Chemical Reactor Analysis and Design Fundamentals - Rawlings
Bio Reactor Design Fundamentals
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Transcript of Bio Reactor Design Fundamentals
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Bioreactor Design – Fundamentals
The most widely used Industrial Bioreactors are:
•Batch Reactors•Continuous Reactors
•Continuous Reactors With Recycle•Semi Continuous Reactors
(“Fill/Draw” Reactors including Sequencing Batch Reactors)
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Bioreactor Design – Fundamentals (Cont’d)DEFINITIONS
“Limiting Substrate”The substrate or substrate(s) (energy source, carbon source and/or nutrient source) which is/are first exhausted in batch growth. This substrate(s) has a direct influence on the kinetics of cell growth.
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Bioreactor Design – Fundamentals (Cont’d)
DEFINITIONS“In Excess”
The substrate or substrate(s) (energy source, carbon source
and/or nutrient source) which is/are NOT exhausted at the end of
batch growth. This substrate(s) has NO EFFECT on the kinetics of cell
growth.
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Bioreactor Design – Fundamentals (Cont’d)
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Bioeactor Design – Fundamentals (Cont’d)
k1* and A are combined to form another constant k and the rate expression
becomes:RATE = k (S / KS + S)
Where k = maximum rate of transport of S ( mol / h)
When S is much larger than KS :RATE ≈ k ≠ f (S)
When S is similar to KS :RATE = f (S)
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Bioreactor Design – Fundamentals (Cont’d)
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Bioreactor Design – Fundamentals (Cont’d)
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Bioreactor Design – Fundamentals (Cont’d)
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Bioreactor Design – Fundamentals (Cont’d)
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Bioreactor Design – Fundamentals (Cont’d)
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Bioreactor Design – Fundamentals (Cont’d)
THE LAG PHASE
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Bioreactor Design – Fundamentals (Cont’d)
THE LAG PHASE
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Bioreactor Design – Fundamentals (Cont’d)
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Bioreactor Design – Fundamentals (Cont’d)
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Bioreactor Design – Fundamentals (Cont’d)
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Bioreactor Design – Fundamentals (Cont’d)
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Bioreactor Design – Fundamentals (Cont’d)
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Bioreactor Design – Fundamentals (Cont’d)
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Bioreactor Design – Fundamentals (Cont’d)
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Bioreactor Design – Fundamentals (Cont’d)
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Bioreactor Design – Fundamentals (Cont’d)
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Bioreactor Design – Fundamentals (Cont’d)
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Bioreactor Design Fundamentals
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Bioreactor Design Fundamentals (Cont’d)
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Bioreactor Design Fundamentals (Cont’d)
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Bioreactor Design Fundamentals (Cont’d)
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Bioreactor Design Fundamentals (Cont’d)
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Bioreactor Design Fundamentals (Cont’d)
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Bioreactor Design Fundamentals (Cont’d)
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Bioreactor Design Fundamentals (Cont’d)
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Bioreactor Design Fundamentals (Cont’d)
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Bioreactor Design Fundamentals (Cont’d)
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Bioreactor Design Fundamentals (Cont’d)
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Bioreactor Design Fundamentals (Cont’d)
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Bioreactor Design Fundamentals (Cont’d)
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Bioreactor Design Fundamentals (Cont’d)
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Bioreactor Design Fundamentals (Cont’d)
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Bioreactor Design Fundamentals (Cont’d)
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Bioreactor Design Fundamentals (Cont’d)
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Bioreactor Design Fundamentals (Cont’d)
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Bioreactor Design Fundamentals (Cont’d)