copy1300

Theoretical Exploration of

Protein Liquid Crystal

Multi port fitment - can be used for nutrient addition

gas exhaustfoam trap acid

addition media filling inoculation

1L Disposable bioreactor bag

Sampling port

Thermal Jacket

Perfusion connection

Connection for pH T or DO probe with aseptic connector Easy drain connector

Frame Lock

Frame

Frame Lock

Closed Reactor Magnetic Stirring

USB Data Control Unit

Frame Frame

Transmission Coupler

Magnetic Agitator

Single-use Bioreactor

Disposable Vessel

1 Liter Desktop

Thermal Liquid Frame

Magnetic Stirring

Hayden3246

IP All Rights 2011

CleanCase

Access Panel

Hinge

Bubble Jet

Sparger

H20 Port H20 Port

GLYCERINE 2XR

Live cell

Bioreactor

Loom Port

Fore

Aft

Continuous Seine Pharmaceutical Protein Liquid Crystal Bulk Cycle Bioreactor Loom

CLONE STAGE

LOOP

INDUCTION

EXHAUST

CLEAN ASSEMBLY

RECEPTION INJECTION

GLYCERINE XR100L

BIOLOOM

SOUP

GOOP

COIL

BATH

STUFF BLOOM DANCE

HARVEST

PROGRAM

PRANCE

BASE

MIX

MOLECULAR FORGE

Hayden3246

IP All Rights 2011

Production Research Facility Layout

Biophysics of Electron Transfer and Molecular Bioelectronics

This comprehensive guide to the biophysics of metalloproteins and the mechanisms of charge transfer through systems involving them aims to outline a summary of scientific results obtained by the world-wide research in recent years The volume appears at a time of significant progress within the field when technologies derived from it are granted central recognition for their role in the development of biotechnology electronics and material sciences

Content Level raquo Research Related subjects raquo Atomic Molecular Optical amp Plasma Physics - Biochemistry amp Biophysics - Optical amp Electronic Materials

Optical modeling of liquid crystal biosensors Hwang DK Rey AD Source Department of Chemical Engineering McGill University 3610 University Street Montreal Quebec H3A 2B2 Canada Abstract Optical simulations of a liquid crystal biosensor device are performed using an integrated opticaltextural model based on the equations of nematodynamics and two optical methods the Berreman optical matrix method [J Opt Soc Am 62 502 (1972)] and the discretization of the Maxwell equations based on the finite difference time domain (FDTD) method Testing the two optical methods with liquid crystal films of different degrees of orientational heterogeneities demonstrates that only the FDTD method is suitable to model this device Basic substrate-induced texturing process due to protein adsorption gives rise to an orientation correlation function that is nearly linear with the transmitted light intensity providing a basis to calibrate the device The sensitivity of transmitted light to film thickness protein surface coverage and wavelength is established A crossover incident light wavelength close to lambda(co) approximately 500 nm is found such that when lambdagtlambda(co) thinner films are more sensitive to the amount of protein surface coverage while for lambdaltlambda(co) the reverse holds In addition it is found that for all wavelengths the sensitivity increases with the amount of protein coverage The integrated device model based on FDTD optical simulations in conjunction with the Landau-de Gennes nematodynamics model provides a rational basis for further progress in liquid crystal biosensor devices

Theoretical Exploration of

Protein Liquid Crystal

Multi port fitment - can be used for nutrient addition

gas exhaustfoam trap acid

addition media filling inoculation

1L Disposable bioreactor bag

Sampling port

Thermal Jacket

Perfusion connection

Connection for pH T or DO probe with aseptic connector Easy drain connector

Frame Lock

Frame

Frame Lock

Closed Reactor Magnetic Stirring

USB Data Control Unit

Frame Frame

Transmission Coupler

Magnetic Agitator

Single-use Bioreactor

Disposable Vessel

1 Liter Desktop

Thermal Liquid Frame

Magnetic Stirring

Hayden3246

IP All Rights 2011

CleanCase

Access Panel

Hinge

Bubble Jet

Sparger

H20 Port H20 Port

GLYCERINE 2XR

Live cell

Bioreactor

Loom Port

Fore

Aft

Continuous Seine Pharmaceutical Protein Liquid Crystal Bulk Cycle Bioreactor Loom

CLONE STAGE

LOOP

INDUCTION

EXHAUST

CLEAN ASSEMBLY

RECEPTION INJECTION

GLYCERINE XR100L

BIOLOOM

SOUP

GOOP

COIL

BATH

STUFF BLOOM DANCE

HARVEST

PROGRAM

PRANCE

BASE

MIX

MOLECULAR FORGE

Hayden3246

IP All Rights 2011

Production Research Facility Layout

Biophysics of Electron Transfer and Molecular Bioelectronics

This comprehensive guide to the biophysics of metalloproteins and the mechanisms of charge transfer through systems involving them aims to outline a summary of scientific results obtained by the world-wide research in recent years The volume appears at a time of significant progress within the field when technologies derived from it are granted central recognition for their role in the development of biotechnology electronics and material sciences

Content Level raquo Research Related subjects raquo Atomic Molecular Optical amp Plasma Physics - Biochemistry amp Biophysics - Optical amp Electronic Materials

Optical modeling of liquid crystal biosensors Hwang DK Rey AD Source Department of Chemical Engineering McGill University 3610 University Street Montreal Quebec H3A 2B2 Canada Abstract Optical simulations of a liquid crystal biosensor device are performed using an integrated opticaltextural model based on the equations of nematodynamics and two optical methods the Berreman optical matrix method [J Opt Soc Am 62 502 (1972)] and the discretization of the Maxwell equations based on the finite difference time domain (FDTD) method Testing the two optical methods with liquid crystal films of different degrees of orientational heterogeneities demonstrates that only the FDTD method is suitable to model this device Basic substrate-induced texturing process due to protein adsorption gives rise to an orientation correlation function that is nearly linear with the transmitted light intensity providing a basis to calibrate the device The sensitivity of transmitted light to film thickness protein surface coverage and wavelength is established A crossover incident light wavelength close to lambda(co) approximately 500 nm is found such that when lambdagtlambda(co) thinner films are more sensitive to the amount of protein surface coverage while for lambdaltlambda(co) the reverse holds In addition it is found that for all wavelengths the sensitivity increases with the amount of protein coverage The integrated device model based on FDTD optical simulations in conjunction with the Landau-de Gennes nematodynamics model provides a rational basis for further progress in liquid crystal biosensor devices

Multi port fitment - can be used for nutrient addition

gas exhaustfoam trap acid

addition media filling inoculation

1L Disposable bioreactor bag

Sampling port

Thermal Jacket

Perfusion connection

Connection for pH T or DO probe with aseptic connector Easy drain connector

Frame Lock

Frame

Frame Lock

Closed Reactor Magnetic Stirring

USB Data Control Unit

Frame Frame

Transmission Coupler

Magnetic Agitator

Single-use Bioreactor

Disposable Vessel

1 Liter Desktop

Thermal Liquid Frame

Magnetic Stirring

Hayden3246

IP All Rights 2011

CleanCase

Access Panel

Hinge

Bubble Jet

Sparger

H20 Port H20 Port

GLYCERINE 2XR

Live cell

Bioreactor

Loom Port

Fore

Aft

Continuous Seine Pharmaceutical Protein Liquid Crystal Bulk Cycle Bioreactor Loom

CLONE STAGE

LOOP

INDUCTION

EXHAUST

CLEAN ASSEMBLY

RECEPTION INJECTION

GLYCERINE XR100L

BIOLOOM

SOUP

GOOP

COIL

BATH

STUFF BLOOM DANCE

HARVEST

PROGRAM

PRANCE

BASE

MIX

MOLECULAR FORGE

Hayden3246

IP All Rights 2011

Production Research Facility Layout

Biophysics of Electron Transfer and Molecular Bioelectronics

This comprehensive guide to the biophysics of metalloproteins and the mechanisms of charge transfer through systems involving them aims to outline a summary of scientific results obtained by the world-wide research in recent years The volume appears at a time of significant progress within the field when technologies derived from it are granted central recognition for their role in the development of biotechnology electronics and material sciences

Content Level raquo Research Related subjects raquo Atomic Molecular Optical amp Plasma Physics - Biochemistry amp Biophysics - Optical amp Electronic Materials

Optical modeling of liquid crystal biosensors Hwang DK Rey AD Source Department of Chemical Engineering McGill University 3610 University Street Montreal Quebec H3A 2B2 Canada Abstract Optical simulations of a liquid crystal biosensor device are performed using an integrated opticaltextural model based on the equations of nematodynamics and two optical methods the Berreman optical matrix method [J Opt Soc Am 62 502 (1972)] and the discretization of the Maxwell equations based on the finite difference time domain (FDTD) method Testing the two optical methods with liquid crystal films of different degrees of orientational heterogeneities demonstrates that only the FDTD method is suitable to model this device Basic substrate-induced texturing process due to protein adsorption gives rise to an orientation correlation function that is nearly linear with the transmitted light intensity providing a basis to calibrate the device The sensitivity of transmitted light to film thickness protein surface coverage and wavelength is established A crossover incident light wavelength close to lambda(co) approximately 500 nm is found such that when lambdagtlambda(co) thinner films are more sensitive to the amount of protein surface coverage while for lambdaltlambda(co) the reverse holds In addition it is found that for all wavelengths the sensitivity increases with the amount of protein coverage The integrated device model based on FDTD optical simulations in conjunction with the Landau-de Gennes nematodynamics model provides a rational basis for further progress in liquid crystal biosensor devices

Continuous Seine Pharmaceutical Protein Liquid Crystal Bulk Cycle Bioreactor Loom

CLONE STAGE

LOOP

INDUCTION

EXHAUST

CLEAN ASSEMBLY

RECEPTION INJECTION

GLYCERINE XR100L

BIOLOOM

SOUP

GOOP

COIL

BATH

STUFF BLOOM DANCE

HARVEST

PROGRAM

PRANCE

BASE

MIX

MOLECULAR FORGE

Hayden3246

IP All Rights 2011

Production Research Facility Layout

Biophysics of Electron Transfer and Molecular Bioelectronics

This comprehensive guide to the biophysics of metalloproteins and the mechanisms of charge transfer through systems involving them aims to outline a summary of scientific results obtained by the world-wide research in recent years The volume appears at a time of significant progress within the field when technologies derived from it are granted central recognition for their role in the development of biotechnology electronics and material sciences

Content Level raquo Research Related subjects raquo Atomic Molecular Optical amp Plasma Physics - Biochemistry amp Biophysics - Optical amp Electronic Materials

Optical modeling of liquid crystal biosensors Hwang DK Rey AD Source Department of Chemical Engineering McGill University 3610 University Street Montreal Quebec H3A 2B2 Canada Abstract Optical simulations of a liquid crystal biosensor device are performed using an integrated opticaltextural model based on the equations of nematodynamics and two optical methods the Berreman optical matrix method [J Opt Soc Am 62 502 (1972)] and the discretization of the Maxwell equations based on the finite difference time domain (FDTD) method Testing the two optical methods with liquid crystal films of different degrees of orientational heterogeneities demonstrates that only the FDTD method is suitable to model this device Basic substrate-induced texturing process due to protein adsorption gives rise to an orientation correlation function that is nearly linear with the transmitted light intensity providing a basis to calibrate the device The sensitivity of transmitted light to film thickness protein surface coverage and wavelength is established A crossover incident light wavelength close to lambda(co) approximately 500 nm is found such that when lambdagtlambda(co) thinner films are more sensitive to the amount of protein surface coverage while for lambdaltlambda(co) the reverse holds In addition it is found that for all wavelengths the sensitivity increases with the amount of protein coverage The integrated device model based on FDTD optical simulations in conjunction with the Landau-de Gennes nematodynamics model provides a rational basis for further progress in liquid crystal biosensor devices

Production Research Facility Layout

Biophysics of Electron Transfer and Molecular Bioelectronics

This comprehensive guide to the biophysics of metalloproteins and the mechanisms of charge transfer through systems involving them aims to outline a summary of scientific results obtained by the world-wide research in recent years The volume appears at a time of significant progress within the field when technologies derived from it are granted central recognition for their role in the development of biotechnology electronics and material sciences

Content Level raquo Research Related subjects raquo Atomic Molecular Optical amp Plasma Physics - Biochemistry amp Biophysics - Optical amp Electronic Materials

Optical modeling of liquid crystal biosensors Hwang DK Rey AD Source Department of Chemical Engineering McGill University 3610 University Street Montreal Quebec H3A 2B2 Canada Abstract Optical simulations of a liquid crystal biosensor device are performed using an integrated opticaltextural model based on the equations of nematodynamics and two optical methods the Berreman optical matrix method [J Opt Soc Am 62 502 (1972)] and the discretization of the Maxwell equations based on the finite difference time domain (FDTD) method Testing the two optical methods with liquid crystal films of different degrees of orientational heterogeneities demonstrates that only the FDTD method is suitable to model this device Basic substrate-induced texturing process due to protein adsorption gives rise to an orientation correlation function that is nearly linear with the transmitted light intensity providing a basis to calibrate the device The sensitivity of transmitted light to film thickness protein surface coverage and wavelength is established A crossover incident light wavelength close to lambda(co) approximately 500 nm is found such that when lambdagtlambda(co) thinner films are more sensitive to the amount of protein surface coverage while for lambdaltlambda(co) the reverse holds In addition it is found that for all wavelengths the sensitivity increases with the amount of protein coverage The integrated device model based on FDTD optical simulations in conjunction with the Landau-de Gennes nematodynamics model provides a rational basis for further progress in liquid crystal biosensor devices

Biophysics of Electron Transfer and Molecular Bioelectronics

This comprehensive guide to the biophysics of metalloproteins and the mechanisms of charge transfer through systems involving them aims to outline a summary of scientific results obtained by the world-wide research in recent years The volume appears at a time of significant progress within the field when technologies derived from it are granted central recognition for their role in the development of biotechnology electronics and material sciences

Content Level raquo Research Related subjects raquo Atomic Molecular Optical amp Plasma Physics - Biochemistry amp Biophysics - Optical amp Electronic Materials

Optical modeling of liquid crystal biosensors Hwang DK Rey AD Source Department of Chemical Engineering McGill University 3610 University Street Montreal Quebec H3A 2B2 Canada Abstract Optical simulations of a liquid crystal biosensor device are performed using an integrated opticaltextural model based on the equations of nematodynamics and two optical methods the Berreman optical matrix method [J Opt Soc Am 62 502 (1972)] and the discretization of the Maxwell equations based on the finite difference time domain (FDTD) method Testing the two optical methods with liquid crystal films of different degrees of orientational heterogeneities demonstrates that only the FDTD method is suitable to model this device Basic substrate-induced texturing process due to protein adsorption gives rise to an orientation correlation function that is nearly linear with the transmitted light intensity providing a basis to calibrate the device The sensitivity of transmitted light to film thickness protein surface coverage and wavelength is established A crossover incident light wavelength close to lambda(co) approximately 500 nm is found such that when lambdagtlambda(co) thinner films are more sensitive to the amount of protein surface coverage while for lambdaltlambda(co) the reverse holds In addition it is found that for all wavelengths the sensitivity increases with the amount of protein coverage The integrated device model based on FDTD optical simulations in conjunction with the Landau-de Gennes nematodynamics model provides a rational basis for further progress in liquid crystal biosensor devices

Optical modeling of liquid crystal biosensors Hwang DK Rey AD Source Department of Chemical Engineering McGill University 3610 University Street Montreal Quebec H3A 2B2 Canada Abstract Optical simulations of a liquid crystal biosensor device are performed using an integrated opticaltextural model based on the equations of nematodynamics and two optical methods the Berreman optical matrix method [J Opt Soc Am 62 502 (1972)] and the discretization of the Maxwell equations based on the finite difference time domain (FDTD) method Testing the two optical methods with liquid crystal films of different degrees of orientational heterogeneities demonstrates that only the FDTD method is suitable to model this device Basic substrate-induced texturing process due to protein adsorption gives rise to an orientation correlation function that is nearly linear with the transmitted light intensity providing a basis to calibrate the device The sensitivity of transmitted light to film thickness protein surface coverage and wavelength is established A crossover incident light wavelength close to lambda(co) approximately 500 nm is found such that when lambdagtlambda(co) thinner films are more sensitive to the amount of protein surface coverage while for lambdaltlambda(co) the reverse holds In addition it is found that for all wavelengths the sensitivity increases with the amount of protein coverage The integrated device model based on FDTD optical simulations in conjunction with the Landau-de Gennes nematodynamics model provides a rational basis for further progress in liquid crystal biosensor devices

Bionanomolecular Electronic Engineering 1st Order Biomer CPU LCD Protein coat Carbon60 Neuraglion Implantable Device

Molecular Forge Processor

1 Million (Meg) Lemma Device Yield Stage

NanoSilo Cooling Tower BATH SHOCK SHELL

Biomolecular Materials Centrifuge

Carbon Scaffold Dock C60 Reservoir

Continuous Seine Pharmaceutical Protein Liquid Crystal Bulk Cycle Bioreactor Loom

EM CYCLE COIL BURN

HANNAKE I6

Theoretical Exploration of

Protein Liquid Crystal Electronic Gel

Protein Liquid Crystal Electronic Gel

HOW DO BIO-NEURAL GEL PACKS GET HERE

ASSEMBLY LOOM BATH WEAVE

PROGRAM BURN MARKET

Bio-neural gel packs are organic computer circuits composed of sythetic cerebral neurons suspended in a Protein Liquid Crystal Electronic Gel medium These gel packs are based on the organic organization of the humaniod brain and work a quantum faster than silicon chips relying on a best-guess decision-making process rather than a calculation based on all possible actions

hPL Protein 478 Protein Liquid Crystal Electronic Gel The technology level assessment of Protein Liquid Crystal Electronic Gel has shown this product to be of a similar state fiction echography of Star Trek This portends a phenomenal new technology and markets It is not if it is now

hPL Protein 478 Protein Liquid Crystal Electronic Gel Pack Logic Schema

NSA CSS CIA DOD NASA DOE

Molecular Forge Processor

1 Million (Meg) Lemma Device Yield Stage

NanoSilo Cooling Tower BATH SHOCK SHELL

Biomolecular Materials Centrifuge

Carbon Scaffold Dock C60 Reservoir

Continuous Seine Pharmaceutical Protein Liquid Crystal Bulk Cycle Bioreactor Loom

EM CYCLE COIL BURN

HANNAKE I6

Theoretical Exploration of

Protein Liquid Crystal Electronic Gel

Protein Liquid Crystal Electronic Gel

HOW DO BIO-NEURAL GEL PACKS GET HERE

ASSEMBLY LOOM BATH WEAVE

PROGRAM BURN MARKET

Bio-neural gel packs are organic computer circuits composed of sythetic cerebral neurons suspended in a Protein Liquid Crystal Electronic Gel medium These gel packs are based on the organic organization of the humaniod brain and work a quantum faster than silicon chips relying on a best-guess decision-making process rather than a calculation based on all possible actions

hPL Protein 478 Protein Liquid Crystal Electronic Gel The technology level assessment of Protein Liquid Crystal Electronic Gel has shown this product to be of a similar state fiction echography of Star Trek This portends a phenomenal new technology and markets It is not if it is now

hPL Protein 478 Protein Liquid Crystal Electronic Gel Pack Logic Schema

NSA CSS CIA DOD NASA DOE

Theoretical Exploration of

Protein Liquid Crystal Electronic Gel

Protein Liquid Crystal Electronic Gel

HOW DO BIO-NEURAL GEL PACKS GET HERE

ASSEMBLY LOOM BATH WEAVE

PROGRAM BURN MARKET

Bio-neural gel packs are organic computer circuits composed of sythetic cerebral neurons suspended in a Protein Liquid Crystal Electronic Gel medium These gel packs are based on the organic organization of the humaniod brain and work a quantum faster than silicon chips relying on a best-guess decision-making process rather than a calculation based on all possible actions

hPL Protein 478 Protein Liquid Crystal Electronic Gel The technology level assessment of Protein Liquid Crystal Electronic Gel has shown this product to be of a similar state fiction echography of Star Trek This portends a phenomenal new technology and markets It is not if it is now

hPL Protein 478 Protein Liquid Crystal Electronic Gel Pack Logic Schema

NSA CSS CIA DOD NASA DOE

Protein Liquid Crystal Electronic Gel

HOW DO BIO-NEURAL GEL PACKS GET HERE

ASSEMBLY LOOM BATH WEAVE

PROGRAM BURN MARKET

Bio-neural gel packs are organic computer circuits composed of sythetic cerebral neurons suspended in a Protein Liquid Crystal Electronic Gel medium These gel packs are based on the organic organization of the humaniod brain and work a quantum faster than silicon chips relying on a best-guess decision-making process rather than a calculation based on all possible actions

hPL Protein 478 Protein Liquid Crystal Electronic Gel The technology level assessment of Protein Liquid Crystal Electronic Gel has shown this product to be of a similar state fiction echography of Star Trek This portends a phenomenal new technology and markets It is not if it is now

hPL Protein 478 Protein Liquid Crystal Electronic Gel Pack Logic Schema

NSA CSS CIA DOD NASA DOE

hPL Protein 478 Protein Liquid Crystal Electronic Gel The technology level assessment of Protein Liquid Crystal Electronic Gel has shown this product to be of a similar state fiction echography of Star Trek This portends a phenomenal new technology and markets It is not if it is now

hPL Protein 478 Protein Liquid Crystal Electronic Gel Pack Logic Schema

NSA CSS CIA DOD NASA DOE

hPL Protein 478 Protein Liquid Crystal Electronic Gel Pack Logic Schema

NSA CSS CIA DOD NASA DOE

NSA CSS CIA DOD NASA DOE