BIOENGINEERED NANOROBOTICS FOR CANCER THERAPY
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Transcript of BIOENGINEERED NANOROBOTICS FOR CANCER THERAPY
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WELCOME
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Guided by, Presented By, Mrs. ABHILA.R.KRISHNA SIVAJITH.S ASST. PROFESSOR EC-B,S7 ECE DEPARTMENT ROLL NO:30 TKMIT TKMIT
BIOENGINEERED NANOROBOTICS FOR CANCER THERAPY
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OVERVIEW Introduction Nanorobots Nanorobot Core Power Supply Propulsion Sensing and Actuation Control and Decision Making Integration Advantages Disadvantages Application Conclusion
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IntroductionCancer
Uncontrolled Growth Of CellsSpread all over the body It Cause death
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Treatment
Kills Healthy CellsFatigueHair Loss
Side Effects
Radiation Therapy Chemotherapy
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NanoRobotsThe technology of creating machines or robots
at or close to the microscopic scale of a nanometer (10−9 meters).
Nanorobots are devices made from DNA that are so small they can be injected into the bloodstream and carry a payload of drugs to specific cells.
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Cure Using Nanorobots
Inject nanorobots into patient
Detect cancer Cells Destroy Cells Do not affect on
Healthy Cells
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Contd. Nano Infinitesimally Small Scale of Manufacturing And Fabricating Materials
NanoRobot Tiny machine Perform specific task
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Nanorobot CoreThe core is a polysaccharide-based nanoparticle or cyclic
peptide nanotubeCyclic peptide has ability to self-assemble into
monodisperse nanotubes, are well suited to the coreCapable of carrying a payloadAllow the incorporation of propulsive, sensing and
actuating componentsFloat freely inside the bodyDetect the tumor effectively
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Core of Nanorobots
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Cant use conventional sources ATP released from core Production of heat in the human body Inclusion of electrodes in nanorobots and
electrolytes in human blood will act as battery Combination of chemical reactions in human
blood and chemicals in nanorobots will lead to the formation of fuel source
Power Supply
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Propulsion
Fully functional flagella isolated from E.coliArtificial bacterial flagella(ABF) to move in 3DABF are often fabricated from helical nanobelts with soft
magnetic heads composed of Cr/Ni/AuIt has ability to drive the nanorobots into the tumor tissue
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Sensing and Actuation Capable of sensing and recognizing the targeted
cancer cellsChemical sensors which detect the target moleculesAptamers (derived from the latin aptus, meaning to
fit) are artificial nucleic acid (DNA or RNA) Biomarkers can be specific cells, molecules, or genes,
gene products, enzymes, or hormones.
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Schematic of the cyclic peptide nanorobot core with the aptamers designed for closing and locking the nanotube.
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Aptamer-target interaction
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Control and Decision Making
Use directional control, which is necessary for tumor targeting
Phototactic control to direct the nanorobot to the tumor location
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Integration
First step is fabrication of power supply(ATP containing nanoparticle)
Second step is load the power supply into the coreFinal step is attachment of propulsion system to the
core
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Nanorobots can be used in blood cell to detect pathogens.
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AdvantagesSmall SizeInexpensive(if mass produced)No maintenanceAutomatedPainless TreatmentEasily DisposableAffect only cancer cellsRapid elimination of disease.
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Disadvantage
Initial Design Cost highVery complicate design
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Applications
Breaking up blood clots Fighting cancer Parasite Removal Breaking up kidney stones
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ConclusionWith the introduction of nanorobots, humans can
overcome many type of diseases
It can also helpful in the detection of diseases
Decision making nanorobots are the future of nanorobotic technology
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References R. Baum, “Nanotechnology: Drexler and Smalley make the case for
and against ‘molecular assemblers’,” Chem. Eng. News, vol. 81, pp. 37–42, 2003.
M. Sitti, “Microscale and nanoscale robotics systems [grand challenges of robotics],” IEEE Robot. Autom. Mag., vol. 14, no. 1, pp. 53–60, Mar. 2007.
https://en.wikipedia.org/wiki/Nanorobotics http://hansmalab.physics.ucsb.edu/phys150/nanotech.pdf http://nano-bio.ehu.es/files/nanorobots_work.pdf http://www.roboticsbible.com/power-sources-of-nanorobots.html http://icmr.nic.in/ijmr/2010/august/0803.pdf
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Thank You