Biology 151 lecture 1 2012 2013
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Transcript of Biology 151 lecture 1 2012 2013
Monday, June 18, 2012
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Monday, June 18, 2012
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Monday, June 18, 2012
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Monday, June 18, 2012
BIOLOGY 151 (INTRODUCTION TO IMMUNOLOGY)
1. Orientation2. Overview of Immunology a. History of Immunology & Famous Personalities b. General Properties & Components of the Immune System
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ORIENTATION
COURSE DESCRIPTION: Structure and Function of the Immune System; Antigen-Antibody Reactions; Genetic Control of the Immune System and Basic Immunological Techniques
COURSE CREDIT: 3 units (2 units lecture and 1 unit laboratory)
PREREQUISITES: Biology 10, 21, 22; Chemistry 40 and 40.1
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ORIENTATION
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ORIENTATION
COURSE OBJECTIVES
Monday, June 18, 2012
ORIENTATION
COURSE OBJECTIVES
Describe and differentiate the general properties and components of the immune system with focus on antigens and antibodies;
Monday, June 18, 2012
ORIENTATION
COURSE OBJECTIVES
Describe and differentiate the general properties and components of the immune system with focus on antigens and antibodies;
Distinguish and compare innate and adaptive immune responses of the body during a pathogenic or non-pathogenic challenge;
Monday, June 18, 2012
ORIENTATION
COURSE OBJECTIVES
Describe and differentiate the general properties and components of the immune system with focus on antigens and antibodies;
Distinguish and compare innate and adaptive immune responses of the body during a pathogenic or non-pathogenic challenge;
Recognize and demonstrate which diagnostic procedures will best detect antigens and antibodies;
Monday, June 18, 2012
ORIENTATION
COURSE OBJECTIVES
Describe and differentiate the general properties and components of the immune system with focus on antigens and antibodies;
Distinguish and compare innate and adaptive immune responses of the body during a pathogenic or non-pathogenic challenge;
Recognize and demonstrate which diagnostic procedures will best detect antigens and antibodies;
Be familiar with the mechanisms of the different immunodeficiencies;
Monday, June 18, 2012
ORIENTATION
COURSE OBJECTIVES
Describe and differentiate the general properties and components of the immune system with focus on antigens and antibodies;
Distinguish and compare innate and adaptive immune responses of the body during a pathogenic or non-pathogenic challenge;
Recognize and demonstrate which diagnostic procedures will best detect antigens and antibodies;
Be familiar with the mechanisms of the different immunodeficiencies;
Define and differentiate the types of vaccines and their uses; and
Monday, June 18, 2012
ORIENTATION
COURSE OBJECTIVES
Describe and differentiate the general properties and components of the immune system with focus on antigens and antibodies;
Distinguish and compare innate and adaptive immune responses of the body during a pathogenic or non-pathogenic challenge;
Recognize and demonstrate which diagnostic procedures will best detect antigens and antibodies;
Be familiar with the mechanisms of the different immunodeficiencies;
Define and differentiate the types of vaccines and their uses; and
Determine the ethical considerations in the study and applications of Immunology in research
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CALENDAR OF ACTIVITIESDATE ACTIVITY
June 19 (2 hours) ORIENTATION & OVERVIEW OF IMMUNOLOGY
History of Immunology and Famous Personalities
General properties and components: the cells and their function
June 26 (2 hours) ANTIGENS AND ANTIBODIES
July 3-10 (4 hours) INNATE & ADAPTIVE IMMUNITY
July 17-24 (4 hours) HUMORAL & CELLULAR IMMUNITY
July 31 EXAMINATION 1
August 7 (2 hours) PATHOGENESIS OF BACTERIAL INFECTIONSa. Immunity to bacteriab. Important bacterial infectionsc. Serological diagnosis to detect antigens and antibodies
August 14 (2 hours) PATHOGENESIS OF VIRAL INFECTIONSa. Immunity to virusesb. Important viral infectionsc. Serological diagnosis to detect antigens and antibodies
August 21-24 BIOWEEK CELEBRATION: CLASS POSTER PRESENTATION
August 28 (2 hours) PATHOGENESIS OF FUNGAL INFECTIONSa. Immunity to fungib. Important fungal infectionsc. Serological diagnosis to detect antigens and antibodies
September 4 (2 hours) PATHOGENESIS OF PARASITIC INFECTIONSa. Immunity to parasitesb. Important parasitic infectionsc. Serological diagnosis to detect antigens and antibodies
September 11 EXAMINATION 2
September 18 ( 2hours) IMMUNODEFICIENCIESa. Immunologic tolerance and hypersensitivitiesb. Selected immunodeficiencies (e.g. HIV, etc)
VACCINES a. types of vaccines and their designb. Philippine laws on vaccinationc. vaccine challenges
September 25 CLASS PLENARY REPORT: VACCINE CHALLENGES (HIV, pandemics, vector-borne or zoonotic diseases)
October 2 EXAMINATION 3
EXAM 1: JULY 31, 2012
EXAM 2: SEPT 11, 2012
EXAM 3: OCT 2, 2012
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COURSE REQUIREMENTA. Lecture (60%)
Lecture exams (3)! ! 60%
Quizzes! ! ! 20%
Plenary Report!! 20%
B. Laboratory (40%)
Laboratory exams (2)!! 50%
Laboratory reports! ! 10%
Journal report! ! ! 10%
Quizzes! ! ! 10%
Laboratory performance! 10%
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EXAMS & QUIZZES
EXAMS
sit-down, written exam; class hours
objective and critical thinking type
QUIZZES
individual, pair, group, class quizzes
written, oral or take-home
no make-up for missed quizzes!
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CLASS plenary
CONFERENCE-TYPE OF PAPER PRESENTATIONS
3 PAPERS: VACCINE CHALLENGES (HIV, pandemics, vector-borne or zoonotic diseases)
TASKS: Speakers, Master of Ceremonies, Moderator, Reactors, Technical Group, Logistics Group, Refreshments Group, Press Group, etc
CLASS GRADE: Absent during the presentation is given a ZERO (0) mark
Monday, June 18, 2012
your grade
PFG = lecture (60%) + laboratory (40%) rating
NOTE: This will be the final grade when exempted to take the final exams.
If the student will take the finals the rating will be computed as follows, which should be no lower than 60% or 3.0:
RATING = PFG (80%) + Score in Finals Exam (20%)
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OUR TEXTBOOK
Abbas, Abul K. and Andrew H. Lichtman. 2004. Basic Immunology: Function and Disorders of the Immune System. 2nd ed.
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POLICIESThe student should be able to pass (PFG = 3.0) both lecture and laboratory component to pass the course
There will be no make-up exams, missed exams will qualify students to take the final examination. The score in the final exam may replace the missed exam. However, in the case of two missed exams, the other exam will have a score of zero (0)
The student should be able to incur a PFG of 2.0 or better to be exempted to take the written final exam
Should the student fail the final exam, an oral removal exam to satisfy the course competencies will be given to pass the course. The grade to be given here shall only be a “pass” (3.0) or “fail” (5.0)
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QUESTIONS???Monday, June 18, 2012
RECALL from BIOLOGY 120THE WAR WITH
MICROBES...
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HOW WE FIGHT INFECTIONS...
www.youtube.com/watch?v=T_4TrNRa3v8Monday, June 18, 2012
TODAY....Looking back.........
famous personalities
how it all started
Who’s who of our immune system...
cells
general functions
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International Journal of Infectious DiseasesVolume 3, Issue 1, July-September 1998, Pages 54-60
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!▪! 2001 – Discovery of FOXP3 – the gene directing regulatory T cell development!▪! 2005 – Development of human papillomavirus vaccine (Ian Frazer)
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CELLS & ORGANS OF THE IMMUNE SYSTEM
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INNATE
HUMORAL
complement system
CELLULAR
monocytes (macrophages, dendritic cells)
NKC (natural killer cells)
granulocytes (mast cells and , basophils, eosinophils, neutrophils)
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ADAPTIVE
HUMORAL
antibodies
complement system
CELLULAR
B cells
T cells
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organs of the immune system
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MUST KNOW...ANTIGEN
ANTIBODIES
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OJT: IMMUNE CELLS
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OJT: IMMUNE CELLS
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OUR IMMUNE SYSTEMPhysiologic function of the immune system:
prevent infections
eradicate established infections
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vaccines: stimulation of our Immune System
OUR IMMUNE SYSTEM
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INNATE: immunity which mediates the initial protection against infections
always present in health individuals
block the entry of microbes and rapidly eliminate microbes that do succeed in entering host tissues
ADAPTIVE: immunity which!develop more slowly and mediates innate immunity
more effective defense against infections
specific or acquired
stimulated by microbes that invade tissues
adapts to the presence of microbial invaders
overview: host defense mechanisms
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overview: host defense mechanisms
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OVERVIEW: HUMORAL & CELL-MEDIATED IMMUNITY
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NOTE: ADAPTIVE RESPONSE
Immunity may be induced in an individual by infection or vaccination (active immunity) or conferred on an individual by transfer of antibodies or lymphocytes from an actively immunized individual (passive immunity)
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SPECIFICITY & MEMORY
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OVERVIEW: PHASES OF ADAPTIVE IMMUNITY
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MAJOR CHARACTERS OF THE IMMUNE SYSTEM
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THE EFFECTOR FUNCTIONS
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When naive lymphocytes recognize microbial antigens and also receive additional ("second) signals induced by microbes, the antigen-specific lymphocytes proliferate and differentiate into effector cells and memory cells
Naive lymphocytes express receptors for antigens but do not perform the functions that are required to eliminate antigens
Differentiation into effector cells and memory cells is initiated by antigen recognition, thus ensuring that the immune response that develops is specific for the antigen
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END OF LECTURE 1
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