhen the level is decreased. It also canexcreted cholesterol into bile when the levelof the cholesterol is increased

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 39/111

39

Protein Metabolism

Protein being recycled are first broken down into amino

acids. Hepatocytes convert amino acids to fatty acid, ketone

 bodies, glucose or oxidize them to carbon dioxide andwater 

There are two ways of protein metabolism ± Deamination

a conversion consists of removing the amino group from the aminoacids and converting it to ammonia

 ± Transamination

the transfer of an amino group from an amino acid to pyruvic acid or toan acid in the Krebs cycle-can synthesized nonessential amino acids

Ornithine Cycle shows the formation of urea

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 40/111

40

Metabolism of excess amino acid

Excess amino acid

Keto acid + NH3

Glucose

Glycogen Fats

Krebs

cycle

Ornithine

cycle

deamination

H2O + CO2 urea

CO2

Production of organic base

 Nucleotide synthesis

 Nucleic acid synthesis

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 41/111

41

Ornithine cycle (urea cycle)

citruline

arginosuccinate

arginine

ornithine

H2O

urea

Carbamoyl phosphate

Pi

aspartate

 NH3

ATP

AMP + PPi

fumarate

Deamination of amino acid

NH3 + CO2 + H2O

2 ATP

2 ADP + Pi

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 42/111

42

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 43/111

43

That¶s all for today

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 44/111

44

K idney

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 45/111

45

Objectives Kidney structure and nephron

Urine formation involving ultrafiltration and

reabsorption Urine concentration by counter current

multiplier mechanism

Water regulation by ADH

Osmoregulation of mineral ions by aldosterone

pH regulation of the tissue fluid

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 46/111

46

Introduction

yKidney

 ± main function in homeostasis

 ± urine formatian ; eliminate the nitrogen by products of protein metabolism and maintain

water balance

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 47/111

47

Urinary system

Kidney ± pair of bean-shaped organ (about 10 cm long in human), located in

the region of the lower back 

Ureter  ± urine exits the kidney through this duct

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 48/111

48

Urinary bladder 

 ± ureter of both kidneys carries the urine to a urinary bladder 

Urethra

 ± during urination, urine leaves the body through this and sphincter muscles near 

the junction of the uretra and the bladder control urination

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 49/111

49

Structure of kidney

andnephron

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 50/111

50

Structure of kidney

renal pelvis

 ± within the kidney , the mouthof the ureter flares open toform a funnel-likestructure.and has cup-shapedextensions that receive urinefrom the renal tissue

 ± This tissue is divided into :-

renal cortex

 ± outer region

renal medulla

 ± inner region

nephron

 ± microscopic excretory tubules

  ± Each kidney composed of roughly 1 million nephrons

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 51/111

51

Structure of nephron Bowman¶s capsule

  ± a hollow, cup shaped ( diameter b

200Qm) in the cortex of the kidney.

Glomerulus

  ± the cupped wall region and bloodvessel

 ± blood ±filtering unit

Proximal convoluted tubule

 ± close to the capsule , highly coiled anddiameter b60Qm

 ± Located in the cortex of the kidney.

Loop of Henle

  ± hair-pin shaped and have descendinglimb & ascending limb

 ± Located in the medulla of the kidney.

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 52/111

52

Distal convoluted tubule ± located in the cortex of thekidney.

Collecting duct ± end of kidney and located in

the medulla of the kidney  ± Several nephrons feed into

the same collecting duct

  ± The collecting ducts alleventually drain into the  pelvis of the kidney, from

where the urine flows intothe ureter.

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 53/111

53

Nephron and blood

circulation

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 54/111

54

Nephron and blood circulation

Renal artery

 ± blood enters the kidney bythe renal artery which  branches into afferentarteriole.

Afferent arteriole  ± brings blood towards each

Bowman¶s capsule,dividing to form a network of capillaries calledglomerulus in the hollow of the capsule.

Efferent arteriole

 ± blood leaves the Bowman¶scapsule (capillaries) in anefferent arteriole, which isnarrower than the afferentarteriole

The efferent arteriole

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 55/111

55

The efferent arterioledivided to form second setof capillaries whichsurround the proximal and

distal convoluted tubulesand the loops of Henle inthe medulla

The capillaries of the vasarecta (peritubular  capillaries) run parallel tothe loops of Henle and thecollecting duct in themedulla.

Blood leaves the kidneythrough the renal vein

Renal arteryÄ afferent arterioleÄ glomerulusÄefferent arterioleÄ vasa rectaÄ renal vein

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 56/111

56

Urine Formation

U i F ti

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 57/111

57

Urine Formation

1) Ultrafiltration in

Bowman¶s capsule

Ultrafiltration of the blood

  ± it filters out molecules which

are much smaller than red

  blood cell and plasma

 proteins

  ± occurs as blood pressure

forces water ,urea, salts, and

other small solutes from the blood in the glomerulus into

the lumen of Bowman¶s

capsule.

Factors contribute to ultrafiltration process:-

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 58/111

58

Factors contribute to ultrafiltration process:

i. The hydrostatic blood pressure in the glomerulus is higher than inother capillaries.

due to the high resistance to outflow presented by the efferent arteriole, which issmaller in diameter than the afferent arteriole

ii. Large amount of glomerulus filtrate large surface area for filtration provided by the highly coiled glomerulus capillaries

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 59/111

59

iii. High permeability of the glomerulus The wall of Bowman¶s capsule in contact with capillaries consists of 

specialized epithelial cell called podocytes. These cells have numerous

cytoplasmic extension called foot processes that cover most of the

capillaries.

Foot processes of adjacent podocytes are separated by narrow gaps called

filtration slits.

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 60/111

60

The perforated walls of the

capillaries and the podocytes form

a filtration membrane that permitsfluid and small solutes dissolved in

the plasma, such as glucose, amino

acids, sodium, potassium,chloride,

 bicarbonate, other salts, and urea,

topass through and become part of 

the filtrate.

This filtrate membrane holds back 

 blood cells, platelets, and most of 

the plasma protein.

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 61/111

61

2) R eabsorption (proximalconvoluted tubule, loop of 

Henle, distal convolutedtubule)

As the glomerular filtrates flowthrough the nephron, varioussubstances move out of it. Thenthey cross the cells that make upthe nephron¶s wall into the blood inthe capillaries running alongsidethe nephron.

Most reabsorption takes places asthe fluid flows through the proximal convoluted tubule.

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 62/111

62

Capillaries reabsorb usefulmolecules such as glucose,amino acids, vitamins, most of the water, sodium andchloride ions.

The kidney tubules are beingadapted to increase thereabsorption efficiency by thefollowing factors.

a. The proximal and distaltubule are long and winding.Therefore both the surfacearea , and the time availablefor reabsorption are increased.

a. The tubules have walls whichare only one cell thick.Diffusion is efficient onlyover very small distances.

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 63/111

63

c. The cells of the proximal and distal convulated tubules have a brush border of microvilli which increase the surface area in contact with the fluid, and thereforeincrease the rate at which substances can be absorbed from it.

d. The bases of the proximal tubule cells are irregular in shape where they are adjacentto a blood capillary and there are numerous intercellular spaces. The cells areideally adapted for the diffusion of absorbed substances into the capillary network that surround the tubule.

They also contain numerous mitochondria which are the sites of aerobic respiration. The energy is required for active uptake when substances are moved across cells such as sodium ions and glucose.

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 64/111

64

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 65/111

65

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 66/111

66

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 67/111

67

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 68/111

68

Urine concentration by counter current multiplier mechanism

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 69/111

69

Definition:

µcountercurrent¶

 ± fluids past each other inopposite directions.

 ± fluid flow down(descending limb) and up(ascending limb) of theloop.

µmultiplier¶

 ± fluid flow down thedescending limb, highconcentration of NaCl andmost hypertonic round the

hairpin ± fluid flow up the ascending

limb, less concentrated of  NaCl; hypotonic

Urine concentration located in loop of Henle

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 70/111

70

The function of the loop

of Henle ± to conserve water.

 ± the longer the loop of Henle, the more concentrated theurine that can be produced.

 ± loop of Henle create a water   potential gradient betweenthe renal filtrate and the  peritubular (medullary)fluid which bathes the loop;create a very highconcentration of salts in the

tissue fluid in the medullaof the kidney.

Urine concentration located in loop of Henle.

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 71/111

71

Urine concentration by counter current multiplier mechanism

This mechanism based of:-

i. The descending limb thin walls.

high permeable to water and  permeable to most

ions/solutes.

its function is to allow

substances to diffuse

easily through its wall andwater would follow

 by osmosis.

ii Th di li b

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 72/111

72

ii. The ascending limb

the thin ascending limb

o this is the lower half of theascending limb and has

o thin wall like the descendinglimb.

o impermeable to water but

 permeable to ions

the thick ascending limb

o this is the upper half of theascending limb and has thick 

walls.o impermeable to water but

 permeable to ions.

o actively reabsorb sodium andchloride from the tubule to

 blood

Urine concentration by counter current multiplier mechanism

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 73/111

73

Urine concentration by counter current multiplier mechanism

There is a gradient of 

 NaCl across the medulla

The filtrate which enters

the loop of  Henle is

isotonic with the

 peritubular fluid

Only the thin part of thedescending limb is freely

 permeable to water.

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 74/111

74

The sodium and chloride ions

are actively pumped out of the

thick ascending limbs , into

the tissue fluid outside.

As the two limb are so close toone another, this produce a

high concentration of sodium

and chloride ions around the

descending limb.

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 75/111

75

When the fluid flows down thedescending limb, it is surrounded bytissue fluid with a high

concentration of ions and therefore alow water potential.

This causes water in the descendinglimb drawn out by osmosis.

The water moves straight into thecapillaries (vasa recta) surroundingthe loop of Henle.

At the same time, sodium and

chloride ions diffuse into the fluid inthe tubule, down their concentrationgradient.

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 76/111

76

The effect is cumulative and

therefore the filtrate at the bottom of the descending limb and as it beginsto turn the hairpin, it has lost a lot of water and gained a lot of sodiumand chloride ions ( moreconcentrated than at either end).

As the fluid flows up the ascendinglimb, it continues to lose sodiumand chloride ions, and therefore become less concentrated.

The filtrate entering the distal tubuleis hypotonic to the peritubular fluid.

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 77/111

77

Function of complex of blood capillaries runsalongside the loop of Henle:

 ± supply oxygen and nutrients so that cells in the walls of the loop can produce the large amount of ATP for active transport.

 ± take away much of the salt and water from the tissuefluid in the medulla, helping to maintain the gradients

 built up by the loop.

H d hi h i h l

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 78/111

78

How does this mechanism help to

conserve water?

The final part of each nephron, the collecting duct,also passes through the medulla of the kidney.

As the fluid flow through the collecting ducts,water can be drawn out of them, by osmosis, intothe concentrated tissue fluid in the medulla.

The more concentrated the tissue fluid, the morewater can be drawn out, and the moreconcentrated the urine can be.

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 79/111

79

Water regulation by ADH

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 80/111

80

Water regulation by ADH

Concepts

The kidney play central role in the regulation of the water content of the body or osmoregulation.

The water content of the blood is monitored by

osmoreceptor cells in the hypothalamus and these

cells produce antidiuretic hormone, ADH.

Summarize

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 81/111

81

Su e

Source Target tissue Actions Factors that

StimulateR elease

Produced in

hypothalamus;

released by

 posterior 

 pituitary gland

Distal

convoluted

tubule and

collecting ducts

Increases

  permeability of 

the collecting

ducts to water,

increasing

reabsorption and

decreasing water 

excretion

Low fluid intake

decreases blood

volume and

increases

osmotic pressure

of blood;

receptors in

hypothalamus

stimulate posterior 

 pituitary

Water regulation by ADH

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 82/111

82

g y

Low intake of water 

Water content of the blood is lower than normal, the body begins todehydrate, causing the blood volumeto decrease.

The concentration of salts dissolved

in the blood becomes greater 

Osmotic pressure increase.

Osmoreceptor in hypothalamus aresensitive to this osmotic change andstimulate the posterior lobe of the pituitary to release more ADH

ADHmakes the collecting duct wall

more permeable to water 

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 83/111

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 84/111

84

High intake of water

Water content of the blood is higher than normal, the body fluids begin todilute, causing the blood volume to increase. 

Concentration of salts dissolved in the blood becomes less

Osmotic pressure decrease.

Osmoreceptor in hypothalamus are sensitive to this osmotic change and

stimulate the posterior lobe of the pituitary to release less ADH

ADH makes the collecting duct wall less permeable to water

Less osmotic uptake of water is allowed (less water reabsorption)

Large volumes of diluted urine are produced

This water loss reduces the solute concentration of the blood

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 85/111

85

Osmoregulation of mineral ions by aldosterone

Osmoregulation of mineral ions by aldosterone

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 86/111

86

The maintenance of the  plasma sodium level iscontrolled by aldosterone.

Secreted by the cortex

region of the adrenalgland.

Aldosterone stimulates the

distal tubule to increasesodium reabsorption andthereby maintains the balance of salt and water inthe body fluids.

Osmoregulation of mineral ions by aldosterone

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 87/111

87

When blood sodium level decrease

A decrease in blood sodium leadsto a decrease in blood volume because less water enters the blood by osmosis.

Reduces blood pressure.

This decrease in pressure andvolume stimulates a group of secretory cells, the juxtaglomerular complex, situated between the

distal convoluted tubule and theafferent arteriole, to release anenzyme called renin.

Renin passes into the blood here

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 88/111

88

Renin passes into the blood whereit acts on its substrate, a proteincalled angiotensinogen,converting it to angiotensin.

The arrival of angiotensin at theadrenal glands causes aldosteroneto be secreted into the blood.

Therefore, increase the rate of reabsorption of sodium ions fromthe distal convoluted tubules.

Thus, fewer sodium ions are lostin the urine, and more are retainedin the blood.

Thus causes more water to enter the blood by osmosis, raising itsvolume and hence its pressure.

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 89/111

89

 pH regulation

of 

the tissue fluid

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 90/111

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 91/111

91

Carbon dioxide reacts with water to produce carbonic

acid:

CO2 + H2O H2CO3

Carbonic acid dissociates to produce hydrogen ionsand hydrogencarbonate ions:

H2CO3

H+ + HCO3

-

 pH regulation of the tissue fluid

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 92/111

92

p g

The kidney help to regulate pH by altering the rate at which they excrete

hydrogen ions.

Hydrogen ions are continually secreted into the fluid as it passes along thenephron.

The rate at which they are secreted depends on the pH of the blood.

An equivalent number of hydrogen ions must therefore be excreted in urine tomaintain acid-base balance.

In addition, the kidneys assist the lungs by eliminating CO2 that enters the renaltubules during filtration or that diffuses into the tubular fluid as it travels toward

the renal pelvis.

Hydrogen ions are secreted into the tubular fluid along the proximal convoluted tubule,the distal convoluted tubule, and the collecting duct.

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 93/111

93

If the blood fluid pH is low (acidosis - developed

when the normal plasma buffer mechanisms are

stressed),

 ± more hydrogen ions are secreted into the tubules or the

collecting duct from the blood.

 ± more hydrogen ions are lost from the body in the urine.

 ± Addition of that is removal of CO2, activity of buffers

in the tubular fluid and reabsorption of NaHCO3

 ± A fall in pH also stimulates the kidney cells to produce

the base ion ammonium (NH4

+) which combines with

acids brought to the kidney and then excreted asammonium salts.

If blood pH is high (alkalosis)

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 94/111

94

If blood pH is high (alkalosis),

  ± then fewer hydrogen ions are secreted into the

nephron; ± they remain in the body rather than passed out in the

urine.

 ± The collecting system transports HCO3

- into tubular 

fluid while releasingHCl into peritubular fluid.

 ± The concentration of HCO3

- in plasma decreases,

 promoting the dissociation of H2CO3

and the release

of hydrogen ions. ± The additional H+ generated at the kidneys help return

the pH to normal levels.

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 95/111

95

Water

concentration in

plant

Objectives

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 96/111

96

Objectives

i. The role of stomata in water loss throughtranspiration

ii. Significance of transpiration

iii. Plant adaptation to the habitats

 ±  Xerophytes

 ±  Hydrophytes ±  Mesophytes

 ±  Halophytes

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 97/111

BerpenyakitTidak berpenyakit

Pengumuman Jabatan Pertanian

Bagaimana hendak mengenali penyakit Lembu Gila.

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 98/111

98

The role of stomata in

water loss throughtranspiration

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 99/111

99

The role of stomata in water loss through

transpirationSignificance of transpiration

Loss of water from plants¶surface is called transpiration

Water normally leaves the plant as water vapour.

The change from the liquid state to the vapour state

requires the addition of energy which is provided by thesun, and it is this energy that maintains the flow of water throughout the entire plant.

T i i f h b i f

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 100/111

100

Transpiration occurs from the stomata by evaporation of water from cells and diffusion of the water vapour throughstomata, the pores found in the epidermis of leaves andgreen stems.

About 90% of the water is lost through transpiration.

Water in the plant is in direct contact with water in soil andwith water vapour in the air around the plant.

Water movement from higher water potential to the lower water potential is called potential gradient.

The gradient is maintained by solar energy and evaporationof water from the surface of the plant (transpiration)

Water is essential for plant metabolism, but is continuously beingl t t th t h th h th t t

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 101/111

101

lost to the atmosphere through the stomata.

Photosynthesis requires a supply of CO2

entering the stomatafrom the atmosphere.

Therefore, plants need to minimize the loss of water to theatmosphere and the need to allow the diffusion of CO2.

Closing the stomata can control water loss.

However, the opening of stomata at times helps CO2 to enter anddissolves in the water on the walls of the intercellular spaces

 below the stomata, before entering the plant¶s cells.

A plant must responds both to the need to conserve water and therequirement of CO2

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 102/111

102

Plant adaptation to the habitats

Xerophytes

Hydrophytes

Mesophytes

Halophytes

The rate of transpiration depends on whether 

conditions like humidity and the time of the day.

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 103/111

103

Xerophytes

Plants which grow in dry habitats and subjected todrought.

Example : cactus

Adaptations to reduce water loss

It has a very long, shallow, spread-out root system.

It has a swollen , succulent stems or leaves.

It has specialized leaves that may be hairy, rolled or reduced to spikes or reduced leaf size.

It has a round shape, giving it a low surface area tovolume ratio.

Adaptations to reduce water loss

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 104/111

104

It has a very long, shallow, spread-out root system.

It has a swollen , succulent stems or leaves.

It has specialized leaves that may be hairy, rolled or reduced to spikes or reduced leaf size.

It has a round shape, giving it a low surface area to volume ratio.

The stomata are sunken into pits and surrounded by hairs.

It has hairs over its surface which trap moisture.

It has thick layers of epidermis and heavily waxed on the cuticle of the leaves.

It has crassulacean acid metabolism (CAM) mechanism of photosynthesis; their stomatastay closed during the heat of the day and open during the cooler, more humid night.

Some spesies survive in the seed or spore stage and germinate, grow, flower and seed in ashort time following rainfall.

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 105/111

105

Hydrophytes

plant that lives either in very wet soil or

completely or partially submerged in

water Examples : pondweed

( El odea sp), waterlily ( Nymphaea sp).

Adaptation to survive in very wet condition;

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 106/111

106

Adaptation to survive in very wet condition;

It has absence or reduction of a root systems

It has specialized leaves (ribbonlike leaves) that may be either floatingor finely divided, with little or no cuticle

It has a few xylem tissues

It has many air holes/air chambers in the stem (for O2 and CO2storage which supply oxygen to the roots and enable them to float)

Epidermis :

to absorb nutrients from the water, not for protection (absorpingnutrients and water through their leaves)

contained chlorophyll

No stoma ± if there is, it will be at the upper part of a leaf 

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 107/111

107

Mesophytes

Plants growing under conditions in which

there is normally an adequate water supply

The majority of angiosperm plant spesies

are mesophytes, and they faced with the

 problem of water loss by evaporation fromall aerial parts

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 108/111

108

Adaptation to reduce water loss

Presence of cuticleProtected stomata whose diameters can be

regulated

Variable leaf shape

Abscission (leaf fall)

Ecological distribution based upon tolerance to

dehydration

It has stoma closed when it is very hot (daytime ±afternoon)

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 109/111

109

Halophytes

Plants which live in an environment where there is plenty of water,but they have difficulty obtaining it because it is salty

Conditions like this are found in estuaries and salt marshes

Plants adapted to live in salty conditions

Salinity changes according to environment

Examples : S  partina sp(cord grass) and mangroves

Adaptations to water conservation :

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 110/111

110

It has root cells with very low water potentials (high transpiration ability ; thereforecell water potential are lower than habitat water potential).

It has hydatode at the side of the leaves or special salt glands at the margins to excreteexcessive salt by active transport onto the leaf surface.

It has roots submerged in salt water/ knee root ± above the surface of the salty muds(mangrove)

It has an extensive systems of rhizomes for propagation.

It has adventititous root for anchorage and uptake of water as well as ions.

It has root systems that are able to tolerate high salinities. Many spesies haveextensive roots which are able to store water when it is freely available.

It is capable of storing water in its succulent tissues.

It has respiratory roots/pneumatophores which are dotted with lenticels, (small vent-like openings) that take in air and channel it to the parts of the root that are buried beneath the mud (mangrove).

8/7/2019 Biology sem1- chap9

http://slidepdf.com/reader/full/biology-sem1-chap9 111/111

That all for thischapter